sleeping

Computers to be used to find blueprint for new influenza drug

...fighting other diseases such as the South American sleeping sickness, Chagas Disease. ...

Finding Cures For Tropical Diseases: Is Open Source An Answer?

...ed drugs are for tropical diseases, such asAfrican sleeping sickness and dengue fever. While patent incentiveshave driven commercial pharmaceutical companies to make Western healthcare the envy of the world, the commercial model only works ifcompanies can sell enough patented products to cover their R&Dco...

Effective Cancer Treatments Follow The Clock

...r "about a day") cycle that governs functions like sleeping and waking, rest and activity, fluid balance, body temperature, cardiac output, oxygen consumption and endocrine gland secretion. In their experiments, the researchers measured the animals' body weight as an indicator of response to the anti-cancer ...

Wisconsin researchers identify sleep gene

...ged counterparts rebound on the following night by sleeping longer and more deeply. Flies also sleep more in their youth than later in life, when their sleep is fragmented, as with humans. In other studies, the scientists also observed that caffeine has the same stimulating effects on human and fly sleep, an...

Newly discovered protein an important tool for sleeping sickness research

...ily by a deadly parasitic disease known as African sleeping sickness. The disease is caused by organisms calle...somes, which are spread by the tsetse fly. African sleeping sickness affects approximately 500,000 people in sub-Saharan Africa, a quarter of whom will die this...

Breakthrough System for Understanding Ocean Plant Life Announced

...ily by a deadly parasitic disease known as African sleeping sickness. The disease is caused by organisms calle...somes, which are spread by the tsetse fly. African sleeping sickness affects approximately 500,000 people in sub-Saharan Africa, a quarter of whom will die this...

Compound might defeat African sleeping sickness, clinical trial beginning this month

...sappeared in the late 1950s. That disease, African sleeping sickness, or trypanosomiasis, largely succumbed to... effectiveness in subjects with the early stage of sleeping sickness. Scientists are launching a Phase III trial this summer involving for the first time hundre...

Gene controlling circadian rhythms linked to drug addiction

...erience problems with their circadian cycles - not sleeping as much and becoming more hyperactive - they also found cocaine more rewarding than control mice, demonstrated by their strong preference for the location where the drug was administered. In addition, Clock-deficient mice produced more dopamine than...

Opiates Better Than Sedatives For Treating Newborns In Withdrawal

...hat lead to excessive weight loss and dehydration, sleeping problems and fever. Disruption in the mother-child bonding process has also been reported, and there is an increased risk of sudden infant death syndrome. In the studies, newborns suffering from NAS were treated with opiates (morphine, methadone, pa...

Researchers discover new route to hemoglobin synthesis

...hat lead to excessive weight loss and dehydration, sleeping problems and fever. Disruption in the mother-child bonding process has also been reported, and there is an increased risk of sudden infant death syndrome. In the studies, newborns suffering from NAS were treated with opiates (morphine, methadone, pa...

New understanding of jet lag

...r - the biological clock that regulates waking and sleeping cycles - has two parts that fall out of synchrony during light schedule shifts of six hours, the time it takes to fly across the Atlantic. The finding may explain, at least in part, why transmeridian travelers suffer from jet lag, the malaise experi...

Computers close in on protein structure prediction

...ut their computers to work at night while they are sleeping to search the atomic landscape for the lowest energy structure of proteins. To improve protein structure prediction further, Baker's group has also started a distributed computing project that they are hoping will be aided by members of the public. ...

North & South American researchers find architectural abnormalities in T. cruzi ribosome

...rasitic relatives Trypanosoma brucei, which causes sleeping sickness in Africa, and Leishmania, a parasite spread by sand flies. Higher resolution models of the ribosome structure will be needed to design targeted drugs, Frank said. ...

Pillows - a hot bed of fungal spores

...added: "Since patients spend a third of their life sleeping and breathing close to a potentially large and varied source of fungi, these findings certainly have important implications for patients with respiratory disease - especially asthma and sinusitis." ...

Morning grogginess more debilitating than sleep deprivation, according to CU-Boulder study

...frequently pause for quick naps in their vehicles' sleeping berths during cross-country excursions, he said. Wright and his colleagues said further studies are needed to measure the effects of nap interruption and "recovery sleep" in on-call, sleep-deprived individuals. The study also illuminates the challe...

Gene variation increases SIDS risk in African Americans

... was based, in part, on the assumption that babies sleeping on their bellies had more spells of interrupted breathing or apnea. One of the immediate consequences of apnea is a slight increase in acid levels inside oxygen-hungry muscle cells. When the researchers compared cells with the Y1103 mutation agains...

A large step forward in the fight against African sleeping sickness

Each year, over 300,000 people die of African sleeping sickness (trypanosomiasis). Researchers from the F...ple who have contracted this disease. >African sleeping sickness About 400,000 people worldwide suffer from the deadly African sleeping sickness. The disea...

New Research Shows Artificial Light at Night Stimulates Breast Cancer Growth in Laboratory Mice

...tonin, a hormone that helps to regulate a person’s sleeping and waking cycles. The new study shows that melatonin also plays a key role in the development of cancerous tumors. “We know that many tumors are largely dependent on a nutrient called linoleic acid, an essential fatty acid, in order to grow,?said D...

African parasite makes component of fat differently from all other organisms

Studying the parasite that causes African sleeping sickness, scientists at Johns Hopkins have discove...could be good targets for designing drugs to treat sleeping sickness." The single-celled trypanosome that causes African sleeping sickness, transmitted betwee...

DNA to the defense

...has shown that the parasite known to cause African sleeping sickness has evolved an unusual chromosomal struct...s week in the journal Genome Research . African sleeping sickness, or trypanosomiasis, is caused by a protozoan parasite known as Trypanosoma brucei . Ende...

Brain region linked to fly slumber

...cur in vertebrates. Sleeping flies are similar to sleeping humans. Both are groggy when woken suddenly and need extra slumber if sleep deprived. It's therefore possible, the authors argue, that a mechanism regulating both sleep and learning could be evolutionarily conserved. So studying the mushroom bodies m...

Ecstasy can harm the brains of first-time users

...d cause depression, anxiety, confusion, difficulty sleeping and decrease in memory. However, no previous studies have looked at the effects of low doses of the drug on first-time users. Dr. de Win and colleagues examined 188 volunteers with no history of ecstasy use but at high-risk for first-time ecstasy ...

Public Library of Science to launch new, open access journal on neglected tropical diseases

...s, leprosy, hookworm, schistosomiasis, and African sleeping sickness. The journal, supported by a $1.1 million grant from the Bill & Melinda Gates Foundation, will begin accepting submissions in 2007. "PLoS Neglected Tropical Diseases will promote science, policy, and advocacy for diseases of the poor,...

Resistance and genetic sensitivity to sleeping sickness

...uman African trypanosomiasis, more commonly called sleeping sickness, is induced by a parasite, the trypanosom...velopment of innovative control strategies against sleeping sickness. ...

First biomarker for human sleepiness identified in fruit flies

...p one day will try to make up for the lost time by sleeping more the next day, a phenomenon referred to as increased sleep drive or sleep debt. To identify a marker for sleep debt, Shaw decided to look in saliva. Easily accessible, saliva contains many of the substances found in blood and urine, making it ...

New study suggests promising drug combinations for sleeping sickness

...inical trial evaluating new drug combinations for sleeping sickness, carried out by the international humanit...LoS Clinical Trials. African trypanosomiasis, or sleeping sickness affects many tens of thousands of people each year in sub-Saharan Africa and is a serious ...

Need to pull an all-nighter?

...enging the gas once it's produced. The opposite ?a sleeping pill made from nitric oxide donors -- would be much harder, he says, since these compounds would likely break down before ever reaching the brain. However, one of the ways nitric oxide promotes sleep is by stimulating production of a signaling molec...

A potential biological cause for sudden infant death syndrome

...rcent of the SIDS infants in this study were found sleeping on their stomach or side....

Army research mission focused on autism

...he said. "We need to determine what is causing the sleeping disorders and the GI (gastrointestinal) symptoms that present in the majority of these children. We cannot just give these kids pharmaceutical interventions for their entire lives. We need effective treatments that address the root cause of the probl...

Scientists identify a gene that may suppress colorectal cancer

...osomes (tiny parasitic protozoa that cause African sleeping sickness), the loss of Atp5a1 gene function leads to death. To date, no mutations in the human ATP5A1 gene have been identified—further supporting its essential role in the cell. “In humans, ATP5A1 is located on chromosome 18, in a region t...

Children who sleep more weigh less

...eration. Specifically, the researchers found that sleeping an additional hour reduced young children’s chance...esults suggest that many American children are not sleeping enough,?said lead researcher Emily K. Snell of the School of Education and Social Policy and the Ins...

Leeches ferry infection among newts

...ecting humans, such as malaria, chagas disease and sleeping sickness. All these diseases are transmitted through a vector, an organism that spreads disease from one animal to another. The researchers found evidence for leech-borne transmission of a little-known fungus-like organism of the genus Ichthyopho...

Sleepless for science: Flies show link between sleep, immune system in Stanford study

...d how does the immune system know that you are not sleeping properly"" said Schneider. "How do those messages get sent back and forth"" Their findings also raise the question of why the flies have a change in their sleep pattern when infected. The researchers speculate that from an evolutionary standpoint,...

The insect vector always bites twice

...ations or pressure from human activities. Malaria, sleeping sickness and so on lead to the death of millions of people in the world. African countries are particularly strongly hit. The expansion of Dengue fever and the recent epidemics of Chikungunya and West Nile disease illustrate the trend. The pathogens...

Prenatal Stress Keeps Infants, Toddlers up at Night, Study Says

...ews to tired new moms and dads for whom a soundly sleeping child spells out well-deserved respite it may car...r own mood-disturbance may harm their unborn babys sleeping habits, development and emotional health may want to consider psychological treatment, OConnor said....