Ulcerative in Biological News

Enzyme involved in inflammatory bowel disease discovered at Penn State College of Medicine

... to help the half-a-million Americans affected by ulcerative colitis and Crohn's disease, collectively ... associated with both Crohn's disease and ulcerative colitis with low meprin levels. "This ... the genetic control of inflammation, and of ulcerative colitis and Crohn's disease in particular," Bond ...

New genetic markers for ulcerative colitis identified, researchers report in Nature Genetics

... genetic markers associated with risk for ulcerative colitis. The findings, which appear today as an ... new treatments that specifically target them. ulcerative colitis is a chronic, relapsing disorder that ... diarrhea (oftentimes bloody) and abdominal pain. ulcerative colitis and Crohn's disease, another chronic ...

Scientists successfully treat new mouse model of inflammatory bowel disease

... most common forms of IBD are Crohn's disease and ulcerative colitis (UC); in extreme cases, they can be ... individually in unsuccessful clinical trials as ulcerative colitis treatments, but now we have colleagues ... almost exactly replicated the most acute types of ulcerative colitis." Unlike prior models of IBD, the mice ...

Clinical studies show REMICADE reduces incidence of bowel surgeries in ulcerative colitis patients

... for patients with moderately to severely active ulcerative colitis (UC). According to a primary analysis of long-term extension data from the Active ulcerative Colitis 1 and 2 trials (ACT trials), there is a ... and only biologic approved for the treatment of ulcerative colitis. The analysis of the ACT extension ...

NIH expands Human Microbiome Project; funds sequencing centers and disease projects

... B. Young, M.D., Ph.D., University of Michigan, Ann Arbor Digestive tract: ulcerative Colitis $1 million Some patients who suffer from ulcerative colitis, a type of inflammatory bowel disease that causes inflammation and ...

Johnson & Johnson honors 2008 recipients of the Dr. Paul Janssen Award for Biomedical Research

... diseases including rheumatoid arthritis, ankylosing spondylitis and ulcerative colitis. The safety and efficacy of anti-TNF therapies has been well ... to TNF blockade in Crohn's disease, psoriasis, ankylosing spondylitis and ulcerative colitis," said Feldmann. "Blocking other cytokines such as IL-6 has been ...

New genes found for inflammatory bowel disease in children

... which can affect any part of the gastrointestinal tract, and half have ulcerative colitis, which is limited to the large intestine. IBD that begins in ... to each patient." The study team also found an association between ulcerative colitis and genes on the major histocompatiblity complex (MHC) on ...

Getting better with a little help from our 'micro' friends

... causes a disease in the mice that is similar to Crohn's disease and ulcerative colitis. However, when the animals were co-colonized with B. fragilis, ... of illnesses that cause inflammation in the intestines, including ulcerative colitis and Crohn's disease, is estimated to affect one million Americans. ...

Stem cell focus for IBD wound healing

... The study could eventually lead to the development of new drugs which use natural molecules to spark the recovery of patients suffering from ulcerative colitis and Crohn's disease, reducing their risk of associated complications such as scarring, bowel obstructions and tumour growth. Funded with a ...

Weill Cornell science briefs June/July 2008

... because most IBD-sufferers are young teens or in their 20s, and are the most likely patient-group to miss a dose. IBD includes two diseases: ulcerative colitis and Crohn's disease. Both cause inflammation in the gastrointestinal (GI) tract, leading to bloody diarrhea, abdominal pain and weight loss. ...

Inflammation triggers cell fusions that could protect neurons, Stanford research shows

... animals with higher-than-expected numbers of fused cells also had an inflammatory skin condition common to aging laboratory mice called idiopathic ulcerative dermatitis. This type of chronic inflammation affects the entire immune system of the animal and causes a systemwide immune response. The ...

Crohn's disease gene identified

... are strongly associated with Crohn's disease and ulcerative colitis, according to a report by a consortium of ... 26 online Science Express. Crohn's disease and ulcerative colitis, collectively called inflammatory bowel ... that might better manage Crohn's disease and ulcerative colitis." Previous genetic studies found a ...

Gut research yields new anti-cancer approach

... study that led to the discovery of the anti-cancer effect, researchers were looking for new ways to reduce inflammation seen in Crohn's disease and ulcerative colitis, bowel diseases that cause pain and diarrhea. Specifically, they were comparing the effect on inflammation of encouraging the action of the ...

Prevention is the best option: fighting autoimmune diseases

... the important role of T cells in the prevention of autoimmune diseases in humans. In a study involving 38 patients with Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease (IBD), and 43 healthy controls, Assoc Prof Fazekas and colleagues found that healthy ...

U of M researchers find immune-activating cells in intestines

... of cells may be important in many responses in the gastrointestinal system, which may be helpful in studying diseases and conditions such as ulcerative colitis, and Crohn's disease. The research was done in collaboration with scientists at Harvard University. ...

Parasitic worms used to fight bowel disease

... of all sorts early in life in order to develop sufficiently. Intriguingly, inflammatory bowel disease, which has two forms ?Crohn's disease and ulcerative colitis ?is virtually unknown in the developing world, while it is increasing dramatically in developed societies. When people from developing ...

Scientists look to the Bahamas as a model for coral reef conservation

... likely to progress to disease than the initial infection. Furthermore, as many infectious diseases have decreased, autoimmune diseases such as ulcerative colitis, Crohn's disease and diabetes have increased. "All these observations have been made without necessarily trying to pull it all together," ...

Learning to love bacteria: Stanford scientist highlights bugs' benefits

... likely to progress to disease than the initial infection. Furthermore, as many infectious diseases have decreased, autoimmune diseases such as ulcerative colitis, Crohn's disease and diabetes have increased. "All these observations have been made without necessarily trying to pull it all together," ...