Transcriptome in Biological News

New genomic technique uncovers coral transcriptome

... methods, researchers have uncovered the larval transcriptome of a reef-building coral ( Acropora millepora ). ... and John Colbourne, developed a new method for transcriptome analysis based on next-generation 454 sequencing technology. De novo transcriptome analysis is a cost-efficient alternative to ...

New technique used to profile anthrax genome

... but going to a deeper level and defining the transcriptome has been a much more difficult task," said ... one gene at a time, and a completely defined transcriptome was out of reach for even the most widely studied ... Bergman noted. "Sequencing-based transcriptome profiling has several huge advantages over ...

New plant study reveals a 'deeply hidden' layer of the transcriptome

... La Jolla, CA Cells keep a close watch over the transcriptome the totality of all parts of the genome that are ... in plants and a deeply hidden layer of the transcriptome that is tightly regulated by exosome activity, ... down exosome activity, you see changes in the transcriptome that are not visible under any other ....

Cancer signatures uncovered

... analysis of the relationship between the neoplastic and developmental transcriptome provides an outline of trends in cancer gene expression. The research, ... genes or processes to the biology of aggregates on the order of the entire transcriptome is likely to be useful in establishing highly robust molecular ...

Deep sequencing study reveals new insights into human transcriptome

... of the human transcriptome. They found that 34% of the polyadenylated transcriptome mapped to so far non-annotated genomic regions. Obviously a large number ... first time to explore directly the complexity and dynamics of the human transcriptome with a reasonable effort. This will lead to a new picture of the mammalian ...

Charting the epigenome

... postdoctoral researcher and co-first author Ryan Lister, Ph.D. The transcriptome encompasses all RNA copies or transcripts made from DNA. The bulk of ... methylation at single-base resolution and to sequence the complete transcriptome within a reasonable timeframe. Collaborating scientists at the ARC ...

Landmark project to map genomics of complex ant systems

... other microbes that benefit the ants and their crops. As a recipient of the highly competitive 10 Giga-base Grant Program for DNA sequencing and transcriptome analysis from Roche Applied Sciences, Gerardo put together a project to not only sequence ant genomes for the first time, but also the genomes of ...

New early detection studies of lung cancer in non-smokers launched today

... from Subjects with Lung Cancer Arising in Current, and Never Smokers (Principal Investigator (PI): Hanash) Genome analysis: Mining the Genome and transcriptome in Lung Cancer from Never Smokers (PI: Gazdar) Cellular alterations: Mitochondrial Mutations in Lung Cancer from Never Smokers (PI: David Sidransky, ...

GEN highlights increasing use of digital gene expression profiling

... of expression profiling data. The scientists predict that with the continuously increasing number of reads at reduced costs, RNASeq, a.k.a. whole transcriptome shotgun sequencing, will become affordable for standard differential gene-expression analysis. DNAStar recently introduced QSeq, the first product ...

Earthworm detectives provide genetic clues for dealing with soil pollution

... soil contaminants on L. rubellus in the open access journals, BMC Biology and BMC Genomics. Using a new 8,000-element microarray, they describe the transcriptome profile of L. rubellus exposed to copper, cadmium, the polyaromatic hydrocarbon fluoroanthene, and the agrochemical atrazine. In both studies this ...

Giant panda genome to be sequenced

... genome sequence, the researchers will do a survey of the genetic variations in the panda population. The fine map of the pandas genome and the transcriptome studies will provide an unparalleled amount of information to aid in understanding both current and past status of the species, including historical ...

Washington University increases fleet of Roche Genome Sequencer FLX Systems

... portions of the human genome to identify genetic variations that may be associated with human diseases. This will include using the instruments for transcriptome analysis of individual tumors, an approach that the Genome Sequencing Center has pioneered as part of its ongoing studies of acute myeloid leukemia. ...

454 Sequencing uncovers a genetic basis for different social behaviors in wasp

... Sequencer generates hundreds of thousands of long, highly-accurate reads in a single run, giving researchers unprecedented detail and accuracy for transcriptome profiling and gene expression applications, explained Michael Egholm, Ph.D., Vice President of Research and Development at 454 Life Sciences. These ...

Mammalian Transcriptome Mapped

... Wahlestedt continues. The mammalian transcriptome has already revealed a number of new and ... below) was once thought to be rare, but the transcriptome reveals that it takes place to an extent that few ... of mammalian development. How They Mapped the transcriptome The results that appear in a special section ...

Biomarkers isolated from saliva successfully predict oral and breast cancer

... power of 95 percent by using only the salivary transcriptome samples and 88 percent by using only serum transcriptome samples for oral squamous cell carcinomas," said Wong. "For oral cancer, salivary transcriptome has a slight edge of that of ...

Learning the language of DNA

... a comprehensive analysis of the human and mouse transcriptomes. A senior member of the consortium and IMB researcher Professor David Hume said transcriptome describes all of the information read from the genome by a cell at any given time. "Essentially, we need to understand the language that cells ...

Genomatix Microarray Analysis Pipeline achieves Affymetrix GeneChip compatible?status

... with the new Affymetrix tiling and exon array technology, I expect that our tools will drive far greater understanding of genomic organization and transcriptome regulation." "Affymetrix is pleased to be working with Genomatix in their efforts to develop advanced tools for analyzing GeneChip data," said ...

Scientists reveal molecular secrets of the malaria parasite

... are switched on as the parasite enters the mosquito. Hall's group identified the gene regulation by comparing the genes expressed in the sexual stage transcriptome with the proteomes of both the sexual stage and a developmental stage in the mosquito. Several genes were identified for which transcripts were ...

Scientists decipher genome of fungus that can cause life-threatening infections

... who is SLU's Associate Dean for Research and who helped coordinate the C. neoformans genome project. Heitman says, "The genomic sequence and transcriptome analysis are already proving to be invaluable to researchers working to understand and cure this infectious disease." He says the genome sequence ...