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Another Look Finds Promising Proteomics Test is Not Biologically Plausible

...ported dramatic results using mass spectrometry to search for a pattern of proteins in blood. In several sets of blinded samples, the test detected all patients who had ovarian cancer and only misdiagnosed three healthy individuals. But among others who subsequently tested the study’s data for reproducibil...

New species from old data

...ported dramatic results using mass spectrometry to search for a pattern of proteins in blood. In several sets of blinded samples, the test detected all patients who had ovarian cancer and only misdiagnosed three healthy individuals. But among others who subsequently tested the study’s data for reproducibil...

Cracking the olfactory code in bees

...ported dramatic results using mass spectrometry to search for a pattern of proteins in blood. In several sets of blinded samples, the test detected all patients who had ovarian cancer and only misdiagnosed three healthy individuals. But among others who subsequently tested the study’s data for reproducibil...

Signaling protein builds bigger, better bones in mice

...ported dramatic results using mass spectrometry to search for a pattern of proteins in blood. In several sets of blinded samples, the test detected all patients who had ovarian cancer and only misdiagnosed three healthy individuals. But among others who subsequently tested the study’s data for reproducibil...

New Technique for Tracking Gene Regulators

...500 bases of a CREB-binding site, they are able to search theregion around the specific locations for CREB binding sequences orgenes that might be regulated by CREB.Using this technique, the scientists have identified some 6,302genome-binding sites for CREB, including many that are located nearknown genes. ...

Scientists find missing enzyme for tuberculosis iron scavenging pathway

...istant strains of M. tuberculosis has prompted the search for new drug targets and a better understanding of the mechanism of resistance in this bacterium. Several spans of DNA in the M. tuberculosis genome have been annotated as antibiotic resistance genes due to their sequence similarity to existing anti...

Purdue proves concept of using nano-materials for drug discovery

...e proteins, and the chambers could then be used to search for drugs that deactivate the pumps, Lee said. Such an advanced technology could be used to quickly screen millions of untested drug compounds that exist in large pharmaceutical "libraries." The chips could dramatically increase the number of experi...

HIV Infection Still On The Rise

... prevention, write the authors. For instance, the search for a vaccine against HIV has so far produced only negative results, while microbicides have proved disappointing. Although the ABC message (abstinence, be faithful, use a condom) is popular with the American government, its application in other part...

New SARS Protein Linked To Important Cell Doorway

... most of its pathogenic punch. Their computerized search highlighted a section of the SARS genetic code that shared several features with immune evasion proteins previously identified in other viruses. Some genetic codes contain sequences of protein-building instructions that the organisms never use, and t...

The BIOS Initiative - open source biotechnology is born

...patents in many countries, to create comprehensive search capabilities and to assist with opportunities for patent system reform. CAMBIA has also just added the INPADOC patent status database to its free online service, now allowing any searchers to know the dynamic status of patent applications and patents...

Newly Discovered Compound Blocks Known Cancer-Causing Protein

...g also inhibited Ras, so the scientists decided to search for an effective and specific molecule that could ... the molecule and verify its chemical structure. A search of the chemical literature turned up no previous description of the chemical, leading the scientists...

White blood cell waste disposal system plays critical regulatory role

...they migrate out of the blood and roam the body in search of potentially harmful foreign substances. Neutrophils have a short lifespan and often die via a programmed cell death pathway called apoptosis within a matter of hours. Dying neutrophils are recognized and ingested by cells in the body tissues calle...

Agilent Technologies releases automated literature search tool for biology researchers

.... (NYSE: A) today released an automated literature search tool for the multidisciplinary study of biological...oratory for Agilent Laboratories. "This literature search tool was developed within Labs to facilitate our own research collaborations and has proved very suc...

Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits

...ecome routine for all biologists with computerized search programs, the most popular of which is called BLAS... developed a computerized tool called PathBLAST to search through the Database of Interacting Proteins for protein interactions that are conserved in the thre...

Falling ants glide back to trunk to avoid dangers of forest floor

...ng a mosquito colony in the laboratory, he goes in search of mosquitoes and larvae in the canopy where they live, mostly above private land around the city. Using ropes and cave-climbing equipment, he ascends trees and collects mosquito larvae from water-filled tree cavities and also collects adult females ...

International HapMap consortium expands mapping effort

...rs are already using HapMap data to accelerate the search for genes involved in common diseases, as well as ...s to zero in on that particular genomic region and search for specific genes involved in that disorder. This approach can reduce the work and expense of searc...

Protein offers way to stop microscopic parasites in their tracks

...to use the recently completed Toxoplasma genome to search for the protein that lets the parasite detach glue spots at the back of the belt. Scientists led by the Institute for Genomic Research in Rockville, Md., posted the completed Toxoplasma genome online last year. Geneticists at Washington University's ...

Multiple Campylobacter Genomes Sequenced

... how Campylobacter species cause disease. In their search for clues, Derrick Fouts and coworkers have completely sequenced the genome of C. jejuni strain RM1221 (isolated from a chicken carcass) and compared it with the previously sequenced C. jejuni strain NCTC 11168 and with the unfinished sequences of C....

Gene Signatures Predict Interferon Response For Multiple Sclerosis Patients

...e point. The authors used statistical analyses to search for gene expression profiles that were associated with patients' therapeutic outcomes. They looked for patterns in analyses of single genes, gene pairs, and gene triplets, and found their model's predictive accuracy increased with gene number. They a...

Not-for-profit publishers call NIH public access rule a missed opportunity

... would be better served if NIH created an enhanced search engine that works like Google to crawl the journal...nvisible to those who use NIH's MEDLINE website to search for health information," noted James M. George, MD, president of the American Society of Hematology....

Navigating an integrated yeast network

...re the first to integrate so many types of data to search for network motifs. The authors conclude that most network motifs found in the integrated S. cerevisae network can be understood in terms of just a few network themes, associated with specific biological phenomena. Their results also show that thema...

White Blood Cell 'Waste Disposal' System Plays Critical Regulatory Role

...they migrate out of the blood and roam the body in search of potentially harmful foreign substances. Neutrophils have a short lifespan and often die via a programmed cell death pathway called apoptosis within a matter of hours. Dying neutrophils are recognized and ingested by cells in the body tissues calle...

Mystery Blood Vessel Disorder Implicated In 'Mini' Strokes

...associated abdominal aortic aneurysm and carefully search for associated cardiac symptoms," said author Pierre Amarenco, M.D., of Bichat University Hospital in Paris. Beyond the immediate clinical implications, the study may offer more important clues for further research. It may be that dolichoectasia cau...

CoPub Mapper: mining MEDLINE based on search term co-publication

...with specific keywords were co-mentioned. MEDLINE search strings for 15,621 known genes and 3,731 keywords were generated and validated. PubMed IDs were retrieved from MEDLINE and relative probability of co-occurrences of all gene-gene and gene-keyword pairs determined. To assess gene clustering according ...

Scientists journey to southern Africa to unravel the secret world of elephant communication

...way in Etosha National Park start to move north in search of water. It could be that they are sensing underg...veling alone or forming small bachelor herds." The search for a mate in this vast wilderness is further complicated by the elephant's reproductive biology. Fe...

New tumor-suppressor gene discovered

...occur. "Genetic techniques helped us to narrow our search for this fly's mutation to a few candidate genes within a very small part of one huge chromosome," Lai explains. The scientists narrowed the tumor-causing candidates down to two genes, then performed molecular-biology experiments with them both, reve...

Biomarkers isolated from saliva successfully predict oral and breast cancer

...tools that could be done in a doctor's office. The search for such tests, however, has been stalled until recently with the advance of several emerging technologies including improved methods to identify, collect, preserve and amplify genetic material and proteins. In this study, the UCLA team found they c...

Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression

...e sequences of the microRNA were known, a computer search through the three billion letters of the human genome should find those matching sequences. But this didn't work. The homology searches yielded far fewer targets than expected and could not account for all known microRNAs. The reason, says Han, is t...

Habitat use by North Pacific right whales, Eubalaena japonica, in the Bering Sea and Gulf of Alaska

...200 m deep which may simply reflect the paucity of search effort elsewhere. From the commercial whaling era to the late-1960s, right whales were commonly seen in waters greater than 2000 m deep, indicating that their distribution is not restricted to shallow continental shelves. North Pacific right whale si...

Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia

...sed a comprehensive genetic screening technique to search for genes that are differentially expressed in ALL cells that demonstrated cross-resistance to two or more commonly used chemotherapeutic agents. The researchers identified several genes that were differentially expressed in ALL cells that exhibited...

Study reveals candidate targets for anti-retroviral therapeutics

...ed an interactive program (GOnet) allowing them to search through large amounts of genetic and biochemical data to identify "clusters," or related groups of genes, that are most likely to affect key points in the Ty3 lifecycle. In total, they identified 130 genes that affect the replication of the retroviru...

The lopsided brain: Attention bias is shared by humans and birds

...irds' bodies were positioned at the midline of the search area, both chicks and pigeons showed a considerable leftward bias in pecking. The experiment is similar in concept to those that reveal pseudoneglect in humans--so-called cancellation tasks in which subjects are asked to "cancel-out" evenly distribut...

Gladstone investigators discover how resting T cells avoid HIV infection

...be overcome by Vif. The results have launched the search for a new class of antiviral drugs that block the action of Vif, which would leave A3G poised and able to unleash its antiviral effect from inside viral particles. In resting T cells, though, HIV is defenseless against A3G, because there is no Vif in...

Tendency to hair loss inherited from the mother

... initial step they succeeded in narrowing down the search to a series of areas on various chromosomes. In an area where the largest contribution was suspected lay the gene for the androgen receptor. "One variant of this gene was found among men who suffered from premature balding at a very early stage very ...

wFleaBase: the Daphnia genome database

...e wFleaBase, which currently contains functions to search and extract information from expressed sequenced tags, genome survey sequences and full genome sequencing projects. This new database is built primarily from core components of the Generic Model Organism Database project, and related bioinformatics...

Designing vaccines by computer

...immune response. They can then employ computers to search for similar sequences in the thousands of sequences now available. When the search finds something promising it can be experimentally tested to see if it will trigger a response. Dr ...

Bobbing birds do it for a reason

...aging whooping cranes control head-bobbing as they search for food in the grass near their feet. The tallest...non-invasive computer-video techniques. The cranes search both for mobile prey (frogs and insects) and for items such as acorns, seeds, and tubers. The resear...

Molecular thermometers on skin cells detect heat and camphor

...red TRPV3 a few years ago by conducting a computer search through an early-assembled draft of the human genome. Its sequence similarity to other temperature-gated proteins led them to identify and clone TRPV3 as a possible molecular thermometer--perhaps the first one that makes skin cells able to sense warm...

Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves

Weizmann Institute findings might advance search for new therapies for injured nerve fibers. Long d... hope that these findings might advance the future search for new therapies for injured nerve fibers. ### The research team also included Prof. Rony Seger o...

15-year hunt finds cause of pseudothalidomide syndrome

...lsewhere has successfully completed a 15-year-plus search for the genetic problems behind the very rare Roberts syndrome, whose physical manifestations often include cleft lip and palate and shortened limbs that resemble those of babies whose mothers took thalidomide during pregnancy. The discovery, which ...

Butterfly migration could be largest known

...n into adults in the spring, they migrate north in search of fresh food and breeding grounds, powered by a supply of yellow fat they have built up over the winter. Painted ladies migrate every year, but usually less conspicuously and in far fewer numbers. This year, however, exceptionally high winter rainf...

Insects, viruses could hold key for better human teamwork in disasters

...arge groups of participants to spread, collect and search for information," Gupta said, adding that "the resulting software systems can scale to networks with hundreds or thousands of first responders, as well as withstand unresponsive participants and poor communication channels. "This behavior is very si...

Fungus Effective Against Winged Termites

... winged termites swarming furiously to scatter and search for mates isn't one of them. In New Orleans, as the swirling, airborne masses of termites become more conspicuous, researchers with the Agricultural Research Service (ARS) are busy developing a biopesticide that could someday knock down large number...

Searching the depths of the straits of Florida for disease cures

...ek expedition to explore the Straits of Florida in search of organisms that produce chemicals with the poten...t. The team will also conduct daily scuba dives in search of shallow-water organisms for biomedical testing. Though Harbor Branch has used its submersibles t...

Alien woodwasp, threat to US pine trees, found in N.Y.

...rative Agricultural Pest Survey (CAPS) program, in search of any of 10 exotic species of bark beetles, when he stumbled across the specimen of S. noctilio . "I recognized it immediately," says Hoebeke, a taxonomic expert who has examined tens of thousands of insects sent to him from agencies and scholars o...

Natural tumor suppressor in body discovered by UCSD medical researchers

...off" position. The scientists conducted a database search of the human genome for a phosphatase, which is an enzyme that acts as a catalyst in regulating cellular processes by removing phosphate molecules. Based on the chemical components of Akt, they specifically looked for a phosphatase linked to the PH d...

High-powered gene profiles provide clues to genes involved in common form of lung cancer

...logical advances have brought new precision to the search for gene abnormalities associated with cancer. In ...ons, respectively. This enabled them to narrow the search for genes that were the targets of the irregular regions. Intriguingly, all of the genes already kno...

Research on antibiotics receives historical recognition

... Selman Waksman, Ph.D., and his students began the search for antibiotics produced from actinomycetes, micro...ning methods developed by Waksman. This deliberate search for chemotherapeutic agents contrasts with the discovery of penicillin, which came through a chance ...

MicroRNAs play a big part in gene regulation - and evolution

...l Genomics tapped into the power of computation to search for microRNAs and their target genes in the entire genomes of seven Drosophila species. The authors then compared identified matches to matches they had found previously in vertebrates. The results provide the most extensive microRNA target gene pre...

Improved statistical tools reveal many linked loci

...method can be applied to more complex organisms to search for even larger numbers of linked loci and to provide insights into the many interlocking pathways that make up the gene regulatory network. Citation: Storey JD, Akey JM, Kruglyak L (2005) Multiple locus linkage analysis of genomewide expression in ...

Bioinformatics reveals new gene regulation system

...érida, Mexico. Gelfand and Rodionov started their search using a technique called phylogenetic footprinting...entire genome before it divides to reproduce. The search revealed a conserved palindromic sequence occurring upstream of many ribonucleotide reductase (Nrd) ...

Achilles heel of the herpes virus possibly found

...tein for entry into cells." She explains that the search for the mechanisms by which HSV enters cells has been hindered by the fact that the virus is very good at entering so many kinds of cells. The many possibilities for virus binding to cells make deciphering the entry process a difficult problem to sol...

Researcher gets NSF grant to create mutant maize lines

...d library that allows researchers to do a database search for a DNA sequence and identify a single line of maize with a single disruption in the genome," says Brutnell, who notes that the project could expand the understanding of the functions of about 20 percent of the maize plant's entire genome. Once sc...

Newly discovered genetic disease sheds light on body's water balance

...blood samples from each baby boy and his mother to search for the cause of the unique disorder. They learned that Raymond Fenwick, a scientist with Quest Diagnostics Nichols Institute, was developing an assay that could be used to sequence the AVPR2 gene that codes for the V2 receptor. Fenwick sequenced th...

New tool reveals secrets of migrating cells

... outer layer, or cortex, of the thymus, perhaps in search of that life-altering signal. Robey hopes to use ... Witt, suggest that this exploration probably is a search for a signal that will decide the cell's fate. In their experiments on one lobe of the mouse thymus,...

Can our genes tell the story of our divergence?

...gy. One way to find such genetic signatures is to search for genes that reveal signs of positive natural selection. The assumption is that genes touched by positive selection will show more functionally significant molecular changes than unaffected regions. In the new study, Rasmus Nielsen, Michele Cargill...

Scientists discover that three molecules may be developed into new Alzheimer's drugs

...scientists has discovered three molecules –?from a search of 58,000 compounds –?that appear to inhibit a key...lated by the enzyme. They then performed a library search of small molecules (58,000 of them) in an attempt to find those that would prevent phosphorylation. ...

Scientists at Galileo Pharmaceuticals confirm inflammatory response linked to glucose levels

...scientists has discovered three molecules –?from a search of 58,000 compounds –?that appear to inhibit a key...lated by the enzyme. They then performed a library search of small molecules (58,000 of them) in an attempt to find those that would prevent phosphorylation. ...

Mass production of human papillomavirus could lead to gains against cervical cancer

...que to study the early process of infection and to search for vulnerabilities in that process, said Ahlquist. "The early stages of infection -- before the virus becomes established -- could be a very important phase for intervention," he said. Ahlquist also said that the production technique could offer a ...

MicroRNA tweaks protein that controls early heart development

...targets in mammals. He then used those criteria to search the entire mouse genome for potential microRNA targets. "If this method of predicting targets turns out to be correct and specific, I think it will go a long way to opening the field more broadly, providing scientists who study microRNAs with an eas...