reuptake in Biological News

Chinese slimming capsules

... examination of the formulation has shown that it also contains the active substance sibutramine, which resembles amphetamine and which inhibits the reuptake of serotonin and noradrenaline in the brain. The sibutramine dose in each capsule corresponded to twice the daily maximum dose of the prescription ...

The genetics of fear: Study suggests specific genetic variations contribute to anxiety disorders

... the enzyme COMT. Serotonin is a brain chemical involved in mood regulation. The serotonin transporter, which is the target of selective serotonin reuptake inhibitors (SSRI) used to treat anxiety and depression, harbors a common polymorphism in its gene. This polymorphism can come in two different ...

Researchers iron out new role for serotonin

... including alcoholism, depression, autism and obsessive-compulsive disorder. SERT is also a major target for medications like the selective serotonin reuptake inhibitors (SSRI) used for treating depression. Thanks to a serendipitous mix-up in an animal order, Blakely and first author Ana Carnerio, Ph.D., ...

Likely cause of postpartum blues and depression identified

... interleukin-1 beta. If our hypothesis holds true, lowering interleukin-1 beta levels may be a better treatment option." He notes that while serotonin reuptake inhibitors, commonly used for depression, work well in these women, transferring the drug to the baby during nursing can be problematic. But ...

New treatment mechanisms for schizophrenia

... in the discovery of a completely novel means of adjunct therapy for schizophrenia that is analogous to the use of SSRIs [selective serotonin reuptake inhibitors] for the treatment of depression." In the second article, Hashimoto and colleagues demonstrated that repeated administration of the ...

Insulin's brain impact links drugs and diabetes

... Library of Science Biology (PLoS Biology). The psychostimulant drugs amphetamine and cocaine, as well as related medications for ADHD, block the reuptake of the neurotransmitter dopamine by dopamine transporters (DATs) and increase the level of dopamine signaling. Some of these compounds, including ...

High dopamine transporter levels not correlated with ADHD

... attempt to compensate for lower dopamine levels by reducing the number of reuptake proteins. This would explain the positive correlation between transporter levels and inattention: as the number of reuptake proteins rises, the amount of dopamine would decline, leading to a higher ...

Commonly used antidepressants may also affect human immune system

... They do not know yet, however, whether these SSRI (selective serotonin reuptake inhibitors) drugs "including the brands Prozac, Zoloft, Paxil and others" ... way of stimulating a T cell response." Drugs that block serotonin reuptake "likely change some of the parameters of T-cell activation, but we don't ...

Adolescent but not adult hamsters are more aggressive on low dose of fluoxetine

... are different. Thus, she says, "It is unwise to expect a drug to work the same in juveniles as in adults." Fluoxetine, a selective serotonin reuptake inhibitor (SSRI), is the only medication approved to treat depression in children and adolescents. However, it has carried an FDA "black box" ...

Nobelist discovers antidepressant protein in mouse brain

... with each other by secreting messengers, such as serotonin, which bind to receptors located on the surface of receiving cells. Serotonin selective reuptake inhibitors (SSRIs), medications commonly prescribed for anxiety and depression, compensate for reduction in serotonin signaling by boosting levels ...

Gene variation affects tamoxifen's benefit for breast cancer

... drug Paxil can prevent tamoxifen from being activated, while the antidepressant drug Effexor does not. These drugs, selective serotonin reuptake inhibitors or SSRI's, are often used to treat hot flashes, a common side effect of tamoxifen. In this current study of 256 women with breast ...

Scientists discover the body's marijuana-like compounds are crucial for stress-induced pain relief

... those in pain. A new drug increasing the body's own marijuana-like compounds could work similar to something like Prozac, which blocks the body's reuptake of the compound serotonin, causing it to be active longer, Hohmann said. Apparently, several parts of the brain are involved in the effect, most ...