CO2 sensing proves critical for fungal pathogens to adapt to life in air and human hosts
...w that CO2 sensing in C. albicans is essential for superficial (skin) infections, in which yeast must be able to grow despite significantly lowered CO2 levels present at the skin surface. Based on their findings, the authors conclude that CO2 sensing is a vital mediator of fungal virulence in different host envi...Anemone genes reveal versatile building blocks for body plans
... vertebrates and many other animals. Despite their superficial dissimilarities, Cnidarians and other animals share a common ancestor--which existed over 500 million years ago--and, consequently, many genes. As illustrated by the new findings, scientists are now studying how these shared genes are used by radial ...Researchers give name to ancient mystery creature
...founding are the animal's teeth, which resemble in superficial ways, those of primitive relatives of ungulates, the group of mammals which includes horses and cows. But despite that link to ungulates, which are traditionally herbivores, Horolodectes was thought to have dined on small insects and grubs. "It had s...... as a way to treat, for example, systemic and more superficial infections caused by fungi such as Candida albicans (the causative agent of thrush). "The class of drugs called azoles are able to kill off fungal infections by blocking the actions of one of its P450s that is essential for maintaining the cell st...Researchers design pulsed mircrojet system to deliver protein drugs without pain or bruising
... "The microjet system delivers precise doses into superficial skin layers, thereby mitigating pain," says Samir Mitragotri, a professor of chemical engineering at UCSB and a lead author of the paper. The system was designed as an alternative to the macro-scale systems that had been causing pain and bruising. "W...Clot-dissolving agent may be beneficial in treatment of severe frostbite
... to be necessary. Exclusion criteria would include superficial frostbite, involvement of the tips of the distal phalanges and contraindications to tPA, including concurrent trauma, neurological impairment or recent surgery or hemorrhage.” “Additional studies are warranted to confirm our findings and to determ...