Squamous in Biological News

Study links virus to some cases of common skin cancer

... Institute. The researchers examined tissue samples from 58 people with squamous cell carcinoma (SCC), a highly curable form of skin cancer that is ... evidence that the virus might play a role in causing some cases of squamous cell carcinoma," says principal investigator Amanda E. Toland, assistant ...

New diagnostic advance seen for head, throat cancer

... "poorly differentiated" tumor cells that caused the most deadly types of squamous cell carcinomas in the larynx, throat, tongue and other parts of the head. ... expression and the aggressive nature of the cancer. Head and neck squamous cell cancers are the sixth most common cancers in the world, the ...

Regulation of cell proliferation by the OGF-OGFr axis is dependent on nuclear localization signals

... protein (eGFP) was constructed. Experiments with a human cancer cell, a squamous cell carcinoma of the head and neck, revealed that translation of OGFr ... a Phase I clinical, trial, and Phase II trials for pancreatic cancer and squamous cell carcinoma of the head and neck are in progress. Co-author Dr. ...

Saliva proteins could help detection of oral cancer

... PHILADELPHIA Clinicians could detect oral squamous cell carcinoma, a form of oral cancer, using a simple test that detects ... Researchers collected saliva samples from 64 patients with oral squamous cell carcinoma and 64 healthy patients. Five candidate biomarkers were ...

Time (and PPAR-beta/delta) heals all wounds

... promotes or inhibits epithelial cancers (4-6). Tan's group has already found that fibroblasts lacking the protein can increase the proliferation of squamous carcinoma cells; they now plan to investigate PPARβ/δ's expression in tumor-associated fibroblasts. "Fibroblasts often play important roles ...

Stowers Institute's Workman Lab discovers novel histone demethylase protein complex

... as an oncogene, which has the potential to cause a normal cell to become cancerous. Overexpression of such a gene product can lead to esophageal squamous carcinoma and prostate cancer. The Workman Lab's efforts to learn more about the dynamic regulation of H3K36 methylation may lead to the discovery of ...

H. Pylori bacteria may help prevent some esophageal cancers

... of Tehran in Iran analyzed results from 19 published studies examining the associations of H. pylori with esophageal adenocarcinoma and esophageal squamous cell carcinoma, another type of esophageal cancer. ...

Pre-cancerous condition linked to chronic acid reflux faces several hurdles

... basis of Barrett's is an abnormal change, or dysplasia, in the oesophagus. Normally, the oesophagus is lined with flat-shaped cells known as squamous cells. However, in patients with Barrett's, the cell lining consists of rectangular-shaped columnar cells. This process of normal cells morphing ...

How what and how much we eat (and drink) affects our risk of cancer

... dense fat diet with either dose of TPA, the researchers noted. The impact of dietary energy balance manipulation on the conversion of papillomas to squamous cell carcinomas in this model of multistage skin carcinogenesis is also being assessed. These researchers have also shown that dietary energy ...

Rising skin cancer rates are more likely to affect wealthy people, says 12-year review

... most common skin cancers - basal cell carcinoma, squamous cell carcinoma and malignant melanoma - accounted ... And men were twice as likely to suffer from squamous cell carcinoma than women, accounting for 357 of ... Affluence didn’t, however, seem to affect squamous cell carcinoma. Malignant melanomas showed ...

High-powered gene profiles provide clues to genes involved in common form of lung cancer

... two major subtypes of NSCLC, adenocarcinoma and squamous cell carcinoma, and found that their genomic profiles overlap in every area but one: squamous cell carcinomas contain an area of gene ... raises the possibility that adenocarcinoma and squamous cell carcinoma arise from an error in the same ...

Biomarkers isolated from saliva successfully predict oral and breast cancer

... "biomarkers" isolated in saliva predicted oral squamous cell carcinoma in about nine out of 10 cases. A ... and blood from 32 patients with primary oral squamous cell carcinoma and 40 breast cancer patients, and ... using only serum transcriptome samples for oral squamous cell carcinomas," said Wong. "For oral cancer, ...

Cancer vaccines -- Taking a jab at cancer by stimulating the immune system

... of all cancers. Wild type sequence p53 as a vaccination target for squamous cell carcinoma of the head and neck: Abstract 5113 Researchers from ... multiple parts of the immune system into targeting p53 in head and neck squamous cell cancer. A phase I clinical trial of the vaccine is currently underway ...

Study: Harmless virus kills some cancers

... a common, non-disease-causing virus to kill cervical, breast, prostate and squamous cell cancer cells in laboratory cultures, according to Penn State College ... the same approach in four types of cancer ?cervical, breast, prostate and squamous cell - all epithelial cell cancers. Epithelial cells are those that cover ...

Genes and biomarkers that allow doctors to choose the right therapy for the right patient

... the Translational Genomics Research Institute (TGen). The TGen researchers have found 164 genes that are involved in regulating the sensitivity of squamous cell head and neck cancer cells to lapatinib, a cancer drug that was recently approved for use in metastatic breast cancer under the name Tykerb. ...

Signal protein shows promise for blocking tumor promoters in skin cells

... and mice with the tumor-forming Src kinases expressed in their skin. Within six months, the group expects to know whether Srcasm can decrease squamous cell carcinoma formation in skin, mentions Seykora. ...

Abnormal overexpression of p53 is a predictive molecular biomarker

... predictive biomarker test for a gene-based drug. Researchers at Introgen Therapeutics, Inc., in Austin, Texas, found that patients with advanced squamous cell carcinoma of the head and neck cancer (SCCHN) whose pre-treatment tumor samples over-expressed p53 protein were significantly more likely to ...

Long-term cancer risk follows stem cell transplant recipients

... The median time to diagnosis was almost 7 years after transplant. The most commonly reported second cancers were cancers of the skin (basal and squamous cell), lung, oral cavity, and colon. Furthermore, data analysis showed that the risk more than tripled for patients who received their ...

Gene first linked to rare disease may trigger skin cancer, other tumors

... conducted a preliminary analysis of CYLD levels in human skin cancers originating from the epidermis, including basal cell carcinomas (BCC) and squamous cell carcinomas (SCC). BCC and SCC represent the two most common forms of skin cancer, which together affect an estimated one million Americans ...

Biomarkers may hone anti-aging therapies

... cancer removed in the Vanderbilt Mohs Clinic. Mohs micrographic surgery is a treatment for skin cancer, particularly the most common forms: basal and squamous cell carcinomas. Sligh and colleagues were surprised to find a panel of mitochondrial DNA deletions in the tumor-free skin that was adjacent to ...

HPV subtype associated with squamous cell skin cancers

... with human papillomavirus (HPV) types called beta HPVs may be associated with an increased risk of developing a major type of skin cancer known as squamous cell carcinoma (SCC), according to a new study in the March 15 issue of the Journal of the National Cancer Institute. In addition, the presence ...

Forsyth scientists find three bacteria associated with oral cancer

... in the July 7 Journal of Translational Medicine, suggests that elevated levels of three particular bacteria in saliva indicate the presence of oral squamous cell carcinoma (OSCC)--one of the deadliest of cancers because it often goes undetected in its early stages. "Finding bacteria associated with ...

Compound from Chinese medicine shows promise in head and neck cancer

... In a previous study published in November 2004 in Clinical Cancer Research, Bradford, Carey and their team treated cell cultures of head and neck squamous cell carcinoma with the (-)-gossypol compound and found it inhibited tumor cell growth. Additional testing in animals was also positive and showed ...