trauma

Gene therapy converts dead bone graft to new, living tissue

...mising development for the thousands of cancer and trauma patients each year who suffer with fragile and failing bone grafts. The findings were posted online Feb. 13 and will appear in the March 1 issue of Nature Medicine. The procedure, designed by a team led by Edward M. Schwarz, Ph.D., associate profess...

Brain-injury rehabilitation depends on acetylcholine circuitry

...the brain to recover from such injury as stroke or trauma depends on a particular circuitry of neurons that "talk" to one another using the brain chemical acetylcholine, researchers led by James Conner and Mark Tuszynski in the Neural repair Group at UCSD have discovered. Their finding in rats could help en...

Doctors closer to using gene analysis to help trauma patients

... genetic tool with the potential to identify which trauma and burn patients are most likely to become seriou...he vast majority of patients who experience severe trauma or burn injuries actually do well,?said Lyle Moldawer, a surgery professor in UF’s College of Medici...

Penn Researchers Use Robotic Surgery

...otic Surgery (TORS) which greatly reduces surgical trauma for patients. Their initial findings will be presented Monday, May 16th at 11:45 a.m., at the combined annual meetings of otorhinolaryngology (ear, nose and throat) experts ?the Triologic Society, May 13th through16th, in Boca Raton, Florida. PENN p...

Two new retroviruses—transmitted from animals—identified

...otic Surgery (TORS) which greatly reduces surgical trauma for patients. Their initial findings will be presented Monday, May 16th at 11:45 a.m., at the combined annual meetings of otorhinolaryngology (ear, nose and throat) experts ?the Triologic Society, May 13th through16th, in Boca Raton, Florida. PENN p...

Using nanoparticles, in vivo gene therapy activates brain stem cells

...e to repair neurological damage caused by disease, trauma or stroke," said Earl J. Bergey, Ph.D., co-author and deputy director of biophotonics at the institute. The group's next step is to conduct similar studies in larger animals. ...

New complete muscle grown in the lab

...-grown muscles could replace tissue lost to severe trauma such as burns, or build up muscle that has weakened or wasted away in diseases like AIDS. Until now, most scientists have not attempted to provide engineered tissue with its own blood supply. Instead, they have implanted the new tissue into the body...

New Lab Research May Help Those Deafened By Immune System Attack

..., whether due to immune system attack, loud noise, trauma or medications, can diminish or destroy hearing. The U-M team has developed a monoclonal antibody, called KHRI-3, that attaches to IESCA in the inner ear, and can be detected in living animal systems and cell cultures. It has allowed them to study I...

Muscle repair: Making a good system better, faster; implications for aging, disease

...ng damage from overuse during exercise, surgery or trauma can be stymied. Furthermore, as we age, muscle repair slows noticeably, and in Duchenne Muscular Dystrophy and other degenerative muscle diseases, normal repair functions can't cope with disease progression. Researchers from the University of Illino...

Chernobyl: The true scale of the accident

...lated to better reporting, not radiation. Did the trauma of rapid relocation cause persistent psychological or mental health problems? Stress symptoms, depression, anxiety and medically unexplained physical symptoms have been reported, including self-perceived poor health. The designation of the affected ...

Study reveals genomics of inflammation from severe injury

...ivity in the white blood cells of a large group of trauma and burn patients over longer periods of time. The glue grant team includes scientists from Stanford Genome Technology Center in Palo Alto, Calif.; University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School in New Brunswi...

Study Unlocks Insects?Secret for Love in the Dark

...ivity in the white blood cells of a large group of trauma and burn patients over longer periods of time. The glue grant team includes scientists from Stanford Genome Technology Center in Palo Alto, Calif.; University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School in New Brunswi...

New neurons take baby steps in the adult brain

...c lateral sclerosis, or nerves that are damaged by trauma or injury. In none of these systems are new neurons formed or integrated to any great extent naturally. ...

Clinical trial to test stem cell approach for children with brain injury

...ng children, and the main reason children die from trauma is brain injury, Cox said. The proposal was under review for a year. The U.S. Food and Drug Administration approved Cox's Investigational New Drug (IND) application in September. The UT-Houston CPHS, the university's institutional review board for ...

Scientists crack code for motor neuron wiring

... in people whose spinal cords have been damaged by trauma or disease. The studies suggest that the code -- which involves members of the family of transcription factors encoded by the Hox genes -- could also govern the establishment of other spinal cord circuits. This circuitry includes interneurons that co...

Researchers develop portable 'vein finder' for faster, more accurate injections

When medics are treating trauma patients, every second counts. Yet bruises, burns, and other physical conditions often make it difficult to locate veins and administer lifesaving drugs or solutions. In response, a team of Georgia Institute of Technology researchers is developing a...

How 'hot' emotional brain interferes with 'cool' processing

...ther people, and that a distracter associated with trauma may grab control of brain processing and essentially take off-line those areas of the brain we use to stay on task. It's as if when you're sad, the world seems sadder and all you see is bad news." "Our aim is to reverse that with drug treatment, so ...

World first research to speed up cure for ear infections

...n ear drums burst as a result of a loud explosion, trauma or most commonly by infection spread by a common cold or sore throat. LEHI's Senior Research Scientist Dr Reza Ghassemifar, said he was looking forward to starting the three-year research project after securing a $238,600 grant from the Garnett Pass...

Weizmann Institute suggests that immune cells help to maintain cognition and brain cell renewal

...ALS), and the nerve degeneration that results from trauma or stroke. In their earlier research, Schwartz and her team provided evidence to suggest that T cells directed against CNS components do not attack the brain but instead, recruit the help of the brain's own resident immune cells to safely fight off ...

Wound monitor 'sniffs out' infections

...pplications for the device will include monitoring trauma injuries, chronic ulcers and in military field hospitals. Manchester will coordinate a European team of engineers and medical experts, which will include consultants from the Department of Burns and Plastic Surgery at Wythenshawe Hospital (Mancheste...

Mayo Clinic researchers challenge sepsis theory

... syndrome like sepsis that can happen in cancer or trauma or in response to drugs -- is that this receptor gets released from its constraint. That's the first step that actually initiates sepsis." Research is underway to discover new therapies that could prevent, blunt or reverse the release of the constrai...

Hopkins researchers discover genetic switch that turns off an oxygen-poor cell's combustion engine

...lls are starved for oxygen - as during exertion or trauma -- the genetic switch that the Hopkins researchers found deliberately shuts off the cell's mitochondrial combustion engine, which scientists had long - and erroneously -- believed ran down on its own due to lack of oxygen. "The unexpected discov...

Spray-on skin relieves emotional trauma for child burn victims

... skin is helping child burns victims cope with the trauma of scarring, according to a study by University of Queensland researchers at the Royal Children's Hospital in Brisbane. A study has shown most children reported an improvement in the appearance of their scars and were happier when they used the pro...

Scientists discover why cornea is transparent and free of blood vessels, allowing vision

...tein could heal corneas that have undergone severe trauma or help shrink tumors fed by rapidly growing abnormal blood vessels," he says. "In fact, the next step in our work is exactly this." ...

New research promising for improving brain cell survival after brain injury

... to patients suffering brain injury from stroke or trauma so save as many neurons as possible. "Such a drug would limit damage to the brain after the injury, as well as the subsequent few days when injured nerves release 'suicide factors' that cause surrounding, healthy neurons to die en masse. "This ...

Gene chip technology shows potential for identifying life-threatening blood infection

...patients recovering from surgery, pancreatitis, or trauma from a car accident or fall. Because these patients are also hooked up to IV fluids, catheters or ventilators, they are also prone to bacterial infections, including pneumonia, that can quickly spiral out of control and lead to sepsis. Although bo...

PNAS study reveals why organs fail following massive trauma

...ing multiple organ failure. That is one reason why trauma is the leading cause of death for Americans aged 4...y a significant role in determining whether or not trauma is fatal," said Carol L. Miller-Graziano, Ph.D., professor of Surgery and of Microbiology & Immu...

Replacing insulin is top-ranked breakthrough foreseen for health in developing world

...or organs impaired by congenital defects, disease, trauma and other causes. It moves beyond traditional transplant and replacement therapies to include the use of stem cells, soluble molecules, genetic engineering, tissue engineering, and advanced cell therapy. There is increasing research in regenerative...

Gene therapy inhibits epilepsy in animals

...ial episode of SE or an injury such as severe head trauma is known to raise the risk of later developing epilepsy, so this study suggests that strategies aimed at modifying signaling pathways in the brain after such an insult may help prevent epilepsy," said Dr. Brooks-Kayal. "The approach would likely be d...

New study aims to stop sepsis in its tracks

... at more than a dozen institutions. Like dedicated trauma teams, the sepsis teams will focus all their attention on one patient at a time and will follow a scripted protocol to stabilize, diagnose, and treat sepsis. The protocol includes a sequence of resuscitation methods to deliver fluids, restore bloo...

Researchers first to map gene that regulates adult stem cell growth

...s and central nervous system damage as a result of trauma or stroke. The researchers also are looking into the possible role the gene plays in transforming healthy stem cells into cancerous ones, such as in leukemia and lymphomas. If the gene does in fact play such a role, it is possible that it also coul...

Traumas like Sept. 11 make brains more reactive to fear

...One of the first studies to look at the effects of trauma on the brains of healthy people, it is published i...s later in life, according to other studies. Also, trauma has been found to make the brain's emotional processing centers -- particularly the amygdalae, the p...

Clot-dissolving agent may be beneficial in treatment of severe frostbite

...e authors write. “While many other areas of burns, trauma and critical care have advanced significantly in their treatment modalities, the saying ‘Frostbite in January, amputate in July’ is still relevant today.” Kevin J. Bruen, M.D., and colleagues at the University of Utah, Salt Lake City, studied the ...