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Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats
...m of cholesterol) and triglycerides ?another fatty substance ?that are secreted into the bloodstream. PGC-1beta belongs to a specific family of co-activators, proteins that interact with other proteins to turn genes on and off and adjust their activity, like a dimmer switch that varies the brightness of a lig...Controversial drug shown to act on brain protein to cut alcohol use
...iathrough UCSF for medical research on alcohol and substance abuse, andby the Department of Defense....Antibiotic Resistant Bacterium Uses Sonar-like Strategy to “See?Enemies or Prey
...s releases twosubstances into the environment. One substance sticks to foreign cells.The second substance reports back and tells the Enterococcus to makethe toxin. If no cells are in the area, the first sub...Sea skate experiment sheds light on human cell transport
...rchers made their discovery by using a plant-based substance to block an enzyme that causes phosphorylation. The result: The gates wouldn't open. These findings are published in the current issue of the American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, along with an accompanyi...Substance protects resilient staph bacteria
... catheters, artificial joints and heart valves. A substance found on the surface of Staphylococcus epidermidis has, for the first time, been shown to protect the harmful pathogen from natural human defense mechanisms that would otherwise kill the bacteria, according to scientists at the Rocky Mountain Laborat...Scientists discover how plants disarm the toxic effects of excessive sunlight
...nglet oxygen, which is a highly reactive and toxic substance that destroys biological molecules. "We've discovered a pathway that cells use to turn on certain genes and respond to singlet oxygen," says Timothy Donohue, a professor of bacteriology in the university's College of Agricultural and Life Sciences a...FDA Clears the Way for Generic Versions of Transdermal Patches to Treat Chronic Pain
...ugs with a recognized medical use. As a controlled substance in Schedule II of the Controlled Substances Act (CSA), Fentanyl also comes under the jurisdiction of the Drug Enforcement Administration (DEA), which administers the CSA. Schedule II drugs are subject to manufacturing quotas set by DEA with input on ......ugs with a recognized medical use. As a controlled substance in Schedule II of the Controlled Substances Act (CSA), Fentanyl also comes under the jurisdiction of the Drug Enforcement Administration (DEA), which administers the CSA. Schedule II drugs are subject to manufacturing quotas set by DEA with input on ...Revolutionary nanotechnology illuminates brain cells at work
...end of the molecule making a "biosensor." When the substance of interest binds to the sensor, the sensor backbone becomes reoriented, and the reorientation can be detected. Since light is a vibration, the same response occurs with two fluorescent dyes that have overlapping, but slightly different colors–in thi...Defenseless plants arm themselves with metals
...Environmental Protection Agency regional hazardous substance research center. Salt collaborated in this research with John Freeman, a former graduate student now at the University of Colorado, Fort Collins. Graduate students Daniel Garcia and Amber Hopf and postdoctoral scientist Donggium Kim at Purdue's Cent...Potential Drug Target For Treating Cocaine Abuse Found
A substance similar to a drug used in the treatment of Parkins...ts of experiments showing that mice treated with a substance similar to the drug benztropine did not show any of the typical hyperactive behavior when later inje...Embryonic Stem Cells Treated With Growth Factor Reverse Hemophilia In Mice: UNC Researchers
...). The genetically altered mice lack the clotting substance factor IX, which in humans results in the hereditary bleeding disorder known as hemophilia B. This disease, much less common than hemophilia A, affects roughly one of every 35,000 people, primarily males. Although embryonic stem, or ES, cells can di...While on trail of dioxin, scientists pinpoint cancer target of green tea
...chew on willow bark to receive the benefits of the substance salicin ?they simply take an aspirin –the current research opens the door to extending the health benefits first discovered in green tea to people who never touch the beverage. Isolating the chemicals that protect against cancer would also sidestep q...Atmosphere may cleanse itself better than previously thought
...e the minute quantities of radiation absorbed by a substance called methyl hydroperoxide when it breaks up in sunlight and forms OH radicals. Methyl hydroperoxide is one of the substances that can absorb light in the lower UV spectrum, and the team theorizes that the sensitive laser technique, called action sp......to be a profitable option if the quantities of the substance needed are small or if the growth can be optimised in combination with other reared organisms. Nicole de Voogd's research was funded by NWO. ...New miniaturised chip dramatically reduces time taken for DNA analysis
...with electrochemical sensors. These can identify a substance by chemically interacting with it and converting this interaction into an electrical current that they measure. To detect DNA, the new miniaturised electrochemical genosensors have a probe containing DNA fragments that complement the DNA they aim to...How exactly does the brain control breathing?
... retrofacial region) and loaded with a transmitter substance called glutamate. Their close proximity to the ven...he blood. His cells do not contain glutamate but a substance called serotonin. Experimental Physiology asked each author to stake out his claim and provide rebu...Combination therapy leads to partial recovery from spinal cord injury in rats
...stration to date that producing a nerve-insulating substance called myelin can lead to functional improvements in animals with spinal cord injury. Previous studies have shown that the loss of myelin around nerve fibers contributes to the impaired function after a spinal cord injury. However, until now it has n...Mechanism for the captation of nutrients in plants- unknown to date
... have shown that, in the presence of saccharose (a substance produced in leaves to be subsequently distributed ...dreds of substances enter vegetable cells and each substance has its specific transporter, or even if one transporter can recognise 3 or 4 different substances, ...Speak up: Louder neurons form more connections
...mersed 3-day-old fish in a breathable, Jell-O-like substance that kept the fish alive but immobile. The researchers could then focus video cameras on the fish’s developing brain to watch how the branches of individual neurons grew and shrank over time. It turns out that determining which of the branches will ...Confirmation of human protein interaction data by human expression data
...mersed 3-day-old fish in a breathable, Jell-O-like substance that kept the fish alive but immobile. The researchers could then focus video cameras on the fish’s developing brain to watch how the branches of individual neurons grew and shrank over time. It turns out that determining which of the branches will ...Scientists reveal how disease bacterium survives inside immune system cell
...s that are toxic to cells, including a bleach-like substance called hypochlorous acid. Once the bacteria are killed, the involved neutrophils self-destruct in a process known as apoptosis. Recent evidence suggests that this process is vital to resolving human infections. A. phagocytophilum is unusual in that ...Newly discovered genetic disease sheds light on body's water balance
... plasmid that responds to cAMP. Luciferase is the substance that lights up in fireflies. Feldman showed that wild-type cells contain low levels of light from luciferase -- and thus low levels of cAMP. In Feldman's experiments, cells with the R137C mutation proved to have four times as much cAMP as wild-type ...Scalpel-free surgery could reduce risk of HIV and hepatitis exposure for health care workers
...tend toward low socioeconomic status and increased substance use, most university hospitals in the United States are located in urban areas and serve a similar patient population, added Makary. Other authors on the report are Eric S. Weiss, Theresa Wang, Dora Syin, Peter Pronovost, David Chang and Edward Corn...Purdue scientists may have found key to halting spinal cord damage
...urdue University researchers may have isolated the substance most responsible for the tissue damage that follow... I have already had our hands in developing PEG, a substance that coats damaged spinal cells so that their membranes can heal and also oscillating field stimulat...Attacks of King George III's madness linked to key metabolism molecule
...ay have been exposed to arsenic contamination of a substance his doctors gave him as treatment. PGC-1 alpha is a "transcriptional coactivator" that acts as an on-off switch for a number of genes involved in manufacture of glucose in the liver and in the "heating system" of brown fat cells that help prevent da...Researchers devise new technique for creating human stem cells
...nic stem cells in the presence of a detergent-like substance that caused the two cell types to fuse. The researchers demonstrated that they had achieved fusion of the two cell types by searching the fused cells for two distinctive genetic markers present in the somatic fibroblast and stem cells. The researcher...Bitter or sweet? The same taste bud can tell the difference
...te signals to the brain, depending on what kind of substance is on the tongue. Given the current findings, Herness thinks that CCK tells the brain that something bitter is on the tongue, while NPY sends a message that something sweet is being eaten. "We were surprised to see that NPY had the exact opposite ac...A slight difference and significant similarities
...new, unwanted substances. However, a comprehensive substance comparison between individual plant varieties is costly, as hundreds of substances have to be measured simultaneously. Former Max Planck research group head Oliver Fiehn, who has been working at the University of California in Davis since the beginni...UF researchers kill resistant bugs one bandage at a time
... the researchers' method of chemically bonding the substance to fabrics and other materials. This method allows the substance to be efficiently mass produced and permanently adhered to wound dressings or ready-to-wear clothing...Researchers find molecule that inhibits regrowth of spinal nerve cells
...he researchers found that a component of myelin ?a substance that normally insulates and stabilizes long nerve fibers in adult vertebrates ?chemically blocks the ability of nerve cells to grow through myelin that is released when the spinal cord is damaged. While other myelin components also block nerve growth...Researchers find how some antibiotics kill bacteria
...models of each antibiotic, approximating what each substance looked like on the atomic level and exactly how each bound to and affected a key component of bacteria called RNA polymerase. RNA polymerase is the machinery that keeps bacteria going ?a bacterium cannot carry out gene expression without it. Cut off...NYU chemists use computer simulation to enhance understanding of DNA transcription
...earch has indicated that chromatin--a chromosome's substance consisting of histone proteins and DNA--exhibits salt-dependent conformations. Specifically, chains of nucleosomes, the building blocks of chromatin that appear as bead-like structures along DNA, fold into a condensed fiber as salt increases. This fo...Long-sought flower-inducing molecule found
...s one could show that the induced leaves produce a substance that is transported to the shoot tips where it ind... 30-ies a Russian scientist called this mysterious substance "Florigen". During the following 70 years scientists have been involved in an intense hunt trying to...Scientists closer to new cancer detection method
...orresponding and readily binding to a sought-after substance such as cancer protein. In this case, the target was platelet derived growth factor, or PDGF, a protein that regulates cell growth and division. Elevated PDGF levels have been linked to different forms of cancer, and have been found in patients wit...A substance found in the Welsh national flower, which could offer hope for sufferers of Alzheimer's disease, is being supported for large scale manufacture by Cardiff University's Manufacturing Engineering Centre (MEC). Alzheimer's disease is the most common fo...New discovery: If it weren't for this enzyme, decomposing pesticide would take millennia
...n of an enzyme that evolved to act on some natural substance yet to be identified." Horvat carried out the work in Wolfenden's laboratory by analyzing what happened to the pesticide's residue at various temperatures and then extrapolating the results to room temperature to see how long the pesticide would las...Anti-cancer Compound In Beer Gaining Interest
...lly first discovered in 1913, isolated as a yellow substance found in hops. Researchers started studying its molecular structure in the 1950s, but for decades the only people who showed any real interest in it were brewers, who were trying to learn more about how hops help impart flavor to beer. In the 1990s,...Give thanks for the cranberry, say dental researchers
...can cause cavities, and the natural acidity of the substance may contribute directly to tooth decay. Instead of advocating mass consumption of cranberry juice, Koo hopes to isolate the compounds within the juice that pack an anti-cavity punch. The substances could then be added to toothpaste or mouth rinse di...War on terror meets war on cancer
...pe ratio mass spectrometry," can determine where a substance was produced by "weighing" various forms or isotopes of an element in the substance ?such as the ratio of rare oxygen-18 to common oxygen-16. Additional uses of the method may result...Russian 'surrogate' alcohols are a killer
...consistent with historical lessons which show that substance abuse is often widespread during periods of rapid transition, such as the industrial revolution." Shkolnikov concurs. "When thinking about the Russian health crisis, one should not overlook certain societal forces operating in the post-Soviet era,"...Plants have a double line of defence
...ties of the PEN2 enzyme, a glycosyl hydrolase. The substance released by it appears to have a fungicidal effect, which kills the pathogen. The researchers, on the other hand, observed that when PEN2 is missing, the plants become more susceptible not only to grass powdery mildew fungi but also other pests ?for...Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke
...-2) to make prostaglandin E2 (PGE2), a hormonelike substance long linked to inflammation and other effects. The Hopkins study results suggest that PGE2 causes brain damage following stroke by binding to the EP1 receptor on nerve cells. Therefore, blocking PGE2 activity directly rather than inhibiting COX-2 cou...Compound from marine bacteria shows potential as multiple myeloma therapy
...fied in sediment samples from the ocean floor. The substance has shown strong anticancer properties in laboratory tests. Nereus Pharmaceuticals holds an exclusive license to the compound for drug development. Experiments with NPI-0052 began at Dana-Farber in 2003, said Dharminder Chauhan, PhD, lead author ...Federal grant funds research on novel HIV therapy
...than a decade of investigation by Dr. Douglas into substance P, a neurotransmitter long known to be active in t...agues discovered in 1997 that immune cells produce substance P and its receptor, neurokinin-1, and later showed that incubation with substance P raised HIV level...DNA gene vaccine protects against harmful protein of Alzheimer's disease
...human trial, the protein was injected along with a substance called an adjuvant, which increased the immune response to abnormal excessive levels, causing the dangerous brain inflammation. In addition, the immune response in humans may have involved antibodies called Th1, which were probably partly responsible...Environmental tobacco smoke linked to behavior problems in children and pre-teens
...f cotinine in the children's blood. Cotinine is a substance produced when nicotine is broken down by the body and can be measured in blood, urine, saliva and hair. It is considered the best available marker of environmental tobacco smoke exposure. Dr. Yolton found a relationship between cotinine levels and ...HIV/AIDS rates in Tijuana, Mexico increasing at alarming rate
...ess of HIV/AIDS and, for some, the need to turn to substance use and sex work to fill the perceived void ?all contributing factors that can lead to increased vulnerability to HIV infection. Although homosexual/bisexual men continue to be the groups most affected by HIV/AIDS in the border region, needle shar...Human prostate grown from embryonic stem cells
... a human prostate, secreting hormones and PSA; the substance in the blood used to diagnose prostate disease," she said. Professor Gail Risbridger, Director of MIMR's Centre for Urological Research and leader of the research project, said the discovery will have a significant impact on prostate cancer and BPH ...Growth hormone is made in the brain, report scientists
Scientists have found that growth hormone, a substance that is used for body growth, is produced in the brain, according to an article published in this week's Proceedings of the National Academy of Sciences. The researchers -- from three institutions –?found that growth hormone is produced within the h...Gene needed for butterfly transformation also key for insects like grasshoppers
...still have the large head and the stubby legs." A substance called juvenile hormone is present at each step of nymph development in insects that do not experience complete metamorphosis, and the researchers found that juvenile hormone correlates with the expression of the broad gene during the nymphal stage. ...Cell therapy slows progression of an inherited neurological disease; Improves motor skills in mice
...ly begins early in life. In the disease, the fatty substance sulfatide accumulates in the brain due to the lack of an enzyme and causes loss of the white matter or myelin protecting nerve fibers. Without myelin, nerves cannot conduct impulses to and from other areas of the body, resulting in symptoms including...Cholesterol gets 'thumbs up' for role in digit development
...ugh cholesterol has a bad rap as the sticky, fatty substance responsible for clogging arteries, Vanderbilt University Medical Center researchers recently found that the attachment of cholesterol to an important developmental protein controls the development of fingers and toes in mice. Without cholesterol, mic...Potential vaccine developed for deadly leishmaniasis disease
...ine manufacturers achieve this by adding a booster substance ?an adjuvant. The standard existing adjuvant, alum, has limitations. Potential alternative adjuvants are toxic, expensive or have other problems. Seeberger’s candidate vaccine combines the delivery vehicle, immune-stimulating antigen and adjuvant in...Newly discovered protein kills anthrax bacteria by exploding their cell walls
...ti hopes to combine PlyPH with a non-toxic aqueous substance developed by a group in California that will germinate any anthrax spores it comes in contact with. As the spores germinate, the PlyPH protein will kill them, usually in a matter of minutes. The combined solution could be used in buildings, on transp...New compound protects against liver cancer
...derived from oleanolic acid, a naturally occurring substance found in many plants. Other oleanolic derivatives are known to reduce tumor growth in animals and humans. Researchers believe CDDO-Im works by activating Nrf2, a master switch known to direct certain enzymes to stimulate the cell's defense mechanism...Curry and cauliflower could halt prostate cancer
...thyl isothiocyanate (PEITC), a naturally occurring substance particularly abundant in a group of vegetables that includes watercress, cabbage, winter cress, broccoli, Brussels sprouts, kale, cauliflower, kohlrabi and turnips. "The bottom line is that PEITC and curcumin, alone or in combination, demonstrate sig...Forsyth scientists gain greater understanding of how embryos differentiate left from right
...g ciliary, serotonergic (serotonin is the chemical substance involved in transmitting signals between neurons), and ion flow mechanisms. The data was strengthened by the operation of this mechanism through all three vertebrates. This is important because prior data was very fragmented and different asymmetry-......responsible for the assimilation of ammonium, this substance is not modified in moderate concentrations in the pea but it is so in spinach. Regarding the main metabolic modifications, these take place in the roots in the case of the pea and in the leaves in the case of spinach. Moreover, in the roots of the pe......etic retinoid, i.e. our body does not produce this substance naturally. Natural retinoids are used to treat various diseases (e.g. those of the skin) but they turn out to be quite poisonous in the doses required ?they are not well tolerated. This is why synthetic retinoids are created. Specifically, the Un...Other ContentshypercholesterolemiapracticepracticepracticepracticepracticepracticepracticepracticepracticefarsightednessfarsightednessfastingfastingfastingfastingfastingfastfastfastfastfastfastfastfastfastconvulsionsconvulsionsfecesfecesfecesfecesOther TagsPAPPAPPAPPAPPAPPAPChromogenMixerRADISHOther Tagsstruggle 2struggle 3struggle 4struggle 5struggle 6contradictory 2serves 2serves 3serves 4serves 5serves 6serves 7serves 8serves 9
(Date:8/20/2008)...Wireless Data Communications Link School ...L, N.J., Aug. 20 /PRNewswire-FirstCall/ -- BIO-key...leader in finger-based biometric,identification an...d the,availability of MobileSRO(TM) and MobileCamp...ent solutions for K-12 schools and higher,educatio...
(Date:8/20/2008)...2008 New phase 2 data published today in The Lan...4 demonstrates activity in nonsense-mutation cysti...h PTC124 results in statistically significant impr...nts with nonsense-mutation CF. The study was cond...n Jerusalem, Israel and sponsored by PTC Therapeut...
(Date:8/20/2008)...s have created a tiny motorized ,positioning devi... being ,developed for applications that include b...puter hard drives. , The device, called a monoli...anipulator" that precisely moves or senses movemen...tery environments for probing ,biological molecul...
(Date:8/20/2008)...etic code of a simple saltwater creature could hel... function in humans and other species. , A study...s down the genetic code of Trichoplax , a simple ... the world, even in the common household aquarium.... , genes that are also found in other animals - ou...
Breaking Biology News(10 mins):BIO-key(R) Announces Emergency Alert and Management Solutions for Schools and Campuses 2BIO-key(R) Announces Emergency Alert and Management Solutions for Schools and Campuses 3PTC124 shows activity in cystic fibrosis; Phase 2 proof-of-concept data published in Lancet 2PTC124 shows activity in cystic fibrosis; Phase 2 proof-of-concept data published in Lancet 3New 'nano-positioners' may have atomic-scale precision 2New 'nano-positioners' may have atomic-scale precision 3Genome of saltwater creature could aid understanding of gene grouping 2As Billions in Blockbuster Drug Revenue Goes Off Patent Life Sciences Companies are Challenged to Fundamentally Change Future R 26D Strategies Accor 4345 1As Billions in Blockbuster Drug Revenue Goes Off Patent Life Sciences Companies are Challenged to Fundamentally Change Future R 26D Strategies Accor 4345 2As Billions in Blockbuster Drug Revenue Goes Off Patent Life Sciences Companies are Challenged to Fundamentally Change Future R 26D Strategies Accor 4345 3Radius Completes Enrollment of Phase II Clinical Trial of BA058 for Osteoporosis 1676 1Radius Completes Enrollment of Phase II Clinical Trial of BA058 for Osteoporosis 1676 2EnVivo Pharmaceuticals Announces Initiation of Clinical Safety and Biomarker Study of Alpha 7 Nicotinic Agonist EVP 6124 in Patients with Schizophre 1674 1EnVivo Pharmaceuticals Announces Initiation of Clinical Safety and Biomarker Study of Alpha 7 Nicotinic Agonist EVP 6124 in Patients with Schizophre 1674 2EnVivo Pharmaceuticals Announces Initiation of Clinical Safety and Biomarker Study of Alpha 7 Nicotinic Agonist EVP 6124 in Patients with Schizophre 1674 3New Scan Sees Tumors Deep Inside Body 15749 1New Scan Sees Tumors Deep Inside Body 15749 2[0] BIO-key(R) Announces Emergency Alert and Management Solutions for Schools and Campuses[0] PTC124 shows activity in cystic fibrosis; Phase 2 proof-of-concept data published in Lancet[1] New 'nano-positioners' may have atomic-scale precision[0] Genome of saltwater creature could aid understanding of gene grouping
(Date:8/21/2008)... New names and fresh websit... UME/GME administration software , ... one45 Software, a leading provider of healthcare ... of Cytiva Software Inc. (CRX:TSX.V), announced to...hcare education administration products., , ,Compl...
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(Date:8/20/2008)... Survey Report Is Available at http://ww...Newswire/ -- A new survey released today,documents...re leveraging,health information technology (HIT) ...The survey results highlight the need for many HIT...dization and,interoperability to optimize clinical...
(Date:8/20/2008)...use postponed reproductive onset in teen, adult fe...EDNESDAY, Aug. 20 (HealthDay News) -- Alcoholism i...ccording to a study that compared women,s and men,... age when they had their first child. , The re...ian twins born between 1893-1964 (3,634 female and...
Breaking Medicine News(10 mins):Health News:Cytiva's one45 Software Rebrands Healthcare Education Administration Products 2Health News:Cytiva's one45 Software Rebrands Healthcare Education Administration Products 3Health News:Cytiva's one45 Software Rebrands Healthcare Education Administration Products 4Health News:Questex Acquires Leading Spa Industry Portal and Spa Executive Business Networking Site and Events 2Health News:Questex Acquires Leading Spa Industry Portal and Spa Executive Business Networking Site and Events 3Health News:New Health IT Survey for Care Management Services Shows Opportunities for Integration, Standardization and Innovation 2Health News:New Health IT Survey for Care Management Services Shows Opportunities for Integration, Standardization and Innovation 3Health News:Women's Alcohol Use Tied to Delayed Childbearing 2[0] Cytiva's one45 Software Rebrands Healthcare Education Administration Products[0] Questex Acquires Leading Spa Industry Portal and Spa Executive Business Networking Site and Events[0] New Health IT Survey for Care Management Services Shows Opportunities for Integration, Standardization and Innovation[0] Women's Alcohol Use Tied to Delayed Childbearing
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