Umbilical in Biological News

Children's Hospital Oakland scientists first to discover new source for harvesting stem cells

... are far more stem cells in placentas than in umbilical cord blood, and they can be safely extracted for ... is highly likely that placental stem cells, like umbilical cord blood and bone marrow stem cells, can be ... cell, or a red blood cell. Using stem cells from umbilical cord blood, Children's Hospital Oakland ...

New technology enhances therapeutic potential of cord blood stem cells

... increases the efficiency and responsiveness of umbilical cord blood for bone marrow transplants and may ... being presented at the 6th Annual International umbilical Cord Blood Transplantation Symposium, June 6-7 in ... leukemia. The cells, which are collected from the umbilical cord after the baby is delivered and separated ...

Umbilical cord blood cell therapy may reduce signs and symptoms of Alzheimer's disease

... 2008) Targeted immune suppression using human umbilical cord blood cells may improve the pathology ... Following a series of low-dose infusions of human umbilical cord blood cells into mice with Alzheimers-like ... inflammation observed in Alzheimers. Human umbilical cord blood cell therapy appeared to suppress ...

Umbilical cord blood cell therapy in an animal model of Alzheimer's disease

... based on targeted immune suppression using human umbilical cord blood cells may improve the pathology and ... Following a series of low-dose infusions of human umbilical cord blood cells into mice with Alzheimers-like ... CD40L, two pro-inflammatory molecules. Human umbilical cord blood cell therapy was associated with ...

Bacterial infections in premature babies more common than previously realized

... 23 and 32 weeks of gestation have positive umbilical blood cultures for two genital mycoplasmas ... at delivery, the higher the rate of a positive umbilical cord blood culture. The data, derived from the ... 351 women/infant pairs in the population who had umbilical cord blood cultures for U. urealyticum and M. ...

U of M begins nation's first clinical trial using T-reg cells from cord blood in leukemia treatment

... The T-regs in this study are isolated from umbilical cord blood (blood collected from the placenta or ... trial in the world that uses T-regs derived from umbilical cord blood. This trial is designed to find the ... in immune suppressed patients undergoing a double umbilical cord blood transplant for leukemia, other blood ...

Low vitamin D during pregnancy linked to pre-eclampsia

... to 22 weeks pregnancy and again just before delivery. Samples of newborn umbilical cord blood also were tested for 25 hydroxyvitamin D, an indicator of ... on vitamin D from the mother, low vitamin levels also were observed in the umbilical cord blood of newborns from mothers with preeclampsia. A vitamin ...

Stem cell research: From molecular physiology to therapeutic applications

... malfunctioning or damaged cells and tissues in patients. Recent studies have shown that pluripotent stem cells derived from adult bone marrow, the umbilical cord and the placenta could also be induced to differentiate into a variety of different tissues. In this issue, we have invited several scientists ...

Experimental treatment halts hypoxic-ischemic brain injury in newborns

... mostly unknown, although some studies point to the possibility of problems with the placenta, maternal blood pressure or complications related to the umbilical cord. Close to 20 percent of newborn children with hypoxic-ischemia die and 25 percent of those who survive suffer from lifelong neurological ...

CWRU receives $5 million from Ohio Third Frontier Commission

... within CWRU and CC which will be the first of its kind in the State of Ohio. Cell Targeting will apply its cell "painting" technology to direct umbilical cord blood stem cells to specific locations in the body to increase cell dosage and improve engraftment. Zhenghong Lee (UHCMC) and Jeremy Rich ...

Just in time for spring: Scientists find the cellular on and off switch for allergies and asthma

... treating these and other related diseases." Ryan and colleagues made this discovery in mouse experiments that examined cells from bone marrow and umbilical cord blood that ultimately help create a type of immune cell (mast cells). Too many mast cells lead to an over-aggressive immune response, which ...

Olympus advances technology for laparo-endoscopic single-site surgery

... through just one incision in the belly button. In Laparo-Endoscopic Single-Site surgery (LESS), the TriPort access system is placed into the umbilical incision of between 12-25mm, allowing single-port access for up to three surgical and imaging instruments that can be either straight or bent, ...

World premiere in stem cell research in Montreal

... patients will be able to obtain new bone marrow within the next few years. "It could be possible to envision transplants for all adults from existing umbilical cord blood banks. The stem cell content of these blood banks is currently too limited for large-scale use in adults," Dr. Sauvageau affirmed. ...

Magnetic nano-'shepherds' organize cells

... said. "Any type of tissue we'd ultimately want to engineer will have to be three-dimensional." For their experiments, the researchers used human umbilical vein endothelial cells. Others types of cells have also been used, and it appears to the researchers that this new approach can work with any type of ...

Oh baby, interventional radiology makes childbirth safer

... who suffer from a rarebut increasingly frequentbirth condition when a woman's placenta (attached both to the wall of the uterus and to the baby's umbilical cord) grows or "invades" into the uterine wall. "Minimally invasive interventional radiology treatmentsthat safely and immediately control bleeding ...

Smoking during pregnancy may impair thyroid function of mom and fetus

... birth weight and impaired neuropsychological development of the baby. Dr. Vaidya and his colleagues also measured thyroid hormone levels in the umbilical cord of babies born to smoking mothers and found that smoking-related changes in thyroid function extend to the fetus. Dr. Vaidya believes that ...

Repeat C-section before 39 weeks raises risk of neonatal illness

... newborn sepsis, seizures, necrotizing entercolitis, hypoxic ischemic encephalopathy, required ventilator support within 24 hours of birth, had umbilical cord arterial pH (a measure of oxygenation) below 7.0, an Apgar score at five minutes of three or below, was admitted to a neonatal intensive care ...

Cell movements totally modular, Stanford study shows

... Meyer lab's larger effort to find order in the overwhelming complexity of the inner workings of cells. First they grew the cells (originally from umbilical cord tissue) into sheets and watched what happened when they scratched some of the cells away: They were looking to see the movements of individual ...

Pittsburgh researchers identify source of multipotent stem cells with broad regenerative potential

... tissues in the human body have in common. These cells can be extracted easily and painlessly from convenient sources such as fat tissue, dental pulp, umbilical cord and placental tissue, then grown in culture to large numbers and, possibly, re-injected into the patient to heal a broken bone, a failing joint ...

Children's national co-leads nationwide study of landmark sickle cell treatment

... marrow transplant physician Naynesh Kamani, MD , will serve as the study co-chair for a new national clinical trial of unrelated donor marrow and umbilical cord blood transplants for severe sickle cell disease . Children's National will join more than 20 other medical institutions in the first-ever ...

Vitamin A pushes breast cancer to form blood vessel cells

... a role in binding endothelial cells together into a structure. When they then mixed the treated cancer cells with endothelial cells taken from human umbilical cord blood, structures similar to blood vessels developed within the tumor masses grown in culture. This makes sense, says Byers, because vitamin ...

Florida researchers receive JDRF 'Excellence in Clinical Research Award'

... three researchers are involved in several innovative JDRF-funded studies to accelerate the development of a cure for type I diabetes, including using umbilical cord blood stem cells as a potential therapy and investigating drug treatments used in tandem to provide immune suppression while boosting the ...

MIT: Prenatal arsenic exposure detected in newborns

... and Chandni Valiathan, graduate student at MITs Computational and Systems Biology Initiative. The team analyzed blood that had been collected from umbilical cords at birth. The exposure of mothers to arsenic during their pregnancy was independently determined by analyzing toenail clippings the most ...

UC San Diego physicists tackle knotty puzzle

... the weaving of the string end through the coils. The paper cites other researchers who have proposed a similar effect to explain why knotting of the umbilical cord of fetuses is relatively rare, occurring only about one percent of the time. Confinement to the amniotic sac may restrict the probability of ...

Depression, aging, and proteins made by a virus may all play role in heart disease

... and type-2 diabetes. The researchers developed a model to test these linkages by using endothelial cells that line the inside of veins in umbilical cord tissue. They wanted to see how the cells themselves, as well as the immune macrophages, reacted when exposed to the virus as well as the dUTpase ...

Research shows cord blood comparable to matched bone marrow

... University of Minnesota researchers report that umbilical cord blood transplants may offer blood cancer ... the preferred graft, with matched and mismatched umbilical cord blood. There is considerable controversy in ... bone marrow transplants with those who received umbilical cord transplants. While all bone marrow donors ...

Adult stem cells from human cord umbilical cord blood successfully engineered to make insulin

... engineered adult stem cells derived from human umbilical cord blood to produce insulin. The researchers ... calls it "the first demonstration that human umbilical cord blood-derived stem cells can be engineered" ... Upon Tyne in the United Kingdom, used human umbilical cord blood because it is an especially rich ...

Potential heart benefit found in stem cells

... Stem Cell Therapy (Abstract 921-105) / Human umbilical Cord Blood Derived Mesenchymal Stem Cell Has A ... menstrual blood-derived endometrial cells and umbilical cord blood-derived mesenchymal cells show ... In a second study, the same team collected human umbilical cord blood-derived mesenchymal stem cells ...

Fish and chips: A fast track to understanding blood development

... researchers at the University already perform umbilical cord blood transplants to treat disease. But ... stem cells harvested from a single collection of umbilical cord blood to effectively treat adults and older ... could generate enough cells from a single umbilical cord to treat more patients. Importantly, the ...

Infants with Rare Genetic Disease Saved By Cord Blood Stem Cells

... preserved if they receive stem cells from umbilical cord blood before symptoms of the disease ... child's life." Kurtzberg pioneered the use of umbilical cord blood from unrelated donors in 1993 and her ... days to a year) were treated with unrelated donor umbilical cord blood. Cells from the donor "engrafted" or ...

Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells

... preserved if they receive stem cells from umbilical cord blood before symptoms of the disease ... child's life." Kurtzberg pioneered the use of umbilical cord blood from unrelated donors in 1993 and her ... days to a year) were treated with unrelated donor umbilical cord blood. Cells from the donor "engrafted" or ...

U of MN researchers turn cord blood into lung cells

... at the University of Minnesota have, for the first time, coaxed umbilical cord blood stem cells to differentiate into a type of lung cell. The ... team first derived the Multi-Lineage Progenitor Cell TM (MLPC TM ) from umbilical cord blood. This stem cell, which was first isolated and characterized by ...

Study uncovers placental microtransfusions lead to transmission of AIDS virus during childbirth

... at the University of Melbourne. The study involved measuring -- in umbilical cord blood samples -- a protein known as placental alkaline phosphatase as ... birth," Meshnick said. "We figured that if we found it in blood from the umbilical cord, which links the placenta to the baby, that would be an indication of ...

100 percent of pregnant women have at least one kind of pesticide in their placenta

... Thanks to gynaecologists, the nurses and the midwives who participated in the study, biological samples were extracted from the blood, the umbilical cord and the placenta during childbirth. The following day, an epidemiological survey was carried out by trained survey statisticians. The survey ...

Researchers first to map gene that regulates adult stem cell growth

... desired to help a patient recover from cancer. Another possible use for Latexin would be to help increase the number of stem cells available in umbilical cord blood, which also is used to transplant healthy stem cells in blood marrow transplants. Currently, stem cell transplants with cord blood can ...

Nanoparticles can track cells deep within living organisms

... Partlow, a doctoral student in Wickline's lab, describes using perfluorocarbon nanoparticles to label endothelial progenitor cells taken from human umbilical cord blood. Such cells can be primed to help build new blood vessels when injected into the body. The researchers believe nanoparticle-labeled stem ...

Anti-fungal drug stops blood vessel growth

... that an antifungal drug would have such a role.? In their search for antiangiogenesis drugs, the researchers worked with cells from human umbilical cords, a rich source of blood vessels, and exposed them to 2,400 existing drugs - including FDA- and foreign-approved drugs, as well as nonapproved ...

Vitamin D deficiency widespread during pregnancy

... Study between 1997 and 2001. Samples of maternal blood were collected prior to 22 weeks pregnancy and again just before delivery, Samples of newborn umbilical cord blood also were tested for 25 hydroxyvitamin D, an indicator of vitamin D status. Finding such a proliferation of vitamin D insufficiency in ...

Technology for monitoring fetal oxygen during labor offers no apparent benefit

... blood and oxygen to the tissues. The researchers theorized that such drops in heart rate might have been caused by inadvertent pressure on the umbilical cord when inserting the sensor, or because of manipulation of the baby's head. "In this study of more than 5000 women delivering at 14 ...