somatic

Mitochondrial DNA mutations play significant role in prostate cancer

...he researchers found both germ-line(inherited) and somatic (acquired) mutations in the prostate cancersamples.Because COI mutations are known to be more common in individuals ofAfrican descent, the scientists also analyzed a group of patients andcontrols of European ancestry. In this group they found the COI...

Of mice and men's (and women's) contraceptives

... opposed to all other cell types, which are called somatic cells. "There are many proteins whose deletion wil... male and female infertility without affecting the somatic cells." Animals deficient in the protein ?called MSY2 ?are infertile, but are otherwise healthy and...

Scientists generate patient-specific stem cells, Science study says

...imilar cell line from a woman who donated both the somatic cell and the oocyte; however, the donor was a spinal cord patient. The ten additional new lines resulted from nuclear transfer with skin cells of males or females and oocytes from biologically-unrelated females. Other improvements over the last pap...

SuperLigands - a database of ligand structures derived from the Protein Data Bank

...imilar cell line from a woman who donated both the somatic cell and the oocyte; however, the donor was a spinal cord patient. The ten additional new lines resulted from nuclear transfer with skin cells of males or females and oocytes from biologically-unrelated females. Other improvements over the last pap...

Human Eggs Can Develop From Ovarian Surface Cells In Vitro

...tablished that fetal mammalian eggs originate from somatic stem cells. More recent research of adult human ovaries has shown that oocytes and granulosa cells (the layer of small cells that form the wall of the ovarian follicle) may originate from OSE cells and assemble together to form new primary follicles ...

Researchers discover mechanism for multiplying adult stem cells

... lab are also exploring whether activating Oct4 in somatic cells, such as skin cells, would make it easier for these cells to be reprogrammed when used as donors for nuclear transplantation. If so, it may help scientists more efficiently "customize" embryonic stem cells that could be used to treat diseases s...

Scientists succeed in cloning human embryos from eggs matured in the lab

...ected into the empty oocytes the nuclei taken from somatic cumulus1 cells (i.e. non-germ cells) of another person ?a process known as non-autologous nuclear transfer. After time for nuclear re-programming the oocytes were artificially activated by incubation in a medium containing calcium ionophore, which en...

Invitrogen Launches i-Path -- A Unique Systems Biology Platform at BIO 2005

...ected into the empty oocytes the nuclei taken from somatic cumulus1 cells (i.e. non-germ cells) of another person ?a process known as non-autologous nuclear transfer. After time for nuclear re-programming the oocytes were artificially activated by incubation in a medium containing calcium ionophore, which en...

Researchers devise new technique for creating human stem cells

...reating human embryonic stem cells by fusing adult somatic cells with embryonic stem cells. The fusion causes...ls. This approach could become an alternative to somatic cell nuclear transfer (SCNT), a method that is currently used to produce human stem cells. SCNT invo...

Nanowires can detect molecular signs of cancer, scientists find

...lomerase, an enzyme inactive in most of the body's somatic cells but active in at least 80 percent of known human cancers. In testing of extracts from as few as 10 tumor cells, these receptors allowed real-time monitoring of telomerase binding and activity. Lieber says nanowire arrays could easily be scaled...

Sleeping beauty plays a significant role in identifying cancer genes

... discovery in solid tumours using transposon-based somatic mutagenesis in the mouse," Nature, Vol. 436, No. 7...ns N. "Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system," Nature, Vol. 436, No. 7047. ...

AACR Favors 'full spectrum of stem cell research biology'

...me, the AACR position supports the "ethical use of somatic cell nuclear transfer," noting that the technique, "promises to reveal the role of specific genetic alterations in tumorigenesis and further refine evaluations of drug activity, as well as generate immune-compatible material for transplant therapies....

miRNAs and musculature

... the mutant larvae after feeding reveals disrupted somatic musculature, strongly suggesting a role for Dmir-1 in the maintenance of muscle integrity and identity in times of stress induced by growth. Dr. Sokol proposes that "Mir-1 could function generally to maintain muscle cell identity by ensuring that mR...

Research casts doubt on circulating stem cells

...n practice their impact is, at best, minimal. The somatic cells mark genetic traits believe by the body to be no longer needed by sticking a label on them ?a sort of molecular "Don't use!" sign. "We have tried to remove this label by chemical means, too, in an effort to get the nuclei of the bone marrow-der...

Chernobyl: The true scale of the accident

...the genetic effects of radiation were seen in both somatic and germ cells of plants and animals. Prohibiting agricultural and industrial activities in the exclusion zone permitted many plant and animal populations to expand and created, paradoxically, "a unique sanctuary for biodiversity." Does dismantlemen...

Researchers offer proof-of-concept for Altered Nuclear Transfer

...NT has been described as an ethical alternative to somatic cell nuclear transfer (SCNT), also known as therapeutic cloning. For SCNT, a donor nucleus, for example one taken from a skin cell, is implanted into a donor egg cell from which the nucleus had been removed. This egg cell is then tricked into think...

Cloned stem cells prove identical to fertilized stem cells

...the basis for therapeutic cloning. Also known as somatic cell nuclear transfer, therapeutic cloning is a promising approach to create individually customized cellular therapies for treating certain disorders. Demonstrated in mice but not in humans, it begins with stem cells derived from a cloned embryo. Bu...

Study finds how organs monitor themselves during early development

...s and 2) intermingled cells, which are neighboring somatic cells in the ovary. The surface of the intermin...em. The scientists had a hunch that PGCs and the somatic cells communicate. "Dr. Gilboa's experiments clearly show there is a feedback mechanism, whereby the...

With few factors, adult cells take on character of embryonic stem cells

...ow the creation of pluripotent cells directly from somatic cells of patients," Yamanaka said. While the fin... factors can generate pluripotent cells from human somatic cells," Yamanaka said. Use of c-Myc, a gene implicated in many human cancers, may not be suitable fo...

With few factors, adult cells take on character of embryonic stem cells

...ow the creation of pluripotent cells directly from somatic cells of patients," Yamanaka said. While the fin... factors can generate pluripotent cells from human somatic cells," Yamanaka said. Use of c-Myc, a gene implicated in many human cancers, may not be suitable fo...

New technology addresses female fertility preservation

...Immature follicles (the female egg and surrounding somatic cells) can be preserved at any time but are difficult to mature when removed from their normal environment. A team of scientists from Northwestern University has developed a three-dimensional culture system that encapsulates follicles and allows imm...

Origen publishes in Nature a robust and versatile method for creating transgenic chickens

...tiate into embryonic germ cells that contribute to somatic tissue. "As well as the practical applications of...mmit in cell culture to either the germline or the somatic lineages provides a very useful new tool for understanding some of the earliest and most fundamental...

Development of gene therapy

...ith technical implementation, initial successes in somatic gene therapy are on the horizon, for example in treating adenosine deaminase deficiency and chronic granulomatous disease. There are also initial indicators that point to the efficacy of gene therapy in treating chronic lymphatic leukaemia and haemop...

Researchers create genetically matched embryonic stem cells for transplantation

...IT to demonstrate the first use of another method, somatic cell nuclear transfer, to create customized embryo... stem cells to repair genetic defects in mice. But somatic cell nuclear transfer (sometimes called therapeutic cloning) is a technically demanding and ineffici...

Cloned mice created from fully differentiated cells, a milestone in cloning research

...e that Dolly the sheep and other mammals cloned by somatic cell nuclear transfer were most likely derived fro...bryo by using a nucleus that's been removed from a somatic cell ?any cell other than a reproductive cell ?and transferring it into an unfertilized egg that has...

Xie Lab demonstrates the role of microRNA pathway

...ontrolling self-renewal of germline stem cells and somatic stem cells in the Drosophila ovary. The paper,...f two types of stem cells —germline stem cells and somatic stem cells," said Dr. Jin. "In the future, the small RNAs responsible for stem cell regulation could...

St. Jude study solves mystery of mammalian ears

...restin, which drives this cellular contraction, or somatic motility. The contraction pulls the tufts of cilia...n-mammals. One group of scientists believes that somatic motility in mammalian outer hair cells is simply a way to change the height of the cilia in the flui...