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Chromosomal in Biological Technology

Chromosome breakpoints contribute to genetic variation

... elsewhere in the chromosomes. This suggests that chromosomal organization plays an important evolutionary ... function. Scientists once hypothesized that chromosomal breakage and recombination occurred randomly ... the breakpoints occurred more often in specific chromosomal regions than in others. In 2004, Lewin and his ...

Ambry Genetics Announces the Addition of Array CGH Services Through Partnership With Baylor College of Medicine

... arrays through a partnership with Baylor College of Medicine . Large chromosomal abnormalities that are associated with over 270 genetic syndromes can be ... and genome-wide studies (GWAS). Array CGH is used to detect genome-wide chromosomal imbalances with a single laboratory test consisting of multiple probes ...

Beyond associations: Colorectal cancer culprit found

... cancer cases and controls, identifying all variants residing in this chromosomal region common to colorectal cancer patients. Houlston and colleagues ... likely the causal basis for colorectal cancer risk associated with this chromosomal region. Houlston explained, "Our efforts show that many different ...

Artemis Health Licenses Prenatal Cell-Free DNA Analysis Technology from Stanford University

... to develop a non-invasive prenatal blood test that accurately predicts chromosomal and genetic disorders. "We are thrilled to expand our proprietary ... tests for use in early pregnancy to diagnose genetic abnormalities and chromosomal aneuploidies (abnormal number of chromosomes). Through a single maternal ...

Former Telomolecular CEO Clarifies SEC Settlement

... to treat diseases of aging and cancer, particularly diseases related to chromosomal telomere shortening. The Company worked with a number of known U.S. ... of the same DNA. Studies performed by UCLA suggest that the elongation of chromosomal telomeres might prove to be effective and safe in the treatment of HIV in ...

JCI table of contents: Dec. 3, 2007

... differentiation, including the expression of genes found in platelets and chromosomal duplication. Similarly, megakaryocytes from mice deficient in STAT1 lacked the chromosomal duplication inherent to this cell type. The authors concluded from these ...

Empire Genomics and Reprogenetics Join Forces to Improve Preimplantation Genetic Diagnosis (PGD)

... determines gains or losses of genetic material to streamline screening for chromosomal defects such as Down's syndrome. DNA microarray technology places DNA ... New York, utilizes proprietary techniques to identify and quantify chromosomal abnormalities. Specifically the company has evolved array-based ...

New Initiative Has Shocking Effect: Thousands of Missourians with Abnormal Chromosome Structures Are Not Human

... and scientifically unsound that it would exclude Missourians with common chromosomal abnormalities like Down, Klinefelter and Turner syndromes from its ... do not have a "complete set" of genetic information through small chromosomal variations. Added Dena Ladd, a longtime child and patient advocate, "It's ...

Fallopian tubes offer new stem cell source

... and are able to differentiate into muscle, fat, cartilage and bone cell lines. The cells' chromosome complement showed no abnormalities, suggesting chromosomal stability. Jazedje comments, "In addition to providing an additional potential source for regenerative medicine, these findings might contribute to ...

International science consortium publishes analysis of domestic cattle genome sequence

... a form of mental retardation and other neurological and birth defects. In the domestic cattle genome, researchers found that some of these chromosomal rearrangements affect genes related to immunity, metabolism, digestion, reproduction and lactation. For instance, researchers think some of these ...

Lentigen Corporation Announces Exclusive Licensing Agreement With Case Western Reserve University to Develop Novel Stem-Cell Therapy for Brain Cancer

... sequence is then incorporated into the cell via reverse transcription creating a DNA complex. This complex enters the nucleus incorporating into the chromosomal DNA creating a stable molecule. The gene sequence is integrated in the chromosome and is copied along with the DNA during ongoing cell division. ...

On the trail of rogue genetically modified pathogens

... artificial vector sequences into different subgroups based on shared sequence; these shared sequences were then compared with the natural plasmid and chromosomal sequence information so as to find regions that are unique to the artificial vectors. Nearly all the artificial vector sequences had one or more ...

DMetrix and the Armed Forces Radiobiology Research Institute Announce Cooperative Research and Development Agreement

... integrated and highly reliable system to be used to acquire digital images of whole microscope slides and to identify and quantify radiation-specific chromosomal damage to predict acute radiation syndrome and help determine patient treatment options. "After a thorough review of the commercially available ...

CuraGen and TopoTarget Announce Initiation of an NCI-sponsored Phase II Clinical Trial of Belinostat for Thymoma and Thymic Carcinoma

... activity of belinostat will also be evaluated by assessment of protein expression, changes in p21 and protein hyperacetylation, and identification of chromosomal gains or losses. Patients will be enrolled at multiple sites in the United States. "Several key targets of HDAC inhibition, including modulation of ...

Third Wave Broadens Market, Releases Genetic Technology to Early Adopters

... platform has been successfully extended to chromosomal analysis, opening a new market to the company. ... analyte-specific reagents (ASRs) for prenatal chromosomal analysis to the University of California, Los ... Wave intends to broadly launch Invader ASRs for chromosomal analysis during the fourth quarter of 2004. We ...

Amplification of genome-representative DNA from limited sources with GenomePlex WGA technology for use in genetic alterations studies

... geometric amplifications.

chromosomal imbalances: trisomy 21 and trisomy 18 ... WGA technology with a CGH array to detect chromosomal abnormalities in patients with mental and ... to establish methods that allow identification of chromosomal abnormalities without any bias when only small ...

Glossary for The BioPharm Guide to Fermentation and Cell Culture

... an immune response. artificial chromosome Synthesized DNA in chromosomal form for use as an expression vector. aseptic ... in DNA. mutation A permanent change in DNA sequence or chromosomal struc ture. mycoplasma parasitic microorganisms that ...

SNPs Powerful Tools for Association Studies

... an ordered set of alleles located on one chromosome. They reveal whether a chromosomal segment was maternally or paternally inherited and can be used to ... laboratory (except for the X and Y chromosomes, which are not part of a chromosomal pair in males) the most common way of determining haplotypes is by ...

Electrophoretic Karyotypes of Wine Strains of Saccharomyces cerevisiae

... University, Corvallis, OR 97331-6602 Abstract chromosomal profiles of wine strains of Saccharomyces cerevisiae were ... S. cerevisiae provides useful qualitative data concerning their chromosomal constitutions, a more valuable quantitative analysis that might ...

Resolution of Linear DNA Fragments From 23 Kilobases to 6 Megabases Using Biphasic Linear Switch-Time Ramping

... on a single gel (Figure 1). The gel shown in Figure 1A was 0.5% chromosomal Grade Agarose made in 0.5x TBE (45 mM Tris borate, 1.0 mM EDTA, ... and S. cerevisiae chromosomes on 0.5%, 0.4%, 0.3% and 0.2% chromosomal Grade Agarose gels. Discussion ...

MicroRNA Profiling by Array Analysis Reveals Critical BioMarkers

... leukemia (CLL) patients commonly exhibit a chromosomal abnormality at 13q14. No known tumor suppressor genes ... had the rearrangement. (4) A comparison of the chromosomal locations of 186 miRNA genes and cancer-associated ...

Molecular Cloning Systems Gets Distributor

... Agencourt will be the sole distributor of Lucigens CloneSmart cloning kits and research products. Researchers often encounter certain genes, chromosomal regions or entire genomes that are especially difficult to clone. Lucigens CloneSmart technology was designed specifically to eliminate many of the ...

Molecular Cloning Systems Gets Distributor

... Researchers often encounter certain genes, chromosomal regions or entire genomes that are especially difficult to clone. Lucigen's CloneSmart technology was designed specifically to eliminate many of the ...

Barriers Outlined for Wisconsins Biotech Growth

... vivarium or rat housing facility -- in the center. Physiogenix develops and sells specialized research rat models developed through a process of chromosomal substitution. The customized rats help researchers screen potential new drug compounds, study the mechanisms of the disease, and better predict human ...

Wisconsin-based Third Wave reports increased revenue for 2003, fourth quarter

... for high-volume customers, launch a HCV genotyping assay, establish clinical trials program for an HCV viral load prototype assay, release a prenatal chromosomal analysis product, release a HPV detection product and introduce various CYP450 products that are designed to better identify drug response in ...

NimbleGen microarrays speed genetic findings

... in producing the specific arrays. The company's ability to "rapidly generate custom-designed, high density oligo arrays targeted to the specific chromosomal regions we were interested in provide us the key data in our study," he said. "Having these tools in hand gave us, in a single experiment, what ...

IPO-bound NimbleGen traveling in fast company

... Institute . Dr. Andrew Sharp, a senior fellow of the University of Washington, said NimbleGen's high-density arrays, which were targeted to specific chromosomal regions, provided in a single experiment what would have taken months to discover using conventional methods. The company has entered into a ...

Quantitative Analysis of the Cell Cycle in Imaging Applications

... their environment and grow (synthesize RNA and proteins). Once conditions are optimal, cells commit to DNA synthesis (S phase) and replicate their chromosomal DNA. The G2 phase (second gap) follows when cells continue to grow and prepare for mitosis (M phase, division). The G2 gap allows time for the cell ...

Laser Capture Microdissection of Cells Labeled with Enhanced Green Fluorescent Protein

... when expressed as a free protein, fixation is required to prevent leaching of the protein and retain fluorescence after cryosectioning. Recently, chromosomal expression of EGFP from transgenic reporter constructs has been adopted for use as a cell type-specific label in transgenic mice. The combination of ...

GenomiPhi amplification of FFPE tissue DNA for array CGH

... The characterization of FFPE samples by clinical laboratories is mostly limited to cytogenetic techniques that analyze genetic changes at the chromosomal level (1). Because DNA purified from FFPE tissue slides is highly degraded, damaged, and available only in small quantities, there has been little ...

GenomiPhi: protocol for BAC amplification and fabrication of slides for array CGH

... methods produced similar DNA yields, sensitivity and performance. We also showed that BAC DNA generated by the GenomiPhi method detected all 8p12 chromosomal amplifications that were also detected by the DOP-PCR method in an MDA-MB-134 breast cancer line. References ...

Transformation of Filamentous Fungi by Microprojectile Bombardment

... to result from a single cross-over event (type I or type II as illustrated by Lemke and Peng, 1995) between the plasmid and chromosomal DNA. Conclusions Aspergillus nidulans conidia are an ideal target for transformation by ...

Quantitation of GAD67 Gene Expression in Prefrontal Cortex of Schizophrenia Patients Using the iCycler iQ Detection System and Molecular Beacons, Rev A

... the 58C annealing steps. Assessment of DNA Contamination in RNA Samples In order to measure the level of contaminating chromosomal DNA, all RNA samples not treated with reverse transcriptase and their respective cDNA samples were subjected to PCR using GAD67 ...

Identification of Disease Causing Mutations in Phenylketonuria by Denaturing Gradient Gel Electrophoresis Using the DCode System

... The disease most frequently is caused by mutations in the phenylalanine hydroxylase gene. This gene is situated at the human chromosomal locus 12q22-q24.1 and encodes a hepatic enzyme that hydroxylates phenylalanine (PAH; phenylalanine 4-monooxygenase, EC ...

The let-7 microRNA Family Regulates RAS: Implications for Development and Oncogenesis

... by Takamizawa and colleagues [8]. In addition, several human let-7 family members have been mapped to chromosomal intervals that are deleted in lung cancers [9], providing a possible explanation for the reduced let-7 ...

Cancer-Related miRNAs Uncovered by the mirVana miRNA Microarray Platform

... target mRNAs. More than 200 miRNAs have been identified in humans, and many of the miRNA genes are located at chromosomal fragile sites associated with cancer [1]. Studies of miRNA expression profiles in cancer samples have ...

Measuring multiple apoptosis parameters with the Agilent 2100 bioanalyzer

... quick confirmation and quantitation of apoptosis in cell populations. A fast and simple protocol was applied for the extraction of fragmented, chromosomal DNA. The increased sensitivity and sizing accuracy of the DNA LabChip kit compared to conventional agarose gel electrophoresis also means that ...

PCR principles

... of more than one sequence at a time (multiplex PCR) made it possible to compare two or more complex genomes, for instance to detect chromosomal imbalances. ...

Transfection Reagent Selector Kit Handbook

... Stable transfection With stable or permanent transfection, the transfected DNA is either integrated into the chromosomal DNA or maintained as an episome. Although linear DNA results in lower DNA uptake by the cells relative to supercoiled DNA, it ...
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