Trials in Biological News

Advances in lung cancer research announced at conference

... brain metastasis, so that informed therapeutic trials can be undertaken, could enable a paradigmatic ... Healthcare of results from two Phase I clinical trials for a drug called TH-302. The two clinical trials are both evaluating the safety and effectiveness ...

New drug may reduce heart attack damage

... muscle death in the aftermath of a heart attack, trials in preclinical models have found. The drug ... a full recovery after a heart attack. Safety trials of Dz13 are now underway ahead of Phase 1 human ... Professor Khachigian said other, independent trials of Dz13 were about to get underway to target ...

Results from trials of DHA in Alzheimer's disease and age-related cognitive decline

... Disease (ICAD 2009) in Vienna. One of the trials was conducted by the Alzheimer's Disease ... two studies and other recent Alzheimer's therapy trials raise the possibility that treatments for ... Alzheimer's and mild cognitive impairment therapy trials concerns a possible interaction between certain ...

New lab test offers better prediction of HIV microbicide safety

... microbicide gels have been assessed in clinical trials after passing laboratory and animal safety tests. ... of safety before proceeding to clinical trials that typically cost millions of dollars, involve ... safety before advancing a product to clinical trials involving thousands of women," she adds. Dr. ...

Debate on admin. of magnesium sulfate to pregnant women to prevent cerebral palsy in pre-term infants

... and meta-analysis of six randomized controlled trials involving 4796 women and 5357 infants. Writing in ... conversation, they each talk about the available trials and observational studies and the strengths and ... that "three large, randomized placebo-controlled trials of antenatal magnesium sulfate (MgSO4) for fetal ...

Green tea may affect prostate cancer progression

... according to Cardelli. However, some human trials have found contradictory results. The few trials conducted to date have evaluated the clinical ... suggested that additional controlled clinical trials should be done to see if combinations of ...

NIH announces new program to develop therapeutics for rare and neglected diseases

... potential therapies from entering into clinical trials for rare or neglected disorders. While we do not ... can a potential treatment move to clinical trials in patients. Unfortunately, the success rate ... to test the therapy in patients. Clinical trials go through several stages that take several years ...

SNM's clinical trials network gains added support from industry leader

... Reston, Va.The SNM Clinical trials Network, an initiative designed to address the ... imaging professionals, inaugurated the Clinical trials Network in late 2008 to facilitate more ... trials. A formal introduction to the Clinical trials Network was provided at a two-day workshop in ...

Potential new HIV drug may help patients not responding to treatment

... D-1mT is currently in Phase I clinical trials to test its safety and potential efficacy as a ... hope that if D-1mT proves safe in the initial trials for cancer and shows further promise for treating HIV, trials for using D-1mT as a treatment for HIV could ...

UC Davis bench-to-bedside research: Promising treatment in clinical trials

... has entered Phase II of human clinical trials to evaluate its efficacy. The compound, a ... biotechnology company, to clinical trials proved as steep as the mountains he climbs. ... countries." Meanwhile, the clinical trials under way represent two firsts, said James Sabry, ...

Using hair to manage HIV/AIDS and predict treatment success

... testing hair to monitor pill-taking in clinical trials of single or dual antiretrovirals in high risk, ... than men taking these regimens. The safety trials of these medications were conducted in trials consisting largely of men, and the highest ...

Dana-Farber oncologists present at ASCO GU -- predict prostate cancer survival using Source MDx test

... in clinical trials. The Prostate Cancer Clinical trials Consortium (PCCTC) will begin a prospective, ... test in forthcoming larger, multi-site clinical trials with the Prostate Cancer Clinical trials Consortium." These data also show that ...

Mental fatigue can affect physical endurance

... and once when they were mentally rested. The trials took place in the laboratory on different days. ... measurements did not vary between the two trials when compared at specific points in time. However, because the non-fatigued trials went longer, heart rate and blood lactate levels ...

Researchers isolate protein domain linked to tumor progression

... When a promising cancer drug reached clinical trials in the 1990s, researchers were disappointed by ... Sciences (PNAS). "The failure of the clinical trials suggest that the proteinases were not only ... why inhibiting the catalytic domain in the drug trials would have both the favorable impact of stopping ...

New test for breast cancer will help guide treatment choices

... current treatments will be referred to clinical trials of investigational drugs and treatments, opening ... group is currently designing prospective clinical trials using the test, which they refer to as the Breast Bioclassifier. Bernard plans to run these trials at Huntsman Cancer Institute and collaborating ...

Trailblazing rural community shows green heating oil a viable option

... elsewhere in the county are taking part in the trials which started in December. Lisa Cook, head ... general of OFTEC, said: "Results from the field trials have been extremely encouraging to date. The ... members who are conducting their own field trials alongside this project. "Having a liquid ...

ABC publishes monograph on scientific and clinical research of Sinupret

... reviewed in the monograph include four clinical trials regarding acute sinusitis, two clinical trials regarding chronic sinusitis, one meta-analysis of clinical trials evaluating treatment of sinusitis, two ...

TGen Clinical Research Services at Scottsdale Healthcare and Mayo Clinic study new cancer drug

... potential to treat solid tumors. Clinical trials of the drug TH-302 are being conducted at TGen ... Dr. Weiss said. Phase 1 and Phase 1/2 trials are underway to investigate the safety and ... activity in these tumors. Both Phase 1 and 1/2 trials continue to enroll patients with other solid ...

Robo-surgery: As safe and capable as a human assistant in key-hole gallbladder removal

... can now perform this task: this study looked at trials involving 'Endoassist', 'Aesop', 'Passist' and ... researchers considered data from five randomised trials that included a total of 453 patients. The ... was no appreciable difference. "We need more trials that see whether the success rates using robotic ...

International copper industry defines role in the fight against hospital infections

... Results of laboratory testing and clinical trials indicate that they can. Scientists from around ... as antimicrobial and the initiation of clinical trials in three U.S. hospitals. The EPA registration ... community-acquired infections. The clinical trials are comparing the amount of bacteria found on ...

Vitamins C and E and beta carotene again fail to reduce cancer risk in randomized controlled trial

... a lower risk of cancer. Results from randomized trials that address the issue, however, have been ... in agreement with a recent review of randomized trials indicating that total mortality was not affected ... reviewed data from previous randomized controlled trials that examined supplement use and cancer ....

Pregnant women with asthma can be more confident about some medicines

... best studied and can be regarded as safe. More trials of other essential medicines are necessary ... Efficiency in Health Care (IQWiG), more data from trials could reassure women who worry about the safety ... www.informedhealthonline.org . More trials on medications in pregnancy are necessary ...

Phase III data show efficacy/safety of iclaprim in patients with complicated skin infections

... results from two pivotal Phase III clinical trials at the 48th Interscience Conference on ... treatment option for physicians." The ASSIST trials The ASSIST trials were randomized, multi-center, double-blind, ...

New test promises quicker, more accurate evaluation for cystic fibrosis patients

... patients and not sensitive enough for clinical trials of many new medications," said Dr. Milene ... expensive to conduct phase 2 or phase 3 trials of medications long enough to detect the changes ... extremely useful in clinical care of patients and trials of new CF therapies." The researchers are now ...

Media invitation: 20th EORTC-NCI-ACR Symposium on Molecular Targets and Cancer Therapeutics

... in phase I trial of solid tumours: phase II trials planned; Scientists discover pattern of gene ... including medullary thyroid cancer. Phase III trials planned; Researchers discover that a genetic ... with bowel, kidney and prostate cancer: phase III trials on-going. Please note: the details contained ...

Johnson & Johnson honors 2008 recipients of the Dr. Paul Janssen Award for Biomedical Research

... have collaborated on basic research and clinical trials that have transformed the treatment of people ... developed for an unrelated condition. Clinical trials revealed rapid and dramatic improvement of ... therapies has been well established in clinical trials and through experience with more than one million ...

TGen and Washington University researchers discover new approach to treating endometrial cancer

... because there are already drugs in clinical trials that inhibit FGFR2 function,'' Pollock said. ... to the ACS. Pollock plans to start clinical trials with an FGFR inhibitor in endometrial cancer patients within a year. The trials will be conducted in collaboration with Dr. ...

Immune system protein accurate predictor of survival in pediatric septic shock

... a powerful tool for diagnostics and clinical trials of new septic shock therapies, according to a ... risk patients out of interventional clinical trials of experimental therapies, said Hector Wong, ... low-risk septic shock patients from clinical trials of experimental or potentially high-risk ...

Footrot vaccine closer than ever

... University scientists have started clinical trials to find a successful vaccine against footrot in sheep. The trials have been made possible with funding of $663,000 from Australian Wool Innovation (AWI) The trials over three years are taking place at Monash ...

UC Davis stem researchers demonstrate safety of gene therapy using adult stem cells

... that is the hallmark of cancer." Gene therapy trials using human bone marrow cells began in the early ... eighteen cell and gene therapy clinical therapy trials during their 12 years as colleagues, including stem cell gene therapy trials for adenosine deaminase deficiency, also known as ...

New research shows no link between aromatase inhibitors and cardiovascular problems

... for the oestrogen receptor (ER+). Several trials have shown that AIs are more effective than ... France), looked at the results from several trials of AIs in order to compare the effects of AIs ... transient decrease in cholesterol levels. In trials that compared AIs with tamoxifen, increases were ...

Antioxidant users don't live longer, analysis of studies concludes

... both the content and quality of existing medical trials on a topic. Most people do eat not enough ... to include only large, randomized controlled trials to assess mortality. Most of the trials that showed no deaths were not proper ...

2 new therapies show promise for cancer patients

... TGen today announced the results of two clinical trials that show promise for patients battling cancer. ... (BCC) and pancreatic cancer. The Arizona trials were conducted at TGen's Clinical Research ... trial. This was a phase I trial, and phase I trials are usually designed to test safety, hoping it ...

Vaccine for Ebola virus

... the first time, after entering Phase 1 clinical trials in autumn 2006. Ebola virus infection of ... been very useful as animal models. Ebola vaccine trials using nonhuman primates have provided unambiguous ... rapidly, says Dr Sanchez. Successful human trials will mean that we can vaccinate healthcare ...

Mayo Clinic Proceedings January tip sheet

... issue of Mayo Clinic Proceedings. While some trials have suggested that antioxidants have beneficial effects, results from other trials have been negative. It has been unclear which ... the study, two authors reviewed all randomized trials on antioxidants for cancer prevention(1968-2005) ...

Fish oil -- helpful or harmful?

... Toronto researchers. In a systematic review of trials where patients with implantable cardioverter ... (epidemiologic) studies and randomized controlled trials that intake of recommended amounts of DHA and EPA ... further research and large randomized controlled trials are needed before long-chain omega-3 fatty acids ...

Cold treatment opens doors for citrus exports to Japan

... NSW Department of Primary Industries (DPI). trials undertaken at NSW DPIs Gosford Horticultural ... them of the results of extensive replicated trials conducted at Gosford and in Western Australia. ... to cold treatment than the MFF. The trials show that QFF were killed after 14-16 days ...

Economical, nonpolluting solutions to greenhouse growing found

... Gizas and Dr. Dimitrios Savvas recently conducted trials of four grades of pumice to determine the most ... environment. Gizas and Savvas conducted four trials in heated greenhouses using gypsophila (commonly ... moisture retention were also determined. The trials clearly showed that the most balanced and safe ...

2 carotid artery stenting studies show results comparable to AHA guidelines

... D.C., October 23, 2007 - Two carotid stenting trials examining patient outcomes demonstrated results ... Protection System. The key objective of both trials was to determine whether carotid stenting could ... at 30 days. The demographics of patients in both trials were similar. The 30-day composite endpoints ...

Phase 2 of Singapore's Biomedical Sciences Initiative gains momentum for clinical research

... to support and strengthen late phase clinical trials in Singapore. These are some of the new ... This includes late Phase 2 Phase 4 clinical trials and selected epidemiology and outcome research ... the various public hospitals to coordinate large trials across the multiple sites. Progress of BMS ...