Thrombosis in Biological News

12-month ATLANTA trial data show sustained benefit of Catania Stent

... ATLANTA Trial. The results include zero percent thrombosis in patients discontinuing dual anti-platelet ... the results showed zero (0.0) percent stent thrombosis (Academic Research Consortium, or ARC-defined), ... were no deaths, myocardial infarctions, or stent thrombosis in a significantly complex patient population. ...

New drug may reduce heart attack damage

... ahead of Phase 1 human trials. A paper outlining the animal study appears this month in the high-impact cardiovascular journal Arteriosclerosis, thrombosis and Vascular Biology . "While this drug doesn't prevent the heart attack, it does reduce the damaging effects of the blockage on the heart once ...

A novel target for therapeutics against Staph infection

... The group found that ClfA binds to the blood-clotting protein fibrinogen (Fg) at a site that is also responsible for inducing platelet activation and thrombosis (clot inside a blood vessel). The results show significant structural differences in how staphylococcal and platelet receptor proteins recognize ...

NIH's Genes, Environment and Health Initiative adds 6 studies

... Multiethnic Genome-Wide Scan of Prostate Cancer. John Heit, M.D., Mayo Clinic, Rochester, Minn.; $1.1 million. Genome-Wide Association of Venous thrombosis (Blood Clots in Veins). Braxton Mitchell, Ph.D., University of Maryland School of Medicine, Baltimore; $1.1 million. Genetic Risk to Stroke in ...

Tumor-inhibiting protein could be effective in treating leukemia

... then for chemotherapy because normal cells are susceptible to chemotherapy treatment," said Tuszynski, who is also a member of the Sol Sherry thrombosis Research Center in Temple's School of Medicine. He added, however, that Angiocidin must remain present with the differentiated cells or they will ...

Quest for better treatment for effects of menopause

... (fats) along the walls of the arteries, and which restricts the blood flow, causing high blood pressure. If these plaques break, the result is a thrombosis that can block the artery, causing, amongst other things, heart attack. To slow down the natural drop in oestrogen level and thus prevent ...

Saliva can help diagnose heart attack, study shows

... College of Dentistry tested saliva from 56 people who had a heart attack and 59 healthy subjects for 32 proteins associated with atherosclerosis, thrombosis and acute coronary syndrome. They found these proteins were in higher concentrations in saliva of heart attack victims, and that specific salivary ...

New horizons in modelling surface processes

... of nanocomposite materials known as UCL-NanoTM for use in heart surgery. These nanomaterials overcome previous problems such as the risk of thrombosis (blood clotting) and are being used to develop arterial bypass graft, stent and heart valves. Professor Mike Gillan, Director of the UCL Materials ...

$13 million federal grant for research into vascular disease awarded to Weill Cornell

... (plaque formation). By the end of this 20-year program in 2011, it is hoped that the array of molecular links that define atherogenesis and thrombosis will have been identified. ...

Medical breakthrough for organ transplants and cardiovascular diseases by Flemish researchers

... applications. Scientists can now begin to investigate whether PHD1-blockers can prevent the damage caused by blockage of a blood vessel through thrombosis or after a heart attack (in which the cardiac muscle experiences a shortage of oxygen). New treatment alternatives may also be possible for strokes, ...

Ultra-low-dose aspirin might decrease bleeding severity in portal hypertension

... has been demonstrated to have a prothrombotic effect at a very low dose. In an elegant study design, including a model of in vivo Laser induced thrombosis in rats, bleeding time and prostanoid dosing, this research was performed by doctors from the Laboratory of Haematology of the Faculty of Pharmacy at ...

Nicotine may accelerate atherosclerosis, may be as dangerous as tar

... Cigarette smoke is linked to risk for cancer, chronic lung disease (emphysema and chronic bronchitis), cardiovascular disease (atherosclerosis, thrombosis and vascular dysfunction), stroke and cataracts as well as poor wound healing. ...

Jefferson scientists find high glucose before surgery raises risk of dangerous complications

... surgery run an increased risk of developing blood clots, deep vein thrombosis and even pulmonary embolism after surgery. Boris Mraovic, M.D., ... Another 10 percent have raised levels due to pre-surgery stress. Deep vein thrombosis occurs in approximately two million Americans each year. Pulmonary ...

Promising therapies for haemophilia & heart disease

... this research, at the XXth Congress of the International Society on thrombosis & Haemostasis in Sydney today, Wagner said, "We have demonstrated that ... the work of our collaborators shows that the events leading to deep vein thrombosis are reduced. P-selectin inhibitors have also been shown to be ...

UCSD researchers create roadmap to integrin activation

... of Medicine have reconstructed the signaling pathways that impact activation of a receptor that is critical to the control of bleeding and to the thrombosis that occurs in heart attacks and strokes. Their work to take apart and re-build the signaling pathway that regulates activation of the body's most ...

'Molecular assassin' targets disease gene

... technology, but focusing on a different master regulator, Egr-1, has also been published this month by Professor Khachigian's group in the Journal of thrombosis and Haemostasis and shows that heart muscle damage is reduced by the drug after a heart attack. ...

Study shows pine bark naturally decreases severe chronic venous insufficiency

... in the United States develop leg ulcers due to CVI. If left untreated, leg and ankle swelling can lead to dangerous conditions such as deep vein thrombosis (DVT). Previous studies have shown Pycnogenol® to be effective in encouraging improved circulation and helping to prevent travel-related DVT. Like ...

New understanding of COX-1 and COX-2 enzymes could revise classification of pain meds

... for COX-2: an enzyme called microsomal prostaglandin E synthase (mPGES)-1. The researchers showed that this drug did not predispose the animals to thrombosis or elevate blood pressure. ...

Therapeutic prospects beyond Vioxx

... FitzGerald and his colleagues showed that deletion of mPGES-1, in contrast to deletion or inhibition of COX-2, did not predispose the animals to thrombosis or elevate blood pressure. A clue to this surprising finding was that while mPGES-1 deletion suppressed profoundly another product of the COX-2 ...

Aspirin reduces cardiovascular risks in men and women -- but differently

... three enrolled solely men, one included only women, and two enrolled both sexes. The trials were: Physicians Health Study, British Doctor's Trial, thrombosis Prevention Trial, Hypertension Optimal Treatment Trial, Primary Prevention Project and the Women's Health Study. ...

Vascular structure and function improve with diet and exercise

... of a diet and exercise regimen, according to a study presented today at the American Heart Association's Sixth Annual Conference on Arteriosclerosis, thrombosis and Vascular Biology. "Our lifestyle management program appears to improve the health of the vasculature, so it might lower the risk of high blood ...