separation

Purdue proves concept of using nano-materials for drug discovery

... smaller molecules to pass. "This allows us to do separation right in the reactor, which means we can do reactions that could not be done before in such a small device. We can study membrane proteins in a fundamentally new way, which is very important because many future drugs to treat diseases will likely wor...

Integration of Agilent's MS technology, Proteome Systems' software to help scientists in proteomics research

...sts and more laboratories. Using Agilent's protein separation and LC/MS products and Proteome Systems' GlycomIQ software, life scientists will be better able to produce, analyze and integrate complex data on the forefront of proteomics research." ...

Breakthrough isolating embryo-quality stem cells from blood

...minute. This is not yet fast enough for industrial separation of millions of high grade stem cells, but it promises a realistic alternative to embryo use if it can be scaled up. Meanwhile, it is already being used to isolate low-grade stem cells which can develop into skin. In collaboration with medical profess...

Retrovirus struck ancestors of chimpanzees and gorillas millions of years ago, but did not affect ancestral humans

...n three and four million years ago, well after the separation of humans from apes. That split is estimated to have occurred five to seven million years ago. During that period, ancestral humans were likely to be living in the same area of Africa as great apes. African apes may have been susceptibile to the viru...

'Punctuated' evolution in the human genome

...romere, which plays a critical role in chromosomal separation during cell division. Pericentromeric regions contain an abundance of segmental duplications, which are large DNA sequences that exhibit strong similarity to the euchromatic ancestral loci from which they were copied. According to Eichler, the limite...

Rensselaer researchers develop approach that predicts protein separation behavior

...stitute have developed a method to predict protein separation behavior directly from protein structure. This new...iology at Rensselaer. "The ability to predict the separation behavior of a particular protein directly from its structure has considerable implications for biote...

Making plant cells work like miniature factories

...ernationally recognized for his work in developing separation and detection technologies, having won four R&D 100 awards. Also working on the project are Sam Houk, an Ames Lab senior chemist who specializes in identifying trace elements using inductively couple plasma-mass spectrometry, and associate scie...

NHGRI expands effort to revolutionize sequencing technologies

...g and a highly parallel, capillary electrophoresis separation system. Greg Kellogg, Ph.D., Network Biosystems, Woburn, Mass. $4.5 million (3 years) "$100,000 Genome Using Integrated Microfluidic Capillary Electrophoresis" This group will work to improve performance of Sanger sequencing and PCR as compared to ...

Picky female frogs drive evolution of new species in less than 8,000 years

...ntly had diverged enough during their million-year separation that offspring of southern females and northern males failed to develop beyond the tadpole stage. Though crosses involving northern females and southern males successfully produced frogs, the offspring developed more slowly than the offspring of pair...

'Perception' gene tracked humanity's evolution, scientists say

...f genes known to have tracked or guided humanity's separation from the other apes is a short one. Genes controlling the development of the brain almost always turn out to be identical or nearly so in chimpanzees and human beings. And as it turns out, the protein prodynorphin is identical in humans and chimps. ...

Twin molecular scissors link creation of microRNAs with gene-silencing

...ever," Shiekhattar says. "All of the activity ?the separation of the strands, the multiple cutting steps, everything ?is being done in the absence of any energy use." Instead, he says, the different molecules involved have stronger and weaker affinities for each other that govern their stepwise associations an...

Multi-million pound UK Biobank underway

...cially designed automated systems for blood sample separation and for storage, retrieval and tracking of around 10 million biological samples, which must be kept at between -80?C and -200?C for several decades. When UK Biobank is running nationwide, this robotic system will need to handle samples taken from aro...

Enzyme crystal structure reveals 'unexpected' genome repair functions

...re were no specific models for how XPB acts in DNA separation either to initiate transcription or to begin NER. There were also no models for the role that XPB, which is an essential subunit of Transcription Factor IIH (TFIIH) functional assembly complex, might play in changing conformations for TFIIH's alterna...

ANU scientists crack DNA replication mystery

...nds at the same time. "You can think of the strand separation part like a snowplough. The replisome tracks along...When the replisome comes along from one direction, separation of the two DNA strands simply knocks the TUS off as you'd expect. But when it comes from the other d...

Finding a better way to make biodiesel

...ure requires acid neutralization, water washes and separation steps. It's a tedious process that dissolves the catalysts so they can't be used again, Lin said. So Lin and his research team started looking for technologies that would create an easier, more efficient and more economical process. They were also ...

Slow-frozen people? Latest research supports possibility of cyropreservation

...lular ice formation which leads to dehydration and separation into the ice and concentrated unfrozen solution. If we could, by slow cooling/warming, supercool and then warm the cells without the crystallization of water then the cells would be undamaged." ...

Molecular DNA switch found to be the same for all life

...rcase" of the DNA to deform as a first step in the separation and unwinding of its two gene-carrying strands. "It is likely that the AAA+ rings of the replication initiators are open to allow others proteins to dock onto the initiator complex," said Berger. "These other proteins can help add layers of comp...

A protein complex that untangles DNA

...in, makes the chromosomes more compact, making the separation easier", says Camilla Sjögren. The research group has studied the third, less well understood, protein complex, known as the Smc5/6 complex. This protein complex was found to bind to locations on the DNA strand that the researchers had artificiall...

Sandia research to focus on early detection of harmful algal blooms

...y will employ laser-induced fluorescence and other separation methods inherent in Sandia's µChemLab(tm) ("Micro" ChemLab) technology. Along with a small team of Sandia colleagues and external collaborators, they have commenced with the research, which could lead to longer-term funding after the initial "proof o...

PNAS study reveals why organs fail following massive trauma

...ng the one led by Miller-Graziano. She oversaw the separation of white blood cells into pure samples for the PNAS study, and continues to determine cell surface protein expression for the larger Glue grant team. Along with Miller-Graziano, the University of Rochester Medical Center team is led by Paul E. Bank...

MIT's molecular sieve advances protein research

...We can change the pore shape and engineer a better separation system." The sieve structure is based on work Han did earlier at Cornell University with large strands of DNA. The performance of the researchers' current one-dimensional sieves matches the state-of-the-art speed of one-dimensional gels, but Han sai...

Scientists design simple dipstick test for cocaine, other drugs

...imetric sensors that are based on the lateral flow separation of aptamer-linked nanostructures," said Yi Lu, a chemistry professor at the U. of I., and a researcher at the Beckman Institute for Advanced Science and Technology. "The new sensors offer a quick and convenient test that can be utilized by first re...

Sports cheats beware -- new test detects previously undetectable drug

...jected to a further two-stage test ?chromatography separation and mass spectrometric analysis. This lets scientists produce a chemical fingerprint of the molecule ?a fingerprint that uniquely identifies it. "If the drug testing authorities adopt this new test it will close a gap in the current drug testing s...

Researchers to develop active nanoscale surfaces for biological separations

...DNA, which could eventually lead to more efficient separation tools for genomics and proteomics. The researchers are taking their inspiration from nature, mimicking the very membranes that surround our cells to create platforms for separating biological molecules. These "lipid bilayers," which are made up of t...

Baby fish 'smell their way home'

... its sea life, Prof. Kingsford says. "This genetic separation between reefs may be what gives rise to so many different species in coral reef systems." The researchers were intrigued how tiny damsel and cardinal fish, born on one reef, managed to find their way back home to preserve such remarkable populatio...

Mitochondrial genes move to the nucleus -- but it's not for the sex

...t the mating system determines whether or not this separation is permanent. With self-pollination, the components separated by meiosis are brought back together. In contrast, the components are further separated if they mix and match haphazardly during out-crossing. Brandvain said the finding contradicts th...

Gene study shows three distinct groups of chimpanzees

...the gaps in our samples, but we think most of this separation is genuine, a long-term consequence of geographic ...ongoing loss of habitat has increased the physical separation between the three groups. The extent of accumulated genetic difference enabled the researchers t...

Applied scientists create wrinkled 'skin' on polymers

... construction of microfluidic devices for particle separation and mixture and also have potential use in designing biosenors. The researchers have also started a close collaboration with scientists at the Harvard-MIT Division of Health Sciences and Technology aimed at exploring the behavior of living cells on t...

QUT scientists on the way to sifting out a cure for HIV

...it is the membrane texture which is crucial to the separation efficiency of the material," he said. "It is scientifically known that a mesh structure is the most efficient form of filtration and we are the first group to successfully construct such a structure on a nanometre scale with ceramic fibres. "T...

Researchers develop technique for bacteria crowd control

...and identification of small bacterial samples, and separation sicken/live cells. A patent for the device is currently pending. "Using this method, our research succeeded in dramatically increasing the concentration of microorganisms in tiny fluid drops and films. Unlike traditional centrifuging techniques, ...

UW launches study testing adult stem cells for heart damage repair

...the bloodstream. Then, investigators use a cell separation system to remove from the subject's bloodstream a mix of cells containing the stem cells. When this process, known as apheresis, is complete, technologists further process the collected stem cells to select the CD34+ stem cells for use in this invest...

Fascinating spider silk

... protein by dialysis, the researchers observed the separation of two different fluid phases. Whereas one phase c...duct it drops to a slightly acidic level. No phase separation was observed for the synthetic spider protein when the pH was maintained at an alkaline level. At hi...

Plastic that grows on trees

...can increase HMF yield from glucose while reducing separation and purification cost. “The opportunities are endless,” Zhang said, “and the chemistry is starting to get interesting.”...

Researchers shed light on shrinking of chromosomes

... condensation, a process crucial to the successful separation of chromosomes. Using powerful microscopes, resear...safety net if something goes wrong with chromosome separation in earlier phases of division. When the researchers added chemicals to the cell to block the late co...

Studies to find better ways to preserve human eggs, ovarian tissue under way

...tion with a hormone or naturally, you get the last separation of the chromosomes, from 46 to 23,” says Dr. Emmi. That separation enables a future baby to get half his chromosomes from mom and half from dad. Fragile spindles, whic...