Sciatic in Biological News

Peripheral nerve repair with fat precursor cells led to wider nerves and less muscle atrophy

... to obtain. According to the researchers, significant differences in the sciatic functional index (SFI) were observed three weeks post-injury in the ... after 12 weeks, however. "We found that full regeneration of the sciatic nerve occurred in the rats receiving the autograft, the guide, and the ...

West Nile virus' spread through nerve cells linked to serious complication

... results in an animal model, scientists used a suture to close off the sciatic nerve in hamsters. Then they injected West Nile virus directly into the ... both encephalitis and paralysis because the virus was able to follow the sciatic nerve back to the central nervous system. An untreated human patient's ...

Protein identified as critical to insulating the body's wiring could also become treatment target

... or information, like motor nerves, they would be wrapped more." In fact, erbin is enriched in regions with a lot of myelinated axons, such as the sciatic nerve, which runs down the lower back into the legs, the researchers found. Dr. Mei also is exploring the role of neuregulin 1 in cell talk in ...

Limping rat provides sciatica insights

... pain or difficulty in controlling the leg. It is often caused by compression, or pinching, of any of the five nerve roots that combine to make up the sciatic nerve. These roots are the parts of the nerve that pass through openings in the spine to the spinal cord. Surgical simulation of nerve compression ...

Neurons grown from embryonic stem cells restore function in paralyzed rats

... secreted the nerve growth factor GDNF into the sciatic nerve (the sciatic nerve extends from the spine down the back of the ... and GDNF-secreting neural stem cells in the sciatic nerve ?had several hundred transplant-derived ...

A new target for painkillers

... occurs when a herniated disk in the lower back causes pain to one or both sciatic nerves, which extend from the lower back to the hips, buttocks and back of ... Carolina co-authors tied sutures loosely around one of each rat's two sciatic nerves to mimic nerve compression and injury from sciatica. That made the ...

Scientists use gene transfer technology and common virus to block neuropathic pain

... Annals of Neurology paper, VA/U-M scientists tied off a nerve root in the sciatic nerve leading to the left hind paw of eight rats in the study. Tying off ... second group of eight rats received sham surgery, with no damage to their sciatic nerve. A third group served as normal controls. "When we study pain in ...

Scientists use gene transfer technology and common virus to block neuropathic pain in animals

... Annals of Neurology paper, VA/U-M scientists tied off a nerve root in the sciatic nerve leading to the left hind paw of eight rats in the study. Tying off ... second group of eight rats received sham surgery, with no damage to their sciatic nerve. A third group served as normal controls. “When we study pain in ...

Spinal cord bridge bypasses injury to restore mobility

... trouble moving, climbing or grooming. Combining the old with the new, the researchers grafted a 1.5 centimeter piece of the tibial branch of he sciatic nerve to the C3 area of the spinal cord and allowed the nerve fibers to grow and regenerate over three weeks. . At approximately two and a half ...

Potential treatments for neurofibromatosis

... or on the spinal cord. However, a rare form of the disease occurs in infants and young children, with tumors growing on major nerves, such as the sciatic nerve that connects the spinal cord with the leg and foot muscles. The tumors can interfere with the function of the brain and other organs, or ...