Translocation in Biological News

Media highlights for February in Biophysical Journal

... article entitled Passage Times for Polymer translocation Pulled through a Narrow Pore appears in Volume ... available online. Passage Times for Polymer translocation Pulled through a Narrow Pore When polymeric ... at the pore. Present-day techniques can exploit translocation to recognize individual polymeric molecules by ...

Comprehensive look at rare leukemia finds relatively few genetic changes launch disease

... cancer, had that much DNA damage. Even more surprising, 34 percent of patients in this study lacked any apparent CNA, and 28 percent of those with a translocation lacked additional DNA abnormalities. Certain chromosomal re-arrangements are known as translocations. The investigators also found no association ...

Regulation of cell proliferation by the OGF-OGFr axis is dependent on nuclear localization signals

... that the efficacy of the Opioid Growth Factor (OGF, [Met5]-enkephalin), a clinically important antitumor agent, is dependent on nucleocytoplasmic translocation and reliant on the integrity of nuclear localization signals in the OGF receptor (OGFr). This discovery, reported in the May 09 issue of ...

Scripps Research scientists shed light on how DNA is unwound so that its code can be read

... looks like a vise grip. They then found that RSC creates a little bulge in the DNA that can be propagated around the nucleosome and make possible translocation of the DNA with respect to the histones, exposing the DNA so that it can be read. "Imagine a rubber band wrapped twice around a water glass. The ...

Immunotherapy in high-risk pediatric sarcomas shows promising response

... Current studies are underway to test a new version of the vaccine, which utilizes more mature dendritic cells and tumor lysate in lieu of the translocation peptides. Ultimately, effective immunotherapy requires that one is capable of reproducing a strong and sustained immune response to tumor antigens," ...

Global warming experts recommend drastic measures to save species

... movement will prevent many species from shifting where they live in response to changes in local climate. They suggest that human-assisted translocation of individuals, often termed "assisted migration" or "assisted colonization," may be necessary to ensure colonization of new geographic regions as ...

Dioxin risk in soil and plant tissues after long-term biosolids application

... levels of dioxins in biosolids led to concerns that farmland application may result in accumulation of dioxins in soil and their subsequent translocation through the human food chain because several congeners of dioxins have extremely high bioaccumulation potential. The USEPA evaluated the risk of ...

Stowers Institute's Shilatifard Lab identifies new role for factor critical to transcription

... factor ELL is required for the regulation of the temporary interruptions of Pol II transcription in a living organism." "ELL is found in translocation with the MLL gene in childhood leukemia," said Edwin Smith, Ph.D., Research Scientist in the Shilatifard Lab. "We know very little about the role of ...

Lincoln Park Zoo launches first-of-its-kind wildlife reintroduction database

... Wildlife Reintroduction Conference in Chicago, Lincoln Park Zoo announced the launch of a scientific resource called the Avian Reintroduction & translocation Database (ARTD). The first of its kind, this comprehensive, standardized directory will serve as a valuable tool for wildlife managers and ...

Researchers probe a DNA repair enzyme

... cysteine ligands to the cluster, the researchers probed its role in the molecular mechanism of Rad3 enzymes. Some of these mutations uncoupled DNA translocation and ATP hydrolysis, meaning that the engine of the protein could still use the ATP fuel but was no longer capable of moving along the DNA. This ...

Media highlights in the January issues of Biophysical Journal

... stability is not widely-recognized but is potentially of fundamental importance to gene expression. Volume 94, Issue 2, January 15, 2008 translocation of Aquaporin-Containing Vesicles to the Plasma Membrane is Facilitated by Actomyosin Relaxation Christoph P Riethmuller, University of ...

Elevated carbon dioxide changes soil microbe mix below plants

... FACE site. "Overall, the changes we observed support previously reported increases in biomass turnover rates and sustained availability and translocation of the essential nutrients required for increased plant growth under elevated CO 2 ," van der Lelie said. ...

Research identifies protein that signals flowering in squash plants

... because reliable methods for the analysis of translocation through the phloem stream have been developed in ... of putative florigenic signals into the translocation stream.” The authors screened nearly one hundred ... but revealed the presence of FT protein in the translocation stream. This research provides some of the ...

Critical step traced in anthrax infection

... by mutating the region and thereby blocking translocation of the toxin proteins. These recent ... high points along the path to understanding how translocation occurs in this system," Collier said. One of ... will continue to study protein unfolding in translocation during anthrax infection, which may prove to be ...

Mutating the entire genome

... – start with translocation. Existing methods result in the desired translocation of two chromosomes in one of every 1 million to 10 million cells cultured, ... to learn how to treat or prevent cancers, says Capecchi. In many cancers, translocation of two chromosomes is the first step, and if it occurs only in one of ...

UCLA researchers unravel a mystery about DNA

... molecules, one at a time -- a breakthrough in its own right." "The study of molecular machines, the dynamics of their moving parts and their translocation on molecular tracks is of great interest to nanotechnologists at the CNSI," said Weiss, the leader of the UCLA team. "Beyond furthering the ...

New Scripps Oceanography project to study sediments and ecosystem restoration in Venice lagoon

... Venezia Nuova and Thetis SPA, has launched a multifaceted scientific program aimed at providing fundamental information about the effects of sediment translocation in Venice lagoon, a vital facet of the historic city of Venice, Italy. The new effort, a two-year, $1.5 million project for Scripps, is part of ...

Breakthrough Microarray-based Technology for the Study of Cancer

... can be studied using Comparative genomic hybridization (CGH), which undergoes dramatic chromosomal changes, including loss, duplication and the translocation of DNA from one chromosome to another, as cancer develops. Understanding these changes is key to understanding cancer progression as well as ...