Transplantation in Biological News

REGiMMUNE presents enhanced efficacy data in preclinical transplantation models

... of Sirolimus, demonstrated enhanced efficacy in transplantation tolerance induction in models of skin transplantation and acute Graft-versus-Host disease (GvHD). This ... potential of RGI-2001 to induce antigen-specific transplantation tolerance, which is considered a holy grail in ...

Stem cell infusion and hyperbaric oxygen treatment improve islet function in diabetes

... their study results in the latest issue of Cell transplantation (Vol. 17 No.12). "Autologous stem cell ... "A decade ago, research had explored stem cell transplantation and hyperbaric oxygen therapy as stand alone ... Dr. Cesar V Borlongan, Associate Editor of Cell transplantation and Professor at the University of South Florida ...

Shorter wait means longer life for kidney transplant candidates

... to an often ignored but critical aspect of transplantation what happens to patients while they are waiting ... for transplantation," he said. Kidney transplantation doubles life expectancy compared with dialysis ... country, according to the Organ Procurement and transplantation Network. Patients are prioritized by blood type, ...

Advancement in tissue engineering promotes oral wound healing

... (Feb. 3rd, 2009) Oral tissue engineering for transplantation to aid wound healing in mouth (oral cavity) ... work was reported in the current issue of Cell transplantation (17:10/11). According to the study's lead ... Amit Patel, a section editor of the journal Cell transplantation . ...

Studies on imaging and tracking transplanted cells

... studies published in the current issue of Cell transplantation (Vol. 17, No.8) assess various imaging ... imaging published in this issue of Cell transplantation (Vol. 17 No. 8), evaluated the use of cloned ... Florida Health, and associate editor of Cell transplantation . ...

Embryonic stem cells might help reduce transplantation rejection

... possible improvements in organ and bone marrow transplantation for humans. The study results appeared Friday in ... . People who need bone marrow or solid organ transplantation must take immunosuppressive drugs that can cause ... spurring researchers to develop methods to reduce transplantation rejection, said the study's principal ...

Children's Hospital researchers identify genetic mutation that may predict organ rejection

... Research in the Hillman Center for Pediatric transplantation at Children's Hospital. They studied DNA samples ... known mutations in children who received liver transplantation or were given a particular antirejection regimen, ... medications is important because, while they make transplantation possible, they also can have side effects such as ...

Cryopreservation techniques bring hopes for women cancer victims and endangered species

... women, with several children born as a result of transplantation of frozen/thawed ovarian tissue, can be applied ... given birth to babies following the successful transplantation of the frozen/thawed ovarian tissue, including ... number is likely to increase in future as the transplantation technology becomes more mature and widely ...

Researchers discover link between organ transplantation and increased cancer risk

... determined a novel mechanism through which organ transplantation often leads to cancer, and their findings suggest ... assistant professor at Harvard Medical School's transplantation Research Center at Children's Hospital in Boston. ... be that anti-VEGF agents given judiciously after transplantation can reduce future cancer occurrence," he said. ...

New technology enhances therapeutic potential of cord blood stem cells

... the 6th Annual International Umbilical Cord Blood transplantation Symposium, June 6-7 in Los Angeles. Kent W. ... in the Sections of Hematology and Stem Cell transplantation at Rush, is researching a CD26 Inhibitor, a small ... the cord, are most commonly used for bone marrow transplantation when a donor from a patient's family or an ...

New study shows that fetal cells to treat Parkinson's disease may not function long term

... history of Parkinsons disease who underwent transplantation in 1993. After transplantation she experienced improvements in disease symptoms ... and analyzed. She had the longest survival after transplantation that had been reported to date among this studys ...

Penn Veterinary Medicine report new strategy to create genetically-modified animals

... the first report of transgenesis via germ cell transplantation in a non-rodent species, a promising approach to ... that germline transduction and germ cell transplantation in large animals provides an approach that is ... the team used the established germ cell transplantation model in the mouse to investigate whether ...

Breakthrough research identifies how cells from pigs may cure diabetes

... of the Diabetes Institute for Immunology & transplantation at the University of Minnesota and his team, who ... MN. The symposium will be part of The transplantation Societys 2007 Joint Conference ( ... greatest innovators from three sections of the transplantation Society the Cell Transplant Society (CTS), the ...

Clearance of hepatitis C viral infection after liver transplantation

... Touching stories of living donor transplantation are continuously happening in hospitals. One of ... patient from the severely damaged liver, liver transplantation (LT) was considered by Dr. Ichikawa when a loving ... clearance of HCV RNA seemed impossible, the liver transplantation was performed. Unexpectedly and excitingly, ...

First human gets new antibody aimed at hepatitis C virus

... most serious cases of HCV that do not respond to antiviral drugs, liver transplantation is the only option. HCV is the leading indication for liver ... half of the 6,000 liver transplants done each year in the United States. transplantation can be a life-saving treatment; however, in nearly all cases the patient's ...

Placenta-derived stem cells may help sufferers of lung diseases

... 2009) An Italian research team, publishing in the current issue of Cell transplantation (18:4), which is now available on-line without charge at ... agent, we set out to evaluate the effects of fetal membrane-derived cell transplantation in chemically-treated (bleomycin) mice." According to Dr. Parolini, ...

Ovarian transplantation: New technique gives greatly improved results in this delicate operation

... They also followed up nine homozygotic twin patients after fresh ovary transplantation for the duration of ovarian function and pregnancy outcome, and tested ... slow freezing resulted in a 56% loss of viability", said Dr. Silber. transplantation of the tissue resulted in a duration of ovarian function of more than four ...

Hebrew University researchers neutralize tumor growth in embryonic stem cell therapy

... mice. It is assumed that this tumorigenic feature will be manifested upon transplantation to human patients as well. The development of tumors from embryonic stem ... in those cells. This inhibition of this gene just before or after transplantation of the cells could minimize the chances of tumor formation, but the ...

Novel antibody prevents infection by hepatitis C virus

... most serious cases of HCV that do not respond to antiviral drugs, liver transplantation is the only option. Typically 2,000 to 4,000 liver transplants are done ... less than the number of people on the waiting list for available organs). transplantation can be a life saving treatment; however, in nearly all cases the patient's ...

Device protects transplanted pancreatic cells from the immune system

... treating Type 1 diabetes, was published online on April 8 in the journal transplantation . The team of scientists showed that after transplantation, the ... producing beta cells in the pancreas. One of the challenges of cell transplantation therapy to treat diabetes is the need for long term immunosuppression, ...

Multiple route bone marrow stem cell injections show promise to treat spinal cord injury

... without serious adverse events. Publishing in the current issue of Cell transplantation (Vol. 17 No.12), the researchers reported on eight patients with SCI ... of life and demonstrate functional improvements. "Autologous stem cell transplantation of BMCs can promote the growth of blood vessels and, therefore, represent ...

Researchers explore new driver of transplant rejection: Platelets

... biology, published in the January issue of the American Journal of transplantation . "It all began with the observation that when transplant tissue is ... treatment, according to Hamid Rabb, M.D., medical director of kidney transplantation and a professor of medicine at the Johns Hopkins University School of ...

Researchers engineer pancreatic cell transplants to evade immune response

... causes only a minimal immune response in recipients. At present, cell transplantation therapy is limited because transplant recipients are forced to take ... type of cellular transplant from rejection." However, pancreatic cell transplantation could not help treat patients with type 2 diabetes. In this form of the ...

American Chemical Society's Weekly PressPac -- Dec. 17, 2008

... of biodiesel fuel Better antifreezes to preserve donor organs for transplantation Producing a more effective oral form of a powerful disease-fighting ... FOR IMMEDIATE RELEASE Better antifreezes to preserve donor organs for transplantation Journal of the American Chemical Society Chemists in Canada have ...

Transplanted fat cells restore function after spinal cord injury

... Fla. (Dec. 10, 2008) A study published in the current issue of CELL transplantation (Vol.17, No. 8) suggests that mature adipocytes - fat cells - could ... expressed neurotrophic factors, such as BDNF and GDNF, prior to and after transplantation and which likely contributed to the promotion of functional recovery. ...

Innovations in Pediatric Medicine CME conference brings together national pediatrics experts

... director, Dr. Mitchell Cairo, director of pediatric blood and marrow transplantation at Morgan Stanley Children's Hospital of NewYork-Presbyterian and ... University of California, San Diego 1:15 1:45 p.m. Prenatal Stem Cell transplantation -- The Virtues of Tolerance Dr. Alan W. Flake, Children's Hospital of ...

Cardiac cell transplant studies show promise in cardiac tissue repair

... (Sep. 3rd, 2008) Two studies published in the current issue of CELL transplantation (17:6) examine the efficacy of transplanting bone marrow cells (BMCs) for ... group. The second study, carried out at the University of Padua, compared transplantation of two sources of mensenchymal stem cells (MSCs) derived from bone marrow ...

Adult stem cells activated in mammalian brain

... the body healthy cells that may or may not genetically match the patient. transplantation of nonmatching stem cells requires the use of drugs to prevent the body ... But, working with a patient's own cells would eliminate the need for transplantation and immunosuppressant drugs and may be a better alternative, scientists ...

American Chemical Society's Weekly PressPac -- July 2, 2008

... States. In the new study, Yuji Teramura and Hiroo Iwata point out that transplantation of the pancreas's insulin producing cells, so-called islets of Langerhans, ... This is because the body destroys many of the islet cells right after transplantation in an inflammatory reaction triggered by blood clotting on the surface of ...

8-day undersea mission begins experiment to improve coral reef restoration

... coral colonies contain forms of genes that allow them to survive transplantation and other stresses, such as increasing sea temperatures. The team has ... transplantation," said Baums. "We want to know if some corals die after transplantation because they already were weakened by an external force or because they ...

Neural cell transplants may help those with Parkinson's disease

... Tampa, Fla. (May 19, 2008) The current issue of CELL transplantation (Vol. 17:4) features a number of publications by researchers seeking new ... to elucidate the likelihood of favorable outcomes following stem cell transplantation with respect to route of administration, possible modes of action and the ...

Menstrual blood -- a valuable source of multipotential stem cells?

... in part from bone marrow. Published in the most recent issue of Cell transplantation (Volume 17, issue 3), the study examined to what degree MenSCs ... of their studies, they noted the potential for MenSCs in regenerative transplantation therapies for many different organs and tissues. The need for regenerative ...

Stroke victims may benefit from stem cell transplants

... 28, 2008) According to two studies published in the current issue of CELL transplantation (Vol.16 No.10), stroke victims may benefit from human mesenchymal stem ... adult stem cell source for transplant therapy following stroke, says Cell transplantation associate editor Cesar V. Borlongan, Ph.D. of the Medical College of ...

Northwestern Memorial trial may wean kidney transplant patients off antirejection drugs

... is working with Northwestern Memorial Hospitals department of organ transplantation to enroll qualifying subjects in a new research study that seeks to ... person to person, and an HLA compatibility test is performed before organ transplantation to find out if tissues match between a donor and a recipient. The ...

Ireland Cancer Center researchers advance stem cell gene therapy

... presented significant findings that treatment with Rituximab before transplantation results in cure rate and overall survival in patients undergoing autologous stem cell transplantation for Diffuse Large B-Cell lymphoma. Dr. Lazarus and colleagues of ...

NIBIB invests in quantum research

... insulin secreting cells as a replacement strategy for treating diabetes. transplantation of pancreatic islets to restore insulin production is promising; however, ... renal disease is a significant global health problem. Donor kidneys for transplantation are in short supply, with dialysis and filtration as the only alternative ...

Possible hepatitis C vaccine

... virus can lead to liver cancer, and is the most common reason for liver transplantation in both the UK and the USA. We are also currently exploring the possibility of improving liver transplantation success rates by passively infusing people with these antibodies said Dr ...

Stem cell research: From molecular physiology to therapeutic applications

... embryonic stem cells or induced pluripotent stem cells. On the other hand, recent post mortem analysis of patients who received fetal brain cell transplantation revealed that implanted cells are prone to degeneration just like endogenous neurons. Thus it appears that future cell replacement studies will have ...

Ovarian transplantation: First baby is born after a new technique

... after a ten year gap between ovarian cryopreservation and grafting. We believe that it represents a considerable advance on the methods of ovarian transplantation used until now, not least because we are able to obtain large numbers of oocytes. We hope that it will enable more young patients who have been cured ...

Trio of signals converge to induce liver and pancreas cell development in the embryo

... be used for new therapies. With regenerated cells, researchers hope to one day fill the acute shortage in pancreatic and liver tissue available for transplantation in cases of type I diabetes and acute liver failure. Previous studies on pancreas and liver development have focused on individual molecular ...