Ventricular in Biological News

Targeted drug therapy prevents exercise-induced arrhythmias

... The Dutch patient, for example, experienced ventricular tachycardia and ICD shocks whenever he got out ... a drug treatment that reduces or prevents the ventricular tachycardias, and therefore prevents the ICD ... defect in CPVT), and it completely prevented ventricular arrhythmias in the mouse model of CPVT. "So we ...

Study provides insight on a common heart rhythm disorder

... displayed heart disease symptoms, including ventricular arrhythmias, the prevalence of sinus node ... sinus node dysfunction, atrial fibrillation and ventricular arrhythmias. "We were fortunate in this study ... contraction of specialized heart cells called ventricular cardiomyocytes. Cells in the sinoatrial node have ...

Device helps patients survive, regain function til transplant

... device is called the HeartMate II® left ventricular assist device or LVAD. It is one of four in a new ... physicians have for treating patients who require ventricular assistance while they wait for a new heart, and ... (ECMO), the Thoratec and original HeartMate ventricular assist devices, the ...

Adult bone marrow stem cells injected into skeletal muscle can repair heart tissue

... of cell types. "Injecting MSCs or factors released by MSCs improved ventricular function, promoted myocardial regeneration, lessened apoptosis (cell ... MSCs, or trophic factors released by MSCs, into skeletal muscle improved ventricular function, promoted regeneration of heart tissue, decreased cell death and ...

Plasminogen activator inhibitor type-1 -- a potential link between heart failure and diabetes

... mice congenic on a C57BL6 background had comparable PAI-1 content in left ventricular myocardium despite a marked elevation of PAI-1 in plasma in the latter. 6 ... the PAI-1 overexpressing mice exhibited a 2-fold increase in left ventricular (LV) PAI-1 content. Histochemical analysis demonstrated 33% more LV ...

Gene therapy reversed heart damage in heart failure

... the rats who received the ARKct had a significantly increased left ventricular ejection fraction. The treatment also reversed the left ventricular deterioration and normalized the neurohormonal status. Dr. Koch said that ...

Latest advances in interventional cardiology for congenital heart disease presented

... Cliff Kavinsky, interventional cardiologist; and a program on closure of ventricular septal defects by Amin. In addition, specialists from Rush will present ... trials of novel transcatheter closure devices for the treatment of ASD, ventricular septal defects, patent ductus ateriosys and patent foramen ovale. As a ...

Three Dimensional Visualization of Right Ventricle Provides Important Information for Treatment of Patients with Tetralogy of Fallot, According to a Study in The American Journal of Cardiology

... to hemodynamic overload. Entitled "Three-Dimensional Analysis of Right ventricular Remodeling in Repaired Tetralogy of Fallot," the paper was authored by Dr. ... diagnostic tool that can provide measurement of a heart's volume and ventricular ejection fraction. The VentriPoint Diagnostic System, together with its ...

Cell Therapy for Cardiovascular Diseases

... will cover strategies using cell-based therapies to address the chronic ventricular dysfunction underlying these conditions. Cutting Edge Findings ... Dr. Warren Sherman Stem cells in patients with heart failure on left ventricular assist devices, presented by Dr. Eric A. Rose Next-Generation Heart ...

Methadone even at therapeutic levels can kill

... to a growing body of individual case reports linking methadone to a rare ventricular arrhythmia, known as torsade de pointes, which can degenerate into ventricular fibrillation leading to sudden death in the absence of medical ...

Biophysical Society announces 2008 International Travel Awards

... Spatially Restricted Ca2+ Transients Reflect Release by the SR in Rabbit ventricular Myocytes. Maria A. Frias, Universidad de Tucuman, Argentina, ... Chennai, India, Arrhythmia Studies using Computational Model of ventricular Tissue. Carlo Manno, Instituto Venezolano de Investigaciones ...

Top scientists meet for global conference on stem cell therapy for cardiovascular diseases

... will cover strategies using cell-based therapies to address the chronic ventricular dysfunction underlying these conditions. Cutting Edge Findings ... Sherman Stem cells in patients with heart failure on left ventricular assist devices, presented by Dr. Eric A. Rose Next-Generation ...

Fourth Annual International Conference on Cell Therapy for Cardiovascular Diseases

... will cover strategies using cell-based therapies to address the chronic ventricular dysfunction underlying these conditions. Special Sessions on: ... by Dr. Nabil Dib Stem cells in patients with heart failure on left ventricular assist devices, presented by Dr. Eric A. Rose Next-Generation ...

University of Pittsburgh cardiologists identify new cardiac arrest gene

... of the heart. This puts patients at risk for rapid heart rhythms such as ventricular tachycardia and fibrillation. Symptoms often present with no warning, and ... four affected patients. The original family member has had two episodes of ventricular fibrillation that were corrected by ICD shocks. Of note, our ...

Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction

... consistent with human cardiomyocytes, the majority of which represented ventricular cardiomyocytes. Engraftment Following Transplantation To enable ... to dramatically enhance cell survival after injection into the infarcted ventricular wall. Four weeks later, tissue sections from the infarcted hearts were ...

Sudden cardiac death without recognizable cause

... deaths. As the ion channels are involved in stimulation and conduction in the heart, malfunction can cause cardiac arrythmias, which may lead to ventricular fibrillation. These primary electrical heart disorders are mostly subject to autosomal dominant inheritance. This means that family members have ...

Studies point to novel target for treating arrhythmias

... The researchers examined the heart rhythms of mice expressing various troponin mutants that cause HCM and showed that the mice develop ventricular tachycardia (a particular arrhythmia). The risk for this arrhythmia was directly related to the degree of calcium sensitization caused by the ...

Safe new therapy for genetic heart disease

... may significantly reduce the symptoms of genetic heart disease. The related report by Penicka et al, "The effects of candesartan on left ventricular hypertrophy and function in non-obstructive hypertrophic cardiomyopathy: a pilot, randomized study," appears in the January issue of The Journal of ...

UT faculty members win American Heart Association awards for advancing research

... Lombardi presented a manuscript describing the origin of the fat cells in the heart in a disease condition referred to as arrhythmogenic right ventricular cardiomyopathy, which is an important cause of sudden cardiac death in the young, especially athletes. In this disease, which is a genetic disorder, ...

Embryo biopsy does not affect early growth and risk of congenital malformations in PGD/PGS babies

... malformation rates. Two PGD/PGS children, one ICSI child and two SC children had major malformations. In the PGD/PGS group, one child suffered from a ventricular septum defect (a heart problem) and another child had hemivertebrae with gibbus (a malformation of the vertebrae causing a hump). One child from the ...

Brain stem cells can be awakened, say Schepens scientists

... is responsible for learning and memory, while the SVZ is a brain structure situated throughout the walls of lateral ventricles (part of the ventricular system in the brain) and are responsible for generating neurons reponible for smell. So scientists believed that when neurons died in other areas of ...

Children's Hospital leads projects to develop nation's first heart assist devices for young children

... Childrens Hospital of Pittsburgh of UPMC a national leader in the use of lifesaving ventricular assist devices (VADs) for children in heart failure is part of a collaboration that recently has been awarded a $2.3 million grant from the National ...

Fish oil -- helpful or harmful?

... subgroups, such as men with stable angina. The same may also be true for patients with implantable cardioverter defibrillators who have a history of ventricular tachycardia and who are not taking antiarrhythmic medications. Fish oils have promise as beneficial in cardiovascular disease but our work ...

Biophysical Society announces winners of 2008 Student Travel Awards

... Mumbai, India, Kinetics of Misfolding and Aggregation of Amyloid Proteins. Sarah B. Scruggs, University of Illinois at Chicago, Ablation of ventricular Regulatory Light Chain Serine-15 Phosphorylation in Mice Leads to Cardiac Dysfunction in Vivo and Affects Neighboring Myofilament Protein ...

Implanting embryonic cardiac cells prevents arrhythmias

... connections helped activate the transplanted cells deep within the damaged section of the heart tissue. The technique reversed the risk of developing ventricular arrhythmias after a heart attack, the number one cause of sudden death in the Western world. In the past, scientists have transplanted a variety of ...

New data shows benefits of MitraClip for patients with mitral regurgitation

... reverse remodeling of the left ventricle was demonstrated. Reverse remodeling was assessed based on five echocardiographic measures, including left ventricular end-systolic dimension. In line with the reverse remodeling, 94 percent of patients who had a successful result with the MitraClip device had ...

Neural stem cells lend the brain a surprising capacity for self-repair

... in maintaining the cellular wall that lines the ventricular region of the brain in which the SVZ resides. ... the brain. Surprisingly, they reported, the ventricular damage was eventually repaired. SVZ reconstitution and remodeling of the ventricular wall was driven by progenitor cells that escaped ...

Engineered heart tissue offers insights into irregular heartbeats, defibrillator failure

... sought to understand the characteristics of ventricular tachycardia -- a condition characterized by ... to understand how such arrhythmia may lead to ventricular fibrillation, in which the heart's electrical ... in these engineered tissues as would occur in ventricular tachycardia and attempted to halt it with ...

Potential heart benefit found in stem cells

... Autologous Stem Cells on Global and Regional Left ventricular Function and Myocardial Perfusion in Patients ... is the bone marrow. To improve global left ventricular ejection fraction (EF, the volume of blood pumped ... chamber during a single beat) and regional left ventricular wall motion, which is related to ejection ...

Stem cell mobilization therapy appears to be ineffective in repairing damage caused by heart attack

... not alter infarct size (area of damage) or left ventricular function after a heart attack. "Moreover, in ... based on sensitive assessment methods of left ventricular function and infarct size. In conclusion, use of ... marrow–derived stem cell does not improve left ventricular recovery in patients with acute myocardial ...

Python a 'hearty' eater

... including humans, a 10-30 percent increase in ventricular mass can occur following several weeks to months ... training," said Hicks. In the snake, the rapid ventricular growth coincided with an increased production of ... mechanisms leading to cardiac remodeling and ventricular growth in other animals, including humans. ...

Whole-genome study at Johns Hopkins reveals a new gene associated with abnormal heart rhythm

... measures the period of time it takes the heart to recover from the ventricular beat - when the two bottom chambers of the heart pump. Corresponding to ... human heart. And the "lub" part of the "lub-dub" heartbeat corresponds to ventricular contraction. So NOS1AP is active in the right place and time to play a ...

Bone marrow stem cells may heal hearts even years after heart attacks

... Left ventricular function and exercise capacity increased, while the area of heart muscle ... "The main results were at least threefold: an improvement in global left ventricular function by 15 percent, infarction wall movement velocity rose 57 percent, ...

Vascular structure and function improve with diet and exercise

... of the heart and blood vessels at rest were performed as well. Left ventricular diastolic filling (LVDF) measurements indicate the efficiency of the heart to relax. Left ventricular mass is a measure of end organ damage often following the onset of LVDF ...

Heart failure: Intervention possibilities from imaging programmed cell loss

... damaged heart muscle. "We discovered that higher uptake was uptake with a worse outcome. Cell death is one of the biological events that worsens left ventricular events," said Hofstra. "Our results indicate that heart muscle cell death is an active and ongoing process in heart failure, and that annexin ...

Protein overexpression at heart of heart failure

... nonfailing (“Adaptive phase?. In the nonfailing double transgenics, the induction of beta 2a protein expression increased the activity of single ventricular L-VDCC, rendering these channels phenotypically identical to human and mouse heart failure. The authors conclude that electrical remodeling of ...

Mechanical 'artificial hearts' can remove need for heart transplant by returning heart to normal

... to their normal function, potentially removing the need for heart transplantation, according to new research. The mechanical devices, known as Left ventricular Assist Devices (LVADs), are currently used in patients with very severe heart failure whilst they await transplantation. The new study, published in ...

New study shows antibiotic may protect the heart

... be beneficial as a potential therapeutic strategy to limit cell death caused by ischemia or reperfusion injury, and possibly long-term prevention of ventricular remodeling ?the changes in size, shape and function that may occur to the left ventricle of the heart," said Rakesh C. Kukreja, Ph.D., professor of ...

Researchers link two more genes to sudden infant death syndrome

... LQTS-causing gene. RyR2 was targeted because of its involvement in a distinct genetic heart rhythm disease known as catecholaminergic polymorphic ventricular tachycardia (CPVT). "For a parent whose infant died suddenly and mysteriously even five years ago, we were essentially unable to provide them with ...