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Basal in Biological Technology

ConjuChem Provides Development Update

... it can achieve our objective of a more peakless basal insulin with a longer duration of activity." ... needle. About PC-Insulin PC-Insulin is a basal insulin with potential use in patients ... is being developed to have advantages over basal insulin therapies that may show clinically ...

Sanofi Aventis : New Study Results Support the "Basal Plus" Strategy With LANTUS(R) and APIDRA(R) to Improve Blood Sugar Control in Patients With Type 2 Diabetes

... optimisation. In the ELEONOR (Optimising basal plus insulin therapy in type 2 diabetes by ... of insulin glulisine at breakfast or main meal to basal insulin and oral antidiabetic therapy) clinical ... "The results from ELEONOR and OPAL show us that a basal plus strategy is an option for insulin ...

Tigris Pharmaceuticals Presents Results of Breast Cancer Research at AACR Annual Meeting

... negative (ER, PR, and HER-2 negative) breast cancer cell lines with the basal A gene profile subtype were very sensitive to AFP-464, while the triple negative cell lines with the basal B subtype were not. However, when the latter was pre-treated with a ...

FDA Approves Apidra(R) SoloSTAR(R) - a Prefilled Disposable Insulin Pen

... Basal-prandial insulin regimens that combine once-daily Lantus(R) as a basal insulin analog with rapid-acting Apidra(R) at mealtime can closely mimic ... or within 20 minutes after the start of a meal. Along with exercise, a basal insulin, and a proper meal plan, Apidra(R) is proven to help reduce A1C ...

deCODE Discovery Sheds Light on Risk of the Most Common Form of Skin Cancer

... single-letter variations in the human genome (SNPs) that confer risk of basal cell carcinoma (BCC), the most common cancer among people of European ... entitled 'Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigrmentation traits,' appears ...

John Timberlake, Valeritas' Executive Vice President and General Manager, Named Executive of the Year by the Diabetes Foundation

... discreet insulin delivery device that provides both a continuous set basal rate of insulin and on-demand bolus dosing for mealtime coverage. The ... system. The h-Patch(TM) is a simple-to- use, once-daily disposable basal and on-demand bolus delivery system that will enable the millions ...

Curis and Debiopharm Sign an Exclusive License Agreement Covering the HSP90 Inhibitor CUDC-305

... the second half of 2010 from our collaborator Genentech's ongoing Phase II clinical trials of GDC-0449, a Hedgehog Pathway Inhibitor, in advanced basal cell carcinoma, metastatic colorectal cancer and advanced ovarian cancer," said Michael Gray, Curis' Chief Operating and Chief Financial Officer. ...

It's Not Just the Sun: deCODE Discovers Sequence Variants Affecting Susceptibility to Skin Cancer

... academic colleagues from Europe and the United States today present in the journal Nature Genetics the discovery of common genetic risk factors for basal cell carcinoma (BCC) that affect people with fair and dark complexions alike. deCODE had previously discovered five common single-letter variants in ...

Valeritas Announces Appointment of New CEO

... The first use of the h-Patch(TM) technology will be the V-Go(TM) disposable insulin delivery device for continuous delivery both at a pre-set basal rate and for on-demand bolus dosing at mealtimes. In addition to V-Go(TM), Valeritas' delivery technology portfolio includes the h-Patch(TM) for ...

Introducing deCODEme Cardio(TM) and deCODEme Cancer(TM)

... and venous thromboempolism. deCODEme Cancer(TM) measures 29 SNPs associated with risk of prostate, lung, bladder and colorectal cancers, as well as basal cell carcinoma and the common form of breast cancer. Based upon which versions of these SNPs they carry, subscribers will receive a secure online ...

Pilot Study Finds Adding Topical Imiquimod To Laser Therapy Improves The Response Of Port Wine Stain Birthmarks

... immune response modifier agent that is approved by the U.S. Food and Drug Administration (FDA) for the treatment of actinic keratoses, superficial basal cell carcinomas and genital warts. Imiquimod is also known to have anti-angiogenic (inhibits the growth of new blood vessels) properties which might ...

deCODE genetics Announces Third Quarter 2008 Financial Results

... diagnostic test. - Skin cancer. deCODE discovered common versions of two single-letter variations in the human genome (SNPs) that confer risk of basal cell carcinoma (BCC), the most common cancer among people of European ancestry. Unlike the four sets of SNPs previously found by deCODE to ...

Golimumab Phase 3 Data Show Significant Improvement In Physical Function In Patients with Rheumatoid Arthritis

... taking placebo plus methotrexate developed Bowen's disease and squamous cell skin cancer, one patient taking golimumab 100 mg plus placebo developed basal cell cancer, and one patient taking golimumab 100 mg plus placebo developed squamous cell carcinoma. One patient receiving golimumab 100 mg plus ...

One-Year Data Show Golimumab Improved Signs and Symptoms In Patients with Psoriatic Arthritis In Phase 3 Study

... (ISR) occurred in 5 percent of patients receiving golimumab and 3 percent of patients receiving placebo. One case of prostate cancer and 2 cases of basal cell carcinoma were reported in golimumab-treated patients. Through week 52, 5 percent of golimumab-treated patients experienced SAEs and no ...

New properties of skin stem cells

... Institutet responsible for the study. "We're now investigating the part played by the stem cells in the wound-healing process and the development of basal cell carcinoma, the most common form of skin cancer." The stem cells examined by the present study are found in the skin's hair follicles, around ...

deCODE genetics Announces Second Quarter 2008 Financial Results

... susceptibility to sunburn. The deCODE team went on to explore the role of these variants in two major skin cancers -- cutaneous melanoma (CM) and basal cell carcinoma (BCC) -- and found that carrying one set of the ASIP variants, which 15% of the population does, was shown to correspond to a 45% ...

Amylin Pharmaceuticals to Present Promising Data From Diabetes and Obesity Programs at ADA 2008

... poster session on Sunday, June 8 from 12:00 - 2:00 PM PT (3:00 - 5:00 PM ET). 4. Oral Late Breaker: "Pramlintide or Mealtime Insulin Added to basal Insulin Treatment in Patients with Type 2 Diabetes" will be presented by Matthew Riddle, M.D. on Monday, June 9 at 4:30 PM PT (7:30 PM ...

Laser dissection of depression

... They used postmortem human brain tissue that was donated to the Netherlands Brain Bank for research purposes and investigated a region in the basal part of the brain, the hypothalamus, that is known to be of crucial importance for the development of symptoms of depression. This region is 6 mm3 ...

Anadys Pharmaceuticals Commences Phase I Clinical Trial of ANA773 in Cancer Patients

... cancer. Small molecule ligands for this receptor have been identified, including topical imiquimod (Aldara(R)) which is approved for the treatment of basal cell carcinoma in the United States. Imiquimod and other TLR7 agonists have also demonstrated early clinical activity against other tumor types, ...

New Online Learning Tool Fills the Knowledge Gap on Botulinum Toxin Type B for Cervical Dystonia

... that primarily affects the cervical area of the neck. While the exact cause of CD is unknown, scientists believe the problem originates in the basal ganglia area of the brain that is instrumental in movement. The treatment goal is to lessen symptoms of spasms, pain and impaired posture, and to ...

Valeritas Hires Senior Account Management Industry Expert for the Launch of the h-Patch(TM) Disposable Insulin Delivery Device

... medical technologies portfolio is headlined by the h-Patch(TM) insulin delivery system. The h-Patch(TM) is a simple-to-use, once-daily disposable basal and on-demand bolus delivery system that will enable the millions suffering from Type 2 diabetes to discreetly and conveniently deliver insulin ...

Valeritas Hires Trade and Distribution Industry Expert for the Launch of the h-Patch(TM) Disposable Insulin Delivery Device

... medical technologies portfolio is headlined by the h-Patch(TM) insulin delivery system. The h-Patch(TM) is a simple-to-use, once-daily disposable basal and on-demand bolus delivery system that will enable the millions suffering from Type 2 diabetes to discreetly and conveniently deliver insulin ...

Ralf Rosskamp, M.D. Joins Biodel's Scientific Advisory Board

... a lead-developer of endocrinology products. At Aventis, Dr. Rosskamp was responsible for achieving FDA/EMEA approval of Lantus(R), the best-selling basal insulin analog and coordinating the clinical trials for Apidra(R), a rapid-acting insulin analog. In addition, Dr. Rosskamp managed the approval ...

Monitoring Receptor-Mediated Changes in [Ca2+]i Using Single-Wavelength and Dual-Wavelength Indicators on the FlexStation Workstation

... measured as peak fluorescence intensity minus basal fluorescence intensity (Fluo-3 or FlexStation ... was an increase in signal of ~3,200 RFU above basal (1.8 fold increase) whilst with the FlexStation ... Less than a twofold increase in signal above basal was observed when the cells were loaded with ...

Use of Novel FlashPlate Technology to Measure cAMP Accumulation in Chinese Hamster Ovary Cells Expressing Human -2 Adrenoreceptors

... of cells per well that would produce measurable basal and stimulated levels of cAMP, i.e., that would ... between the number of cells added per well and basal levels of cAMP produced. The receptor agonist, ... intra-assay variation, as shown in Figure 2. Mean basal cAMP levels over 10 wells = 1.34 0.04 and ...

An Image-Based Assay of Endothelial Cell Tube Formation as a Model of Angiogenesis

... and trypsinized (trypsin- EDTA, Cambrex, CC-5012) then resuspended into basal media (Cambrex, CC-3162) containing 0.1% BSA (Cat. No. 354331) and seeded ... to 160 μM. Suramin was solubilized in H 2 O and serially diluted into basal media containing 0.1% BSA. After 16-18h, the media was discarded ...

Performance of Ad-A-Gene Cyclic AMP Response Element-Nitroreductase (CRE-NTR): an adenoviral vector gene delivery system

... CRE-NTR gene becomes transiently expressed within those target cells at basal levels. When activated, CREB binds to the CRE sequences within the CRE-NTR ... the CRE-NTR reporter molecule. Transduced U2OS cells appear to have a high basal activity in the absence of forskolin. Addition of forskolin to the ...

The QIAGEN Guide to Animal Cell Culture

... for each cell type must be determined experimentally. Common basal media include Eagle minimal essential medium (MEM), Dulbeccos ... or as a liquid from various commercial suppliers. basal media are usually supplemented just before use with serum, L-glutamine, ...

HTRF IP-One Assay Performed on the PHERAstar and RUBYstar Plate Readers

... was performed in 96-well plates resulting in very close EC 50 values and a very good correlation regarding the %inhibition / basal curve (figure 3). Z' calculations at an agonist concentration equal to EC80 resulted in Z' > 0.78 for both plate readers. ...

In Vitro Measurement of the Second Messenger cAMP: RIA vs. FlashPlate

... by the addition of viable cells (2 x 10 5 ) to LP4 tubes containing forskolin (10 μM) in the presence or absence of 5-HT (10 -10 to 10 -5 M). basal cAMP levels were determined from cells not treated with either drug. Following a 10 minute incubation at 37C, the reaction was stopped using 30% ...

Use of FlashPlate Technology for In Vitro Measurement of [35S]-GTPγS Binding in CHO Cells Expressing the Human 5-HT1B Receptor

... 2a shows the data in terms of absolute counts per minute; Figure 2b shows the same data with each row expressed as a percentage of its individual basal value. Preliminary results on inter-assay variation over three experiments indicate only up to 6% error on mean values (Figure 3a). Further ...

DNA Damage and Repair - Quantification of Sub-Cellular Events Using Automated Confocal Imaging

... can be applied to a high-content screening environment. We noted that even untreated cells contained some foci, suggesting that under basal conditions, some DNA doublestrand breaks are present and repair occurs. Phosphorylated H2AX accumulation was seen immediately after chemical ...

Screening for β2-adrenergic receptor agonists using the pH-sensitive dye,CypHer5, and the IN Cell Analyzer 3000

... (1 µ M) andantagonist alprenolol (1 µ M) were included as internal controls on each plate along with untreated cells for basal fluorescent levels.

Method Live-cell CypHer5 assay 1. Pre-coat ...

Single-Cell Complementation of Barley Mlo Mutants Using a PDS-1000/He Hepta System

... 1997). The 7-transmembrane-domain protein resides in the plasma membrane and is presumed to act as a negative regulator of a basal defense mechanism (Devoto et al. 1999). We have previously shown that transient single-cell expression of wild-type ...

Quantitation of GAD67 Gene Expression in Prefrontal Cortex of Schizophrenia Patients Using the iCycler iQ Detection System and Molecular Beacons, Rev A

... mice (Condie et al. 1997, Kash et al. 1997) suggest that GAD67 is the major isoform and is responsible for the maintenance of basal GABA levels in cells, whereas GAD65 can be rapidly activated in times of high GABA demand. The goal of our study was to compare ...

Quantitation of Lymphangiogenesis Using the iCycler iQ Real-Time PCR Detection System and Scorpions Detection System, Rev A

... Kits and Reagents Primary human umbilical vessel endothelial cells from Clonetics were cultured in endothelial cell basal medium (also from Clonetics). The RNAzol RNA extraction reagent, reverse transcription kits, and PCR master mix were purchased ...

Your Data: Use of pSilencer 1.0-U6 siRNA Expression Vector in the Analysis of Synaptotagmin Location and Function

... included GFP for identification of transfected cells. Silencing of SytV and Syt IX levels did not change basal secretion. However, glucose-induced insulin release was decreased suggesting that inhibition may be by ...

SUPERIOR RNA FOR DEMANDING APPLICATIONS

... available from the following regions of the brain: frontal cortex, occipital cortex, pariental cortex, temporal cortex, basal ganglia, cerebellum, medulla, and thalamus. Other High Quality Total RNAs

High-throughput gene expression analysis to screen for anti-asthma drugs

... to stimulate Th1 and Th2 cells, and the cells were incubated for a further 4 hours. Unstimulated cells were used as a control for basal gene expression levels. The cell cultures were then placed on the BioRobot Gene Expression workstation for fully automated RNA ...
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