Responsiveness in Biological News

New technology enhances therapeutic potential of cord blood stem cells

... A CD26 Inhibitor increases the efficiency and responsiveness of umbilical cord blood for bone marrow transplants and may improve care ... directional homing of stem cells to the bone marrow by increasing the responsiveness of donor stem cells to a natural homing signal. Homing is the process by ...

Research explains link between cholesterol and heart disease

... high blood cholesterol levels. Cholesterol, however, suppresses the responsiveness of cardiovascular cells to TGF-beta and its protective qualities thus ... found that statins, drugs that lower cholesterol levels, enhance the responsiveness of cardiovascular cells to the protective actions of TGF-beta, thus ...

Evolution: Crabs go deep to avoid hot water

... crabs into Antarctica, as well as that of the red king crab Paralithodes camtchaticus in the Barents Sea and along the coast off Norway emphasise the responsiveness of this group to rapid climate change." This study elucidates temperature as a driving force behind the speciation and radiation of a major ...

Versartis presents positive preclinical data on 2 product candidates at ENDO 09

... are confirmed in human clinical trials." "Treatment of auto-inflammation in diabetes with IL-1ra has been demonstrated to increase beta-cell responsiveness in human clinical trials," Dr. Cleland continued. "Our new approach with VRS-826 will provide a less frequently administered treatment that should ...

University of Liverpool awarded $3.3 million for genomics hub

... retaining and enhancing the UK's competitiveness. It makes plain the MRC's commitment to supporting high quality basic research and exemplifies the responsiveness of MRC strategic investment to the needs of the research community." "Inviting regional applications has generated innovative partnerships ...

Male impotence drugs may deserve a second look in women

... states, such as diabetes, to see what it does to these internal pudendal arteries. "What we have seen preliminarily is there is big difference in responsiveness in these arteries. The diabetic pudendal arteries are much more sensitive to contraction," Dr. Allahdadi says. They will look at how drugs like ...

2009 ASPB Summer Undergraduate Research Fellowship award announcement

... B Hanwen Bai, Ohio Wesleyan University Mentor: Chris Wolverton The effects of phosphate availability on root architecture and gravity responsiveness in Arabidopsis I'm eager to carry out the work in my proposal and I'm very grateful to ASPB for the opportunity to spend the summer in a lab. I ...

Understanding natural crop defenses

... sensor that detects other plants crowding in and gives the signal to switch on the synthesis of the plant growth hormone auxin reduces the plant's responsiveness to the hormone jasmonic acid, which orchestrates the synthesis of a whole array of defensive chemicals, the researchers report in an article ...

Research finds new cause of ozone wheezing and potential treatments

... found several proteins which can mediate the hyaluronan effect and can be used as treatment targets. They were also able to block the airway responsiveness by binding the native hyaluronan away, as well as by administering a slightly modified form of hyaluronan. "Although more research is needed before ...

Most US organizations not adapting to climate change

... and regulations that impede change; the lack of clear directions and mandates to take action; political or ideological resistance to the need for responsiveness to climate change; the preoccupation with near-term challenges and priorities and the lingering perception that climate change is a concern only for ...

St. Jude identifies genomic causes of a certain type of leukemia relapse

... called B cells mature and proliferate. Importantly, the relapse-related genetic changes only infrequently involved genes directly regulating the responsiveness to anti-cancer drugs. The analysis also indicated that in most cases, the cancer cells responsible for relapse were related to those that ...

Advice to the new administration: UM foreign and domestic policy guide

... from the bipolar, relative stability of the Cold War to the extreme unpredictability of worldwide security conditions today (requiring agility, rapid responsiveness and broad-based capability). In addition, it is clear that future security concerns will be multiagency and multinational." Gansler calls for a ...

'New' estrogen receptor found to be key player in tamoxifen resistance

... of GUMC's Biomedical Graduate Research Organization. "It identifies a new player and shows some of its downstream signaling and how this affects responsiveness to tamoxifen in these breast cancers." The findings came about after the research team developed the first cell culture model of ...

SAFRAN to Acquire Motorola's Biometrics Business

... Sagem Securite, its existing customers, and Motorola's existing biometrics customers are expected to benefit from increased efficiencies and customer responsiveness from the merger of the two businesses." "Biometrics is a very dynamic business that we believe requires companies to specialize in the technology," ...

Bisphenol A linked to metabolic syndrome in human tissue

... and puts people at a substantially higher risk for metabolic syndrome. Metabolic syndrome is a combination of risk factors that include lower responsiveness to insulin and higher blood levels of sugar and lipids. According to the American Heart Association, about 25 percent of Americans have metabolic ...

bioMETRX, Inc. Closes Angel Round of Funding

... of the company. This funding allows us to ramp revenues before proceeding with our next round of institutional capital. We are encouraged by their responsiveness and continued confidence and support in the company's progress," noted Rick Iler, CFO at bioMETRX. As the global leader in consumer biometric ...

Negligent, attentive mouse mothers show biological differences

... of neglectful and nurturing mothers shortly after birth. In several brain regions - including some implicated in both maternal behaviors and reward responsiveness - they found higher levels of activity as well as signs of abnormal dopamine signaling in the neglectful mothers. These patterns suggest that ...

'Smart' flower bulbs pull themselves to deeper ground

... by light." The research team documented that perception of the light stimulus occurred in the bulblet or the subtending leaf. They also found that responsiveness to light faded as the roots aged. Experiments with light of different wavelengths indicated that the contraction response was triggered most often by ...

K-State Veterinary Lab routinely tests for bluetongue virus

... and undergo proficiency testing each year. "We know that bluetongue virus infections occur in Kansas because we see evidence of immune responsiveness to the virus in serum collected from animals," Anderson said. "However, we seldom see the disease here." The symptoms of bluetongue virus are more ...

Study reveals possible genetic risk for fetal alcohol disorders

... if these findings fit a larger pattern of fetal alcohol-induced problems as the monkeys grow up. At the same time, extreme irritability and stress responsiveness in infants can themselves lead to problems, she says. "If a baby is very irritable and stress reactive, one of the things this can interfere with ...

New GI technologies improve internal organ visualization

... adjust the sedation dosage accordingly. Patient responsiveness was monitored by the anesthesiologist using the ... (MOAA/S) scale and the Automated responsiveness Monitor (ARM) device. The MOAA scale assesses ... patients, 14 (7 colonoscopy and 7 endoscopy) lost responsiveness to ARM during the procedure. One subject ...

Greasing interferon's gears may pave way to greater therapeutic benefits, fewer side effects

... The development of a mechanism to tweak Stat1's responsiveness may prove particularly useful for patients with ... as well, to screen patients for levels of Stat1 responsiveness and use the same treatment strategy to correct ... treatments that use drugs that increase Stat1 responsiveness and consequently enhance the benefits of ...

Engineered molecule amplifies body's immune response

... engineered Stat1 molecule exhibited an increased responsiveness to interferon. Following up on these discoveries, ... to screen patients for the level of Stat1 responsiveness to interferon, and if found to be low, that would ... them candidates for a strategy to improve Stat1 responsiveness using our methods." ...

Dinosaur hearing, listening to muscle noise, quieter cubicles

... to some teaching statements and product descriptions (4pMU1). In wind instruments, an area of controversy has been whether their sound quality and responsiveness are significantly affected by the thicknesses of an instrument wall and the exact materials of which the wall is made. Many acousticians had assumed ...

Brain's reward circuit activity ebbs and flows with a woman's hormonal cycle

... Fluctuations in sex hormone levels during women's menstrual cycles affect the responsiveness of their brains' reward circuitry, an imaging study at the National Institute of Mental Health (NIMH), a component of the National Institutes of ...

Altered perception of reward in human cocaine addiction

... evidence that the brain's threshold for responding to monetary rewards is modified in drug-addicted people, and is directly linked to changes in the responsiveness of the prefrontal cortex, a part of the brain essential for monitoring and controlling behavior," said Rita Goldstein, a psychologist at Brookhaven ...

Nicotine exposure during development leads to hearing problems

... to Metherate, this occurs most likely because the nicotine is mimicking the action of acetylcholine on their shared receptors and increasing responsiveness to sound if those receptors had not been previously damaged. ...

PTEN: the Treg's handbrake

... proliferative capabilities in response to IL-2 and not their other functions. These results identify PTEN as a key protein that regulates the lack of responsiveness of Tregs to IL-2 and could provide researchers with a way to overcome one of the biggest obstacles to harnessing their therapeutic potential. ...

Mass. General study finds potential ovarian cancer stem cells

... in these new therapeutic approaches," Donahoe says. "We intend to keep searching for stem-like cells in patient tumor samples and to study their responsiveness to both chemotherapeutic agents and to novel agents specifically targeted to stem cell as individualized therapy of the future." Donahoe is the ...

Nobelist discovers antidepressant protein in mouse brain

... out the p11 gene in mice. Compared to control mice, knockout mice had fewer receptors at the cell surface, reduced serotonin signaling, decreased responsiveness to sweet reward, and were less mobile, behaviors which are considered depression-like. Also, the 5-HT1B receptors of p11 knockout mice were less ...

Absence of critical protein linked to infertility

... varying conditions during the critical implantation period. In doing so, researchers determined that C/EBPb is a critical mediator of steroid hormone responsiveness in the uterus. "This gene is expressed when the uterus is ready for embryo attachment," said co-author Indrani C. Bagchi, a professor of ...

Phenolic compounds may explain Mediterranean diet benefits

... in blood flow, which were produced by inflating and then deflating a blood pressure cuff. The response is known as ischemic reactive hyperemia. Poor responsiveness to this sort of blood flow test is considered an early warning sign of cardiovascular disease. Previous studies have linked high-fat meals to poor ...

The nude mouse tale: Omega-3 fats save the life of a terminal cancer patient

... cells that were injected into athymic mice--also known as nude mice. His studies also demonstrated that fish oil consumption improves a mouse's responsiveness to chemotherapy. Fish oil research was inspired by observations that Inuit Eskimo populations have less breast and prostate cancer deaths. So ...