It's Not Just the Sun: deCODE Discovers Sequence Variants Affecting Susceptibility to Skin Cancer
... One of these, in the keratin 5 (KRT5) gene on chromosome
12, leads to a subtle but potentially damaging ... greater risk. Another of the SNPs is located on chromosome
9p21, the same region of the genome that deCODE ... to demonstrate that a third risk variant, on chromosome
7q32, confers greater risk if inherited from the ...
Chromosome breakpoints contribute to genetic variation
... contrary to decades of evolutionary thought chromosome
regions that are prone to breakage when new ... cow genome .
"Our results demonstrate that chromosome
breakage in evolution is non-random and that the ... more susceptible to breakage, Lewin said. (The chromosome
analysis was facilitated by Evolution Highway, a ...
deCODE and Celera Partner to Expand use of deCODE Risk Markers for Heart Attack, Stroke and Diabetes
... letter variations in the human genome
(SNPs) on chromosome
9p21 linked to increased risk of heart attack and aortic
aneurysm, SNPs on chromosome
4q25 conferring risk of AF and stroke, and ... who carry two copies of the at-risk SNPs on chromosome
are at an approximately 60% greater than ...
Multinational deCODE Study Identifies New Link Between Inflammation and Heart Attack
... Sweden, Australia, and
South Korea. A SNP on chromosome
2q12 was associated with increased risk ... disease,
and our own discoveries on chromosome
9p21 and in the leukotriene pathway
have helped ... and senior author on
The SNP on chromosome
12q24 associated with heart attack risk is in ...
deCODE genetics Announces Third Quarter 2008 Financial Results
... of the first variant, a version of a SNP on chromosome
8q24, putting them at a 50% higher risk of ... two copies of a common version of another SNP on chromosome
3 were found to be at a 40% higher risk of the ... and sunburn. These SNPs, both located on chromosome
1, may therefore provide new insight into an ...
deCODE genetics Announces Second Quarter 2008 Financial Results
... The SNPs are
located in the LOXL1 gene on chromosome
15, and confer respectively 26-fold
and 8-fold ... deCODE's
analysis of known variants located on chromosome
10q26 and accounting for
approximately 16% of ... near the ASIP
(agouti signaling protein) gene on chromosome
20 that greatly increase the
likelihood of an ...
deCODE Discovers Fourth Major Set of Common Genetic Variants Linked to Risk of Estrogen Receptor-Positive Breast Cancer
... of two common
single-letter variants (SNPs) on chromosome
5 of the human genome that are
associated with ... cancers overall. The paper, 'Common
variants on chromosome
5p12 confer susceptibility to ... that a fourth known set
of variants, located on chromosome
10q26 and accounting for approximately
16% of ...
Venter Institute Scientists Create First Synthetic Bacterial Genome
... the synthetic version of the M.
began first by resequencing the native M. ... genome
of more than 580,000 base pairs. The final chromosome
was again sequenced
in order to validate the ... to transplant a fully synthetic
into a living organism and "boot up" the cell.
Matrix Genomics, Elizabeth Corder, PhD - Gene Variation in the LRRK2 Gene and High Risk for Parkinson's Disease
... general population. The signature is found in the LRRK2 gene located on chromosome
12. The work was led by Elizabeth Corder, PhD, Scientific director at ... general population. The signature is found in the LRRK2 gene located on chromosome
12. The work was led by Elizabeth H. Corder , PhD, Scientific Director at ...
deCODE genetics Announces First Quarter 2009 Financial Results
... 2 diabetes (T2D). The markers include
SNPs discovered by deCODE on chromosome
9p21 linked to increased risk
of heart attack and types of aneurysm, on chromosome
risk of AF and stroke, and in the TCF7L2 gene linked ...
deCODE Discovers Common Genetic Variations Contributing to Low Bone Mineral Density and Risk of Osteoporosis
... are known to be involved in bone and skeletal
development. The SNPs on chromosome
17 are adjacent to the SOST gene, which
encodes sclerostin, a protein involved in the formation of bone. And the SNP
18 lies close to the TNFRSF11A gene that has been implicated in
J. Craig Venter Institute Researchers Publish Significant Advance in Genome Assembly Technology
... homologous recombination (a process that cells naturally use to repair chromosome
Realizing how robustly yeast performed, the team ... is still working on experiments to install a fully synthetic bacterial chromosome
into a recipient cell and thus "boot up" a synthetic chromosome.
Major Independent Study Underscores Utility of deCODE MI(TM) for Better Predicting Risk of Heart Attack, Informing Statin Therapy
... (ARIC) study,
demonstrating that measuring the genetic risk factor on chromosome
detected by the deCODE MI(TM) test complements traditional risk ... deCODE discovered single-letter variations in the human
genome (SNPs) on chromosome
9p21 that increase risk of heart attack, and
launched its deCODE MI(TM) ...
deCODE genetics Announces First Quarter 2008 Financial Results
... receptor-positive (ER+) breast cancer. The latest SNPs are on chromosome
5p12, and although these variants confer modest risk, they are so ... paper also reveals that a fourth known set of variants, located on chromosome
10q26 and accounting for approximately 16% of breast cancers, appear ...
deCODE genetics Announces Third Quarter 2007 Financial Results
... myocardial infarction (MI), or heart attack. The SNPs are located on chromosome
9 and were discovered by deCODE earlier this year. As described in the ... subtype of glaucoma. The SNPs are located in the LOXL1 gene on chromosome
15, and confer respectively 26-fold and 8-fold increases in risk of ...
deCODE Discovers a Gene Linked to Risk of Kidney Stones and Osteoporosis
... and decreased bone mineral
density (BMD). About 60% of the population carry two copies of a
single-letter variation in the human genome (SNP) on chromosome
them at roughly 65% greater likelihood of developing kidney stones than those
who carry no copies. This single variant may thus account ...
Fallopian tubes offer new stem cell source
... stem cells could be easily isolated and expanded in vitro, and are able to differentiate into muscle, fat, cartilage and bone cell lines. The cells' chromosome
complement showed no abnormalities, suggesting chromosomal stability. Jazedje comments, "In addition to providing an additional potential source for ...
Telik Reports Preclinical Results at AACR Annual Meeting
... of Action of Orally Active Aurora Kinase/ VEGFR Inhibitors; Abstract # 1764
Aurora kinases are Ser/Thr kinases that play an important role in chromosome
alignment, segregation and cytokinesis during mitosis. Over-expression of Aurora kinases has been demonstrated in both solid tumors and leukemia and ...
Beyond associations: Colorectal cancer culprit found
... led by Dr. Richard Houlston of The Institute of Cancer Research in the United Kingdom have delved into the biology underlying common variants on chromosome
18 that his group recently found to be associated with colorectal cancer in a GWAS. They sequenced the region of DNA surrounding these markers in a ...
New cow genome sequence released
... synteny map increases the number of syntenic breakpoints by approximately 30%. Salzberg's team also pinpointed a portion of the Bos taurus Y chromosome
for the first time.
"Until the assembly is truly finished - a state that no mammalian genome, including human, has yet reached - we will continue ...
deCODE Discovers First Genetic Variant Conferring Increased Risk of Essential Tremor
... of a total of more than 16,000
patients and healthy subjects from Iceland, Austria, Germany and the United
States. It is located on the long arm of chromosome
15 in the LINGO1 gene,
which encodes a protein that has been shown to affect how neurons are formed
and signal each other. This makes the finding ...
A Scientific Milestone: Sex of Dolphin at SeaWorld San Diego Determined Prior to Conception
... XY Inc. SeaWorld and Busch Gardens Reproductive
Research Center modified the technology to separate dolphin sperm that carry a
female-producing X chromosome
from sperm that carry a male-producing Y
chromosome. Following separation into female and male populations, sperm are
frozen and stored for future ...
deCODE Study Expands Clinical Utility of deCODE AF(TM) for Improving the Diagnosis of Atrial Fibrillation and Preventing Stroke
... CEO of
deCODE, a board-certified neurologist and neuropathologist.
About deCODE AF(TM) and this study
In 2007, deCODE discovered two SNPs on chromosome
4q25 that double the
risk of atrial fibrillation, and later that year launched deCODE AF(TM) to
enable doctors to detect these SNPs in their ....
JCI table of contents: April 22, 2008
... protein, AD is classified as a tauopathy. Other tauopathies include the neurodegenerative disease frontotemporal dementia and parkinsonism linked to chromosome
17 (FTDP-17). Although the tau protein in individuals with AD is not mutated, mice carrying the mutated forms of tau found in individuals with ...
A Smoking Gene: deCODE Shows How a Single Variant in the Sequence of the Genome Confers Nicotine Dependence and Risk of Lung Cancer and Other Disease
... increasing the effectiveness of smoking cessation efforts, and of
predicting risk of lung cancer and PAD.
The SNP, rs1051730, is located on chromosome
15q24 in a nicotine
acetylcholine receptor called CHRNA3. The paper, 'A variant associated with
nicotine dependence, lung cancer and peripheral ...
Lentigen Corporation Announces Exclusive Licensing Agreement With Case Western Reserve University to Develop Novel Stem-Cell Therapy for Brain Cancer
... complex. This complex
enters the nucleus incorporating into the chromosomal DNA creating a stable
molecule. The gene sequence is integrated in the chromosome
and is copied
along with the DNA during ongoing cell division.
About Lentigen Corporation
Lentigen Corporation is a privately owned biotechnology ...
DMetrix and the Armed Forces Radiobiology Research Institute Announce Cooperative Research and Development Agreement
... announced today that they have entered into a
cooperative research and development agreement to improve the speed and
accuracy of detecting dicentric chromosome
aberrations for radiation dose
The agreement will integrate DMetrix's EX-40(R) high-throughput array
microscope imaging system into ...
DNA Testing Systems Inks Agreement with DNAPrint Genomics
... said Yates, "and
probably want to keep it that way." In addition to biogeographical DNA
tests, the company also sells traditional paternity, Y chromosome
and mitochondrial (female-passed DNA) tests.
For more information, visit DNA Testing at
http://www.dnaconsultants.com or call toll free ...
deCODE Discovers Gene Variants that May Help to Distribute the Work of Evolution between Men and Women
... variants in the sequence of the human genome (SNPs) that
regulate one of the principle motors of evolution. Versions of the two
SNPs, located on chromosome
4p16, have a genome-wide impact on the rate of
recombination -- the reshuffling of the genome that occurs in the formation
of eggs and sperm. ...
Discovery of new cause of mental retardation simplifies search for treatments
... brains memory center.
A new mechanism opens possibilities
The VIB scientists research is showing for the first time that the duplication of a chromosome
region − whereby proteins are produced in too high a concentration − can lead to mental retardation. This is totally new information in ...
Susan G. Komen for the Cure Announces Recipients of 2007 Komen Brinker Award for Scientific Distinction
... He is credited with the development and implementation of many
important technologies, including high-speed sorting; flow karyotyping; the
painting probes; development of interphase fluorescent in
situ hybridization (FISH); and the first demonstration using FISH showing
Basic Scientist Mark Roth Wins MacArthur Fellowship
... to be recognized by such a
wonderful organization," said Roth, who has pursued a variety of research
avenues, including studies on gene regulation, chromosome
function, autoimmune disease and, most recently, induced metabolic
hibernation. "The creative work I've been able to do has depended ...
New Initiative Has Shocking Effect: Thousands of Missourians with Abnormal Chromosome Structures Are Not Human
... of this vague and poorly written initiative, but there's one
that's immediately clear. If you're one of the thousands of Missourians
with a chromosome
abnormality, this initiative declares you not to be human
and enshrines that definition into our constitution. I find that deeply
troubling, and I ...
Rice Centromere, Supposedly Quiet Genetic Domain, Surprises
... has exposed a supposedly barren region of a rice chromosome
known as the centromere. The work, published in ... long-term goal of creating an artificial chromosome
for plants, says Jiang. Such a tool, now ... says Jiang, because the centromere of rice chromosome
8 lacks the vast tracts of repetitive non-coding ...
Medical College receives $11 million grant to study high blood pressure
... the impact that genes within specific regions of chromosome
13 have on salt-sensitive high blood pressure and ... how genes, all within four discrete areas of chromosome
13, impact salt-sensitive hypertension and kidney ...
A second project will study one region of chromosome
13 to identify the gene or genes that offer ...
SNPs Powerful Tools for Association Studies
... to analyze SNP alleles only on a single chromosome
in the laboratory (except for the X and Y ... Vega, 2002 and 2003) and on a collection of other chromosome
segments (Gabriel, 2002) indicate that LD ... ethnic groups. For example, sample data from chromosome
22 demonstrate that LD blocks in Caucasians ...
Amplification of genome-representative DNA from limited sources with GenomePlex WGA technology for use in genetic alterations studies
... Down syndrome is caused by an extra copy of chromosome
21 (trisomy 21), and Edwards syndrome is caused by an extra copy of chromosome
18 (trisomy 18). It is extremely important to ... research. CMA uses CGH with bacterial artificial chromosome
(BAC) or phage-derived ...
Electrophoretic Karyotypes of Wine Strains of Saccharomyces cerevisiae
... analysis leading to a direct determination of chromosome
copy number based
on densitometric ...
of cells per strain; 2) variability in chromosome
length observed for
otherwise ... indicate directly the number of copies of each chromosome
further development. Minimal ...
Map and Link Human Genetic Disorders with SSLP Analysis
... as one of a number of polymorphic
markers in chromosome
1p21. The markers were analyzed to generate haplotypes
across the region of chromosome
1 containing COL11A1. Analysis of ... pedigree. Haplotype analysis, using
markers in chromosome
6p21.3, also excluded COL11A2 as a candidate for ...