Apolipoprotein(a): A natural regulator of inflammation
... leukocyte recruitment, evidence for this in vivo
has been lacking.
investigation of Lp(a) function has been impeded ... interaction, inhibits neutrophil recruitment in vivo
and functions as a cell specific suppressor of ...
Researchers create new class of fluorescent dyes to detect reactive oxygen species in vivo
... environment that closely resembles in vivo
conditions. Explants were incubated with ... experiments, the researchers progressed to in vivo
mouse imaging studies. Hydro-Cy7 was selected for the in vivo
tests because of its higher emission wavelength ...
Studies on imaging and tracking transplanted cells
... the researchers for the first time imaged in vivo
human hepatic progenitor cells transplanted into ... treated with SPIO-labeled MSC, indicating that in vivo
the initially cell surface bound iron detached ... in the clinical setting, indicating that in vivo
application of SPIO-labeled MSC needs to be ...
Scripps research scientists identify compounds for stem-cell production from adult cells
... process, but also become useful in in vivo
stem cell biology and, ultimately, the ... cells treated with BIX alone. In vitro and in vivo
characterizations confirmed that transduction of ... impacting healthy cells systemically in an in vivo
Study links nicotine with breast cancer growth and spread
... cancer-prone or cancer cells," Chen said.
studies confirmed these findings. When injected ... MCF7 cells migrated to the lungs.
From in vivo
and in vitro studies, it indicates that nicotine ... to enable tumorigenesis.
"In vitro and in vivo
tests showed that no metastasis occurs when the ...
Mitochondrial dysfunction and redox signaling in atrial tachyarrhythmia
... The facts that equal results were observed in ex vivo
atrial tissue from patients with AF and in ex vivo
rapidly paced tissue samples from patients with ... oxidative stress. The authors say the use of ex vivo
human atrial tissue from patients with and ...
Researchers visualize complex pigment mixtures in living cells
... Life Sciences and lead author of the report, In vivo
hyperspectral confocal fluorescence imaging to ... phycobilins and carotenoids) can be localized in vivo
in cells of the cyanobacterium Synechocystis sp. ... in small cells, and provides a new approach in in vivo
localization of complex mixtures of fluorescing ...
Researchers expand efforts to explore functional landscape of the human genome
... $1.1 million (three years); High-Definition In vivo
Footprinting via Single Molecule Sequencing. This groups goal is to develop an in vivo
method that utilizes single molecule sequencing ... $1.5 million (three years); Generation and In vivo
Validation of Cis-regulatory Maps in Eukaryotic ...
CSIRO deal to commercialize 'artificial gut'
... new foods that is much quicker and more cost-effective than the current in vivo
The GI and RS Analyser is the first of its kind in the ... process in the development phase of products, leaving the standard in vivo
(human) test to the final stage of food development and labelling ...
Penn researchers demonstrate a new model for drug discovery with a fluorescent anesthetic
... the compound is fluorescent, researchers are able to image the compound in vivo
in order to study its physiological effects. Where and how an anesthetic ... appears to be specific in its binding to proteins and also in its in vivo
localization, which should give us the opportunity to determine its ...
NIH grants Phylonix Phase II SBIR to develop high-throughput in vivo zebrafish assays
... Medical Sciences of the National Institutes of Health (NIH) to develop in vivo
zebrafish assays for assessing drug effects on Cytochrome (CYP) P450s. ... and statins such as cerivastatin. A validated, simple, cost-effective in vivo
CYP assay will be useful for profiling drug metabolism prior to performing ...
The medium is the message: Manipulating salmonella in spaceflight curtails infectiousness
... encounters just such conditions not only during spaceflight but also in vivo
in an infected individual when the bacterium makes contact with an ... hints, a full understanding of the complex interplay of forces and the in vivo
mechanisms of Salmonella pathogenesis await further research.
Intraspinal implant of mesenchymal stem cells may not heal the demyelinated spinal cord
... Brain Repair at the University of Cambridge. "A number of in vitro and in vivo
studies have reported that MSCs have differentiated into neuronal cells ... MSCs may possess neural differentiation capabilities in vitro, their in vivo
behavior is unpredictable, said Dr. Hunt and his co-authors. However, ...
Engineers create bone that blends into tendons
... melds into softer tissues, but were also able to implant the technology in vivo
for several weeks.
They created the tissue by coating a ... they have been able to demonstrate that they can implant the tissue in vivo
for several weeks, the team's next step is to show that the tissue can ...
From foe to friend: Researchers use salmonella as a way to administer vaccines in the body
... antigen delivery system that would display regulated delayed lysis in vivo
after invasion into and colonizing internal lymphoid tissues in an ... would be no ability for live bacterial vaccine cells to either persist in vivo
or to survive if shed into the environment," Curtiss added.
Insulin's brain impact links drugs and diabetes
... animals, activity in the striatum was suppressed.
This finding is in vivo
evidence that, in the intact diabetic rat, loss of insulin has compromised ... health and disease.
This is really the first mechanistic connection in vivo
between diabetes and amphetamine action, Galli said. This offers a ...
Brain difference in psychopaths identified
... is called the uncinate fasciculus (UF). However, nobody had ever studied the UF in psychopaths. The team from King's used an imaging method called in vivo
diffusion tensor magnetic resonance imaging (DT-MRI) tractography to analyse the UF in psychopaths.
They found a significant reduction in the ...
Scientists track impact of DNA damage in the developing brain
... and blocked the cells from completing the cell cycle. "The cells appear to undergo permanent arrest," said McKinnon, noting it is one of the few in vivo
examples of the p53 pathway leading to cell cycle arrest rather than apoptosis.
In the hippocampus, which plays a role in memory and emotion, ...
U of M study finds new insight on therapy for a devastating parasitic disease
... within a flatworm model.
"Our discovery of this new biological activity of praziquantel provides a foundation for defining the relevant in vivo
targets of a very important clinical drug," said Jonathan Marchant, M.A. Ph.D., principal investigator of the study. "Using drugs to make organisms ...
Prostate Cancer Translational Research in Europe meeting: Search for biomarkers continues
... TSA, thiram, disalfiram and monensin (are) identified as cancer selective compounds inhibiting VCaP cell growth at nanomolar concentrations.
studies using VCaP cell xenografts showed reduced tumour growth in response to disulfiram exposure; disulfiram was not able to block tumour growth ...
Tips from the journals of the American Society for Microbiology
... reduced replication of both viruses.
"These results suggest a role for the IFN-a/β response in the control of H5N1 virus replication both in vivo
and in vitro, and as such it may provide some degree of protection to the host in the early stages of infection," say the researchers.
Dual role in breast tissue for a protein involved in leukemia
... collaborated with it to promote growth of a type of precancerous lesion of the breast termed a hyperplastic alveolar nodule.
"Our studies in in vivo
mouse models illustrate a dual role for the Stat5a protein in breast tissue. While it can contribute to the growth of one type of precancerous lesion ...
Universitat Autonoma de Barcelona researchers first to clone mice in Spain
... already pointed to improvements in the development of cloned embryos using inhibitors. However, scientists must wait until the end of the in vivo
test period in July to obtain more conclusive data.
Versartis presents positive preclinical data on 2 product candidates at ENDO 09
... Jeffrey L. Cleland, Ph.D., Founder and Chief Executive Officer of Versartis. "Our preclinical data presented today show that VRS-317 demonstrated in vivo
potency equal to daily hGH, and sustained plasma levels and pharmacodynamic responses in monkeys without toxicity. Potential benefits of VRS-317 ...
Microtest Labs Adds Dissolution Testing to its Suite of Analytical and Stability Testing Services
... different processes, analysis of competitor's samples)
To estimate release and absorption rates in humans after an in vitro -- in vivo
correlation is established
Dissolution is a sample preparation technique. Samples still need to be analyzed separately, usually by ...
Vitamin D levels linked to asthma severity
... previous in vitro studies have suggested that vitamin D may affect how airway cells respond to treatment with inhaled steroids, this is the first in vivo
study of vitamin D and disease severity in children with asthma.
Juan Celedn, M.D., Dr. P.H. and Augusto Litonjua, M.D., M.P.H. of Harvard Medical ...
Redefining what it means to be a prion
... several additional avenues of study, including the application of similar strategies to find additional yeast prions, thorough testing of prions in vivo
and in vitro, and scanning of other organisms' genomes for prion candidates.
Basic guides to PCR, labeling neurons featured in Cold Spring Harbor Protocols
... in the April issue. This patch-clamp methodology has been successful for single-cell dye labeling in cultured neurons, brain slices, and in vivo
preparations. A wide range of dyes can be loaded using this method, including probes for morphological reconstruction, ion-sensitive indicator dyes ...
Brain building: Study shows brain growth tied to cell division in mouse embryos
... of a spindle-orienting factor that in normal cells distributes asymmetrically.
Such similarities between Vangl2-lacking cells in vitro and in vivo
will facilitate ongoing studies of the PCP pathway in neurogenesis.
Hormone-mimics in plastic water bottles -- just the tip of the iceberg?
... researchers found evidence of estrogenic compounds leaching out of the plastic packaging into the water. What's more, these chemicals are potent in vivo
and result in an increased development of embryos in the New Zealand mud snail. These findings, which show for the first time that substances ...
Phylonix to present at 2009 Society of Toxicology Annual Meeting
... Pharmaceuticals, Inc., the leading contract research organization for preclinical testing in zebrafish, will present data about the company's in vivo
zebrafish-based assays at the 48th Society of Toxicology (SOT) Annual Meeting being held March 15-19 at the Baltimore Convention Center in Baltimore, ...
GUMC young scientist selected postdoc Fellow at National Space Biomedical Research Institute
... will investigate injury responses including inflammatory signaling induced by space radiation. The study will use a genetic approach in an in vivo
model to investigate the effects of radiation-induced inflammatory signaling on cellular and molecular parameters in the intestine. Exposures, such ...
Rett Syndrome Research Trust advisor makes significant discovery
... 2007 Science publication by Professor Adrian Bird showing reversal of Rett symptoms in adult mouse models of the disorder. Results from ongoing in vivo
mouse studies deleting MeCP2 in glia are promising in terms of supporting the culture studies.
"This new study adds to the growing body of ...
New target for medicine to combat Alzheimer's: VIB scientists confirm protein's key role
... protein as a new player. The VIB researchers have been able to show − in vitro (in cells isolated and studied in the laboratory) as well as in vivo
(in living animals − mice, in this instance) − that blocking GPR3 leads to reduction of the plaques.
Importance of this research
Compounds could be new class of cancer drugs
... Pharmacology, was elected to the National Academy of Sciences for his work on PLDs.
The researchers will now optimize their new compounds for in vivo
studies and to give them characteristics compatible with being good medications. They are also expanding their research into other areas of biology ...
Rice eyes risks of quantum dots
... be quickly weathered by acid rain, he said. Another concern is that acids in the body could break down dots used in such medical applications as in vivo
imaging. "If they degrade faster than they can be excreted, there's the potential for heavy metals to be released into the body," said Alvarez. "Then ...
JCI online early table of contents: Jan. 19, 2009
... at the University of Bristol, United Kingdom, have found that mice lacking the protein PKC-alpha exhibited diminished thrombus formation in vivo
but showed no evidence of overt bleeding, they suggest that PKC-alpha is a potential target for antithrombotic therapy. In particular, they propose ...
Tips from the American Journal of Pathology
... white blood cell recruitment. Instead, annexin A1 colocalized with another FPR family member, FPR-2.
The data by Gastardelo et al "provide in vivo
evidence that endogenous annexin A1 is an essential mediator for homeostasis during the inflammatory process." They go on to propose "that these ...
New research lights up chronic bacterial infection inside bone
... Their report published in the journal Disease Models & Mechanisms ( DMM ), dmm.biologists.org describes how they use a technique called in vivo
bioluminescence to light up bacteria and allow them to see extremely tiny amounts of bacterial cells in living animals. Using this method, they ...
Transplanted fat cells restore function after spinal cord injury
... cells in an in vitro setting. In their study, for the first time fat cells have been shown to successfully differentiate into neuronal cells in in vivo
tests. The fat cells are grown under culture conditions that result in them becoming de-differentiated fat (DFAT) cells.
"These cells, called ...