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Chloride in Biological Technology

SEP Signs REGURIN(R) Deal

... this treatment.[8],[9],[10],[11] "Trospium chloride is central to managing certain types of ... has been well established.[12], [13] Trospium chloride has been recommended by NICE for the second ... for the Trospium Study Group: Once daily trospium chloride is effective and well tolerated for the treatment ...

PDS Biotechnology Corporation Finalizes Commercial Licensing Agreement with Merck Eprova AG to Utilize Merck Eprova's Enantiomers of DOTAP Chloride in Immunotherapies

... Merck Eprova's proprietary chiral lipid DOTAP chloride in Versamune(TM)-HPV and other products in ... The use of enantiomerically pure DOTAP chloride shows enhanced adjuvant activity compared to the ... AG will be providing enantiomerically pure DOTAP chloride manufactured under cGMP for use in clinical and ...

ETHEX Corporation Issues Nationwide Voluntary Recall of Products

... 800 (58177-416-04 & 416-08) Potassium chloride ER Capsules, 10mEq (58177-001-04, 001-08, 001-09, & 001-11) Potassium chloride ER Capsules, 8mEq (58177-677-04 & 677-08) Potassium chloride ER Tablets, 20mEq (58177-202-04, 202-08, 202-09 ...

SENOMYX ANNOUNCES THIRD QUARTER 2008 FINANCIAL RESULTS

... discovery of a number of enhancers of sodium chloride that are active in our salt receptor assays is an ... in taste tests. The ability to decrease sodium chloride without a negative impact on taste could ... is ongoing. The recent discovery of sodium chloride (table salt) enhancers that are active in the ...

PTC124 Shows Promising Activity in Cystic Fibrosis; Phase 2 Proof-of-Concept Data Published in the Lancet

... in statistically significant improvements in the chloride channel function of patients ... conductance regulator (CFTR) protein, a chloride channel which is required for normal function of ... improvements (p<0.05) in CFTR-mediated chloride transport with over half of the patients ...

SENOMYX ANNOUNCES FIRST QUARTER 2009 FINANCIAL RESULTS

... the Company has identified more than 160 enhancers of both sodium chloride (table salt) and potassium chloride that are active in the assays. These enhancers, which represent 12 ...

SENOMYX ANNOUNCES FOURTH QUARTER AND YEAR-END 2008 FINANCIAL RESULTS

... on SNMX-29, Senomyx has identified well over 100 enhancers of both sodium chloride (table salt) and potassium chloride that are active in the assays. These enhancers, which represent 12 ...

PTC Therapeutics Announces Encouraging Additional Phase 2 Results of PTC124 in Cystic Fibrosis

... ) Patients with CF lack the CFTR protein, a chloride channel that maintains proper hydration of epithelial cells in the lung, ... statistically significant (p<0.03) improvements of mean CFTR-dependent chloride secretion in the airways. PTC is currently conducting a third, ...

SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2009 FINANCIAL RESULTS

... of sodium in foods and beverages yet maintain the salty taste desirable to consumers. Senomyx has identified more than 250 enhancers of sodium chloride (table salt) that are active in the proprietary screening assays based on SNMX-29, the protein Senomyx believes is the primary receptor responsible ...

Successful Field-Trial Remediation of 1,2-DCA and VC Contaminated Groundwater in Northern Italy

... an operating petrochemical plant in Northern Italy. The subsurface environment at the site is impacted by 1,2-dichloroethane (1,2-DCA) and vinyl chloride (VC) about 300,000 and 500 ?g/L in groundwater, respectively. Knowing the general persistence of 1,2-DCA in the environment, initial laboratory tests ...

Bioniche Pharma Launches Enlon(R) and Enlon-Plus(R) Injection

... -- - Bioniche Pharma, a leading developer and manufacturer of injectable pharmaceuticals, announced the launch of Enlon (R) (edrophonium chloride injection, USP) and Enlon-Plus(R) (edrophonium chloride, USP and atropine sulfate, USP) Injection. (Logo: ...

Bedford Laboratories(TM) to Begin Shipping Fluconazole Injection in PVC Flexible Containers

... Bedford Laboratories will supply Fluconazole injection as a sterile iso-osmotic solution containing 2mg / mL of fluconazole in 0.9% sodium chloride diluent in the following presentations: 200mg / 100mL in single-dose PVC flexible containers packaged in cartons containing 10 bags and 400mg / ...

Frost & Sullivan Recognizes Kraton Polymers for Developing a New Generation of Polymer Grades Suitable for High-Speed Processing in Nonwoven Manufacture

... applications." Kraton Polymers' has seen technology breakthroughs in tie layers, hot melt butyl sealants, isoprene rubber latex, polyvinyl chloride (PVC) alternatives, enhanced rubber segment (ERS) polymers, and newer adhesives. In the future, the company intends to focus on sulfonated Kraton ...

Sirion Therapeutics Supplemental New Drug Application for Durezol(TM) to Treat Uveitis is Accepted for Review by the FDA

... ingredient in Durezol, is a difluorinated prednisolone derivative that has potent anti-inflammatory activity. Durezol does not contain benzalkonium chloride (BAK), an ocular preservative known to cause corneal toxicity with chronic use. This may also be important consideration for patients with uveitis, ...

Indevus Pharmaceuticals Announces Issuance of U.S. Patent for SANCTURA XR(TM)

... Supernus Pharmaceuticals, Inc. The '978 patent covers the Company's approved product, SANCTURA XR(TM), a once-a-day formulation of trospium chloride which is indicated for the treatment of symptoms of an overactive bladder. Based on calculations made by the United States Patent and Trademark ...

GeneraMedix Inc. Receives Approval for Epoprostenol for Injection 1.5 mg

... epoprostenol sodium equivalent to 1.5 mg of epoprostenol. When reconstituted and diluted for administration with Water for Injection or Sodium chloride Injection, the infusion solution is stable for up to 24 hours at room temperature. GeneraMedix's product differs from other currently available ...

Bioniche Pharma Acquires Baxter's ENLON(R) and ENLON-PLUS(R)

... pharmaceuticals, announced today the acquisition of Baxter Healthcare Corporation's ENLON product line, including: -- ENLON(R) (edrophonium chloride injection, USP) 10 mg/mL, 15 mL vial -- ENLON-PLUS(R) (edrophonium chloride, USP and atropine sulfate, USP) Injection 5 mL ampule -- ...

Baxter to Proceed With Recall of Remaining Heparin Sodium Vial Products

... This recall does not involve Baxter's heparin pre-mix IV solutions in bags: heparin sodium in 5% dextrose injection and heparin sodium in 0.9% sodium chloride injection. "We have assurance from the U.S. Food and Drug Administration that there is an adequate supply in the market to meet the demand for ...

EaglePicher Technologies Receives Battery Power Products and Technology's First Annual Innova Award

... one of the broadest ranges of electrochemistries for implantable applications including lithium-ion, lithium manganese dioxide, lithium thionyl chloride and lithium carbon monofluoride. ...

FDA Accepts Sucampo's sNDA for Lubiprostone (8 mcg) for the Treatment of Irritable Bowel Syndrome with Constipation (IBS-C)

... and Drug Administration (FDA). Sucampo Pharmaceuticals currently anticipates a decision from the FDA in the second quarter of 2008. Lubiprostone, a chloride channel activator with a novel mechanism of action, was developed by Sucampo Pharmaceuticals. The 24-mcg formulation of the drug (AMITIZA(R)) is ...

Quantitation of Oxybutynin in Rabbit Plasma Using the Varian 1200L LC/MS/MS System

... drugs for urinary tract disease is oxybutynin chloride (Figure 1). Because of the severity of the drugs ... suppositories, formulated with oxybutynin chloride were placed in the urethra of female rabbits. The ... Materials and Reagents Oxybutynin chloride from Sigma-Aldrich, Catalog Number O2881. ...

Introducing GenElute HP Endotoxin-Free Plasmid Maxiprep Kit

... in size exclusion columns and cesium chloride density gradients. Therefore, both standard and ... from a separate culture on two cesium chloride gradients (2X CsCl banding). Plasmid ... HP Maxiprep Kit as well as the 2X cesium chloride sample. The most significant difference between ...

Chemical Stability of the Brinkmann Bottletop Dispenser and the Brinkmann Bottletop Buret

... 1 Aluminum chloride 1 / 1 1 / 1 ... 1 Ammonium chloride 1 / 1 1 / 1 ... 1 / 1 Amyl chloride 1 / 1 1 / 1 ...

Chemical Stability of Disposables

... 2 Aluminum chloride 1 / 1 1 / 1 ... 3 / 3 Amyl chloride 3 / 3 3 / 3 ... 2 Benzoyl chloride 2 / 2 3 / 3 ...

High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation

... molybdate - 0.2 g/L Boric acid - 0.02 g/L Cobalt chloride - 0.5 g/L Zinc chloride - 20 g/L Ferrous sulfate . 7 H 2 O - 65.0 g/L Biotin ...

P. pastoris Fermentation using a BioFlo 110 Benchtop Fermentor

... sulfate monohydrate . . . . . . . . .. . .3 g/L Cobalt chloride (anhydrous) . . . . . . . . . . . .. . .0.5 g/L Zinc chloride (anhydrous) . . . . . . . . . . . . . .. . .20 g/L Boric acid ....

Polymer Degradation Mechanisms Encountered in Pyrolysis-GC/MS

... poly methyl methacrylate and poly vinyl chloride (PVC). Experimental ... Side-group elimination poly vinyl chloride In the polymers discussed above, the ... for some vinyl polymers, including poly vinyl chloride 3 , poly ...

Simple Purification of DNA from Plasmid Minipreps, PCR Amplifications and Agarose Gels

... to those obtained for DNA that has been purified using cesium chloride density gradients. For example, 100 pg of a 2.9-kb plasmid purified using either the StrataPrep kit or the cesium chloride density gradient method transformed Epicurian Coli XL2-Blue ...

Highest Transfection Efficiency of an Endotoxin-Sensitive Mammalian Cell Line

... a kit based on anion exchange chromatography, magnetic beads, and cesium chloride density gradient centrifugation. Plasmid yields and purity (as judged by ... Plasmid DNA Purification system (MB: magnetic beads), and cesium chloride density gradient centrifugation (CsCl). Yields and Purity ...

E. coli Fermentation Using a BioFlo 110 Bench-Top Fermentor

... K12 Trace Metals Solution consists of: sodium chloride 5 g/L, zinc sulfate heptahydrate 1 g/L, manganese chloride tetrahydrate 4 g/L, ferric chloride hexahydrate 4.75 g/L, cupric sulfate pentahydrate 0.4 g/L, boric acid 0.575 g/L, sodium molybdate dihydrate 0.5 g/L and 6N sulfuric acid 12.5 ...

Mobile Phase Optimization for the Analysis of an Antibody-Based Fusion Protein and Aggregates using a TSKgel Super SW3000 Size-Exclusion Column

... the expected protein dimer and trimer aggregates are not visible in the chromatogram. By switching from 0.2M sodium chloride to 0.2M of the more chaotropic sodium perchlorate salt, together with a two-fold reduction in the buffer concentration, less ...

Monitoring Receptor-Mediated Changes in [Ca2+]i Using Single-Wavelength and Dual-Wavelength Indicators on the FlexStation Workstation

... for the P2Y 2 -receptor are UTP and ATP; they show similar potencies 7 . One important functional role of the P2Y 2 -receptor is the control of chloride ion fluxes in airway epithelia and mucociliary clearance in the lung, and thus may play a role in cystic fibrosis and other airway disorders. ...

Kinetic determination of vitamin B1

... For the calibration procedure, four thiamine standards were prepared in concentrations of 2.5, 1.25, 0.625, and 0.313 ppm. Mercuric chloride was dissolved in concentrated HCl and diluted to make a 500-ppm Hg 2+ solution, and a phosphate buffer (pH = 12.2) was prepared from Na 3 PO 4 12H 2 ...

Analysis of Blood Serum on the Liberty Series II ICP-AES with the axially-viewed plasma

... as it has a low energy of ionization, is not very sensitive by ICP-AES and, therefore, spectral interference is generally not a problem. Cesium chloride is available in a very pure form and does not build up in the torch injector tube as readily as other alkali salts. The accuracy and ...

Determination of N-nitrosamines in Baby Bottle Rubber Teats by Liquid Chromatography-Atmospheric Pressure Chemical Ionization Mass Spectrometry

... from each of the different formulations were cut up and extracted with methylene chloride. The extract solution was made basic, and the methylene chloride was distilled off. An additional volume of the aqueous phase was distilled into a separatory funnel and extracted with methanol. The extract was ...

Transgenic Zebrafish by Electroporation

... are then washed twice with fresh water. Plasmid Preparation The plasmid RSVCAT is purified by cesium chloride density gradient ultracentrifugation. DNA is suspended in TE (10 mM Tris-HCl, 1 mM EDTA, pH 8.0) and 100 g are digested ...

Optimization of Biolistic Transformation Using the Helium-Driven PDS-1000/He System

... promoter (Jefferson, et al., 1987). Both plasmids were prepared by alkaline lysis (Maniatis, et al., 1982) followed by cesium chloride purification and ethanol precipitation. Biolistic Transformation We recommend using conditions previously reported to ...

RNA & cDNA Purification Using RNAClean

... has also been linked to decreased performance in downstream in vitro translation reactions possibly due to inhibition by chloride ions (Maniatis et al., 1989). Column purification does not require chilling, but it does require multiple centrifugation steps ...

RNA, DNA, and Protein from a Single Sample

... RNA, RNA-free DNA, and/or protein Obtain higher yields than traditional guanidine thiocyanate or cesium chloride methods Compatible with many sample sources (e.g., human, plant, yeast, bacterial, ...
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