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A gene's first 'kiss' sets off that affair known as puberty

...years as men and women, appears to be triggered by the brain's own version of "It takes two to tango," wh...nd Eve ?makes its sudden appearance in a region of the brain called the hypothalamus just as puberty begins, according to a study published in this week's ...

Chemists create 'Superbowl' molecule; May lead to better health

...sion drug delivery, according to a recent study in the Journal of the American Chemical Society. Shaped like a miniature football stadium, the molecule is capable of deli...

DNA Molecules Used To Assemble Nanoparticles

...drug delivery systems, using DNA molecules to bind the particles together. Nanometer-scaled dendrimers c...-to almost any cell," said Dr. James R. Baker Jr., the Ruth Dow Doan Professor of Nanotechnology and director of the Center for Biologic Nanotechnology at ...

Bioartificial kidney under study at MCG

...ents with kidney failure survive is under study at the Medical College of Georgia. MCG Medical Center ha... study taking place in intensive care units across the country to evaluate the efficacy of the renal assist device, says Dr. Harold M. Szerlip, MCG nephrol...

Viral DNA sequence a possible trigger for breast cancer

A small sequence of DNA in the envelope (Env) protein of a mouse breast tumor vir...ncer cells, according to a study by Katz et al. in the February 7 issue of The Journal of Experimental Medicine. The ability of this motif to transform cel...

Wisconsin scientists grow critical nerve cells

...l nervous system pathways that relay messages from the brain to the rest of the body. The new findings, reported online today (Jan. 30, 2005) in the journal Nature Bio...

New push for public health, AIDS spending at African Union summit

...ernment spending on public health, helping to curb the spread of AIDS, which killed 2.3 million Africans ...re will be not just talk about an HIV strategy for the AU but how to tackle an action-oriented plan," Oxfam spokeswoman Shehnilla Mohamed said. "Governmen...

Association of herpesvirus with lung disorder questioned

Contrary to the results of a recent U.S. study, investigators in J...tening form of high blood pressure, as reported in the March 1 issue of The Journal of Infectious Diseases, now available online. The researchers reported...

Man and mouse share genome structures

In the most detailed large-scale study to date of the proteins that package DNA, researchers have mapped a family of switches that turn genes on and off. ...

Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer

...with radical mastectomy and adjuvant chemotherapy, the addition of radiation therapy leads to better surv... follow-up of a randomized trial, which appears in the January 19 issue of the Journal of the National Cancer Institute. The British Columbia randomized r...

Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down

...with radical mastectomy and adjuvant chemotherapy, the addition of radiation therapy leads to better surv... follow-up of a randomized trial, which appears in the January 19 issue of the Journal of the National Cancer Institute. The British Columbia randomized r...

Jump-starting T Cells In Skin Cancer

Advanced melanoma, the most deadly form of skin cancer, can be successful...Coulie and colleagues now show, in two articles in the January 17 issue of the Journal of Experimental Medicine, that these vaccines work by increasing the...

Molecular biology fills gaps in knowledge of bat evolution

... Professor Mark Springer, has published a paper in the Jan. 28 issue of the journal Science that uses molecular biology and the fossil data to fill in many of the gaps. Spring...

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

...searchers have identified a molecular mechanism in the liver that explains, for the first time, how consuming foods rich in saturated fats and trans-fatty acids causes elevated blood l...

A new mechanism of regulating RNA degradation

... only by transcription factors. Then we found that the RNA resulting from transcription could be regulated by the RISC complex (siRNA-mediated degradation via Dicer). And now it seems that regulation at the RNA lev...

FDA Approves Human Hookworm Vaccine for Phase I Safety Trials

... only by transcription factors. Then we found that the RNA resulting from transcription could be regulated by the RISC complex (siRNA-mediated degradation via Dicer). And now it seems that regulation at the RNA lev...

Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer

Deficiencies in the ability of cells to repair damaged DNA are associa...risk of breast cancer, according to a new study in the January 19 issue of the Journal of the National Cancer Institute. DNA repair is the system of def...

Spleen may be source of versatile stem cells

...General Hospital (MGH) researchers discovered that the spleen might be a source of adult stem cells that could regenerate the insulin-producing islets of thepancreas. In a follow-up to that unexpected finding, members of thesa...

Genes In The Interferon System Important In Systemic Lupus Erythematosus

...ed bya team of scientists headed by researchers at the Department of MedicalSciences at Uppsala University. The findings are being published todayon the Web page of the highly prestigious American Journal of HumanGenetics. "These findings are probably t...

UCSB scientists probe sea floor venting to gain understanding of early life on Earth

New keys to understanding the evolution of life on Earth may be found in the microbes and minerals vented from below the ocean floor, say scientists at the University of Califor...

UAB scientists discover the origin of a mysterious physical force

Ever since the 1970s, scientists have been trying to establish the cause of a repulsive force occurring between different electrostatically charged molecules, such as ...

Researchers discover way to make cells in the eye sensitive to light

...e discovered a way to makelight sensitive cells in the eye by switching on a single gene.According to research published online today in Nature, the team fromImperial College London and the University of Manchester, havediscovered that activating th...

Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants

UC Riverside researchers from the Departmentsof Chemical and Environmental Engineeri... Dot bio-conjugates to uncover new knowledge about the binding of a protein at the growingpollen tube tip. This protein plays a critical role along with an...

Source of molecular triggers in cutaneous T cell lymphoma identified

In a study published in the journal Blood, Yale scientists identify the molecular triggers that stimulate Cutaneous T Cell Lymphoma (CTCL) cells to clonally expand into lar...

University of Manchester makes made-to-measure skin and bones a reality using inkjet printers

...ns into a computer. ProfessorBrian Derby, Head of the Ink-Jet Printing of Human Cells Projectresearch te...a surgeon to reconstruct anycomplex disfiguring of the face using CT scans, but with thistechnology we are able to build a fragment which will fit exactly....

Protein discovery could unlock the secret to better TB treatment

... scientists have found a protein that could unlock the secret to quicker, more effective treatment of TB by waking TB bacteria in the body. Once the TB bacteria are active again, the disease becomes treatable using common drugs like a...

Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer

...fy theprincipal type of DNA damage responsible for the onset of skin-tumordevelopment. The researchers' f...an lead to cellular death ?recognized assunburn of the skin ?and may cause permanent changes in the DNA(mutations) that ultimately can result in the onset ...

W.M. Keck Foundation funds study of friendly microbes

You could say that the Human Genome Project missed 99 percent of the genes in the adult body. That's because it didn't sequence genes belonging to the vast communities o...

Yellowstone microbes fueled by hydrogen, according to U. of Colorado study

Microbes living in the brilliantly coloredhot springs of Yellowstone Nati...s and couldadd to understanding of bacteria inside the human body.A team of CU-Boulder biologists led by Professor Norman Pace, one ofthe world's leading e...

It's not all genetic: Common epigenetic problem doubles cancer risk in mice

...n experiments with mice, a team of scientists from the United States, Sweden and Japan has discovered tha...double dose of one protein is sufficient to change the normal balance of cells within the lining of the colon, thereby doubling the risk that a cancer-caus...

Columbia research lifts major hurdle to gene therapy for cancer

...calCenter have discovered a way to overcome one of the major hurdles ingene therapy for cancer: its tende...adicating cancer cells.In a new study published in the Jan. 25 issue of the Proceedings of theNational Academy of Sciences (PNAS), the researchers demonstr...

Dysentery uses 'sword and shield' to cause infection

Scientists have found that the bacterium that causes dysentery uses a 'sword and ... According to research published today in Science, the team from Imperial College London and Institut Pasteur, Paris, found that shigella, the bacteria whi...

Novel technology detects human DNA mutations

...re, Inc. today reported unprecedented benefits in the company's technology for the medical analysis of human DNA. Nanosphere's nanoparticle-based technology allows for rapid, highly-s...

Topical treatment shown to inhibit HIV and herpes simplex virus infection

...ine researchers demonstrated that a gel applied in the vagina provides protection from both the human immunodeficiency virus (HIV) and the herpes simplex Virus. The study, presented at the 12th Co...

Priming embryonic stem cells to fulfill their promise

Bioengineering researchers at the Universityof California, San Diego have invented a process to help turn embryonicstem cells into the types of specialized cells being sought as possibletreatments for dozens of human diseases and healt...

Growth in the sea comes down to a struggle for iron

...now that injecting iron into some major regions of the oceans can stimulate the growth of diatoms and other phytoplankton, but something odd occurs as these tiny marine plants cont...

New, automated tool successfully classifies and relates proteins in unprecedented way

For the first time, researchers haveautomatically grouped ...oteomics," appears in an upcoming special issue of the Journal ofBiomedicine and Biotechnology. "Ourapproach really enables the new field of location prot...

New binding target for oncogenic viral protein

The DNA tumor virus simian virus 40 produces the Large T antigen which inactivates two of the cell's most important cancer-preventing proteins, p53 and pRb. In a study published in the Journal o...

Lack of enzyme turns fat cells into fat burners

Lack of the enzyme, acetyl CoA carboxylase 2or ACC2, appears to turn the adipose or fat cells of mice into fatburners, explaining in part why the animals can eat more and we...

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

...type 2 diabetes later in life. In studies of mice, the researchers found that poor prenatal nutrition impairs the pancreas's ability to later secrete enough insulin in response to blood glucose. "The bottom line i...

Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs

... a clinical trial using stem cells generatedwithin the bone marrow to grow new blood vessels that could improvecirculation in patients with blockages in the arteries of their legs --a condition called peripheral vascular disease (PVD). Individuals with PVD...

Fox Chase Cancer Center scientists identify immune-system mutation

...unologist Dietmar J. Kappes, Ph.D., has identified the genetic mutation that keeps a mouse strain from de...The report by Kappes and his colleagues appears in the Feb. 24 issue of Nature. Kappes' laboratory first discovered the mice with this naturally occurring...

Controversial drug shown to act on brain protein to cut alcohol use

...ontrolled by drugs. Or can it be? Researchers from the University ofCalifornia in San Diego identified a ...nti-addiction drug has been rigorously studied for the firsttime, confirming its ability to block alcohol craving in rodents, andclarifying how it works in...

Neuronal 'traffic jam' marks early Alzheimer's disease

...nts proper transport of proteins and structures in the cells, according to new studies by Howard Hughes M...isease and in human brain samples from people with the disease, researchers observed a characteristic breakdown in neurons that appears to prevent the norm...

Termites feed through good vibrations

Discovery that termites use vibrations to choose the wood they eat may provide opportunities to new met...ations in homes and also may provide insights into the "cocktail party effect" of signal processing ?how to ignore most noise but have some signals that tr...

Current human embryonic stem cell lines contaminated UCSD/Salk team finds

...subjects,according to research by investigators at the University of California,San Diego (UCSD) School of Medicine and the Salk Institute in La Jolla,California.In a study published online January 23, 2005 in the journal Na...

UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims

... contained no references for medical claims; while the majority of references to published material was a...-on-file documents were provided upon request; and the majority of original research cited in the ads was funded by or had authors affiliated with the prod...

Drug That 'Tags' Decision-making Areas Of The Brain May Aid

...smokers, a new drug that attaches only to areas of the brain that havebeen implicated in nicotine addict...isciplinary Tobacco Use Research Centerscientists, the new drug ?Nifrolidine ?is a selective binding agentthat identifies specific areas of the brain respo...

Elusive HIV shape change revealed; Key clue to how virus infects cells

...arvard Medical School have shown how a key part of the human immunodeficiency virus (HIV) changes shape, triggering other changes that allow the AIDS virus to enter and infect cells. Their findings, published in the Feb. 24 issue of the journal ...

Mouse brain cells rapidly recover after Alzheimer's plaques are cleared

...d scientists with their ability to recuperateafter the disorder's characteristic brain plaques are remove...ques,the amyloid beta (Abeta) peptide. In areas of the brain whereantibodies cleared plaques, many of the swellings previously observedon nerve cell branch...

Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer

The genome sequence of the parasitic amoeba Entamoeba histolytica, a leading ...variety of bacterial-like genes that contribute to the organism's unique biology. The report, which appears in the February 24 issue of Nature, presents t...

Key molecule in plant photo-protection identified

...d scientists with their ability to recuperateafter the disorder's characteristic brain plaques are remove...ques,the amyloid beta (Abeta) peptide. In areas of the brain whereantibodies cleared plaques, many of the swellings previously observedon nerve cell branch...

Antarctic ice shelf retreats happened before

...ording to research published this week (24 Feb) in the journal Geology by scientists from Universities of...c Survey (BAS). A study of George VI Ice Shelf on the Antarctic Peninsula is the first to show that this currently 'healthy' ice shelf experienced an exte...

Anti-bacterial additive widespread in U.S. waterways

Many rivers and streams in the United Statesare believed to contain a toxic antim...ccording to ananalysis conducted by researchers at the Johns Hopkins Bloomberg Schoolof Public Health. The chemical, triclocarban, has been widely used for...

Newly-discovered class of genes determines ?and restricts ?stem cell fate

Research on adult stem cells found in the skin hints at a new class of genes, according to a study from investigators at the University of Pennsylvania School of Medicine. These genes ?dubbed pangenes ?can both govern a stem ...

Timing is everything: First step in protein building revealed

...team led by Johns Hopkins scientists has unraveled the firststep in translating genetic information in or...s not one step but two.In a series of experiments, the scientists found that when yeast'sprotein-building machinery recognizes the starting line for a gene...

Tiny particles could solve billion-dollar problem

...finds that nanoparticles of gold and palladium are the most effective catalysts yet identified for remediation of one of the nation's most pervasive and troublesome groundwater pollutants, trichloroethene or TCE. The researc...

UW's Rosetta software to unlock secrets of many human proteins

...tware that will give scientists a huge advantagein the fight against disease.The software, known as Roset...entures licensed Rosetta software withoutcharge to the Institute for Systems Biology (ISB), a non-profitresearch organization. The institute has partnered ...

Plants, animals share molecular growth mechanisms

...on between molecules along a pathway that leads to the creation of long protein strings, called actin fil...i, agronomy associate professor and lead author of the study. Knowledge of the biochemical reactions involved in this process eventually may allow research...

Researchers find how protein allows insects to detect and respond to pheromones

...tware that will give scientists a huge advantagein the fight against disease.The software, known as Roset...entures licensed Rosetta software withoutcharge to the Institute for Systems Biology (ISB), a non-profitresearch organization. The institute has partnered ...