Simplex in Biological News

Study characterizes eczema patients most at risk for dangerous viral infections

... patients who have suffered widespread herpes simplex viral infections of their skin. It is also the ... to widespread infections of their skin by herpes simplex and vaccinia viruses. The herpes simplex virus is common but only rarely causes ...

Rutgers Genetics receives $7.8 million for autism research

... that have a single autistic child. The Simons simplex Collection, as this project is known, will ... research and potential therapies. The Simons simplex Collection will supply the groundwork for a ... and scientists working with the Simons simplex Collection are establishing new and rigorous ...

Nanoemulsion potent against superbugs that kill cystic fibrosis patients

... already proved to be non-toxic, potent killers of bacteria such as Streptococcus pneumoniae, H. influenzae and gonorrhea, of viruses such as herpes simplex and influenza A, and of several fungi. Nanoemulsion treatments for cold sores and toenail fungus are in Phase 3 clinical trials. "We have a ...

Potential new herpes therapy studied

... another weapon for the fight against herpes. The gene-targeting approach uses a specially designed RNA enzyme to inhibit strains of the herpes simplex virus. The enzyme disables a gene responsible for producing a protein involved in the maturation and release of viral particles in an infected cell. ...

Life Sciences Discovery Fund awards health research program grants

... product planning. Three specific vaccine projects will be initially addressed. One in five adults in Washington State is infected with the herpes simplex virus (HSV)-2. Infectious syphilis cases have doubled in the United States since 2000 and E. coli contamination continues to be a persistent problem ...

Nature Medicine study shows Peregrine's bavituximab can cure lethal virus infections

... response. Researchers have found that PS is exposed on the outer membrane of cells infected with HIV, influenza (including avian flu), herpes simplex viruses, hemorrhagic fever viruses, measles and members of the small pox and rabies virus families. Dr. Barton Haynes, director of Duke ...

Bacteria reveal secret of adaptation at Evolution Canyon

... slopes get eight times more solar radiation than the shady, green, lush 'European' north-facing slopes. Scientists studied 131 strains of Bacillus simplex and found that bacteria on different slopes have evolved differently, forming different 'ecotypes' of the same species. "We expected that ...

American Society for Microbiology honors Bernard Roizman

... Roizman has been a leader in the field of virology for nearly half a century. In the 1960s, he was a pioneering investigator in the field of herpes simplex virus (HSV) biology, and he is widely recognized as the leading authority in nearly every area of HSV research. One of Dr. Roizman's most important ...

American Society for Microbiology honors Ekaterina Helwein

... early career scientists for excellence in research in microbiology and infectious diseases. Dr. Heldwein's research is centered on herpes simplex virus and cytomegalovirus. These two viruses have relevance to the susceptibility to and treatment of HIV/AIDS and other diseases of ...

Tumor-targeting viral therapy slows neuroblastoma, malignant peripheral nerve sheath tumors

... continuing development and study of our tumor-targeted viral therapy to fight cancer. Previous research has documented that oncolytic herpes simplex virus (oHSV) and similar viruses can infect and kill human cancer cells without harming normal, healthy cells or causing disease. In their study, Dr. ...

UT Southwestern scientist honored among best in Texas research

... is to develop new drugs that will increase beclin 1 expression and autophagy to help treat patients with diseases such as cancer, HIV and the herpes simplex virus, Dr. Levine said. We also hope to understand better the role autophagy plays in protecting individuals from aging and from developing cancer ...

Penn researchers shine the light of venus to learn how the herpes virus invades cells

... PHILADELPHIA - University of Pennsylvania researchers have uncovered an important step in how herpes simplex virus, HSV-1, uses cooperating proteins found on its outer coat to gain entry into healthy cells and infect them. Further, the studys authors say, ...

Natural compound in broccoli could treat devastating genetic skin disorder

... powers against cancer. Now sulforaphane has demonstrated new skills in treating a genetic skin blistering disorder called epidermolysis bullosa simplex (EBS), Pierre Coulombe and colleagues at the Johns Hopkins University School of Medicine in Baltimore report at the American Society for Cell Biology ...

Natural chemical found in broccoli helps combat skin blistering disease

... etc.), helps prevent the severe blistering and skin breakage brought on by the rare and potentially fatal genetic disease epidermolysis bullosa simplex (EBS). The researchers treated newborn mice with a severe form of EBSso bad they all died within three dayswith a topical solution containing ...

Research holds promise for herpes vaccine

... herpes and other diseases caused by herpes simplex viruses. In a study published earlier this ... with a live, genetically-modified herpes simplex virus type 1 (HSV-1) showed no signs of disease ... An estimated 55 million Americans carry herpes simplex virus type 2 (HSV-2), which causes genital ....

Inheriting a tendency to brain infection

... gene that predisposes individuals to herpes simplex encephalitis, an infectious disease that tends to ... eight out of 10 adults are infected by the herpes simplex virus. For most, the worst symptom is a cold ... There was little published evidence that herpes simplex encephalitis ran in families, which suggested to ...

Scientists use gene transfer technology and common virus to block neuropathic pain in animals

... their success is based on a virus called herpes simplex or HSV ?the same virus that causes cold sores and ... genes that make it possible for the herpes simplex virus to infect a human host, VA/U-M scientists ... of Pittsburgh hold patents related to the herpes simplex virus-based vector. Citation: Annals of ...

High rates of sexually transmitted infections found in young drug users

... and other institutions found high rates of herpes simplex virus 2 and syphilis among young drug users in ... Public Health. The researchers examined herpes simplex virus 2 and syphilis test results in 543 heroin, ... of male participants were infected with herpes simplex virus 2. Women were also more likely to have ...

Turning viruses into allies against cancer

... virus that causes measles and another, the herpes simplex virus, responsible for those lip blisters known ... of Tumors: Abstract 5292 A modified herpes simplex virus, built with a potent immune stimulant to ... Like other oncolytic viruses, the modified herpes simplex virus used in these studies was engineered to ...

Researchers wake up viruses inside tumors to image and then destroy cancers

... researchers know its "sister" kinase, the one produced by the herpes simplex virus, can be imaged by an injected radiolabeled chemical (FIAU), which ... imaging, we have always had to infect cells with active herpes simplex virus so that they can replicate, express TK, and only then could we use ...

Cold sore virus might play role in Alzheimer's disease

... factor for getting Alzheimer's disease, with the form of herpes ?herpes simplex 1 or HSV ?that infects more than 80 percent of Americans and causes cold ... outward sign of the two different phases of the virus's life cycle. Herpes simplex is a chronic infection that lives in a person for a lifetime, periodically ...

Scientists use gene transfer technology and common virus to block neuropathic pain

... pain. The secret to their success is based on a virus called herpes simplex or HSV ?the same virus that causes cold sores and genital herpes. The ... the brain." After removing genes that make it possible for the herpes simplex virus to infect a human host, VA/U-M scientists use it as a carrier to ...

Achilles heel of the herpes virus possibly found

... But until now, scientists haven't fully understood how the herpes simplex virus (HSV) manages to do all of this. And that has stood in the way of ... time as an Italian team's reports about a possible 'key' on the herpes simplex virus surface that may match the 'lock' found by the U-M team. The Italian ...

Gene therapy delivery of nerve growth factors reverses erectile dysfunction in animal model

... either the gene for the glial cell line derived neurotrophic factor (GDNF) or the GDNF family ligand (neurturin) into a genetically engineered herpes simplex virus (HSV). They then injected either of the recombinant viruses into the damaged cavernous nerve of rats. GDNF is an important nerve growth ...

New vaccine prevents CMV infection and disease in mice

... genes that are essential for replication of the virus. These genes – which are also found in other herpes viruses such as chicken pox or herpes simplex – have the same or very similar sequence, structure and function whether in human or mouse viruses, and present a novel target for the host’s T-cells ...

'Insulator' helps silence genes in dormant herpes virus

... By adulthood, most people have suffered at least one bout of painful cold sores brought on by the Herpes simplex virus 1, also known as HSV-1. After the initial infection, the virus usually remains in the body, hiding out in nearby nerve cells where the victim's ...

New drug blocks influenza, including bird flu virus

... a vaccine. The flu-thwarting qualities of the peptide were observed after similar peptides were found by Brandt and his colleagues to stop herpes simplex virus infection. ...

Innovative method for creating a human cytomegalovirus vaccine outlined

... and others with compromised immune systems are at risk for complications. The virus is a member of the herpes virus family, which includes the herpes simplex viruses, the viruses that cause chicken pox (varicella-zoster virus), and infectious mononucleosis (Epstein-Barr virus.) Infectious transmission is ...

Infected for life

... target for intervention in the latent infection. A research team led by Nigel W. Fraser, PhD, Professor of Microbiology, has found that herpes simplex virus-1 (HSV-1), the virus that causes cold sores and ocular keratitis, produces an miRNA molecule. This miRNA is encoded by the Latency-Associated ...

Researchers find 'secret weapon' used by SARS virus

... host cells making messenger RNA or translating it into infection-fighting proteins, only one other virus is known to break down messenger RNA: herpes simplex virus (HSV). Makino credits lead author Wataru Kamitani, a UTMB postdoctoral research fellow, with noticing that the nsp1 protein had an ...

Mice lacking key immune component still control chronic viral infections

... (KSHV, the cause of a form of cancer known as Kaposi's sarcoma). Other herpes viruses that infect humans include the alpha herpes viruses herpes simplex virus 1 and 2, which cause cold sores and genital herpes, and varicella zoster virus, which causes chickenpox. Infection with gamma herpes viruses ...

Knowledge of infection may prevent spread of herpes virus

... now available online. Until recently, there was little evidence to show that knowledge of infection would lead to decreased transmission of herpes simplex virus (HSV) to others. But Anna Wald, MD, MPH, and colleagues at the University of Washington and the Fred Hutchison Cancer Research Center in ...

Unraveling the viral mechanism

... to other kinds of human viruses," said Chiu. In fact, he said, this bacteriophage appears structurally similar although smaller than the herpes simplex virus, which causes cold sores and related infections. That means it should be possible to use these tools to understand better how this and similar ...

Cyclosporine inhibits hepatitis C virus in vitro

... medication is Tacrolimus, although Cyclosporine is also used. The latter drug has been shown to have anti-viral activity against HIV, herpes simplex and vaccinia virus, leading researchers to speculate it might also inhibit hepatitis C virus. To examine this hypothesis, they analyzed the impact of ...

Female sex hormones play a vital role in defense against sexually transmitted diseases

... studies, to be published in the Journal of Virology, show that sex hormones have a profound effect on susceptibility of female mice to the herpes simplex virus, type 2 (HSV-2 ), one of the most common sexually transmitted diseases. Charu Kaushic, assistant professor and supervisor of the studies, ...

Topical treatment shown to inhibit HIV and herpes simplex virus infection

... researchers demonstrated that a gel applied in the vagina provides protection from both the human immunodeficiency virus (HIV) and the herpes simplex Virus. The study, presented at the 12th Conference on Retroviruses and Opportunistic Infections, is the first to show that a gel can retain ...