transplant

Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs

...m cells; andin patients who have had a bone marrow transplant to increase thenumber of white blood cells. It is still considered experimental,however, for use to increase the level of EPCs in patients withperipheral vascular disease.The investigators are seeking patients in whom prior treatments,including surge...

Current human embryonic stem cell lines contaminated UCSD/Salk team finds

...eally, onlyever exposed to serum from the intended transplant recipient.""However, such an approach could not be pursued under existing rulesfor the use of federal grant dollars," Varki said.The first author of the Nature Medicine study is Maria J. Martin,Ph.D., a post doctoral researcher in Varki's lab at UCSD...

Genetically modified natural killer immune cells attack, kill leukemia cells

...n. In this case, NK cells will be derived from the transplant donor, expanded and genetically modified. These mo...ls will then be infused into the patient after the transplant in order to eliminate residual leukemic cells. In another application, NK cells could be obtained fr...

Researchers add new tool to tumor-treatment arsenal

...he immunosuppressive drug rapamycin. Used in organ transplant patients, rapamycin and its derivatives have shown promising anti-tumor activity in phase I and II clinical trials. RAD001 lowers the amount of DNA-damaging agent needed by blocking p53's DNA-repair function, automatically killing the cancer cells w...

Potential Cure for Lymphoma in HIV patients

...ing HIV infection did not worsenas a result of the transplant and associated treatments.“The results of this stu... individuals. It’simportant to know that stem cell transplant is an available and highlysuccessful treatment option for these patients,?said Amrita Krishnan,M.D.,...

Circles Of DNA Might Help Predict Success Of Stem Cell Transplantation

...physicians predict whether a bone marrow stem cell transplant will successfully restore a population of infectio...ysicians predict whether children receiving such a transplant will experience either failure or significant delay in the reconstitution of the T cell population. ...

World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics

... Japan, where he originally did living donor liver transplant training with Dr. Tanaka. Dr. Masumoto was previou...uggested the idea of starting a living donor islet transplant program in Kyoto while lecturing there three years ago. Cadaveric organ donors are scarce in Japan, ...

Norovirus, AIDS vaccine and Hepatitis Virus

... in some cases can cause liver failure requiring a transplant for survival. The protein interferon, produced by animal cells when they are invaded by viruses, is released into the bloodstream or intercellular fluid to induce healthy cells to manufacture an enzyme that counters the infection. One class of interf...

Epstein-Barr virus protein crucial to its role in blood cancers

...in cancers such as lymphoproliferative diseases in transplant or AIDS patients, Burkitt's lymphoma, Hodgkin's ly... studies will be in lymphoproliferative disease in transplant and immunocompromised patients because this is a clear case of EBV-driven B-cell lymphoma. The use ...

Defensins neutralize anthrax toxin

...in cancers such as lymphoproliferative diseases in transplant or AIDS patients, Burkitt's lymphoma, Hodgkin's ly... studies will be in lymphoproliferative disease in transplant and immunocompromised patients because this is a clear case of EBV-driven B-cell lymphoma. The use ...

Viral protein influences key cell-signaling pathway

...current study used a non-infectious form of HIV to transplant the HTLV-1 p12 gene into laboratory-grown T cells. The infected cells then produced a constant level of p12 protein. The researchers then used gene microarray technology to identify which cellular genes out of 33,000 become either more or less active...

Light therapy may combat fungal infections, new evidence suggests

...ho lack a functioning immune system, such as organ transplant recipients, those with HIV/AIDS, and patients treated with steroids or cancer chemotherapy. The fungus' global importance as a health threat has therefore risen in parallel with the increase in immunosuppressive therapies and the worldwide HIV/AIDS e...

Gene therapy promising for growing tooth-supporting bone

...py outside the body using a tissue biopsy and then transplant the genetically-modified cells back into the patient, but this would require two surgical procedures instead of one. The Molecular Therapy paper is titled "BMP Gene Delivery for Alveolar Bone Engineering at Dental Implant Defects," and the work was ...

Rare surgery performed to remove pancreas, prevent diabetes

...lantation, and directs the University's islet cell transplant program, which uses pancreatic cells from brain-de...t diabetics. Contreras is co-director of the islet transplant program. The patient was in intensive care at UAB Hospital for two days following the surgery, and w...

Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells

...England Journal of Medicine. Without an immediate transplant of stem cells, Krabbe infants rapidly begin to los...Blood and Marrow Transplant Program. "Delaying the transplant even a week or two can make a noticeable difference in a child's motor skills, so timely diagnosis a...

Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells

...n. In this case, NK cells will be derived from the transplant donor, expanded and genetically modified. These mo...ls will then be infused into the patient after the transplant in order to eliminate residual leukemic cells. In another application, NK cells could be obtained fr...

Same-Sex Mating Discovered in a Toxic Fungus

...monly in immune-compromised patients such as organ transplant recipients and cancer patients -- whose immune systems are crippled by immunosuppressive drugs or chemotherapy -- and people with HIV/AIDS. The fungus' global importance as a health threat has therefore risen in parallel with the increased use of suc...

MUHC scientists describe genetic resistance to rampant virus

...he life of HIV patients and improve the success of transplant surgery by reducing the risk of rejection. There i...se with a compromised immune system, such as organ transplant recipients, newborns and persons infected with human immunodeficiency virus (HIV). Dr. Vidal believe...

Scientists discover that three overlapping signals in embryo help get the backbone right

... Khokha said. "If you cut out a similar tissue and transplant it in a mouse, you also get the Siamese twin phenomenon. So, we expect it to also be true in humans." ...

Infants with Rare Genetic Disease Saved By Cord Blood Stem Cells

...England Journal of Medicine. Without an immediate transplant of stem cells, Krabbe infants rapidly begin to los...Blood and Marrow Transplant Program. "Delaying the transplant even a week or two can make a noticeable difference in a child's motor skills, so timely diagnosis a...

Stem cell research - new cell lines

...ure population of those cells in large numbers and transplant them into the patient." The researchers are currently in the discovery phase, where they are trying to characterise the three clonal lines they have developed. "It is too early to say anything about these clonal lines, but one of them is inclined t...

Single-donor Islet Transplantation Procedure Shows Promise For Patients With Type 1 Diabetes

...ar. "Our results mark a distinct advance in islet transplant efficacy. We not only achieved insulin independence using islets from only 1 donor pancreas [as compared with 2 to 4 in another trial], we also achieved superior glycemic control (as evidenced by normal results of oral glucose tolerance testing in 4 ...

Precise Timing Enabled Pig-to-rat Transplants To Cure Diabetes

...n their development. "When we again harvested the transplant tissues 28 days after fertilization, it reproduced...h successful pancreatic transplants still reject a transplant of a different type of pig primordia, embryonic kidney tissue, if they are not given immune suppress...

Embryonic Stem Cells Treated With Growth Factor Reverse Hemophilia In Mice: UNC Researchers

...ofessor of surgery and division chief of abdominal transplant surgery. Moreover, he said, the PEP cells robustly engraft within the liver and were not recognized by the immune system as foreign. "Within a few weeks, PEPs became hepatocytes," Fair added. "They went from something that is a very early grandpare...

Experiment station researchers to explore genome of disease-fighting fungus

...ant varieties. "In the nursery industry where you transplant from smaller to larger containers, you can incorporate the fungus as a potting mix amendment that would protect against root-rotting fungi," Kenerley said. Ebbole said their research will "provide resources for the entire scientific community," noti...

Hopkins AIDS experts issue warning about global efforts to provide drug therapies

... disease in the 1960s and allocation of livers for transplant in the 1980s and early 1990s. Like HIV infection,...rpretations of who medically benefited most from a transplant and by a scoring system that favored patients most likely to survive their surgery over those most l...

Circulating stem cells play small role in lung repair

... differences to analyze the repair process in lung transplant patients. Reporting in today's edition of the jou...ung stem cell originated in the bone marrow of the transplant recipient. "It's possible in the future that circulating stem cells could be augmented to play a gr...

Candida albicans Genome Fully Annotated

... differences to analyze the repair process in lung transplant patients. Reporting in today's edition of the jou...ung stem cell originated in the bone marrow of the transplant recipient. "It's possible in the future that circulating stem cells could be augmented to play a gr...

Discoveries by UAB and Florida scientists may help transplanted organs survive longer

...ts may have found a way to dramatically slow organ transplant rejection by as much as several years. That's the promising implication of an animal study carried out by researchers at the University of Alabama at Birmingham (UAB) and the University of Florida (UF) published in today's (May 2) issue of Proceedin...

Identification of specific genes predicts which patients will respond to Hepatitis C treatment

...the senior author of the study. Dr. McGilvray is a transplant surgeon at Toronto General Hospital, University Health Network and an Assistant Professor of Surgery at the University of Toronto. "By manipulating the products of these genes we might be able to improve treatment responses to this chronic disease." ...

New type of rejection blocker protects kidneys after transplant

...has proved as effective in preventing acute kidney transplant rejection as cyclosporine, the standard anti-rejec...essor of medicine and surgery at UCSF and a kidney transplant specialist at UCSF Medical Center. "This is the first clinical trial of a treatment for transplant ...

Survival of heart patients on beta-blockers varies greatly with genetic variation

... cardiology staff in the heart failure and cardiac transplant section at Henry Ford Hospital in Detroit. "Further investigation is needed to determine whether the effect seen is due to the lack of efficacy of beta-blockers in higher-risk patients or if genotype alone is responsible for a worse outcome." Beta-a...

Discovery of T-cell 'traffic control' boosts new drug promise

... approach for treatment of autoimmune diseases and transplant rejection will depend on developing new drugs that block only the immune type of S1P receptor," he adds. "But early studies by a number of researchers are quite promising." Progress will also come from finding "uniquely effective combinations of the...

Monkeying around to improve organ transplantation

...his may be an approach that could be used in human transplant trials. Title: Renal allograft rejection is prevented by adoptive transfer of anergic T cells in non-human primates ...

Simple sea sponge helps scientists understand tissue rejection

Understanding why some transplant patients reject their new organs requires a working knowledge of how cells recognize and accept or reject each other. Xavier Fernndez-Busquets, an MBL researcher visiting from the University of Barcelona, has found the perfect ally in this quest: the...

AACR Favors 'full spectrum of stem cell research biology'

...as well as generate immune-compatible material for transplant therapies." The primary points of the AACR position on stem cell biology are: # Human stem cell research will elucidate critical aspects of cell growth and differentiation that are altered during the formation and growth of tumors. # Research on t...

Researchers identify genes associated with lung transplant rejection

...on of the lung by the recipient's body. "For lung transplant patients, the biggest barrier to long-term surviva...searchers studied lung biopsy samples from 22 lung transplant patients, with the goal of detecting genes and gene products associated with inflammation and format...

Researchers make 'embryonic-like' stem cells from umbilical cord blood

... because it is difficult to obtain enough cells to transplant as well as getting the right tissue type for the patient," Dr McGuckin said. "Using cord blood gets over that obstacle because we can produce more stem cells and, with a global birth rate of 100 million babies a year, there is a better chance of gett...

Insight into the processes of 'positive' and 'negative' learners

... because it is difficult to obtain enough cells to transplant as well as getting the right tissue type for the patient," Dr McGuckin said. "Using cord blood gets over that obstacle because we can produce more stem cells and, with a global birth rate of 100 million babies a year, there is a better chance of gett...

Researchers propose measures to curb lion attacks in Tanzania

... because it is difficult to obtain enough cells to transplant as well as getting the right tissue type for the patient," Dr McGuckin said. "Using cord blood gets over that obstacle because we can produce more stem cells and, with a global birth rate of 100 million babies a year, there is a better chance of gett...

Israeli scientists successfully transplant frozen-thawed ovaries in sheep

... the project, said the next goal was to attempt to transplant ovaries in women at risk of losing their fertility...lood flow resumed immediately, indicating that the transplant had succeeded, one had severe adhesions and it was not possible to attempt oocyte collection, but tw...

Drugs from the deep blue

...t calcium channels range from drugs given to organ transplant patients to suppress the immune system, to treatments for high blood pressure and heart disease. Pessah's research group works with calcium channel modulators and other biomolecules derived from plants and scorpion venom. But when Pessah and Molinsk...

Bone marrow stem cells may heal hearts even years after heart attacks

...p bones of the patients, so there was no threat of transplant rejection. After processing, stem cells from the marrow were infused through a catheter into the coronary artery where the patient's heart attack occurred. "The main results were at least threefold: an improvement in global left ventricular function...

New cell transplantation technique restores insulin production in diabetics

...omplications common to previous techniques used to transplant islet cells. Thirty days after the procedure, all 13 patients were producing insulin without requiring supplemental injections, and none experienced major complications. Liver function tests and blood cell counts were monitored carefully during this ...

New vaccine platform may fight infections with causes from influenza to bioterrorism

...le to develop vaccines for bioterrorism agents and transplant patients, as well as high-risk individuals who have defective CD4+ T-cell function," Dr. Kolls said. "We are excited about the results because they indicate that we can engineer a vaccine to create a new protection for those who are immunosuppressed....

Mechanism for Epstein-Barr virus protein's role in blood cancers discovered

...in cancers such as lymphoproliferative diseases in transplant or AIDS patients, Burkitt's lymphoma, Hodgkin's ly...studies could be in lymphoproliferative disease in transplant and immunocompromised patients. ...

A little telomerase isn't enough

...eople with dyskeratosis congenita is a bone marrow transplant from an unaffected family member. But the team's n...mice suggest that the family member chosen for the transplant -- if there's more than one option -- should not only have normal telomerase levels but also have lo...

Pillows - a hot bed of fungal spores

...ctious cause of death in leukaemia and bone marrow transplant patients. Fungi also exacerbate asthma in adults. The researchers dissected both feather and synthetic samples and identified several thousand spores of fungus per gram of used pillow - more than a million spores per pillow. Fungal contamination o...

Same-sex mating by fungi spawned infection outbreak, evidence suggests

... affects immune-compromised patients such as organ transplant recipients and cancer patients -- whose immune systems are crippled by immunosuppressive drugs or chemotherapy -- and people with HIV/AIDS. In contrast, C. gattii infects individuals with apparently normal immunity. Symptoms include persistent headac...

Scientists use stem cells to grow cartilage

...m the patient, grow them in a laboratory, and then transplant them after the surgery. This work builds on an earlier collaboration between medical researchers and engineers at Imperial College. The team had previously developed the bioactive scaffold which was used as a scaffold to grow the stem cells on. Dr ...

Sperm stem cells closer to being like embryonic stem cells

...elete specific genes from the sperm stem cells and transplant the cells back into male rats, with the goal of producing "knockout," or genetically altered, animals to study health and behavioral effects related to those missing genes. Knockout mice are often used in research, but they are produced using a diffe...

Texas scientists discover how a hepatitis C protein promotes liver cancer

...fection, often causing so much liver damage that a transplant may be a patient's only chance for survival. The most effective treatment available, interferon therapy, works only about half the time and often causes debilitating side effects. Those who fail treatment are at risk for fatal cirrhosis or developing...

Scientists directly view immune cells interacting to avert autoimmunity

...ory T cells to treat autoimmune diseases and organ transplant rejection. By pinpointing where and how regulatory T cells work in vivo in mouse models, the researchers hope to better adapt the regulatory T cells for therapeutic use in the future. For example, Tang said, one can imagine that at the early stage of...

Infant transplant patients resist infections that kill adult AIDS patients

...rchers found that over a 10-year-period the infant transplant patients resisted the same infections that often kill adult AIDS patients. The transplant patients maintained their health even with low T cell counts. The finding could help improve treatme...

Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level

...imately could provide a non-invasive way to detect transplant rejection in patients. "We have reported for the ...ng MRI. This could revolutionize the management of transplant patients," said Ho, professor of biological sciences at the Mellon College of Science. "Successful ...

Researchers map of genetic variations implicated in disease

...mong us affect medical events as diverse as tissue transplant rejection, arthritis, asthma and disease resistance. A detailed study of this region in different people will shed light on which genes are most important. "We analysed the entire MHC region in detail from three individuals that carried different su...

Guiding principles for facial transplantation unveiled

...ing various subjects including, immunosuppression, transplant rejection, technical issues and psychological aspects (both those facing all transplant patients and those unique to facial transplant patients). "As plastic surgeons we fully recognize t...

Rice bioengineers pioneer techniques for knee repair

...; almost all previous attempts to grow replacement transplant tissues involved the use of biodegradable implants that are seeded with donor cells and growth factors. These implants, which engineers refer to as scaffolds, foster the tissue growth process by acting as a template for new growth, but they always pr...

Marine mammals are on the frontline of failing ocean health

...ease in people with suppressed immune systems from transplant surgeries or HIV/AIDS. "When otters get toxoplasmosis, they get far more sick than most humans," says Conrad. This allows researchers to more easily detect and trace the disease ?and calls attention to the flow of pathogens from land to sea that mi...

Testes to incubate stem cells

...to enhance cell growth. The team's next move is to transplant monkey and human cells into the mouse testes system. "It is truly remarkable that mouse testes can sustain these bovine cells in culture," says Elaine Dzierzak, who coordinates a EuroSTELLS project at Erasmus University Medical Centre in Rotterdam. ...