Tumors in Biological News

Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers

... they say shuts down growth of human glioblastoma tumors in cell and animal studies. Glioblastoma is the ... with human glioblastoma, the antibody prevented tumors from growing. For example untreated tumors grew to an average size of 350 cubic millimeters ...

Nanoparticle-delivered 'suicide' genes slowed ovarian tumor growth

... cancer cells reduced the burden of ovarian tumors in mice, and researchers expect this therapy ... after treatment. They found that while treated tumors increased 2-fold, this was significantly less ... mice. Furthermore, four of the treated tumors failed to grow at all, while all ...

A crystal ball for brain cancer?

... have uncovered a new way to scan brain tumors and predict which ones will be shrunk by the drug ... treatment. By linking high water movement in tumors to positive drug response, the UCLA team predicted with 70 percent accuracy which patients' tumors were the least likely to grow six months after ...

Cancer's distinctive pattern of gene expression could aid early screening and prevention

... a Georgia Cancer Coalition Scholar. But why tumors have so many epigenetic changes compared to ... Whether the changes cause or result from tumors is another. "A lot of methylated genes we found ... who also works in breast cancer and brain tumors as well as colon cancer, is finding patterns of ...

Scientists discover gene mutation responsible for hereditary neuroendocrine tumor

... Paragangliomas are rare, generally benign tumors that arise from cells called glomus cells, which ... which was decreased by approximately 95% in tumors from three patients with PGL2. Implications ... PGLs tend to be affected at a younger age with tumors at multiple sites," says Rutter. "Including hSDH5 ...

Dogs, humans, put heads together to find cure for brain cancer

... brain and account for one out of four adult brain tumors -may not be as key for tumor formation as ... extremely difficult," says Breen. "By looking at tumors seen in both humans and dogs we have a simple way ... except that using information from dog and human tumors allows us to concentrate our search on the two ...

Colorectal cancer

... may help identify patients with aggressive tumors at an earlier stage ( Gastroenterology 2009, ... that are falsely regulated in both the primary tumors and their metastases. In this way, the ... a genetic signature which distinguishes tumors with metastatic potential from those that do not ...

Tumor growth and chemo response may be predicted by mathematical model

... The aggressiveness of tumors and their susceptibility to chemotherapy may ... process of cancer growth is not well understood. tumors are complex systems, with changes at the ... of tumor growth in brain cancer. tumors obtain nutrients and oxygen by harnessing the ...

Computer model predicts brain tumor growth and evolution

... a computational computer model of how brain tumors grow and evolve. The model is the product ... tumors, they have also linked their computerized tumors to real-world brain tumors, or "gliomas," and can ... model that mimicked natural biological tumors in all respects. They focused specifically on ...

Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies

... and spread and also to reverse the ability of tumors to suppress the body's natural immune response, ... that our fully human antibody PGN635 localizes to tumors and causes an increase in several inflammatory ... be mature, or activated, to be effective, yet tumors and other pathogens such as viruses often possess ...

Newly discovered epidermal growth factor receptor active in human pancreatic cancers

... cells with activated EGFT had been placed. The tumors began growing. But when treated with erlotinib, they began to shrink. Other tumors without activated pECFR showed no response. ... additional markers of pancreatic cancer in the tumors themselves but also in blood and urine, which ...

TGen researchers discover possible way to block the spread of deadly brain tumors

... target for drugs that could prevent malignant tumors from rapidly multiplying and invading other parts ... are key characteristics of malignant brain tumors known as glioblastoma multiforme, or GBM. Dr. ... at Barrow Neurological Institute, who examined tumors for the study. "As a pathologist, I examined ...

New drug shows promise in treating drug-resistant prostate cancer

... tested the new drugs' effectiveness in mice with tumors derived from drug-resistant prostate cancer ... these compounds caused very dramatic shrinkage of tumors in the mice," Sawyers said. "While treating these ... effect on their tumors, the new drugs caused the tumors to shrink dramatically, and in some animals ...

New medications show promise in treating drug-resistant prostate cancer

... tested the new drugs' effectiveness in mice with tumors derived from drug-resistant prostate cancer ... these compounds caused very dramatic shrinkage of tumors in the mice," said Sawyers. "While treating these ... effect on their tumors, the new drugs caused the tumors to shrink dramatically, and in some animals ...

Fluorescent cancer cells to guide brain surgeons

... Gliomas are malignant brain tumors that arise from glial (supporting) cells of the ... are often resistant to chemotherapy. These tumors grow fine extensions that infiltrate normal brain ... The scientists took advantage of the fact that tumors cover their increased energy needs, among other ...

University of Kansas graduate student researcher takes aim at deadly brain tumors

... therapy, and she is focusing her work on brain tumors specifically. The National Cancer Institute ... in 2008, there were 21,810 diagnoses of brain tumors and other nervous system disorders in the United ... 13,070 deaths. What's worse, in 2007 brain tumors were the leading cause of solid tumor death in ...

Skin cancer study uncovers new tumor suppressor gene

... analysis found that one-quarter of human melanoma tumors had changes, or mutations, in genes that code for ... gene family were thought to be oncogenes and many tumors express high levels of MMP enzymes, researchers ... estimated 6 percent of melanoma patients whose tumors harbor a mutated MMP-8 gene or related tumor ...

Two Hutchinson Center researchers named HHMI Early Career Scientists

... only to watch the drugs lose their power as the tumors developed resistance. He then became a researcher ... of the pathway, he discovered, can help tumors become resistant to chemotherapy drugs. Taniguchi ... uncovers to develop drugs that will re-sensitize tumors to cancer therapies. Malik and Taniguchi will ...

Freezing prostate cancer does a man's body good

... as effective as surgery in destroying diseased tumors and can be considered a first-line treatment for ... approach because earlier detection of smaller tumors increases the likelihood that a small tumor can ... and overtreatment in many men with low-risk tumors has led to a concept in the medical community of ...

Freezing kidney cancer: Hot treatment should be new gold standard for destroying small tumors

... first treatment option for all individuals with tumors that are 4 centimeters in size or smaller. And, ... who are diagnosed with kidney cancer have small tumors that are discovered incidentally. "Cryoablation ... the first treatment option for all patients whose tumors are 4 centimeters or smaller. It should be a ...

MIT student develops new innovations to selectively kill cancer cells

... Using Gold Nano-Antennas to Target and Destroy tumors Since 2004, von Maltzahn has worked closely ... specificity of cancer ablationthe destruction of tumors through the application of heatvon Maltzahn ... gold 'nano-antennas' that can target tumors and convert benign-infrared light into heat. ...

Scientists can predict nano drug outcome

... predicted the outcome of a nano drug on breast tumors in a pre-clinical study. Their research could ... bubbles called liposomes to determine if breast tumors in rodents could be breached by liposomes loaded ... received good images of porous breast tumors which had absorbed the contrast agents. On the ...

Stroma genomic signature predicts resistance to anthracyclin-based chemotherapy in breast cancer

... to address a very puzzling question: Why breast tumors that have very similar conditions in terms of ... type of chemotherapy although their respective tumors are very similar from a clinical point of view," ... this means is that success in treatment, having tumors shrink or disappear altogether, is in part due to ...

New technique images tumor vessel leakiness to predict breast cancer chemotherapy outcome

... a contrast agent that could only leak into tumors with blood vessels that were growing and ... time. "During the three-day time course, some tumors exhibited a rapid and significant increase in ... was accumulating in the tumor, whereas other tumors showed a slow and low increase," said ...

Stress may hasten the growth of melanoma tumors

... medicines might slow the development of those tumors and therefore improve these patients' quality of ... were grown from tissues taken from secondary tumors that had metastasized from a primary site and ... patients, that can be very important since these tumors are able to metastasize, or spread, when they are ...

DNA component can stimulate and suppress the immune response

... role of inflammation in fighting invaders such as tumors and harmful bacteria. Mr. Johnson presented the ... The researchers already knew that IDO protects tumors from the immune system. While working with ... becomes resistant to skin tumor formation, and tumors that do form are smaller and less malignant," Mr. ...

Texas Medical Center researchers win collaborative grants

... or identify small molecule inhibitors to stop tumors while leaving normal cells alone. "We are ... spinal cord, eye and peripheral nerves." tumors in children targeted Attacking cancerous tumors in children will be the focus of a study by ...

Nearly a century later, new findings support Warburg theory of cancer

... of a simple acid within the mitochondria, tumors and cancer cells generate energy through the ... with CL content in several types of brain tumors taken from mice. Bioinformatic models were used ... or composition were present in all types of tumors and closely associated with significant ...

Team finds breast cancer gene linked to disease spread

... vessels in distant organs. The gene also makes tumors more resistant to the powerful chemotherapeutic ... profiles of the so called "poor prognosis" tumors -- those that are likely to come back after the ... The scientists found that MTDH-overexpressing tumors are more likely to metastasize to the lungs, ...

Salk researchers develop novel glioblastoma mouse model

... the development and progression of human brain tumors that arise naturally. "Mouse models of human ... method to faithfully reproduce different types of tumors but also to elucidate the nature of elusive ... mice, which quickly develop tumors. "These tumors are very reproducible, but this approach ignores ...

Common food additive found to increase risk and speed spread of lung cancer

... products, might speed growth of lung cancer tumors and may even contribute to the development of those tumors in individuals predisposed to the disease. The ... phosphates caused an increase in the size of the tumors and stimulated growth of the tumors," Dr. Cho ...

GUMC researchers find gene function 'lost' in melanoma and glioblastoma

... that harbored PTPRD deletions or mutations, these tumors stopped growing and initiated a program of cell ... PTPRD mutations in both the blood and in tumors of a patient with multiple different kinds of ... human genome. The researchers purified DNA from tumors and then used the microarray chip to quantify ...

Novel technique for fluorescence tomography of tumors in living animals

... Tomography' (EPT), the scientists imaged lung tumors in living mice. For this purpose they injected a ... The amount of these proteases is enriched in lung tumors which allows fluorescence imaging of the tumor ... a very sensitive technique for imaging of lung tumors in living organisms, but also has the potential ...

The Burnham buzz

... increase in productivity. Nanoworms Make tumors Squirm Nano-scale worms made out of iron oxide ... has shown that iron oxide nanoworms can bind to tumors when coated with tumor-homing peptides. The team ... to design nanoparticles that will seek out tumors in the body, send a diagnostic signal and release ...

Eating eggs when pregnant affects breast cancer in offspring

... extra choline during pregnancy had slow growing tumors while daughters of mothers that had no choline ... genetic and molecular changes in the rats' tumors that correlated with survival outcomes. For example, the slow growing tumors in rats had a genetic pattern similar to those ...

'New' estrogen receptor found to be key player in tamoxifen resistance

... appear under the microscope as long, very thin tumors actually a single stream of cancer cells that ... cancer type, invasive ductal carcinoma, in which tumors form more discrete lumps. But what the ... binds to the estrogen receptors (alpha) that stud tumors and other breast tissue, not allowing estrogen to ...

Researchers identify Achilles heel of common childhood tumor

... hemangioma slows later in childhood, and most tumors disappear entirely by the end of puberty. However, while the tumors are benign, they can cause disfigurement or ... complications caused by large, badly-placed tumors that obstruct vision, respiration, or other ...

Researchers identify promising gene target for neuroblastoma therapy

... in a single gene in 8 percent of neuroblastomas, tumors of the nervous system that occur in young ... when mutations activate the gene, known as ALK, tumors become "addicted" to -- or dependent on -- the ... this drug will have activity in children whose tumors have these mutations. More studies are needed, ...

Children's National researchers develop novel anti-tumor vaccine

... ISAPs are effective at blocking the growth of tumors in mice by inducing activation of immune cells ... tumor growth using the ISAP approach. "For tumors like neuroblastoma, reduction to minimal residual ... more effectively combat a wide range of these tumors in a personalized fashion." ...

The dietary supplement genistein can undermine breast cancer treatment

... or estrogen sensitive, which means that the tumors grow more rapidly in the presence of estrogen. ... blocked the effects of AD and the breast cancer tumors stopped growing. But when they added genistein ... of the breast cancer drug. Specifically, the tumors began to grow again. They grew fastest at the ...