Skeletal in Biological News

UAB study reveals bone coupling factor key to skeletal health

... a natural give-and-take system that is crucial to skeletal health. The discovery is reported online in the ... to explain the coupling role of TGF beta-1 in skeletal health. Bone remodeling occurs through ... removing old and brittle bone to avoid breaks and skeletal disorders. Bone formation happens as skeletons ...

Muscle atrophy through thick but not thin

... cannibalizes itself, atrophying and breaking down skeletal muscle proteins to liberate amino acids. In a new ... bypassing the thin filaments. We depend on skeletal muscles because they can produce movement, but ... how ubiquitylation was involved in disassembling skeletal muscles. The researchers triggered atrophy in ...

Adult bone marrow stem cells injected into skeletal muscle can repair heart tissue

... that injecting adult bone marrow stem cells into skeletal muscle can repair cardiac tissue, reversing heart ... disease and heart failure. "Since skeletal muscle is the most abundant tissue in the body ... MSCs, or trophic factors released by MSCs, into skeletal muscle improved ventricular function, promoted ...

Award for pioneering stem cell research to mend broken bones

... to look at the development and repair of human skeletal tissue. Fractures, bone loss due to trauma or ... to succeed remains our ability to understand skeletal cell activity, develop appropriate scaffolds and ... the scientists will combine their expertise in skeletal stem cells, scaffolds and materials chemistry to ...

AGU journal highlights -- March 12, 2009

... fundamental questions about the dynamics of the skeletal formation process and the biological origin of ... techniques immediately yield new insights into skeletal formation and hold the potential to rapidly ... labeling experiments show spatially heterogeneous skeletal formation in the scleractinian coral Porites ...

Single adult stem cell can self renew, repair tissue damage in live mammal

... from a mixed population of satellite cells in the skeletal muscle of mice. The skeletal adult muscle stem cells (MusSC), which live just ... The ability to isolate and then transplant skeletal adult muscle stems cells could have a wide impact ...

Vitamin E shows possible promise in easing chronic inflammation

... up to half of a person's body mass consisting of skeletal muscle, chronic inflammation of those muscles ... Vitamin E, in vivo, might have similar effects on skeletal and cardiac muscle, Huey and a team of Illinois ... administration on local inflammatory responses in skeletal and cardiac muscle. In this study, the ...

December 2008 Geology and GSA Today media highlights

... to the grand, from calcite-producing earthworms, skeletal metazoans, and mineral discoveries, to Earth's ... The eve of biomineralization: Controls on skeletal mineralogy Andrey Yu. Zhuravlev and Rachel A. ... control over the mineralogy of emerging skeletal metazoans. The earliest skeletons known were ...

Cholesterol-lowering drugs and the effect on muscle repair and regeneration

... at higher doses may affect the ability of the skeletal muscleswhich allow the body to moveto repair and ... have been reported to have adverse effects on skeletal muscle in both human and animal models causing ... satellite cells (SC)) which play a key role in skeletal muscle repair and regeneration following exercise ...

A stronger future for the elderly

... we should eat to slow down the natural loss of skeletal muscle with ageing. The team from the ... specific age groups to help in it's research. skeletal muscles make up about half of our body weight and ... of a 50 year old. Since the strength of skeletal muscle is proportional to muscle size, such ...

Potential therapy discovered for hypophosphatasia, a congenital form of rickets

... to prevent hypophosphatasia (HPP), a primary skeletal disease of genetic origin. This discovery lays ... form of the TNAP gene would ease the skeletal defects of HPP. The Milln laboratory, in ... and spine. In fact, complete preservation of skeletal and dental structures were observed after 15 ...

Origin of cells for connective tissues of skull and face challenged

... embryonic cells that give rise to connective and skeletal tissues that form the base of the skull and ... wisdom says that the neural crest gives rise to skeletal and connective tissue of the head and face, as ... mutations that caused abnormal development of skeletal and connective tissue of the head and face did ...

Of mice and men: similarities between skeletons of both

... Hebrew University of Jerusalem that details the skeletal structure of the mouse demonstrates a surprising ... York, provides great visual detail of the mouse skeletal structure, utilizing the technology of ... relation to other problems related to fractures, skeletal development and illnesses, including testing of ...

Mouse model provides a new tool for investigators of human developmental disorder

... with this disease include heart defects, seizures, mental retardation, and skeletal abnormalities, and the severity of these symptoms varies between ... due to thickening of the cardiac valves, and they have abnormal facial and skeletal structures compared to normal mice. The mutant mice also have deformities ...

Astronauts may need more intense workouts to maintain muscle fitness in space

... primary course of action to protect the cardiovascular system, bone, and skeletal muscles, astronauts need to find the optimal exercises to stay fit. ... this is an effective prescription that is quite therapeutic in protecting skeletal muscles in a simulated microgravity environment. The next step is to apply ...

Symposium to look at genetic basis of exercise

... Biomedical Research Center. Dr. Hoffman will discuss Genetics and skeletal muscle adaptation to exercise, while Dr. Rankinen will talk on Genetics ... compared sedentary mice that did not have the thrombospondin gene in their skeletal muscle to mice that did have the gene. He found the mice without the ...

World Congress on Osteoporosis 2010 presents outstanding scientific program

... a paradigm to better understand bone physiology, C. Rosen (USA) Extra skeletal effects of vitamin D, B. Dawson-Hughes (USA) Stimulators /inhibitors of ... Emerging therapies, S. Papapoulos (NL) Don't miss the premiere global skeletal health meeting of 2010 - reserve May 5- 8, 2010 on your calendar. ...

While focusing on heart disease, researchers discover new tactic against fatal muscular dystrophy

... diseases have sprung the same microscopic leak that ultimately weakens skeletal muscle in Duchenne and cardiac muscle in heart failure. The leak lets calcium slowly seep into the skeletal muscle cells, which are damaged from the excess calcium in Duchenne. In ...

Lamin A/C deficiency is 'unnerving'

... is ubiquitously expressed, LMNA defects specifically affected striated and skeletal muscle because Nesprin-1 and SUN2 are highly expressed in these tissues. ... Emery-Dreifuss muscular dystrophy patients exhibit similar hallmarks of skeletal muscle functional denervation, suggesting the authors are on the right ...

MSU researcher studies ties between cholesterol drugs, muscle problems

... There is accumulating evidence that the effect statins can have on skeletal muscle including muscle weakness, fatigue and deterioration is ... and their use has tripled in the past seven years. Side effects affecting skeletal muscles have been reported in up to 7 percent of users, though Slade ...

Apelin hormone injections powerfully lower blood sugar

... protein kinase (AMPK), which plays a pivotal role in the control of skeletal muscle glucose and the metabolism of fatty acids. Moreover, they showed ... regulator of AMPK and strengthens the crosstalk between [fat] and skeletal muscle. The involvement of AMPK in apelin-mediated glucose uptake ...

Scientist clears hurdles for muscular dystrophy therapy

... hurdles such as the need to treat all muscles in the body, including both skeletal muscle and heart muscle, have challenged researchers looking for an ... of the body in a large animal model, but a therapy that will work on both skeletal muscle, the type found in arms and legs, and cardiac muscle, such as the ...

Biophysical Society announces 2008 International Travel Awards

... Venezuela, Importance of NCX in the Regulation of Ca2+ Homeostasis in skeletal Muscle. Maria V. Mernea, University of Bucharest, Romania, A ... Stringari, University of Florence, Italy, Structural Dynamics of the skeletal Muscle Fiber in Different Physiological States by Second Harmonic ...

Implanting embryonic cardiac cells prevents arrhythmias

... failing hearts with modest improvement of function, although transplanting skeletal muscle cells made things worse and led to more arrhythmias. Surprisingly, ... for transplantation, researchers at the University of Bonn engineered skeletal muscle to express connexin43 and achieved the same restorative results as ...

Pennsylvania Hospital surgeon receives grant to develop molecular cardiac surgery

... patents for the efficient use of vectors in gene delivery to cardiac and skeletal muscle. Prior to their work, delivery techniques in common use typically ... Stedman generate successful delivery rates approaching 100 percent in both skeletal and cardiac muscle. In addition, their delivery methods enable safe ...

Cell transplants may improve severe urinary incontinence

... current issue of CELL TRANSPLANTATION (Vol. 16 No. 7) discovered that when skeletal myoblasts - progenitor muscle cells with the potential to develop into ... et Marie Curie, Paris and lead author. When grafted into normal striated skeletal muscle they fuse with host muscle fibers where they can form mosaic fibers ...

Dead clams tell many tales

... In these studies, scientists collect data on the living organisms and the skeletal remains found in a specific ecosystem, then evaluate how closely they ... call time-averaged. They're like time exposures," Kidwell said, "because skeletal remains can hang around for a long time. In fact, through radiocarbon and ...

Antioxidant overload may underlie a heritable human disease

... carrying a human mutation earlier linked to so-called protein aggregation skeletal myopathies and cardiomyopathies, in which weakening skeletal and heart muscle contain clumps of proteins. Although the genetic basis ...

Happier, healthier, more productive hens on omega-3?

... which millions more laying hens may suffer bone breakage or fractures in the UK each year. "Fractures vary in severity and often result in gross skeletal damage and even death in some birds. Other than the welfare issue, wastage and loss in production are a considerable financial burden to the ...

Down Under dinosaur burrow discovery provides climate change clues

... in Melbourne. In 2006, in collaboration with colleagues from Montana State University and Japan, Martin identified the 95-million-year-old skeletal remains of a small adult dinosaur and two juveniles in a fossilized burrow in southwestern Montana. They later named the dinosaur species ...

Robo-bats with metal muscles may be next generation of remote control flyers

... the MAV scale, nature tells us that flapping flight like that of the bat is the most effective." The researchers did extensive analysis of bats' skeletal and muscular systems before developing a "robo-bat" skeleton using rapid prototyping technologies. The fully assembled skeleton rests easily in the ...

Mice run faster on high-grade oil

... A previous study by the group, which looked at a range of mammal species, found that those with a relatively high n-6 fatty acid content in their skeletal muscles had a greater maximum running speed. Combined, these two studies suggest that diets enriched in these fatty acids "could also affect the ...

Stem cell surprise for tissue regeneration

... of muscle growth in live mice after birth. As Christoph explained: "The paired-box genes, Pax3 and Pax7 are involved in the development of the skeletal muscles. It is well established that both genes are needed to produce muscle stem cells in the embryo. A previous student, Alice Chen, studied how ...

Studies shed light on collapse of coral reefs

... in recent research, she said, is the enormous complexity of coral biology, and even its similarity to other life forms. A gene that controls skeletal development in humans, for instance, is the identical gene in corals that helps it develop its external skeleton conserved in the different species ...

April 2009 Geology and GSA Today media highlights

... age. The isolation of the island from the mainland is interpreted by Arppe et al. from a distinct increase in the 87Sr/86Sr ratios of the mammoth skeletal remains, reflecting a change in the feeding area of the animals, from the vast plains of the continental self to the more mountainous area of ...

New approach discovered to lowering triglycerides

... complications of diabetes. "Lipoic acid is known to influence glucose uptake, and bring down blood glucose by increasing its transport into skeletal muscle," Moreau said. "Less has been done to study its potential value in reducing triglycerides." Until about 10 years ago, Moreau said, high ...

Meet-the-expert sessions on 20 key topics to enhance scientific programme of IOFWCO-ECCEO10

... S. Adami (Italy) Developmental origins of osteoporotic fracture, C. Cooper (UK) Gait and falls, T. Masud (UK) Don't miss the premiere global skeletal health meeting of 2010 - reserve May 5- 8, 2010 on your calendar. ...

UF scientist tapped by Howard Hughes Medical Institute to pursue 'best ideas'

... and toes, and identified the molecular basis for the loss of legs during whale evolution. The group has also published widely on the origin of skeletal development. Along the way, Cohn's lab noticed striking similarities between the processes that control limb development and those that regulate ...

CellThera and WPI advance in regeneration study

... of re-growing lost tissues. In the new phase of the program, the CellThera/WPI team will try to reprogram and engineer cells to replace damaged skeletal muscle and to restore the normal function of that muscle. Joining the effort for the new phase of this work will be George Pins, PhD, associate ...

Rensselaer receives more than $2 million from New York State to fund stem cell research

... leading to nodules in the neurons of the brain, a condition known as periventricular heterotopia and a progressive shortening of bones known as skeletal chondrodysplasias. These genetic disorders, although rare in humans, provide important insight into how stem cells grow and change during our ...