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spectrometry in Biological News

An easy way to find a needle in a haystack by removing the haystack

... called MAILD, is based on classical mass spectrometry (MALDI-TOF/MS) and enables researchers to measure ... the invention is protected by patent. Mass spectrometry is an analytical technique used to elucidate the ... chemical compounds. In the last two decades mass spectrometry found vast applications in biology, especially ...

UC San Diego and Genentech scientists develop potentially disruptive antibody sequencing technology

... director of the new Center for Computational Mass spectrometry (CCMS) at UC San Diego. "This project is a ... based on mass spectrometry. While mass spectrometry routinely is used to sequence short fragments of ... in UC San Diego's Center for Computational Mass spectrometry will focus on ways to improve the method's ...

Radioactivity: Discover the lowest amounts with new methods

... product measuring set-up. By simultaneous spectrometry of the α- and γ-radiation emitted from ... 2. Improvements of low-level gamma-ray spectrometry Systems at UDO Abstract: The ... operates various low-background gamma-ray spectrometry systems at the underground laboratory (UDO) in ...

UC San Diego researchers eliminate drug discovery bottleneck

... through an innovative collaboration between mass spectrometry experts at the UCSD Skaggs School of Pharmacy and ... decipher the mass of each bead based on the mass spectrometry and determine the order of the beads within the ... This approach called multistage mass spectrometry allowed the UCSD Skaggs School researchers to ...

DOE-funded research projects win 46 R&D 100 Awards for 2009

... to provide greater sensitivity and precise measurements from mass spectrometry instrumentation while requiring smaller samples. Mass spectrometry instrumentation is commonly used for environmental and health analyses, as ...

New biomarker method could increase the number of diagnostic tests for cancer

... & Reproductive Sciences and Faculty Director of the Sandler-Moore Mass spectrometry (SMMS) Core Facility; Simon Allen, PhD, an Assistant Researcher in ... reaction monitoring (MRM) coupled with stable isotope dilution mass spectrometry (SID-MS), which is a technique used by protein scientists to measure the ...

A urine test for appendicitis?

... approach, performing a proteomics study using state-of-the are mass spectrometry (a technique that detects and quantifies proteins in a sample). Their ... judged by histologic review of the appendix specimens. Although mass spectrometry isn't widely available clinically, urine LRG elevations were detected by ...

Cloud computing brings cost of protein research down to Earth

... for analysis of the vast flow of proteomics data generated by mass spectrometry instruments used to determine the elemental composition as well as ... alternative to commercial proteomics search programs, entitled Open Mass spectrometry Algorithm (OMSSA). A second open-source proteomics database search is ...

Orientation of antenna protein in photosynthetic bacteria described

... aspects of the project were done in the Blankenship lab, while the mass spectrometry analysis was done in the Washington University NIH Mass spectrometry Resource Facility that is directed by Gross. The trimeric protein the ...

Stowers Proteomics Center devises method for assigning probabilities to human protein interactions

... counts derived from a series of affinity purifications analyzed by mass spectrometry (APMS) to generate a probabilistic measure of the preference of proteins ... bait. Previous protein interaction networks built using protein mass spectrometry data were largely based on binary yes/no data, where a protein is present ...

MIT gas sensor is tiny, quick

... have taken the common techniques of gas chromatography and mass spectrometry and shrunk them to fit in a device the size of a computer mouse. ... as well as MIT. Their detector uses gas chromatography and mass spectrometry (GC-MS) to identify gas molecules by their telltale electronic signatures. ...

American Chemical Society's Weekly PressPac -- Oct. 31, 2007

... R. Barr and colleagues in a multi-center team effort used a form of mass spectrometry to detect the presence of lethal factor, the key toxin produced by the ... Detection and Quantification of Anthrax Lethal Factor in Serum by Mass spectrometry DOWNLOAD PDF ...

American Chemical Society's Weekly PressPac -- Sept. 12, 2007

... point out. The new test, called gas chromatography-differential mobility spectrometry (GC-DMS), works fast and is small enough for use in the field, they say. ... Forensic Application of Gas Chromatography-Differential Mobility spectrometry with Two-Way Classification of Ignitable Liquids from Fire Debris ...

Carnegie Mellon scientist uses mass spectrometer to weigh virus particle, von Willebrand factor

... diagnosis using mass spectrometry. This is a new frontier in mass spectrometry research, said Bier, associate research professor and director of the ... System, who together study von Willebrand factors. Marks analysis by mass spectrometry displays a lot of the details about the composition of normal human plasma ...

NIST issues human milk and blood serum SRMs for contaminant measurements

... certificates for these SRMs were measured by NIST and the CDC using a number of different methods including gas and liquid chromatography with mass spectrometry detection. ...

American Chemical Society weekly presspac -- June 10, 2009

... has been difficult to measure DNA damage from acetaldehyde with conventional tests. The scientists describe development and use of a modified mass spectrometry method that showed clear indications that marijuana smoke damages DNA. "In conclusion, these results provide evidence for the DNA damaging potential ...

Sulphur in just one hair could blow a terrorist's alibi

... detect these small variations. "The new method is based on combining a laser ablation system and multicollector inductively-coupled plasma mass spectrometry (abbreviated to LA-MC-ICP-MS)", Rebeca Santamara-Fernndez of LGC, lead author of the study, tells SINC. To summarise, the laser makes contact with ...

A combined tooth-venom arsenal revealed as key to Komodo dragon's hunting strategy

... teeth," said Dr Fry. The researchers located and surgically excised the glands from a terminally ill dragon at the Singapore Zoo, and used mass spectrometry to obtain a profile of the venom molecules. The team also analysed which toxin genes were expressed in the dragon's venom gland. The effects of ...

Komodo even more deadly than thought: Research

... dragons have complex venom glands as well. After surgically excising the glands from a terminally ill dragon in a zoo, the researchers used mass spectrometry to obtain a profile of the venom, finding that the toxin was similar to that of the Gila monster and many snakes. The venom causes a severe loss in ...

Two new studies on circadian rhythms

... said Dunlap. "The one in Molecular Cell describes collaborative work with Dr. Scott Gerber in the Norris Cotton Cancer Center. We used mass spectrometry to follow the degree of phosphorylation of over 75 sites on the FRQ clock protein across the day. Most proteins have one or a few phosphorylations, ...

Study validates means to measure possible leukemia marker

... variations in certain proteins that may make good biomarkers in chronic leukemia patients. The study shows that liquid chromatography-mass spectrometry (LC-MS) can measure variations in histones, which are spool-like proteins that help support and store DNA. The technology accurately detected ...

Potentially harmful chemicals found in forest fire smoke

... Fire Science Laboratory in Missoula, Mont. The scientists collected smoke samples in a device that corrals small particles. Using high-resolution spectrometry instruments in EMSL, DOE's Environmental Molecular Sciences Laboratory on the PNNL campus, they then determined which molecules the smoke contained. ...

Newly discovered epidermal growth factor receptor active in human pancreatic cancers

... He believes it would tell a different, more hopeful story. Screening for pancreatic cancer. Dr. Pandey's other goal in his research is to use mass spectrometry to find additional markers of pancreatic cancer in the tumors themselves but also in blood and urine, which would avoid the problems of invasive ...

2009 ASPB Summer Undergraduate Research Fellowship award announcement

... Wolf and Dr. Miller for their encouragement and support. Emily Lin, University of Maryland Mentor: Ganesh Sriram Gas Chromatography-Mass spectrometry Derivatization for Metabolic Flux Analysis I am really excited to receive the ASPB SURF award. First, I thank ASPB for this fellowship to continue ...

American Chemical Society Weekly PressPac -- April 8, 2009

... biochemical description of what puts sperm "in the mood." - MTS ARTICLE #1 FOR IMMEDIATE RELEASE "Use of Differential Isotopic Labeling and Mass spectrometry To Analyze Capacitation-Associated Changes in the Phosphorylation Status of Mouse Sperm Proteins" DOWNLOAD FULL TEXT ARTICLE: ...

Scientists develop method for comprehensive proteome analysis

... separated by molecular weight using high pressure liquid chromatography. Each of the individual peptides was detected and identified using mass spectrometry and database analysis. DNA analysis of the yeast's genome predicts 5027 proteins. The team identified 4,600 proteins, which is not quite the entire ...

New high-throughput screening technique makes probing puzzling proteins possible

... While ABPP has indeed made work with uncharacterized proteins possible, one major drawback is that the technique requires laborious gel or mass spectrometry analyses to determine the results of a given experiment, such as a screen of a particular library of compounds for inhibitory activity. Such readout ...

Tiny samples could yield big predictive markers for pancreatic cancer

... that could all be considered harbingers of cancer in some way," Yeung says. "Now that we know what we are looking for, we can use even more powerful spectrometry techniques to find this pattern of proteins fast enough that it could be used as part of a clinical service." The researchers are looking to ...

Malaria parasite zeroes in on molecule to enhance its survival, team finds

... developed in the neighboring laboratory of Joshua Rabinowitz, an assistant professor of chemistry at Princeton and another author on the paper. Mass spectrometry is a highly sensitive technique that identifies chemicals based on their size and electrical charge. The researchers were interested in seeing how ...

States expand newborn screening for life-threatening disorders

... funding for follow-up and treatment for infants who test positive for disorders identified through screening. The recent advent of tandem mass spectrometry provided the means to identify many conditions from one blood spot. In 2000, the March of Dimes recommended criteria for adding screens in an ...

January-February GSA Bulletin media highlights

... Clark et al., School of Environmental Science, University of Ulster, Coleraine, County Londonderry BT52 1SA, UK. Pages 3-16. Accelerator mass spectrometry carbon-14 dates of fossiliferous marine mud identify two re-advances of the Irish Ice Sheet from the north and central lowlands of Ireland into the ...

December 2008 Geology and GSA Today media highlights

... only be answered by further work. Source of fluids forming distal Zn-Pb-Ag skarns: Evidence from laser ablation-inductively coupled plasma-mass spectrometry analysis of fluid inclusions from El Mochito, Honduras Iain M. Samson et al., Department of Earth & Environmental Sciences, University of ...

GUMC and Oak Ridge National Labs announce unique research partnership

... with ORNL computing capabilities, the researchers are using atmospheric pressure surface sampling and ionization methods in conjunction with mass spectrometry detection to probe paraffin-embedded tissue to map biomarker metabolites in tumor tissue samples. Since many of these tissue samples are linked to ...

Scientists map soils on an extinct American volcano

... at the LSU AgCenter is focusing on the validation of soils data and the use of new field portable technologies such as x-ray fluorescence (XRF) spectrometry and diffuse reflectance spectroscopy (DRS) in soil survey. Accurate soils information is vital not only to agriculture, but also civil engineering, ...

Large reservoir of mitochondrial DNA mutations identified in humans

... replacements) often found in patients with mitochondrial disease. By taking advantage of a high-throughput genotyping system that uses mass spectrometry measurements, the researchers were able to detect mutated mitochondrial DNA at high sensitivity. In each positive case, DNA cloning and sequencing ...

American Society for Microbiology honors Eric Skaar

... used by Staphylococcus aureus to transport iron across the cell wall. During this time, he also pioneered the use of Inductively Coupled Plasma Mass spectrometry (ICP-MS) to measure bacterial nutrient acquisition in vivo. His use of ICP-MS led to the discovery that S. aureus preferentially acquires iron from ...

Protein marker for schizophrenia risk

... a "protein fingerprint" in the blood (due to its accessibility). They compared protein profiles of schizophrenia patients and controls using mass spectrometry and identified two peaks highlighting a significant change. These were identified as alpha defensins, proteins responsible for killing microbes and ...

Europe-wide investment in lipid research will help tackle disease, says new report

... technology did not exist to analyse this complex class of molecules comprehensively. However, the application of an analytical technique called mass spectrometry now allows large numbers of lipids to be analysed rapidly. "This remarkable technological breakthrough will make it possible to better understand the ...

Tests show LLNL detection instrument can monitor the air for all major terrorist threat substances

... anthracis and RDX. In field experiments, SPAMS has been tested at San Francisco International Airport. As part of a background study, the mass spectrometry system analyzed the air for about seven weeks in 2004-05, recording data, though it lacked the capability to set off alarms. The system records were ...

Sugar linkage could lead to better treatment for autoimmune diseases

... Glycomics Center, headed by director and research professor Vernon Reinhold. The center has developed tools and protocols using multidimensional mass spectrometry to determine the structure and functional relationships of these carbohydrates. Reinhold notes that while most biopolymers are linear and thus ...
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