Retinoblastoma in Biological News

St. Jude identifies the specific cell that causes eye cancer, disproving long-held theory

... Neurobiology, is the reports senior author. retinoblastoma arises in the retinathe multi-layered, membrane ... Jude finding is that it unexpectedly showed that retinoblastoma can arise from fully matured nerves in the retina ... horizontal interneurons can multiply to form retinoblastoma also challenges the established scientific belief ...

International team reveals first prognosticator of survival in aggressive cancer

... show that a reduction in the expression of pRb2/p130 can mean a higher risk of recurrence and death from STSs. The gene pRb2/p130, a member of the retinoblastoma family of genes, regulates a portion of the cell cycle. Clinicians have long sought a prognostic test for the disease, which can be highly ...

St. Jude defines eye cancer gene's role in retinal development

... in the United States annually. The determination of N-myc target genes during retinal development may also contribute to the current understanding of retinoblastoma progression, he said. In the course of their study, the researchers discovered that N-myc is not involved in regulating cell survival or neuronal ...

UC health news: molecular pathway may predict chemotherapy effectiveness

... will benefit from chemotherapy drugs, according to new research from a multidisciplinary team at the University of Cincinnati (UC). Known as the retinoblastoma (RB) tumor suppressor, this fundamental molecule regulates cell proliferation in the body. Research has shown that the RB pathway is either entirely ...

Study examines risk of soft tissue sarcomas in hereditary retinoblastoma survivors

... Institute quantifies the risk of hereditary retinoblastoma survivors developing specific subtypes of soft ... this risk persists for decades after the original retinoblastoma diagnosis. The findings emphasize the importance ... for these patients, the authors say. retinoblastoma is a rare cancer of the retina that primarily ...

St. Jude announces breakthrough in eye cancer treatment

... new, locally applied treatment for the eye cancer retinoblastoma that not only greatly reduces the size of the ... in the Nov. 2 issue of the journal Nature. retinoblastoma occurs in about 5,000 young children worldwide ... more effective and less-toxic treatment for retinoblastoma that would eliminate the need for the current, ...

Why mice don't get cancer of the retina

... are more susceptible to developing the eye cancer retinoblastoma than mice because, unlike humans, mice can ... explains why humans with a defective copy of the retinoblastoma gene RB1 are at high risk of developing cancer of ... Center in Memphis, studied the expression of the retinoblastoma proteins Rb (RB1 in humans), p107 and p130 ...

Texas scientists discover how a hepatitis C protein promotes liver cancer

... UTMB group discovered that the tumor-suppressing retinoblastoma protein is present at markedly reduced levels in ... a protein known as NS5B that attaches to the retinoblastoma protein, a critical tumor suppressor, and ... said. He continued: "The way NS5B docks with the retinoblastoma protein is biochemically almost identical to the ...

Mechanism for Epstein-Barr virus protein's role in blood cancers discovered

... EBNA3C (for EBV nuclear antigen)--mediates the degradation of the retinoblastoma protein, an important molecular brake for cell proliferation. Erle S. ... last week in the Proceedings of the National Academy of Sciences. The retinoblastoma protein (Rb) is a major regulator of several genes in charge of cell ...

Tumor-suppressor gene is critical for placenta development

... and oxygen exchange between a mother and her fetus during pregnancy, and perhaps in miscarriages. Those conclusions come from a new study of the retinoblastoma (Rb) gene in mice. In humans, this gene, when mutated, raises the risk of a rare cancer of the eye called retinoblastoma. Two decades ago, it was ...

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

... The researchers began by introducing several mutant genes commonly found in human melanomas. These included genes that interfere with the retinoblastoma (Rb) and p53 tumor suppressor pathways, which normally act to keep cell growth in check, as well as human telomerase reverse transcriptase (hTERT), ...

Ibruprofen and other commonly used painkillers for treating inflammation may increase the risk of heart attack

... The researchers began by introducing several mutant genes commonly found in human melanomas. These included genes that interfere with the retinoblastoma (Rb) and p53 tumor suppressor pathways, which normally act to keep cell growth in check, as well as human telomerase reverse transcriptase (hTERT), ...

Engineered skin offers clues to melanoma development

... The researchers began by introducing several mutant genes commonly found in human melanomas. These included genes that interfere with the retinoblastoma (Rb) and p53 tumor suppressor pathways, which normally act to keep cell growth in check, as well as human telomerase reverse transcriptase (hTERT), ...