responsiveness

Engineered molecule amplifies body's immune response

...e engineered Stat1 molecule exhibited an increased responsiveness to interferon. Following up on these discoveries, ...possible to screen patients for the level of Stat1 responsiveness to interferon, and if found to be low, that would make them candidates for a strategy to improve Sta...

Greasing interferon's gears may pave way to greater therapeutic benefits, fewer side effects

... The development of a mechanism to tweak Stat1's responsiveness may prove particularly useful for patients with su...e, as well, to screen patients for levels of Stat1 responsiveness and use the same treatment strategy to correct low levels of response, according to Holtzman. The re...

The nude mouse tale: Omega-3 fats save the life of a terminal cancer patient

...rated that fish oil consumption improves a mouse's responsiveness to chemotherapy. Fish oil research was inspired by observations that Inuit Eskimo populations have less breast and prostate cancer deaths. So far, though, most studies in this country are limited to animal models, but a case study about D.H., which...

Phenolic compounds may explain Mediterranean diet benefits

...onse is known as ischemic reactive hyperemia. Poor responsiveness to this sort of blood flow test is considered an early warning sign of cardiovascular disease. Previous studies have linked high-fat meals to poor endothelial function lasting for several hours after eating. In order to focus on the role of phenolic...

Absence of critical protein linked to infertility

...t C/EBPb is a critical mediator of steroid hormone responsiveness in the uterus. "This gene is expressed when the uterus is ready for embryo attachment," said co-author Indrani C. Bagchi, a professor of veterinary biosciences in the College of Veterinary Medicine at Illinois. "Its presence indicates a window for s...

Nobelist discovers antidepressant protein in mouse brain

...ll surface, reduced serotonin signaling, decreased responsiveness to sweet reward, and were less mobile, behaviors which are considered depression-like. Also, the 5-HT1B receptors of p11 knockout mice were less responsive to serotonin and antidepressant drugs compared to those of control mice, which further implica...

Mass. General study finds potential ovarian cancer stem cells

... cells in patient tumor samples and to study their responsiveness to both chemotherapeutic agents and to novel agents specifically targeted to stem cell as individualized therapy of the future." Donahoe is the Marshall K. Bartlett Professor of Surgery at Harvard Medical School. ...

PTEN: the Treg's handbrake

...y PTEN as a key protein that regulates the lack of responsiveness of Tregs to IL-2 and could provide researchers with a way to overcome one of the biggest obstacles to harnessing their therapeutic potential. ...

New GI technologies improve internal organ visualization

...d adjust the sedation dosage accordingly. Patient responsiveness was monitored by the anesthesiologist using the Mo... patients, 14 (7 colonoscopy and 7 endoscopy) lost responsiveness to ARM during the procedure. One subject experienced oxygen desaturation (level of breathing and se...

Nicotine exposure during development leads to hearing problems

...ylcholine on their shared receptors and increasing responsiveness to sound if those receptors had not been previously damaged. ...

Altered perception of reward in human cocaine addiction

...d people, and is directly linked to changes in the responsiveness of the prefrontal cortex, a part of the brain essential for monitoring and controlling behavior," said Rita Goldstein, a psychologist at Brookhaven Lab. "These results also attest to the benefit of using sophisticated brain-imaging tools combined wit...

Brain's reward circuit activity ebbs and flows with a woman's hormonal cycle

... levels during women's menstrual cycles affect the responsiveness of their brains' reward circuitry, an imaging study at the National Institute of Mental Health (NIMH), a component of the National Institutes of Health (NIH), has revealed. While women were winning rewards, their circuitry was more active if they wer...

Dinosaur hearing, listening to muscle noise, quieter cubicles

...ntroversy has been whether their sound quality and responsiveness are significantly affected by the thicknesses of an instrument wall and the exact materials of which the wall is made. Many acousticians had assumed that the main important factor was the profile of a wind instrument's bore, the chamber where air vi...