thymus

Fox Chase Cancer Center scientists identify immune-system mutation

...per T cells, so called because they arise from the thymus gland, are essential for combating intracellular viral and bacterial infections (cell-mediated immunity) and also for helping other white blood cells (B cells, derived from bone marrow) generate antibodies against foreign agents that enter the body. ...

Circles Of DNA Might Help Predict Success Of Stem Cell Transplantation

...'s blood, the more likely it is that the patient's thymus gland can act as an efficient factory where stem cells become T cells. The thymus is an immune system organ behind the breastbone that processes immature "precursor" immune cells int...

Discovery Could Lead To Novel Approaches In HIV Treatment

...development of a new method to assess how well the thymus (an organlocated at the base of the neck) works an...ers first developed a method toassess how well the thymus functions. The thymus is involved in thedevelopment of T-lymphocytes, an essential component of the ...

Scientists identify new model Of NK cell development

...e released into the bloodstream and migrate to the thymus where they learn their role. In contrast, B cells, which make antibodies, remain and mature in the bone marrow. Until now, scientists thought NK cells did the same. But Caligiuri, working with Aharon Freud, the lead author of the study and a doctora...

Genetic defects give the immune system the green light to attack the pancreas

...ng specifically to each new invader. Formed in the thymus gland, T-cells begin as “precursor?cells and matur...et of cutting-edge technologies, using cultures of thymus cells from transgenic mice, together with DNA chips and “genome scans.?They compared non-obese diabe...

Fox Chase study shows that weakened T-cell receptor signals change T-cell lineage

... B cells mature there while T cells migrate to the thymus gland, which governs their development. "The reco...ler T cells). Gamma-delta T cells migrate from the thymus to epithelial tissues such as skin and the linings of the lung. While their precise role remains poo...

New tool reveals secrets of migrating cells

...With two-photon imaging, Witt and Robey identified thymus cells they dubbed beeliners moving nearly two cent...ey focuses on the lives of T cells produced in the thymus and distributed via the bloodstream to the lymph nodes, whence they move into the body's tissues. He...

Infant transplant patients resist infections that kill adult AIDS patients

...ants underwent heart transplantation and had their thymus removed. As a result the infants were deficient in...ansplant is carried out in very young infants, the thymus that produces T cells is removed and a drug is given that depletes T cells," said Dr. Platt. "Yet th...

Front-line immune cells mature in four stages, study shows

...in the body, T cells and B cells, developed in the thymus and bone marrow, respectively. However, the site and stages of human NK cell development have eluded investigators until now. The findings advance the understanding of NK cells, which play a key role in triggering broader immune responses such as t...

New pathways for autoimmune treatment identified

...ry cells come out of the bone marrow and go to the thymus where all T cells go for a process of positive and...protein expression in the thymus, Dr. Mi says. The thymus is supposed to express most body proteins so any T cells that would react to them can be eliminated ...

Immune system police learn early and sometimes badly

...archers followed T cells as they spent time in the thymus then moved to the body. They found regulatory T cells learn what to protect while in the thymus and that everything the cells learn may not be good, according to research in the August issue of Im...

UCLA researchers develop T-cells from human embryonic stem cells

...cells. Those cells were then injected into a human thymus gland that had been implanted in a mouse, and the thymus then changed those blood-forming cells into T-cells. Located just above the heart in humans, the thy...

Autoimmune disease triggered if T cells miss a single protein early on

... where autoimmune disease is active, but also the thymus -- the organ where T cells and self-proteins, or s...a severe autoimmune disease in the retina. "The thymus is like a filter," said Mark Anderson, MD, PhD, assistant professor of medicine at the UCSF Diabetes...

Proteins anchor memories in our brain

... where autoimmune disease is active, but also the thymus -- the organ where T cells and self-proteins, or s...a severe autoimmune disease in the retina. "The thymus is like a filter," said Mark Anderson, MD, PhD, assistant professor of medicine at the UCSF Diabetes...

T for two: Scientists show how immune system chooses best way to fight infection

...her a maturing T cell is likely to emerge from the thymus as an effector cell or a regulatory cell. The research suggests that new treatments could be developed to deliberately affect the type of T cells produced, allowing scientists to tackle a number of diseases which are influenced by these different typ...

Thymus transplants gives hope to babies with fatal immune disease

...turn three in September, thanks in large part to a thymus transplant she received at Duke University Medical... show that 75 percent of the babies who received a thymus transplant were alive after one year. The recipient of the first transplant, in 1994, is alive and w...

'Nurse cells' make life and death decisions for infection-fighting cells

...gan in the upper portion of the chest. Loss of the thymus results in severe immunodeficiency and increased s...infection. The function of T cells produced by the thymus is to recognize harmful invaders. Once invaders have been identified, T cells then attempt to elimin...