Testicular in Biological News

Penn researchers discover genetic risk factor for testicular cancer

... that are associated with an increased risk of testicular cancer. testicular cancer is the most common cancer among young men, ... risk factor that can account for most cases of testicular cancer," says Katherine L. Nathanson, MD, an ...

Severe gestational hypertension may protect against testicular cancer

... may give birth to boys at lower risk for testicular cancer, although the exact reasons why are still ... and this lack of estrogens may lower the risk of testicular cancer." Pettersson and colleagues observed 293 cases of germ-cell testicular cancer in the Swedish Cancer Register and 861 ...

Study links water pollution with declining male fertility

... phenomenon and the increase in human male fertility problems caused by testicular dysgenesis syndrome. Until now, this link lacked credence because the list ... causing effects in fish was limited to estrogenic chemicals whilst testicular dysgenesis is known to be caused by exposure to a range of ...

Male cyclists risk sexual problems if they don’t choose the right bike

... a number of male cyclists. Regular cyclists also run a higher risk of testicular damage and impaired testicular function. Mountain bikers run a particular risk, says Mr Nargund, as ...

Safeway Inc. and PCF to fund landmark prostate cancer research collaboration

... review of scientific evidence by cancer researchers at Johns Hopkins that testicular cancer patients, like seven-time Tour de France winner Lance Armstrong, ... rates of survival than others with different kinds of advanced cancer. testicular cancer begins in the testes, which are a few degrees cooler than the rest ...

Human adult testes cells can become embryonic-like

... men with an incurable disorder or disease could have a biopsy of their testes, which Dym says is a common procedure in patients suspected of having testicular cancer. Testes stem/progenitor cells those cells that can go on to produce sperm would be removed from the biopsy tissue, and grown in the ...

Low sperm count may be associated with prenatal testosterone excess

... could constitute a potential risk factor that may conduct to a low sperm count," said Dr. Recabarren. Low sperm counts are also associated with testicular cancer, with an incidence rate 20 fold higher than men with normal sperm analysis, said Dr. Recabarren. The findings from this study highlight ...

Normal-looking sperm may have serious damage; scientists urge more care in selection

... due to reproductive tract infections) and apoptosis are the most studied, but other factors as age, smoking, exposure to air pollution and abnormal testicular warming are believed to increase the proportion of sperm DNA fragmentation." The researchers are now applying DNA fragmentation evaluation to ...

Excellence in open access research celebrated at BioMed Central awards dinner

... syndrome with growth-hormone secreting pituitary adenoma, colonic polyposis, lipomatosis, lentigines and renal carcinoma in association with familial testicular germ cell malignancy: A case report' Journal of Medical Case Reports BioMed Central Publisher Matthew Cockerill said We are delighted with the ...

Penn Veterinary Medicine report new strategy to create genetically-modified animals

... species, AAV-transduced germ cells from goats were transplanted to recipient males in which endogenous germ cells had been depleted by fractionated testicular irradiation. Transgenic germ cells colonized recipient testes and produced transgenic sperm. When semen was used for in vitro fertilization, 10 ...

Enzyme alerts cell's powerful army to repair DNA damage

... Learning more about the processes involved in transcription could pay off in improved treatments in years to come. Cisplatin, a drug used to treat testicular and ovarian cancer, acts by stopping transcription and causing cells to die. Some other chemotherapy drugs block transcription too. But these types ...

Low oxygen in coastal waters impairs fish reproduction

... Peter Thomas found that both male and female fish collected from seasonally hypoxic waters in Floridas Pensacola Bay estuaries had little ovarian and testicular growth, low egg and sperm production, and low levels of reproductive hormones during a time a year when they would normally be increasing in ...

Spike in testicular cancer is focus

... reasons behind the dramatic increase in testicular cancer, now the most common malignant cancer ... Yale Public Health researcher Tongzhang Zheng. testicular cancer is increasing for unknown reasons and this ... hormone disruptors increases the risk of testicular cancer. They will measure the levels of these ...

Injection may prevent infertility in men receiving cancer chemotherapy

... to investigate whether it could be used to avoid testicular damage in mice treated with Taxol. "Clinical ... a single dose of Taxol had induced significant testicular weight loss compared with the control group. An ... Mr. Carmely. "In contrast, we saw only minimal testicular damage in the group that had previously been ...

How the environment could be damaging men's reproductive health

... testes are at higher risk of developing testicular cancer between the ages of about 20 and 40, and ... Cryptorchidism is one of the symptoms of testicular dysgenesis syndrome (TDS) ?a collection of male ... health in Lithuania showed that the incidence of testicular cancer was one of the lowest in Europe and that ...

Human testis harbors HIV-1 in resident immune cells

... and DC-SIGN) were present on cells located within the testis, specifically testicular macrophages. The point was demonstrated further by using explanted ... cells in culture. The finding that HIV-1 can replicate within testicular macrophages is significant because the testis represents a pharmacological ...

Study hints at role of stem cell genes in testicular, breast cancers

... that the activity of several embryonic stem cell genes is elevated in testicular and breast cancers, providing some of the first molecular evidence of a ... focused on seminomas ?tumors that account for 50 percent of the cases of testicular cancer, the most frequent cancer in Caucasian males ages 15-40 -- and ...

Reversing cancer cells to normal cells

... one of a variety of body cells. When aggressive melanoma and other tumor cells (recent findings also report Nodal expression in breast cancer and testicular cancer) regain the ability to express a potent embryonic morphogen like Nodal, the presence of the Nodal and the signals it sends and receives appear ...

Firefighters face increased risk for certain cancers

... they encounter in their profession, the researchers say. The researchers found, for example, that firefighters are twice as likely to develop testicular cancer and have significantly higher rates of non-Hodgkin's lymphoma and prostate cancer than non-firefighters. The researchers also confirmed ...

Exposure to dioxins influences male reproductive system, study of Vietnam veterans concludes

... tract over the past several decades. These include a decrease in sperm production by almost 50 percent, a three- to four-fold increase in testicular cancer, an increase in the incidence of cryptorchidism (undescended testes, a condition where the testes are not in their normal location in the ...

One big biology question solved

... instructions to germ cells, which could lead to the formation of germ cell tumours. "Our research has suggested a possible cause for these common testicular cancers, opening up avenues of investigation which will hopefully one day lead to a cure," Professor Koopman said. The findings of the team will ...

VCU Massey Cancer Center researchers identify a new class of anti-cancer drugs based on platinum

... drugs in the clinic and the most important in terms of treatment. Cisplatin is a chemotherapy drug that is given for the treatment of metastatic testicular or ovarian cancers, and some advanced bladder cancer, and is a very effective drug in combination with other therapies. However, according to ...

Basic research leads to a novel cancer therapy

... colon cancer, esophageal cancer, head and neck tumours, liver cancer, lung cancer, melanoma, ovarian cancer, pancreatic cancer, prostate cancer, and testicular cancer. The studies are in various stages of clinical trials (phases I through III), and most of them are being carried out in combination with other ...

Testes to incubate stem cells

... sustain these bovine cells in culture," says Elaine Dzierzak, who coordinates a EuroSTELLS project at Erasmus University Medical Centre in Rotterdam. testicular cultures could also prove an ideal system to test compounds that might affect sperm-production such as endocrine disruptors or therapeutic drugs. ...

Human embryonic stem cells have the potential to develop into eggs and sperm in the laboratory

... chemicals) might interfere with human development at this stage and cause congenital abnormalities, infertility and possibly cancer (in particular testicular cancer). By developing suitable tests with embryonic stem cells as they differentiate to germ cells we can investigate the action of these chemicals ...

Researchers discover mechanism for multiplying adult stem cells

... flipping a single gene on and off has such an immediate effect on a tumor was unexpected, even though Oct4 is known to be active in certain forms of testicular and ovarian cancer. Still, the most provocative finding was that "Oct4 causes tumors by preventing adult stem cells in these tissues from ...