Why a common treatment for prostate cancer ultimately fails
... versatile than previously thought. Under certain conditions the molecule spurs
growth, and at other times the molecule squelches growth just like the ... But Chang's team unexpectedly found that blocking the receptor actually spurs
other prostate cells to grow.
"The androgen receptor acts differently ...
A crystal ball for brain cancer?
... team saw requires an understanding of how the tumor creates an independent blood supply.
Cancer cells secrete a growth factor called VEGF that spurs
the growth of new blood vessels to supply the tumor with oxygen and nutrients. Avastin blocks VEGF, essentially starving the tumor to death.
Small molecules mimic natural gene regulators
... specific gene to be regulated, and an activation domain that attaches itself to the cell's machinery through a key protein-to-protein interaction and spurs
the gene into action. The researchers wanted to know whether their ATFs attached to the same sites in the transcriptional machinery that natural ...
Large sponges may be reattached to coral reefs
... rope moved along with debris by strong currents. After these events, detached large sponges are commonly found, still alive and intact, between reef spurs
on sand or rubble where they slowly erode under the action of oscillating currents.
"The worldwide decline of coral reef ecosystems has prompted ...
When cancer cells can't let go
... a path for the cell to wriggle through. As they move, cancer cells get traction by temporarily attaching to the ECM through focal adhesions. FAK spurs
focal adhesions to disengage, and it is more abundant in metastatic tumors. Whether FAK also regulates invadopodia was unknown.
When Chan et al. ...
A diet rich in calcium aids weight loss
... Qubec City, March 12, 2009 Boosting calcium consumption spurs
weight loss, according to a study published in the most recent issue of the British Journal of Nutrition , but only in people whose diets are ...
Princeton-led team finds secret ingredient for the health of tropical rainforests
... team found, is essential for controlling the biological conversion of nitrogen in the atmosphere into natural soil nitrogen fertilizer, which in turn spurs
plant growth. "Just like trace amounts of vitamins are essential for human health, this exceedingly rare trace metal is indispensable for the vital ...
Statins may prevent miscarriages
... a protein, C5a, that activates another protein, tissue factor, that is expressed on the surface of certain white blood cells called neutrophils. This spurs
the neutrophils into action, they attack the placenta, and the fetus dies. While investigators had unveiled this basic chain of events, they didn't ...
Laminin builds the neuromuscular synapse
... muscle, the laminin protein has different domains called alpha, beta, and gamma chains. Previous work had shown that the beta2 chain of laminin spurs
differentiation of the nerve terminal. The team has now found evidence that the alpha chains of laminin influence post-synaptic patterning. For ...
Gap junction protein vital to successful pregnancy, researchers find
... the presence of estrogen, the embryo is unlikely to survive.
This is the first study to detail the mechanism by which the steroid hormone estrogen spurs
cell differentiation and blood-vessel growth in the uterus during pregnancy, the researchers report.
The findings, from researchers at the ...
A better way to make hydrogen from biofuels
... reactor, and its cost".
The process starts with a liquid biofuel such as ethanol, which is heated and pumped into a reactor, where the catalyst spurs
a series of chemical reactions that ultimately convert the liquid to a hydrogen-rich gas.
One of the biggest challenges the researchers faced was ...
Chronic exposure to estrogen impairs some cognitive functions
... it does.
Schantz and her colleagues had focused on the prefrontal cortex because it is rich in estrogen receptor beta (ER-beta), a protein that spurs
gene expression and other activities in the cell when it binds to estradiol. Genistein also activates ER-beta.
Some women take genistein ...
Cellular self-eating promotes pancreatitis
... by delivering trypsinogen to the lysosome, where enzymes turn it on.
The researchers gave mice injections of the compound cerulein, which spurs
pancreatitis. Control animals suffered severe damage to the organ, which harbored numerous deteriorating cells. But rodents that lack a gene ...
American Chemical Society's Weekly PressPac -- May 28, 2008
ARTICLE #5 EMBARGOED FOR 9 A.M., EASTERN TIME, June 2, 2008
Bisphenol A: Controversy over widely used plastics chemical spurs
product changes, regulatory debate
Chemical & Engineering News
The controversy over bisphenol A (BPA) is spurring manufacturers to offer ...
First analysis of platypus genome may impact disease prevention
... ... the platypus is one odd duck-billed, egg-laying, lactating mammal. With adaptations like webbed feet to fit its aquatic lifestyle and the poison spurs
that decorate males, the platypus represents for many a patchwork of evolutionary development. But LSUs Mark Batzer, along with an international ...
Duck-billed platypus genome sequence published
... system used when foraging for food underwater, along with thick fur coats adapted for the icy waters in which it resides. Males also possess hind leg spurs
that can deliver venom powerful enough to wound territorial competitors during mating season or cause excruciating pain in other mammals, including ...
Mesothelin engineered on virus-like particles provides treatment clues for pancreatic cancer
... New understanding of a protein that spurs
the growth of pancreatic cancer could lead to a new vaccine against the deadly disease, said researchers at Baylor College of Medicine in Houston in ...
IdentiPHI Opens Paris Office to Boost European Sales and Support
... Growth of identity security market in EMEA spurs
IdentiPHI's company expansion
AUSTIN, Texas, Nov. 28 /PRNewswire/ -- IdentiPHI, Inc., an innovative
leader in ...
First IEEE-USA Innovation Forum coming to Washington area in November
... innovation important to the U.S. economy? Because the conversion of ideas and inventions into useful and affordable products, services and processes spurs
economic activity that drives wealth, creates high-paying jobs and improves our standard of living. Bordogna, former deputy director and chief ...
Study finds blocking angiogenesis signaling from inside cell may lead to serious health problems
Several newly developed angiogenesis inhibitors work by blocking vascular endothelial growth factor (VEGF), an important signaling protein that spurs
growth of new blood vessels. Avastin, an approved angiogenesis inhibitor for colon and lung cancers, inhibits angiogenesis by blocking VEGF signaling ...
Columbine flowers develop long nectar spurs in response to pollinators
... account for the evolution of very long nectar spurs
in flowers, said Hodges. "In Darwin's race, plants with the longest spurs
and pollinators with the longest tongues [to tap ... process--continually drive the plants' spurs
and the pollinator tongues to exceptionally long ...
Hormone helps mice 'hibernate,' survive starvation
... online today in Cell Metabolism.
FGF21, triggered in starving mice by a specific cellular receptor that controls the use of fat as energy, spurs
a metabolic shift to burning stored fats instead of carbohydrates and induces a hibernation-like state of decreased body temperature and physical ...
'Guardian of the genome' protein found to underlie skin tanning
... sun causes skin cells called keratinocytes to make and secrete a hormone called alpha-MSH, which attaches to nearby skin cells called melanocytes and spurs
them to produce skin-darkening pigment called melanin. The chain of events within keratinocytes that leads to alpha-MSH production, however, was a ...
Key to zebrafish heart regeneration uncovered
... heart is removed, the dynamic interplay between a mass of stem cells that forms in the wound and the protective cell layer that covers the wound spurs
the regeneration of functional new heart tissue, Duke University Medical Center scientists have found.
The scientists further discovered that key ...
Scientists aim to thwart use of flu as bioweapon
... by the University of Rochester Center for Biodefense Immune Modeling, is a lecture by Nobel Prize winner Peter Doherty, Ph.D., an expert on how flu spurs
the immune system to defend itself against the infection. Doherty's technical talk on the roles of specific types of T-cells in influenza will be at ...
Two designer drugs hit same lung cancer target, but only one is effective
... E. Johnson, MD, and Jänne, all of Dana-Farber.
Iressa and Erbitux both are designed to squelch the overexpressed, or overactive, EGFR signal that spurs
growth in several types of cancer. In some forms of the disease, including lung cancer of the non-small-cell type, and colorectal cancer, the ...
Beyond genes: Lipid helps cell wall protein fold into proper shape
... named phosphatidylethanolamine, or PE for short.
Phospholipids, unlike their fatty acid and cholesterol cousins, include a phosphate group that spurs
them to form a bilayer with water-friendly outer layers sandwiching an impermeable water-unfriendly inner layer that defines the outer surface of ...
Rats infected as newborns grew up vulnerable to memory problems during an immune challenge
... rats with salt water or with bacterial LPS. Two hours later, they euthenized the rats and checked brain markers of the immune response. Because it spurs
an immune response without live bacteria, LPS helps to reveal how the immune system works on its own, without the complication of side effects.
TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas
... additional copies of this gene or because the cells suffer mutations that affect control over the level of MYC expression. Excess MYC expression spurs
the cells to proliferate. This abnormal behavior then triggers p53 to instruct these overzealous cells to undergo apoptosis.
However, such rogue ...