Relapse in Biological News

St. Jude identifies genomic causes of a certain type of leukemia relapse

... offers a pathway to designing treatments for ALL relapse in children and, ultimately, in adults. The ... more than 80 percent of ALL cases are cured, relapse is a significant problem, with only 30 percent of ... "Examining the new changes that are arising at relapse tells us a lot about the individual genetic ...

Brain-nourishing molecule may predict schizophrenia relapse

... medicines as prescribed is a big reason patients relapse but science has already shown that BDNF levels ... the drug is becoming less effective and a relapse is imminent, the researchers say. Decreased ... levels may be even lower in patients when they relapse and go up, at least for a while, with treatment. ...

Cancer immunotherapy shows long-term promise in lung cancer

... for lung cancer patients, reduces the risk of relapse after surgery -- to the same extent as ... but after complete resection about 50% will relapse and die from their cancer," says Prof. ... the reduction in risk of postoperative cancer relapse is similar to the one obtained with postoperative ...

'Erasing' drug-associated memories may stop drug addiction relapses

... be altered or erased during the process called reconsolidation. Because relapse by drug abusers is often prompted when they recall drug-associated ... the effects of those memories in the future and help individuals resist relapse and maintain their abstinence." Dr Amy Milton, a co-author, said, "This ...

JCI table of contents: Aug. 16, 2007

... which targets BCR-ABL in a different way. However, patients that relapse after treatment with dasatinib, because BCR-ABL mutants emerge that are ... of the cancer returning, or at the very least increase the time before a relapse occurs In the study, which appears online on August 16 in advance of ...

New drug shows promise in treating drug-resistant prostate cancer

... men who initially received benefit from the drug but then relapsed, and their PSA levels came back up. We want to understand the mechanism of that relapse and to try to develop drugs that prevent that renewed resistance." For years, no treatment was available for CRPC; recently paclitaxel a ...

New medications show promise in treating drug-resistant prostate cancer

... men who initially received benefit from the drug, but then relapsed, and their PSA levels came back up. We want to understand the mechanism of that relapse and to try to develop drugs that prevent that renewed resistance," he said. ...

New tumor markers determine therapy intensity

... frequent malignant brain tumor in childhood, indicate precisely how aggressively the tumor will continue to spread and what the chances of disease relapse are. Researchers at the Center for Pediatric and Adolescent Medicine at the Heidelberg University Hospital and the German Cancer Research Center have ...

Positive results in Phase 2 trial of treatment of C-difficile-associated diarrhea

... said Donna Ambrosino, MD, Executive Director of the MBL and Professor of Pediatrics at UMMS. "The demonstration of significant protection from relapse indicates that treatment with monoclonal antibodies against the toxins could reduce this significant and costly public health problem." "These ...

U of MN study shows link between gene variations and cancer survival

... the disease. A research study led by Brian Van Ness, Ph.D., has successfully identified combinations of genes associated with early clinical relapse of multiple myeloma, a cancer of the white blood cells that produce antibodies. These results raise the possibility that a patient's genetic ...

Cocaine: How addiction develops

... Permanent drug seeking and relapse after renewed drug administration are typical behavioral patterns of addiction. Molecular changes at the connection points in the brain's reward ...

CSHL scientists identify and repress breast cancer stem cells in mouse tissue

... in model systems to see if the effects we see in cell culture are mirrored in real tumors and then, to gauge what effect that has on metastasis and relapse following therapy. It has been known for some time that stem and progenitor cells possess unique defenses, as compared with mature, or ...

St. Jude finds factors that accelerate resistance to targeted therapy in lymphoblastic leukemia

... targeted therapy drug, imatinib, or Gleevec, which has revolutionized the treatment of chronic myelogenous leukemia, (CML) is often unable to prevent relapse of a particularly aggressive form of acute lymphoblastic leukemia (ALL). Targeted therapy drugs are designed to block the activity of a specific ...

'Western' diet linked to increased risk of colon cancer recurrence

... who eat a diet high in red meat, fatty products, refined grains, and desserts a so-called Western diet may be increasing their chance of disease relapse and early death, report researchers at Dana-Farber Cancer Institute. The study, published in the Aug. 15 issue of the Journal of the American ...

Novel therapy combinations gain ground in treating hepatitis

... Therapy of 72 Weeks for Peginterferon / Ribavirin relapse Patients with Chronic Hepatitis C [Abstract ... studies have shown that with 48 weeks of therapy, relapse rates are near 20 to 30 percent, but with an ... plus RBV for 72 weeks in patients with a prior relapse to 48 weeks of treatment. A total of 81 patients ...

Mayo Clinic study finds two genes predict outcome for breast cancer patients

... of women who are and are not at risk for early relapse or cancer-related death. Results of the study ... previously discovered as a potential marker of relapse in hormone-receptor positive breast cancer ... was an independent marker of early breast cancer relapse or death in lymph node-negative breast cancer. ...

AIDS-related cognitive impairment exists in two separate forms

... Profiles of 16 Genes Predict Prostate Carcinoma relapse and Disease Free Survival in Formalin-Fixed, ... administer, appears to be a better predictor of relapse and disease-free survival than the Gleason Score, ... said. "It is very difficult to predict relapse and cancer recurrence in men who have a score of ...

Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers

... Profiles of 16 Genes Predict Prostate Carcinoma relapse and Disease Free Survival in Formalin-Fixed, ... administer, appears to be a better predictor of relapse and disease-free survival than the Gleason Score, ... said. "It is very difficult to predict relapse and cancer recurrence in men who have a score of ...

In SAD patients, autumn antidepressants can prevent winter depression

... then followed over the winter season. The relapse rate was 16% for patients taking bupropion ... spring, there was no increase in the depression relapse rate compared with the placebo group. Patients ... dealing with a condition where the pattern of relapse is somewhat predictable and the symptoms being ...

New compound prevents alcoholic behavior, relapse in animals by blocking stress response

... corticotropin-releasing factor (CRF), which is also thought to trigger relapse in rats that have developed a long-term dependency on alcohol. The ... of alcohol in both cases and eliminated the rats?susceptibility to relapse under stress. Yet the compound did not affect their native curiosity or ...

Successful lung cancer surgery not enough to break nicotine dependence in many smokers

... Epidemiology Biomarkers & Prevention, is the first to look at smoking relapse among people who were "forced" to quit due to impending surgery. ... many of these patients continue smoking despite the risk, but the rate of relapse ranged from a low of 13 percent to about 60 percent. This study was unique ...

Research shows cord blood comparable to matched bone marrow

... with a lower risk of graft versus host disease, a potentially lethal complication, especially when HLA types are mismatched. Rates of leukemia relapse also are lower with mismatched umbilical cord blood transplants. This study also showed that in addition to having a good match, higher cell doses ...

Cancer stem cells similar to normal stem cells can thwart anti-cancer agents

... transporters, even if the bulk of the tumor responded to chemotherapy. According to Dr. Donnenberg, the very fact that cancers can and do relapse after apparently successful therapy indicates the survival of a drug-resistant, tumor-initiating population of cells in many types of refractory ...

Gene expression test reveals ER and HER-2 status of breast tumors

... than, existing pathology tests. "This moves us closer to developing an integrated single genomic test that could estimate the risk of cancer relapse after surgery, determine the ER and HER2 receptor status, and also gauge the sensitivity of the tumor to hormone therapy and chemotherapy," says ...

St. Jude projects 90 percent cure rate for ALL

... cells to drugs, or merely due to the use of inadequate doses of those agents," Evans said. "By having the tools to precisely assess the risk of relapse in a specific patient, we can design the most effective treatments possible at the start of therapy. That's a key element of our success in raising ...

Gene expression profile helps predict chemotherapy response in ovarian cancer patients

... cancer cells, most patients will unfortunately experience a relapse. The goal of our current research is to help determine which patients will relapse and which will not, and to better understand the reasons for this." Cannistra's group has been working to develop a genetic profile of ovarian ...

Gene variation affects tamoxifen's benefit for breast cancer

... medicine at the U-M Medical School. "Our study suggests that women who inherit a genetic variant in the CYP2D6 gene appear to be at higher risk of relapse when treated with five years of tamoxifen." Researchers at the U-M Comprehensive Cancer Center were among the group to discover CYP2D6 metabolizes ...

Microarray technology for tailoring breast cancer therapy

... using DNA microarray analysis. From these samples they identified the genetic signatures shown by 38 patients who had a poor prognosis - defined as relapse or death from any cause within 5 years. The remaining 121 patients were defined as the 'good prognosis' group. The researchers also used gene ...

Many smokers fail to quit after cancer diagnosis

... effectiveness, overall survival, risk of other cancers, and quality of life, up to one-half of cancer patients who smoke continue to do so or relapse after trying to quit. The report, published in the January 1, 2006 issue of CANCER, a peer-reviewed journal of the American Cancer Society, says ...

'License to kill' enables powerful immune attack cells in mice

... practice," Yokoyama says. "It could also help us match bone marrow transplants in a way that increases the immune system's ability to fight off a relapse of the leukemia." ...

Genes linked to treatment resistance in children with leukemia

... failure in childhood ALL. This risk was further increased if the child also had a TYMS 3/3 genotype. No genotype was associated with hematological relapse among patients in the lower-risk arm of the study. The researchers also looked for evidence of leukemia in each patient's central nervous system ...

Methamphetamine Abuse, HIV Infection Cause Changes in Brain Structure

... well studied, although it is known that abusers of the drug have impaired decision-making abilities. These could potentially affect treatment and relapse prevention efforts, as well as things like money management and driving performance.?/p> The brain volume changes associated with methamphetamine ...