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Affinity in Biological Technology

ProMetic signs $35 M Long-term Supply Agreement with European Biopharmaceutical company

... provide access to one of ProMetic's proprietary affinity adsorbents for incorporation into this company's ... growth in the demand for ProMetic's proprietary affinity adsorbents," commented Dr. Steve Burton, PBL's ... Agency are now manufactured using ProMetic's affinity adsorbent products," stated Mr. Pierre Laurin, ...

Telik Presents Preclinical Data at 99th Annual Meeting of the American Association for Cancer Research

... Through the use of Telik's Target-Related affinity Profiling (TRAP(R)) screening technology, novel ... anti-tumor activity in vitro. Target-Related affinity Profiling (TRAP(R)): Efficient Cancer ... based on a unique molecular descriptor called an affinity fingerprint. An ...

Anavex appoints Dr. Dimitri Goundis to lead Clinical Development

... drug candidates demonstrate high, non-exclusive affinity for sigma receptors, which are involved in the ... The company's lead drug candidates exhibit high affinity for sigma receptors with strong evidence for ... The company's lead drug candidates exhibit high affinity for sigma receptors with strong evidence for ...

ProMetic to obtain controlling stake in Pathogen Removal and Diagnostic Technologies Inc.

... from human red blood cells with prion protein affinity ligand. Transfusion 2006; 46:1152-1161 Wroe SJ, ... and characterization of novel membrane filter affinity media for protein adsorption. Dr. Carbonell is ... in the development and manufacture of robust affinity separation materials which provide very ...

Anavex 7-1037 reduces rate of cancer tumor growth 69% in pre-clinical studies, compared to currently marketed drug Dacarbazine showing no measurable activity

... has been previously reported to exhibit high affinity for sigma-1 (nanomolar) receptors and moderate (micromolar) affinity for sigma-2 receptors and sodium channels. In ... drug candidates demonstrate high, non-exclusive affinity for sigma receptors, which are involved in the ...

MIT explains spread of 1918 flu

... Two mutations dramatically change the HA binding affinity to receptors found in the human upper airways, ... HA allow flu viruses to bind tightly or with high affinity to the umbrella-shaped glycan receptors. The affinity between the influenza virus HA and the glycan ...

Anavex strengthens Board of Directors

... drug candidates demonstrate high, non-exclusive affinity for sigma receptors, which are involved in the ... drug candidates exhibit high, non-exclusive affinity for sigma receptors with strong evidence for ... lead drug candidates exhibit high, non-exclusive affinity for sigma receptors with strong evidence for ...

Anavex advances drug candidate for treatment of Alzheimer's disease

... drug candidates demonstrate high, non-exclusive affinity for sigma receptors, which are involved in the ... drug candidates exhibit high, non-exclusive affinity for sigma receptors with strong evidence for ... lead drug candidates exhibit high, non-exclusive affinity for sigma receptors with strong evidence for ...

Epitomics Appoints Dr. Zhiqiang An as Chief Scientific Officer

... industries, focusing on therapeutic antibody discovery, humanization and affinity maturation, preclinical and clinical development. Epitomics, ... Antibody) technology which produces antibodies with superior binding affinity and bioactivity in a wide variety of biological assays. Epitomics, Inc. ( ...

Nomad Bioscience: New Plant Biotechnology Company Founded to Focus on Biomaterials and Biopharmaceuticals

... lower manufacturing cost of bioethanol), nanostructured polyadsorbents for affinity purification of biopharmaceuticals (low cost polyaffinity nanoparticles that replace expensive current affinity resins) and nanopatterned electrodes (batteries with improved ...

ProMetic announces Octapharma publication of PRDT'S prion removal resin in Octaplas(R) manufacturing process at 30th International Congress of the International Society for Blood Transfusion meeting in Macao SAR, China

... Svae, Director International Market Access, Octapharma PPGmbH. "The affinity resin product performs well in our manufacturing process and we look ... Ltd ("PBL") specializes in the development and manufacture of robust affinity separation materials which provide very high levels of purification. This ...

Epitomics Announces the Creation of 1000th Rabbit Monoclonal Antibody

... rabbit monoclonal antibodies (RabMAbs(TM)) include high specificity and affinity which provide excellent results in a variety of commonly used ... Antibody) technology which produces antibodies with superior binding affinity and bioactivity in a wide variety of biological assays. The Company is ...

ARIUS presents new findings for anti-cancer antibody programs at AACR

... Trop-2. A humanized version of this antibody has greater higher affinity than the murine version and will be used in a pre-clinical toxicology ... version of ARIUS' CD59 targeting antibody demonstrated equivalent affinity and potency to the murine version, and a CHO cell line producing humanized ...

Prometic to present at the American Chemical Society

... is "Managing the risks from blood-associated TSE infectivity with prion affinity ligands". Dr. Gurgel's lecture titled "Development of a device for prion reduction based on affinity ligand" will be presented on April 8, 2008 at 13:30 (EDT) The ...

ProMetic provides business update - Over $35 million worth of business secured in January

... increased its forecast for P-Capt(R) filters sale in 2008; - Use of affinity prion adsorbent for plasma-derived products to generate in ... thrombin product which is manufactured using a synthetic- ligand affinity adsorbent supplied by ProMetic. This is one of ten licenced products ...

ProMetic announces scale-up of prion removal resin in plasma product for biopharmaceutical use

... Multi-million dollar long-term agreement to supply prion removal affinity resin following regulatory approval anticipated by mid-2008 ... Ltd ("PBL") specializes in the development and manufacture of robust affinity separation materials which provide very high levels of purification. This ...

Palatin Technologies, Inc. Receives U.S. Patent Allowance for Heart Failure Drug Candidate

... PL-3994 incorporates a novel and proprietary amino acid mimetic developed by scientists at Palatin. PL-3994 has an extended half-life, with reduced affinity for natriuretic peptide clearance receptors and increased resistance to neutral endopeptidase, an endogenous enzyme that degrades natriuretic ...

MacroGenics Announces the Initiation of a Phase 2 Clinical Trial to Evaluate the Safety and Efficacy of Monoclonal Antibody MGAWN1 in Subjects with Suspected Central Nervous System Infection Due to West Nile Virus

... product development. The company's product development efforts leverage three proprietary technology platforms: (1) cancer stem-like cells; (2) Dual affinity Re-Targeting (DART), which allows the company to incorporate multiple specificities within a single molecule; and (3) Fc optimization, which enhances ...

Morphotek(R), Inc. Announces a Research Collaboration Agreement with Synageva BioPharma Corporation to Develop Potential Treatments for Cancer and Infectious Disease

... Through the use of its proprietary MORPHODOMA(R) technology, Morphotek develops optimized antibodies, including antibodies optimized for affinity and/or titer, for therapeutic applications and high-titer manufacturing cell lines. The company has assembled a portfolio of lead human and ...

Paulo F. Costa Joins MacroGenics Board of Directors

... product development. The company's product development efforts leverage three proprietary technology platforms: (1) cancer stem-like cells; (2) Dual affinity Re-Targeting (DART), which allows the company to incorporate multiple specificities within a single molecule; and (3) Fc optimization, which enhances ...

Sigma-Aldrich and Atlas Antibodies Announce 2,300 New, Highly Validated Prestige Antibodies(RM)

... the Human Proteome Resource (HPR) Center. The Human Proteome Resource (HPR) Center is performing a systematic exploration of the human proteome with affinity (Antibody) based Proteomics, combining high-throughput generation of affinity-purified (mono-specific) antibodies with protein profiling using tissue ...

Biologist discovers pink-winged moth in Chiricahua Mountains

... of the noctuid family, which often are dull colored. Walsh's moth, in contrast, is bright pink. He also named it after his wife, Lee, who has an affinity for the color. Walsh discovered L. leeae while collecting one evening at Onion Saddle, at about 7,700 feet in the Chiricahuas. Collecting ...

Frost & Sullivan Recognizes Cisbio Bioassays for Technology Innovation

... has remained the functional characterization of 7TM receptors by employing fluorescence technologies. "The determination of ligand binding affinity has been used to delineate the ligand binding site of GPCRs through a site-directed mutagenesis strategy," says Frost & Sullivan's Dr. Sudeep ...

Assay Designs(TM), Inc. Announces Release of First Available Product for Multiplex Analysis of Heat Shock Proteins

... (Hsp27 phospho Ser15, Hsp27 phospho-Ser82, Hsp40, Hsp60, Hsp70 and Hsp90 alpha) in cell lysates. The assay utilizes monoclonal antibodies or antigen affinity purified polyclonal antibodies covalently coupled to latex beads. The detection antibodies are conjugated to biotin followed by a streptavidin-PE ...

Cimzia(R) (certolizumab pegol) Provides Long-Term Remission and Response Rates in Infliximab-Refractory Crohn's Patients

... (IBD). About CIMZIA (R) (certolizumab pegol) Cimzia(R) is the only PEGylated anti-TNF (Tumor Necrosis Factor). Cimzia(R) has a high affinity for human TNF-alpha, selectively neutralising the pathophysiological effects of TNF-alpha. Over the past decade, TNF-alpha has emerged as a major ...

Morphotek(R), Inc and Lonza Group Ltd Enter Into Manufacturing Services Agreement

... Through the use of its proprietary MORPHODOMA(R) technology, Morphotek develops optimized antibodies, including antibodies optimized for affinity and/or titer, for therapeutic applications and high-titer manufacturing cell lines. The antibodies within the company's pipeline are targeted against ...

Kibow Biotech, Inc. to Present at BIO 2009 International Convention: Innovations to Heal, Fuel, and Feed the World

... Kibow Biotics contains three distinct strains of carefully researched and specifically selected beneficial microbes (probiotics) that possess a high affinity for various nitrogenous waste products. When the kidneys are unable to filter toxins normally, the microbes metabolize the renal waste products and ...

Recombinant C-Reactive Protein

... to be excreted without cell lysis. r-hCRP has similar biological property in terms of Ca2+-binding ability to the native protein, and is purified by affinity chromatography. N-terminal amino acid sequence of r-hCRP is the same as that of the native human c-reactive protein. According to Lee ...

Neurocrine Biosciences Reports First Quarter 2009 Results

... Receptor Antagonists for Anxiety/Depression and IBS The CRF collaboration between Neurocrine and GSK has identified multiple unique high affinity and selective antagonists for the CRF1 receptor that are currently in clinical development for mood disorders. GSK has advanced a novel lead ...

Novel Once Daily Anti-Epileptic Zebinix(R) Approved in the European Union

... stabilising its inactive form and preventing its return to the active open state, thereby reducing repetitive neuronal firing. ESL has a much higher affinity for the inactivated state of the channel compared with the resting state which means it is less likely to interfere with normal neuronal function ...

Trubion Presents Preclinical Data on Its SCORPION(TM) Multispecific Therapeutics at the 2009 American Association of Cancer Research Annual Meeting

... a lineage-restricted component of the B-cell antigen receptor, and HLA-DR, an HLA Class II molecule. Target binding by the SCORPION molecule has an affinity similar to Trubion's Small Modular Immunopharmaceutical (SMIP(TM)) proteins or monoclonal antibodies against the same target, but can bind both ...

Amira Initiates Phase I Clinical Trial of Novel DP2 Antagonist

... our Phase I studies." DP2 is also known as CRTH2 or chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes. DP2 is a high affinity receptor for prostaglandin D2 and, in humans, is implicated in Th2-dependent allergic inflammation. "The start of the AM211 clinical studies ...

University of Maryland Announces Finalists for $75K Business Plan Competition

... co-founder and board member, Gloto Corp., co-founder, Solipsys Corporation; Rob Cohen; Craig Dye, member, board of advisors, Articulated Impact & affinity Lab; Brent Goldfarb, assistant professor of management and entrepreneurship, department of management and organization, Robert H. Smith School of ...

Researchers develop new way to see single RNA molecules inside living cells

... their experiments, the team used a bacterial toxin to transport the probes into living cells a delivery technique that when combined with the high affinity of the probes for their targets, required significantly fewer probes than existing techniques. The toxin created several tiny holes in the cell ...

Kibow Biotech, Inc. Launches Breakthrough Probiotic Dietary Supplement for Kidney Health in USA and Canada

... Kibow Biotics contains three distinct strains of carefully researched and specifically selected beneficial microbes (probiotics) that possess a high affinity for various nitrogenous waste products. The microbes metabolize the waste products and use them as nutrients for growth. As the microbes grow and ...

Immunotherapy-Based Provisional Patents Mark Significant Discovery

... B cells of the body's immune system to aid in the recognition and destruction of foreign materials including cancer cells. Because they have a strong affinity for specific regions in proteins found on cancer cells (OFA/iLRP peptides), these antibodies have diagnostic and therapeutic uses. From a diagnostic ...

MMR and Dancing Paws to Participate in Joint Sales Effort to Provide Personal Health Records for Pets

... sales promotion program where a Personal Health Record is being used as an incentive to sell related consumer products and services. As part of its affinity marketing efforts MMR plans on finding similar promotional opportunities to create programs with manufacturers of consumer products and services that ...

Atritech Completes $30 Million Financing

... Partners, Prism Venture Partners, Thomas McNerney Partners, Tullis-Dickerson Partners, The Vector Group, Thoma Cressey Funds, SightLine Funds and affinity Capital. For more information, visit www.atritech.net . About Thomas, McNerney & Partners Thomas, McNerney & Partners is a health ...

MacroGenics Appoints New Vice President of Business Development

... and development of monoclonal antibody therapeutics for oncology through its cancer stem-like cell program. MacroGenics' proprietary DART (Dual affinity Re-Targeting) and Fc-optimization technologies offer ways to improve the function of antibodies and similar molecules. For more information about ...

Palonosetron Warrants Adequate Caloric Intake in Oncology Patients Receiving High Emetogenic Chemotherapy

... developed for the prevention of CINV in patients with cancer, with a long half-life of 40 hours and at least 30 times higher receptor binding affinity than currently available compounds. Palonosetron is a second generation 5-HT3 receptor antagonist, and demonstrates, in clinical trials and clinical ...
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(Date:8/29/2014)... surprising discoveries about the body,s initial responses to ... team found that specialized cells in the intestine ... invasion and are the source of gut inflammation ... , Though aimed at the presence of ... that provides a barrier to protect the body ...
(Date:8/29/2014)... at the Barshop Institute for Longevity and Aging Studies, ... Health Science Center at San Antonio, have found another ... rodent, the naked mole rat. , They reported ... rats protects and alters the activity of the proteasome, ... The factor also protects proteasome function in human, mouse ...
(Date:8/29/2014)... about what genetic changes transform wild animals into domesticated ... is a University of Montana assistant professor, has made ... of the brain and the nervous system were particularly ... 28 in Science and gives answers to ... ., The domestication of animals and plants, a prerequisite ...
Breaking Biology News(10 mins):The early cost of HIV 2Factor in naked mole rat's cells enhances protein integrity 2New research reveals how wild rabbits were genetically transformed into tame rabbits 2New research reveals how wild rabbits were genetically transformed into tame rabbits 3
(Date:8/29/2014)... According to a CNN article, entitled Medical ... new study found that those states who legalized medical ... decrease in the number of painkiller overdoses seen. By ... and comparing various states with and without legalized medical ... about a 25% decrease in painkiller prescription overdoses in ...
(Date:8/29/2014)... 2014 As reported by the Frederick News Post ... Grad (8/17), a graduate of the Frederick County Drug Treatment ... own experience with the program. The graduate, Korey Shorb, put together ... 1 mile walk. He plans to donate the proceeds of the ... those who helped him. Shorb, who graduated in 2008, admitted that ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 Healthpointe has ... will give patients the convenience of visiting with physicians ... doctors through telemedicine. , Healthpointe doctors are always available ... audio). If necessary, the doctor can even see the ... patient’s condition, he or she can prescribe medications that ...
(Date:8/29/2014)... News) -- Astronauts may be at heightened risk ... immune systems, a new study suggests. That could ... asteroids, the moon and Mars undertaken in the future, ... can be dangerous, NASA researchers say. They found ... of International Space Station crew members remains relatively unchanged ...
(Date:8/29/2014)... 2014 (HealthDay News) -- If you have bunions, taking care ... later, an expert says. A bunion is a bump ... bone or tissue moves out of place and extends beyond ... cause debilitating pain and may require surgery to correct, said ... Center in Freehold, N.J. To prevent bunions, avoid wearing ...
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