rejection

Scientists decipher genome of fungus that can cause life-threatening infections

...otherapy,steroid treatments, or therapy to prevent rejection of transplantedorgans. One study indicated that as many as 13 percent of AIDS patientssuffer a life-threatening cryptococcal infection at some point duringthe course of their HIV disease. The disease caused by the fungus,cryptococcosis, sometimes inv...

Artifical cornea lets woman blind 20 years see

...onor tissue. The problem is not necessarily tissue rejection ? although in some cases it is -- but rather progressive growth of blood vessels and scar tissue throughout an implanted natural cornea, according to researchers. The new cornea eventually becomes as opaque as the original. "The cornea is usually ju...

World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics

...The recipients use the same drugs to prevent organ rejection as are used in the Edmonton Protocol. Dr. Shapiro was invited to participate in the operation in Kyoto, Japan, where he originally did living donor liver transplant training with Dr. Tanaka. Dr. Masumoto was previously based in Seattle and had been ...

Embryonic Stem Cells Treated With Growth Factor Reverse Hemophilia In Mice: UNC Researchers

...oblems include poor engraftment, limited function, rejection of engrafted cells by the immune system and teratomas, tumors involving a mixture of tissue not normally found at that site. The new study used a line of mouse ES cells developed in the laboratory of senior co-author Dr. Oliver Smithies, Excellence ...

Circulating stem cells play small role in lung repair

...re vulnerable to pulmonary injury from infections, rejection of the transplanted lung, ischemia, and other fact...ng pneumocytes and the incidence of acute cellular rejection in the tissue, suggesting that stem cell repopulation might be stimulated by greater degrees of inju...

Candida albicans Genome Fully Annotated

...re vulnerable to pulmonary injury from infections, rejection of the transplanted lung, ischemia, and other fact...ng pneumocytes and the incidence of acute cellular rejection in the tissue, suggesting that stem cell repopulation might be stimulated by greater degrees of inju...

Researchers grow stem cells from human skin

...major problems in transplantation medicine: immune rejection and tissue shortage," Atala said. ...

Discoveries by UAB and Florida scientists may help transplanted organs survive longer

... found a way to dramatically slow organ transplant rejection by as much as several years. That's the promising...ical pathway of a potent molecule that could delay rejection of transplanted organs by preventing blood-vessel deterioration. "One of the principal problems for...

New type of rejection blocker protects kidneys after transplant

...as effective in preventing acute kidney transplant rejection as cyclosporine, the standard anti-rejection treat...of medications that must be taken daily to prevent rejection by suppressing the immune system's hostile response to a transplanted organ, Vincenti said he expect...

Discovery of T-cell 'traffic control' boosts new drug promise

...shows the promise of similar strategies to prevent rejection of transplanted organs and tissues without comprom...or treatment of autoimmune diseases and transplant rejection will depend on developing new drugs that block only the immune type of S1P receptor," he adds. "But ...

Monkeying around to improve organ transplantation

...T cells generated ex vivo suppress renal allograft rejection in non-human primates. This may be an approach tha...n human transplant trials. Title: Renal allograft rejection is prevented by adoptive transfer of anergic T cells in non-human primates ...

Simple sea sponge helps scientists understand tissue rejection

...ified as another potential player in sponge tissue rejection reactions, and which is very easy to study in spon...de insights into the machinery behind human tissue rejection and immune responses in hopes of someday being able to control these processes and save lives. ...

AACR Favors 'full spectrum of stem cell research biology'

...association's statement is equally vehement in its rejection of any technology, including stem cell technology, used in human reproductive cloning, noting that, "such attempts have no beneficial goal and can be reasonably assumed to cause harm." At the same time, the AACR position supports the "ethical use of ...

Researchers identify genes associated with lung transplant rejection

...rejection, as well as greater understanding of the rejection process. The study is being published in the Sept...se is unknown, but it is believed to be related to rejection of the lung by the recipient's body. "For lung transplant patients, the biggest barrier to long-ter...

Nanotubes inspire new technique for healing broken bones

...acks, including low strength and the potential for rejection in the body. "Compared with these scaffolds, the high mechanical strength, excellent flexibility and low density of carbon nanotubes make them ideal for the production of lightweight, high-strength materials such as bone," says Robert Haddon, Ph.D.,...

Breast tumors in mice eradicated using cancer vaccine

... of an immune response were best able to cause the rejection of established tumors," she says. "But in the last couple of years it has paid off and we are very excited to see the technology finally being tested in cancer patients. The dream of the cancer immunotherapist is to provide an alternative and more hu...

Diabetes researchers pioneer islet cell xenotransplantation in primate studies

...uch work to be done these studies suggest that the rejection response to porcine islets can be surmounted." "The next step is to prove that these neonatal porcine islet cells could become a source for human transplantation," said Dr. Rajotte. "It's hoped that within the next three to five years, we will be tr...

Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level

...ld provide a non-invasive way to detect transplant rejection in patients. "We have reported for the first time...n. Physicians typically monitor patients for organ rejection following a heart transplant by performing frequent heart biopsies for the first year. Heart biopsie...

Rice bioengineers pioneer techniques for knee repair

... patient are used as a starting place to eliminate rejection risks. Most tissue engineering involves honeycombed plastic templates or hydrogels called scaffolds that are used to guide colonies of donor cells. Donor cells can be either adult stem cells or other immature cells. Athanasiou's latest work was done...

Scientists discover that widely available drug also helps fight kidney disease

...tly used as an immunosuppressant, to help prevent rejection of a new, transplanted kidney. Over 600,000 peop...ppression in kidney transplant patients to prevent rejection of the new kidney. Weimbs and his colleagues wondered about treating kidney patients with rapamycin...

Progress being made in exploring potential use of stem cells to treat heart disease

...t beat) Solving immunological issues surrounding rejection "Exciting new findings over the past 5 years indicate that stem cells could prove effective as protective or regenerative cardiac therapies," says Ivey, who was named in April one of seven current postdoctoral fellows participating in the Gladstone...

Microscopic scaffolding offers a 'simple' solution to treating skin injuries

...es, but these approaches have potential health and rejection risks. "Simplicity is the key," says Professor Tony Ryan, who is leading the team. "Previous attempts to find better ways of encouraging skin cell growth have used chemical additives and other elaborate techniques to produce scaffolds, but their...

With few factors, adult cells take on character of embryonic stem cells

...of human embryos, as well as the problem of tissue rejection following transplantation into patients." Those problems could be circumvented if pluripotent cells could be obtained directly from the patients' own cells. "We have demonstrated that pluripotent stem cells can be directly generated from fibrobl...

Stanford doctors advance in bid to turn mice stem cells into blood vessels

...ariety of limitations, Abilez said, key among them rejection by the immune system. By creating a tissue-enginee...vessel grown from a patient's own stem cells, this rejection could potentially be eliminated, Abilez said. "Our goal is to derive all the different cell types f...

Teasing out tissue from blood

...n. "It's autologous, we don't need to worry about rejection of tissue, and immunosuppression," says Glenn Winnier of Pharmafrontiers, a company in Woodland, Texas. It now claims to have refined a way to produce stem cells from whiteblood cells called monocytes and develop them into many different tissue types...

With few factors, adult cells take on character of embryonic stem cells

...of human embryos, as well as the problem of tissue rejection following transplantation into patients." Those problems could be circumvented if pluripotent cells could be obtained directly from the patients' own cells. "We have demonstrated that pluripotent stem cells can be directly generated from fibrobl...

Failure of 'scout cells' may lead to cancer in transplant patients

...eople whose immune system is suppressed to prevent rejection of a transplanted organ. The cancer, called post-transplant lymphoproliferative disorder (PTLD), arises only in some transplant patients, but doctors don't know why. This study, led by Ohio State University scientists, begins to answer that que...

Therapeutic role found for carbon monoxide

...O provides potent protective effects against organ rejection or blockage of the carotid arteries. But, with these latest findings, explains senior author Leo Otterbein, PhD, it now appears that carbon monoxide can also be used to treat and reverse existing disease. "Our results offer the exciting possibility...

Researchers create genetically matched embryonic stem cells for transplantation

...cells that can be transplanted without the risk of rejection because the cells are compatible with the recipien...te. "It would eliminate tissue matching and tissue rejection problems, a major obstacle to successful tissue transplantation." Embryonic stem cells are "master...

New dyslexia theory blames 'noise'

...d his collaborators interpret the new results as a rejection of the "magnocellular hypothesis" - named for a type of neuron involved in processing fast visual information - that influenced dyslexia research for decades. The researchers found that the magnocellular pathway works normally both in children wi...

An artificial cornea is in sight, thanks to biomimetic hydrogels

.... Donor tissue has problems, Ta notes, including a rejection rate of about 20 percent and a period for visual recovery of six months to a year. "You get a more predictable shape with an artificial cornea," Ta says. "In many countries, tissue availability is a problem," he says. "If the tissue is artificial, ...

Replacing insulin is top-ranked breakthrough foreseen for health in developing world

... cost of treating heart failure by avoiding immune rejection and costly immunosuppressive regimens. The 3rd-ranked application: using engineered immune cells and novel vaccination strategies to improve immunity from infectious disease, would assist countless developing country victims, many of them their soci...

Distinguishing friend from foe in the battle against cancer

...apamycin, an immunosuppressant used to block organ rejection after transplants, also inactivates proteins stimulating cell division and in clinical trials has been combined with other drugs to halt cancer cell growth. But to cancer cells, rapamycin is both friend and foe. "Rapamycin is not as successful as i...

T for two: Scientists show how immune system chooses best way to fight infection

...duals receiving transplants, may help suppress the rejection response. Now, a team of researchers has discovered a novel mechanism determining whether a maturing T cell is likely to emerge from the thymus as an effector cell or a regulatory cell. The research suggests that new treatments could be developed ...

Artificial cornea offers better results for infants, some blind patients

...ed well in children," said Gearinger. "The risk of rejection is huge, and it just goes up with every subsequent...issue can trigger a variety of problems, including rejection by the immune system as well as difficulties such as scarring from infections or out-of-control grow...

Proteins may predict lung transplant rejection

...oteins that were highly predictive of chronic lung rejection up to 20 months before the rejection occurred. Lung transplant patients have the highest mortality rate of organ recipients, about 45% o...

Low levels of neurotransmitter serotonin may perpetuate child abuse across generations

...baby rhesus monkeys endured high rates of maternal rejection and mild abuse in their first month of life, their brains often produced less serotonin, a chemical that transmits impulses in the brain. Low levels of serotonin are associated with anxiety and depression and impulsive aggression in both humans and m...

Type of stem cell found to reside in transplanted lungs

...bility that the cells may be able to help with the rejection of donated organs and with various kinds of lung d...of lung transplant patients who experience chronic rejection of donated lungs, with rejection rates of about 60 percent during the first five years after transpl...

Implanting dopamine generators in brain cells obtains improvement in Parkinson's in monkeys

...of carrying out autoimplants, thus avoiding tissue rejection or immunosupressor treatment. Research Research was undertaken with monkeys who had Parkinson's induced by the administration of a neurotoxin (MPTP) and which were subsequently injected into the striate area of the brain with fragments from t...