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rigidity in Biological News

Dense tissue promotes aggressive cancers

... interesting effect where cells actually sense the rigidity and degrade more," Weaver said. The team examined how cells convert a sense of matrix rigidity into intracellular signals, a process called ... prognosis for patients. "The idea that tissue rigidity leads to a more aggressive phenotype had been out ...

Stanford researchers publish comprehensive model for medical device development

... point out that such standardization does not always permit product developers to streamline their processes where it would make sense. In turn, such rigidity can inhibit innovation, which often occurs in a less-structured way. "Clearly there are benefits associated with having a rigorous process and ...

Rot's unique wood degrading machinery to be harnessed for better biofuels production

... material of whole plantsis to find effective means to work around the polymer lignin, the scaffolding that endows the plant's architecture with rigidity and protection from pests. By doing so, the organic compound cellulosethe long chain of glucose (sugar) units can be unbound, broken down, ...

Modified plants may yield more biofuel

... the lignin content, they are trying to modify the connections in lignin, without compromising either the biosynthesis of lignin or the structural rigidity of the plant. The Penn State geneticists and biochemists took a gene from beans and engineered it into a poplar tree. This gene produces a ...

Normalizing tumor vessels to improve cancer therapy

... cells, which may explain the increased vessel permeability. Ghosh and colleagues also found that tumor capillary cells sense and respond to matrix rigidity differently than normal cells. When placed on a stiff surface, mimicking the tumor matrix, the cells tended to keep spreading even after normal ...

Genes and nutrition influence caste in unusual species of harvester ant

... studies on Pogonomyrmex harvester ants have found colonies in which becoming a worker or gyne is determined exclusively by genetic differences. Such rigidity constrains the colony's ability to adaptively adjust to environmental realities. For example, colonies that have few workers and yet produce a lot of ...

Treating chronic pain, migraine & muscle spasticity through inhibition of neurotransmitter glutamate

... a number of diseases and disorders. These include migraine and other forms of chronic pain such as neuropathic pain as well as muscle spasticity and rigidity secondary to spinal cord trauma, stroke and multiple sclerosis. ...

July 2008 GEOLOGY and GSA Today media highlights

... crust, which are compensated by uplift due to buoyancy forces, which act from the deep earth. These forces, however, are smoothed out by the flexural rigidity of the lithosphere. Therefore, the isostatic readjustment results not only in smaller subsidence of topography in the eroded fjord, but also in the ...

Cell-based therapy shows promise in patients with Parkinson's disease

... cells involved in movement. Without enough dopamine, this balance is disrupted, resulting in tremor (trembling in the hands, arms, legs and jaw); rigidity (stiffness of the limbs); slowness of movement; and impaired balance and coordination the hallmark symptoms of PD. PD affects one in every 100 ...

Fighting pollution the poplar way: Trees to clean up Indiana site

... and lead researcher Clint Chapple, biochemistry. They are currently investigating ways to alter the composition of poplar lignin, which provides rigidity to the plant cell wall by binding to strands of cellulose, a complex sugar that can be converted into ethanol. Chrysler will fund the Kokomo ...

New mechanical insights into wound healing and scar tissue formation

... efforts have to be made to prevent the stem cells from turning prematurely into fibroblasts instead of the desired cell type. Controlling the rigidity of the cell culture is therefore critical. This new understanding of the mechanical nature of fibroblast activation could be used to reduce or ...

St. Louis University scientists identify chemical that triggers Parkinson's disease

... cells die or are damaged, the symptoms of Parkinsons disease begin to appear. These include tremors and shaking, slowness of movement, rigidity and stiffness, and difficulty with balance. Scientists have long known that a key protein called alpha-synuclein plays a role in the development ...

DOE publishes update of plan: 'Facilities for the Future of Science: A 20-Year Outlook'

... contemporary science and technology are undergoing change, as always, and the Office [of Science] has been careful not to adhere with inappropriate rigidity to the 2003 snapshot, but to respond to technological progress in reordering and restructuring its priorities. Some planned facilities have been ...

Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing

... to closed, Mamonova used a variety of chemical-modeling techniques, including molecular dynamics simulations, continuum electrostatics studies, and rigidity and hydrogen-bond analyses. Many of these tasks are theoretically and computationally intensive, and Mamonova frequently relied on the ...

Researchers track how spores break out of dormant state

... and prion diseases. “The extreme physical and chemical resistance of Bacillus spores suggests that evolutionary forces have captured the mechanical rigidity and resistance of these amyloid self-assembling biomaterials to structure the protective outer spore surface,” Plomp said. When exposed to a ...

Scientists identify molecular cause for one form of deafness

... said. "Because the new organization causes the bundles to be more than a thousand times floppier, they cannot respond to sound in the same way. The rigidity of these bundles is essential for hearing." Wong and his co-authors ?Illinois postdoctoral research associate Kirstin Purdy and Northwestern ...

Tissue engineering for craniofacial reconstruction

... rigid, biodegradable scaffolds with interconnected pores. These scaffolds are of particular interest in craniofacial tissue engineering, due to the rigidity of the resulting foams and the ease of fabrication. ...

Iowa State researchers improving plastics made from corn and soy proteins

... metals ?it, for example, can be used to help locomotive wheels roll more easily around curves in a track. Senti said biodegradable plastics that add rigidity to the company's product would be very useful in outdoor applications. And so the company wants to help the researchers with some field tests. ...

Amphetamines reverse Parkinson's disease symptoms in mice

... of dopamine and the animals exhibit all the symptoms of Parkinson's disease for up to 16 hours. Those symptoms included severely impaired movement, rigidity and tremor. When treated with L-DOPA, the symptoms disappeared as the animals resumed normal movement. Surprisingly, the researchers reported, ...

Scientists detect probable genetic cause of some Parkinson's disease cases

... dopamine, a brain signaling chemical (neurotransmitter). Without it, individuals can develop tremor or trembling in hands, arms, legs, jaw, and face; rigidity or stiffness of the limbs and trunk; bradykinesia, or slowness of movement; and postural instability or impaired balance and coordination. Patients ...
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