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DNA Molecules Used To Assemble Nanoparticles
...r carries three single-strands of DNA, each with a sequence specific to the DNA attached to other kinds of dendrimers. Put into solution with these other tinker toys, the molecule would self-assemble into a four-dendrimer complex carrying one drug, one target, and one fluorescent. ...Viral DNA sequence a possible trigger for breast cancer
A small sequence of DNA in the envelope (Env) protein of a mouse br...y unrecognized trigger for breast cancer. The DNA sequence in question is usually found in immune cells and helps trigger the activation and proliferation of t...W.M. Keck Foundation funds study of friendly microbes
... genes in the adult body. That's because it didn't sequence genes belonging to the vast communities of bacteri...loping new computational methods for mining genome sequence data so that bacterial species can be more rapidly and accurately classified. A large publicly acces...It's not all genetic: Common epigenetic problem doubles cancer risk in mice
... because they are missing another gene, H19, whose sequence overlaps the region that usually shuts off one copy of IGF2. As a result, these mice lack H19 and have double IGF2. To isolate the effect of the extra IGF2, Rolf Ohlsson at the Uppsala University, Sweden, developed a set of mice missing only the con...Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
The genome sequence of the parasitic amoeba Entamoeba histolytica, a l...de study of an amoeba. It is also the first genome sequence to be published from this class of amitochondrial human pathogens. The analysis reveals the degrada...Scientists Replicate Hepatitis C Virus in Laboratory
...es that have enzymatic function and can cleave RNA sequence at specific locations. These two ribozymes were designed to generate the correct ends of the HCV genome and to act as start and stop buttons to gene activity. The construct was “naked,?meaning that it contained only nucleic acids, the genetic materia...Affymetrix Unveils Plans to Double Plant and Animal Genome Microarray Offering
...nd animal research communities to consolidatetheir sequence data on the Affymetrix industry-standard GeneChip brandplatform. In 2004 Affymetrix worked closely with global researchcommunities to launch eight plant and animal genome arrays: Vitisvinifera (grape), soybean, wheat, rice, maize, bovine, chicken, an...Newly discovered virus linked to childhood lung disorders and Kawasaki disease
...imately, two specimens were identifiedin which the sequence of chemical building blocks of the gene differedfrom that of known human coronaviruses. The Yale investigators, termingthe novel virus indicated by their findings the New Haven coronavirus,then used probes specific for the virus to screen respiratory...Ancient olfaction protein is shared by many bugs, offering new pest control target
...e of evolutionary conservation of the Or83b coding sequence among the fruit fly, the medfly (a citrus pest), t...ell was restored, arguing not only that the gene's sequence has been conserved over 250 million years of evolution but that the gene's function in olfaction has...New Technique for Tracking Gene Regulators
...traditionalgene-sequencing methods to decipher the sequence of A, T, G, and C onthese fragments and then locat...ntists then“glue?together the tags into chains and sequence them.While small in length, the tags are large enough to allow computersearches to locate their spec...Whole genome fine map of rice completed
After the completion of a draft sequence of the Chinese hybrid rice genome, which was publi...ce, Indica and Japonica, are better than the draft sequence published in 2002. The fine maps were assembled with whole genome shortgun approach. Through searche...Scientists find missing enzyme for tuberculosis iron scavenging pathway
...otated as antibiotic resistance genes due to their sequence similarity to existing antibiotic resistance genes...f Auckland in New Zealand explains, "Generally the sequence of the open reading frame is compared with the sequences of genes for other proteins (most of which ...Found: Missing sequence of the human Y chromosome
...as one of the few holes remaining in the"finished" sequence of the human genome reported last October by theIn...rs that comprise the humangenome. The high-quality sequence spanned more than 99% of theeuchromatic (gene-containing) portion of the genome with an accuracy of9...Color-blind method opens new doors in DNA sequencing
... "We could eventually do direct detection of a DNA sequence from native DNA" without manipulation now performe... for further software processing to yield readable sequence information. "Genome sequencing, by its very nature, is a process that begs for precision, and the ...Clam embryo study shows pollutant mixture adversely affects nerve cell development
...we go rightthrough the embryo," says Reinisch. The sequence of images yields athree-dimensional representation of the embryos' developing neurons.Reinisch and company examined periodically recorded images to see whateffect, if any, the chemicals had. They also measured the levels ofproteins in the normal and ...Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
...onship to Ras. Let-7 in humans is identical to the sequence in the worm, and both binding site and pathway for Ras are highly conserved. Tissue from lung cancer tumors, compared with their normal adjacent tissue, had reduced let-7 and increased Ras -- the brakes on Ras were removed in lung tumors. "The disc...Study identifies predictors of HIV drug resistance in patients beginning triple therapy
...we go rightthrough the embryo," says Reinisch. The sequence of images yields athree-dimensional representation of the embryos' developing neurons.Reinisch and company examined periodically recorded images to see whateffect, if any, the chemicals had. They also measured the levels ofproteins in the normal and ...A bacterial genome reveals new targets to combat infectious disease
...ton Slatko and colleagues present the complete DNA sequence of the Wolbachia pipientis strain within Brugia malayi, a parasitic nematode responsible for lymphatic filariasis. This Wolbachia genome is small, only about a million base pairs, and many metabolically critical genes have degraded through mutation ...Solution to Pollution: New Bacteria Eats Toxic Waste
... Biology professor. The Department of Energy will sequence the genetic material of the microbes, and the researchers will then participate in the annotation process by which genes in the sequences will be identified. The researchers will be able to understand the genetic material that allows these bacteria t...Scientists decipher genome of fungus that can cause life-threatening infections
...orators helped to interpret and analyze the genome sequence data.C. neoformans, an oval-shaped yeast, is an op...solates.TIGR's Fraser says the Cryptococcus genome sequence will benefit a widerange of biomedical research into the increasingly significant humanpathogen. Sta...Researchers identify target for cancer drugs
...help activate Akt by adding a phosphate group to a sequence of its amino acids (a process called "phosphorylation"). This process occurs not only in human cells but in other organisms such as the fruit fly. Finding this complex conserved in species as diverse as flies and humans supports the claim that the m...New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
...croarrays and unique biochemical tests to scan the sequence of 10 human chromosomes -- one third of the human genome sequence -- and found that roughly 15 percent of the DNA sequence analyzed was transcribed; most sites of tra...Highly adaptable genome in gut bacterium key to intestinal health
...d other gut bacterial species. The complete genome sequence of B. theta was generated two years ago in the same laboratory. The researchers inoculated germ-free mice, who have no intestinal bacteria, with B. theta. The mice were fed a diet high in complex carbohydrates and low in simple sugars. Ten days late...Scientists reveal molecular secrets of the malaria parasite
...y levels, including the integration ofdraft genome sequence data with microarray and protein expressiondata," says Carlton. "This project also shows the power ofcollaboration between international institutes with different areas ofexpertise. It was remarkably productive collaboration."...Scientists discover unique microbe in California's largest lake
...sstudied the DNA of the new organism. By analyzing sequence data for thesmall subunit ribosomal RNA gene, which encodes part of the cell'sprotein synthesis machinery, they demonstrated that chlorophylld-producing blue-green algae (more technically known as cyanobacteria)have acquired a piece of DNA from a pro...New SARS Protein Linked To Important Cell Doorway
...ad no proof yet that SARS actually made use of the sequence their analysis identified. Geneticists call such s...etic information open reading frames, and the SARS sequence therefore came to be known as open reading frame 7a, or orf7a. To produce the orf7a protein, resear...Jumping gene helps explain immune system's abilities
...er jumping genes' proteins, even though theoverall sequence is quite different."Because of its similarities both to V(D)J recombination and to otherfamilies of jumping genes, Hermes is the first real link between thetwo processes," says Craig. "It also is likely to be a good model tofigure out what's happenin...UCSD Discovery Shows How Embryonic Stem Cells Perform 'Quality Control' Inspections
...er jumping genes' proteins, even though theoverall sequence is quite different."Because of its similarities both to V(D)J recombination and to otherfamilies of jumping genes, Hermes is the first real link between thetwo processes," says Craig. "It also is likely to be a good model tofigure out what's happenin...New therapy for HIV/AIDS eliminates needles and excessive toxicity
...er jumping genes' proteins, even though theoverall sequence is quite different."Because of its similarities both to V(D)J recombination and to otherfamilies of jumping genes, Hermes is the first real link between thetwo processes," says Craig. "It also is likely to be a good model tofigure out what's happenin...DNA Recombination and Repair—A New Twist to RecA Function
... impose direction to the exchange, to bypass short sequence heterogeneities, and to stall replication so DNA lesions can be mended. But how RecA molecules within a filament coordinate and organize their activities to carry out these functions has remained obscure. Cox et al. addressed this problem in the tes...Gene sequencing explains bioremediation 'bug'
...er jumping genes' proteins, even though theoverall sequence is quite different."Because of its similarities both to V(D)J recombination and to otherfamilies of jumping genes, Hermes is the first real link between thetwo processes," says Craig. "It also is likely to be a good model tofigure out what's happenin...Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells
...t eventually becomes. That process is a mysterious sequence of metabolic and genetic changes." There are, he says, metabolic similarities between stem cells and cancer cells, and researchers would like to clearly identify the differences. "Stem cells are therapeutic," says Naviaux. "How are their spectra dis...Plants defy Mendel's inheritance laws, may prompt textbook changes
...chromosome," Pruitt said. "Some other type of gene sequence information that we don't really understand yet is...ce cycle, Pruitt believes that this particular DNA sequence is just a trigger for the phenomenon. He suspects that a number of other genes and the proteins they...Study of genomic DNA leads to new advances in cancer diagnostics
... Using an enzyme (Alu I) that cuts DNA at a common sequence in the human genome, Dr. Maniotis's group classified cells based on sensitivity or resistance to DNA digestion. Non-malignant cells were sensitive to DNA digestion by Alu I while highly malignant cells were resistant. These results suggest that a cel...RNA project to create language for scientists worldwide
...ce RNA structure prediction and simulation and RNA sequence analysis. His work is supported by the National Institutes for Health and the American Chemical Society. Leontis describes RNA molecules as "the software controlling how the genes are expressed to make proteins." They are unique in being able to sto...TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas
...ir p53 function." Grosveld's team found that this sequence of events modeled in the mouse also occurs in human lymphoma patients. Combined elevated TEL2 and MYC expression occurred in the B lymphocytes of over a third of patients with a B lymphoma called B-acute lymphoblastic leukemia. "These results offer ...Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits
...rmitted biologists to identify the precise subunit sequence of every gene in the genomes of everything from ma...bined with databases that list the precise subunit sequence of proteins as well. Cross-species DNA and protein comparisons have become routine for all biologist...Unexpressed But Indispensable -- The DNA Sequences That Control Development
... largely unknown, making their discovery by simple sequence analysis difficult. In this issue, Greg Elgar and ... be fundamental to vertebrate development. Through sequence alignment with increasingly strict criteria, they identified 1,373 highly conserved non-coding eleme...UF Researchers Map Bacterial Proteins That Cause Tooth Loss
...re able to fill hundreds of gaps in the organism’s sequence of roughly 2,000 proteins. “The approach used in this study is very exciting,?said Hansel Fletcher, Ph.D., an associate professor of microbiology and molecular genetics at Loma Linda University in Loma Linda, Calif. “For the first time, we are able ...Affymetrix and the Karolinska Institutet Announce Translational Medicine Strategic Alliance
...clinical relevance of both gene expression and DNA sequence variation in key areas of unmet medical needs. "Today we have access to a very broad range of population-based clinical materials and data, that we want to study in order to understand the importance of genetic factors for emergence and treatment of...How an AIDS-Related Cancer Unleashes Inflammation
...oratory, but whose function remained unknown. "The sequence of the kaposin B gene is very unusual; there's no homology to any known gene," said Ganem. "So, we had no clue as to what the protein did. Since it was a very simple protein, we believed that it had no enzymatic function itself, but acted by binding ...Sequencing of marine bacterium will help study of cell communication
...es that may have toxin activity. "Analysis of this sequence has revealed surprising parallels with Vibrio chol...ciate professor of biology at Virginia Tech. This sequence research is described in the PNAS online early edition the week of February 7, 2005, (www.pnas.org),...Genrate: a generative model that finds and scores new genes and exons in genomic microarray data
... microarrays to validate predicted exons in genome sequence and find new gene structures. However, current met...sues) and co-location and density of probes in DNA sequence data. GenRate balances probabilistic evidence derived from different sources and outputs scores (lo...LUCA technologies confirms real-time methane generation
...nt Butte microbial consortium. Through partial DNA sequence analysis, the company has identified Clostridia and Thermatoga as two of the key members of this consortium. Clostridia form a broad genus of bacteria known for their diverse metabolic pathways. Clostridia frequently thrive in anaerobic environments ...Pathogen-Mimicking Vaccine As Strategy For Cancer Therapy
...vestigation. The paper shows that the CpG 7909 DNA sequence is safe, and increases the immune system's ability to recognize and destroy cancer cells. The Phase I study was conducted by the Lausanne Branch of the Ludwig Institute for Cancer Research (LICR) at the Lausanne University Hospital in Switzerland, in...Multiple Campylobacter Genomes Sequenced
In 1995, the first complete bacterial genome sequence was published. Now, nearly 200 bacterial genomes have been completed, and a new one hits the scientific press most weeks. This burgeoning industry is not just scientific “stamp collecting,?however. Having all these genome sequences may provide useful...Variation in women's X chromosomes may explain differences among individuals, between sexes
...ding Willard and Carrel, reported the complete DNA sequence of the human X chromosome. In animals, sexual identity is governed by sex chromosomes. In humans and other mammals, males have one X and one Y chromosome, while females have a pair of X's. Many genes on the male Y chromosomes have been lost over ev......L chief scientist, "it was not known from the gene sequence if a protein was even expressed. Now that we have high confidence that many of these hypothetical genes are expressing proteins, we can look for what role these proteins play." Before this study, nearly 40 percent of the genetic sequences in Shewane...Stem cells from brain transformed to produce insulin at Stanford
...rsity in Japan, added a cocktail of chemicals in a sequence that they knew might prod the stem cells to mature into insulin-producing cells. After some trial and error, they found the right combination and sequence. The end result was a dish full of cells that could produce insulin and release it in response ...Fibril Shape Is The Basis Of Prion Strains And Cross-species Prion Infection
...mans. The new mouse strain had the same amino acid sequence as the original mouse strain but completely differ...rs to be the deciding infective factor, amino acid sequence is still important because it defines a set of possible preferred fibril shapes that prions can adop...Increased risk of osteoporosis associated with gene that one in five people have
...one year past menopause. They analyzed the genetic sequence of each woman's CYP1A1 gene to identify which of the genetic variants they possessed. One of the variations of the gene, known to be present in 19 percent of the general population, was found in women who had significantly lower blood estrogen level...HIV-1 spread through six transmission lines in the UK
...ry of the HIV-1 subtype B strain from sampled gene sequence data. Molecular data on HIV-1 has become increasingly available since the introduction of routine HIV-1 gene sequencing for drug resistance. Scientists used this data to follow the changing number of infected individuals through time and estimate the...Navigating an integrated yeast network
... genetic interactions, transcriptional regulation, sequence homology and expression correlation. The authors are the first to integrate so many types of data to search for network motifs. The authors conclude that most network motifs found in the integrated S. cerevisae network can be understood in terms of j...Researchers uncover sequence of major rice pathogen
...nowledge is limited to date, Dean says. The genome sequence should give researchers "a better idea of what typ...d the Broad Institute, issued a preliminary genome sequence of M. grisea, and made it publicly available so other researchers could work to solve the problems r...Study reveals new technique for fingerprinting environmental samples
...ncing has made to biomedical sciences. "These DNA sequence fingerprints can be used to provide highly accurat...early all environments makes it a daunting task to sequence the multitude of organisms one at a time. With the EGT approach, an abbreviated sequencing effort en...NIH Researchers Discover How Insulin Allows Entry of Glucose Into Cells
... Institutes of Health have discovered the critical sequence of events by which insulin stimulates the entry of glucose into fat cells. The study, appearing in the May 9 Journal of Cell Biology, was conducted by researchers from the National Institute of Child Health and Human Development and the National Ins...New tumor-suppressor gene discovered
...hat had somehow become inserted into the molecular sequence of the gene. This mutation was a type of "transpos.... "We did not find many clues when we compared the sequence of the mats gene with the sequence of other genes in the public databases," Lai says. "But we did fi...Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression
...targeting] not only depends on their complementary sequence but on whether these proteins are around to stabil...e trying to predict the microRNA targets using the sequence homology of the full-length microRNAs. In their Cell article, Han and his colleagues show that you ......worked to crack the genetic code, the nucleic acid sequence of As, Cs, Gs and Ts making up the DNA of genes. T...he unit of epigenetic information, just as the DNA sequence is the unit of genetic information." Depending on the precise nature of the histone modification, an......for the first time released the chip design, probe sequence and annotation information for all of its microarr...ret and verify or contradict one's work. With this sequence information, the research community will be better equipped to interpret data generated with Agilent...Other ContentslavagelavagelavagelavagecystcystcystganglionganglionganglionganglionunionunionunionunionservicesservicesservicesservicesservicesservicesservicesservicesserviceswelfarewelfarehospitalhospitalhospitalhospitalhospitalhospitalhospitalhospitalOther TagsKidneyKidneyKidneyKidneyKidneyKeratinKingdomKnock
(Date:7/24/2008)...setts General Hospital (MGH) investigators has dev...d medicine a robust method for generating synthet...s for inactivation or repair. In the July 25 iss...n efficient, publicly available method to engineer...n be used to induce specific genomic modifications...
(Date:7/24/2008)...from Columbia University,s Mailman School of Publi...ues in infant health and preventing mother-to-chil...ttings, HIV-infected mothers had been advised that...ld exclusively breast-feed, followed by a rapid we...g to the study conducted in Lusaka, Zambia by Mail...
(Date:7/24/2008)...ve found a molecular link between circadian rhythm...ry reveals new possibilities for the treatment of ...Paolo Sassone-Corsi, Distinguished Professor and C...tified that an essential protein called CLOCK that...balance with another protein called SIRT1 that mod...
(Date:7/24/2008)...rrently burning through a study area where project...go. Managers used data and analysis from the Gotch...anning, analysis, and implementation of treatments... The Gotchen LSR, lies on the east slope of the C...0 acres of the Mount Adams Ranger District on the ...
Breaking Biology News(10 mins):Consortium develops new method enabling routine targeted gene modification 2Early cessation of breastfeeding by HIV+ women in poor countries and child survival 2Early cessation of breastfeeding by HIV+ women in poor countries and child survival 3Circadian rhythm-metabolism link discovered 2Landscape study may offer solutions for fire managers 2UPDATE 3A Nebivolol Lowers Blood Pressure in African Americans With Stage I II Hypertension as Demonstrated in a Study Published in the Journal of Cli 722 1UPDATE 3A Nebivolol Lowers Blood Pressure in African Americans With Stage I II Hypertension as Demonstrated in a Study Published in the Journal of Cli 722 2UPDATE 3A Nebivolol Lowers Blood Pressure in African Americans With Stage I II Hypertension as Demonstrated in a Study Published in the Journal of Cli 722 3Substance abuse practitioners ask what is recovery 3F 5226 1Substance abuse practitioners ask what is recovery 3F 5226 2Dont tell mother she has cancer 5223 1Dont tell mother she has cancer 5223 2Weizmann Institute scientists discover 3A A risk distribution law for evolution 1071 1Weizmann Institute scientists discover 3A A risk distribution law for evolution 1071 2(Date:7/25/2008)...nificant Improvements in Members, Health, ATLANTA...r in health,care quality management solutions for ... entered into a long-term agreement with Wellmark,...ion on Quality(SM) Incent and,Reward Best Practice...,primary care clinicians to promote improved quali...
(Date:7/25/2008)...liance to be presented at Fenway Park ...y 25 /PRNewswire/ -- CVS/pharmacy announced today,...4 million in just 21 days,through its annual in-st...,the seventh year of the annual fundraising effort...for ALS research. This year,s fundraiser took,plac...
(Date:7/25/2008)...am delivers immediate cost savings for http://www...to language interpreters] to firms switching lang... , Washington, D.C. (Vocu...nc.com/index.html [(Language Learning Enterprises...anslation, and language instruction services to th...
(Date:7/25/2008)...tion will be used to facilitate the planning and d..., Hauppauge, NY (PRWEB) Ju...ing integrator of enterprise collaboration solutio...elepresence, audio visual integration, and managed...s donated video conferencing equipment to Mt. Sina...
Breaking Medicine News(10 mins):Health News:MDdatacor Extends Contract with Wellmark, Inc. 2Health News:MDdatacor Extends Contract with Wellmark, Inc. 3Health News:CVS/pharmacy Raises Record-breaking $4.4 Million for ALS Research Through Annual ALS Fundraising Campaign 2Health News:LLE Launches Over-the-Phone Interpretation OPI Easy Switch Program 2Health News:LLE Launches Over-the-Phone Interpretation OPI Easy Switch Program 3Health News:Mt. Sinai's Children's Trauma Institute Treatment and Service Adaptation Center Receives Video Conferencing Donation From IVCi 2[0] MDdatacor Extends Contract with Wellmark, Inc.[0] CVS/pharmacy Raises Record-breaking $4.4 Million for ALS Research Through Annual ALS Fundraising Campaign[0] LLE Launches Over-the-Phone Interpretation OPI Easy Switch Program[0] Mt. Sinai's Children's Trauma Institute Treatment and Service Adaptation Center Receives Video Conferencing Donation From IVCi
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