repressor

At long last, scientists figure out how plants grow

... And it's this complex of auxin, SCF(TIR1) and the repressor that signals enzymes to destroy the repressor, thereby turning on the repressed gene. "The key interaction is between TIR1 and the repressor," Estelle said. "Nihal was able to get that to work in a test tube, but the interaction would only occur if ...

Bioinformatics reveals new gene regulation system

...regulatory transcription factor that bound it, the repressor nature of the signal, and other genes also regulat...he duo predicted that the NrdR-box functioned as a repressor sequence. Next, the researchers identified the transcription factor protein that binds to the NrdR-...

Free-energy theory borne out in large-scale protein folding

...ce's studies were carried out on monomeric lactose repressor protein, or MLAc, a variant of the protein used by E. coli to regulate expression of the proteins that transport and metabolize lactose. MLAc contains about 360 amino acids. While scientists know proteins containing 100 or fewer amino acids fold in ...

Dying of excitement

...nscription factor AP-2 into a binding site for the repressor GCF2 -- a swap that inhibited promoter activity in transfected rat brain cells. Whether the mutant promoter decreases EAAT2 expression in the human brain, as would be predicted, remains to be tested. ...

Study identifies new role for breast cancer susceptibility gene

...turation. The researchers found that a defect in a repressor complex formed by BRCA1, CtIP, and another known transcription repressor, ZBRK1, released the gene for ANG1 from repression and promoted survival of neighboring blood vessel cells and formation of capillary-like structures. Further studies demonstrat...

Genetic snooze button governs timing of spring flowers

...ing," Amasino explains. "The meristem is where the repressor (gene) is expressed and is where it is shut off." The key to initiating flowering, according to the Wisconsin group's studies, is the ability of plants to switch those flower-blocking genes off, so that they can bloom and complete their pre-ordaine...

A simple feedback resistor switch keeps latent HIV from awakening

... viruses manage this problem by encoding intricate repressor circuits that efficiently block transcription. But... viruses, specifically HIV, appear to lack similar repressor circuits. In a new study, published online in the open access journal PLoS Biology, Leor Weinberger ...

Molecular 'on/off switch' controls immune defenses against viruses

...searchers found that RIG-I and LGP2 each contain a repressor domain, a sort of docking site that controls the actions of each protein. The domain is the key site that regulates the ability of RIG-I to bind to its signaling partners, including LGP2, acting as a switch for controlling immune response, Dr. Gale s...

Researchers identify a key regulator for skin stem cells

...ells in their immature state. The newly identified repressor switch could provide part of the answer. Led by Howard Hughes Medical Institute investigator Elaine Fuchs, the researchers published discovery of this regulator, known as Tcf3, in an article in the October 6, 2006, issue of the journal Cell. Oth...

Genome sequencing reveals key to viable ethanol production

...hat diffuses into the cell. There it deactivates a repressor for two genes, which wake up and start pumping out the two triggers the full production of wood-degrading enzymes CelC and LicA. Wu’s paper shows the first time the triggering pathway for enzyme production in this bacterium has been revealed, and i...