Recombinant in Biological News

ExcellGene SA first company to offer contract manufacturing in 250 Liter OrbShake bioreactor

... company to offer to its clients production of recombinant proteins at the 50L to 200L scale in OrbShake ... to our clients gram to 10s of gram quantities of recombinant proteins at unparalleled speed, quality and low ... innovative technologies for the production of recombinant proteins from mammalian cells in bioreactors. As ...

ExcellGene and Khner achieved milestone in development of novel 250 Liter mammalian cell culture bioreactors

... of growing mammalian cells for the production of recombinant proteins in an orbitally shaken bioreactor.  ... in reactors with the ultimate goal to produce recombinant proteins more efficiently.” explains Dr. ... innovative technologies for the production of recombinant proteins from mammalian cells in bioreactors. As ...

InVitria Announces Launch of Recombinant Albumin for Diagnostics

... the commercial launch of two protease-free recombinant albumin products. InVitria’s recombinant Albumin-DX and recombinant Albumin-DX (Lipid-Free) perform better in ...

Tailor-made recombinant proteins in mammals

... chemical modifications to specific sites on recombinant proteins including the monoclonal antibodies so ... tags," which they previous developed for recombinant proteins expressed in bacteria, to label proteins ... by mammalian systems. "Proteins made with recombinant DNA are a major weapon in the armory against ...

Research identifies type of vaccine that holds promise in protecting against TB

... study participants received the investigational recombinant BCG vaccine. Researchers compared five immune ... research demonstrated that the concept of using a recombinant vaccine holds promise in being able to better ... area will continue as scientists test a similar recombinant BCG vaccine that expresses the same and ...

Viral recombination another way HIV fools the immune system

... exchange genetic information, creating a third, recombinant strain of the virus. It is known that the ... itself appears to be a random event, recombinant strains that are better able to evade the immune ... lead to the development of an uncontrollable, recombinant viral strain. Streeck notes, "Given the ...

From foe to friend: Researchers use salmonella as a way to administer vaccines in the body

... in the paper, "Regulated programmed lysis of recombinant Salmonella in host tissues to release protective ... manufactured by a vaccine company, the attenuated recombinant salmonella vaccine after entry into the immunized ... features required for biological containment of a recombinant attenuated salmonella vaccine," they added. ...

FSU researcher using computers to hone cancer-fighting strategies

... computers to determine how substances known as recombinant immunotoxins can best be modified in order to ... methods," Chen said of his research. recombinant immunotoxins, Chen explained, are new drugs that ... -- it is essential to explore how the efficacy of recombinant immunotoxins can be enhanced without resorting to ...

New technology for boosting vaccine efficiency

... body produce a viral protein. This is called a recombinant vaccine. recombinant vaccines give the most hope today as anti-viral ... preventing a disease progression. In order for a recombinant vaccine to be effective, the produced viral ...

Emergence of recombinant forms of HIV: dynamics and scaling

... of therapy. The dynamics of the emergence of recombinant forms of HIV in infected individuals remains ... a detailed account of the emergence and growth of recombinant forms of HIV following infection with diverse ... that link the relative prevalence of recombinant forms of HIV to the overall extent of infection. ...

GUMC discovery highlights new direction for drug discovery

... proteins are disordered. In their 15-year search for a new treatment for Ewing's sarcoma, Toretsky and his colleagues were the first to make a recombinant EWS-FLI1 fusion protein. They used it to discover that the fusion protein stuck to another protein, RNA helicase A (RHA), a molecule that forms ...

Anti-biotech groups obstruct forest biotechnology

... been in direct opposition to widespread scientific and professional opinion from around the world, including from ecologists, that the trait, not the recombinant method, should be the focus of assessments." Another key part of the problem, the researchers said, is finding enough scientists to participate in ...

Powe Award supports research on how enzymes enable the pathogenicity of 2 human disease organisms

... have siderophores, an inhibitor should not be toxic to us." Using modern biology techniques, Sobrado's group is the first in the world to obtain recombinant functional siderophore hydroxylases from M. smegmatis (a model organism of M. tuberculosis ) and A. fumigatus . "We have been able to obtain ...

Versartis presents positive preclinical data on 2 product candidates at ENDO 09

... Society's Annual Meeting in Washington, DC. Versartis, through a unique licensing agreement with Amunix, Inc., uses the Amunix proprietary recombinant PEGylation (rPEG) technology to extend the half-life of established biologics. The preclinical Versartis compounds have the potential for ...

InVitria Sponsors ESACT 2009 in Dublin, Ireland

... Recent publications, along with customer results has validated that another of InVitria’s leading cell culture supplements, Cellastim , a recombinant human serum albumin, outperforms other forms of albumin for growth and productivity. Cellastim is a key component in stem cell media and is used to ...

Swine flu experts gather at New York Academy of Sciences May 28

... is the subject of a landmark afternoon symposium hosted by the New York Academy of Sciences on Thursday, May 28. Speakers will discuss the new recombinant virus, epidemiology, treatment, vaccine development and the public health implications of a worldwide pandemic. Reservations are required to ...

InVitria to Unveil Powerful Cell Culture Media Component ZAP-CHO

... the most difficult assay challenges. * Cellastim —Cellastim outperforms plasma-derived albumin, bovine serum albumin and other sources of recombinant albumin. * Lacromin —Lacromin is a CHO growth-factor that outperforms insulin and IGF-1. About InVitria - www.InVitria.com InVitria ...

EMBL scientists develop first fully automated pipeline for multiprotein complex production

... research, but they are notoriously hard to study. Their abundance is often too low to extract them directly from cells and generating them with recombinant methods has been a daunting task. A new technology to produce multiprotein complexes, developed by researchers at the European Molecular Biology ...

UTSA, Health Science Center collaborate with Merck & Co. to develop chlamydia vaccine

... team of researchers was the first to demonstrate that, in animal models of genital chlamydial infection, a vaccine composed of a select group of recombinant C. trachomatis antigens can successfully accelerate bacterial clearance, and importantly, preserve female reproductive function. Scientists from ...

Biolex presents Locteron US Phase 2a hepatitis C data at EASL

... that worldwide sales of interferon products for the treatment of hepatitis C will approach $6 billion by 2016. Locteron combines BLX-883, a recombinant interferon alpha produced by Biolex in its patented LEX SystemSM, with PolyActive, an advanced controlled-release drug delivery technology developed ...

New orthopaedic society launched to promote research, use of biologic treatments

... for chronic tendonitis, disc regeneration, and accelerated healing; molecular and cell biology and biomaterials for tendon-to-bone healing; and recombinant bone morphogenic proteins to repair fresh fractures. Current research suggests that these biologic treatments may be used alone or in combination ...

Scientists identify human monoclonal antibodies effective against bird and seasonal flu viruses

... not typically stimulate antibodies against the stem, perhaps because it is less accessible than the head region. In this study, the scientists used recombinant purified protein, not virus, so the antigenic part of the virus recognized by the antibodies was fully exposed. Seasonal influenza occurs each ...

Scientists identify human monoclonal antibodies effective against bird, seasonal flu viruses

... not typically stimulate antibodies against the stem, perhaps because it is less accessible than the head region. In this study, the scientists used recombinant purified protein, not virus, so the antigenic part of the virus recognized by the antibodies was fully exposed. Seasonal influenza occurs each ...

Carnegie's Donald Brown receives lifetime achievement award from Society for Developmental Biology

... specific genes and reconstructing their control in the test tube. Many of these studies termed "genetics by gene isolation," took place before the recombinant DNA era and established facts about genes such as their structure, their evolution, and the signals in and around genes that control where they start ...

Scripps scientists develop first examples of RNA that replicates itself indefinitely

... enzyme would make a mistake by binding one of the subunits from one of the other replicating enzymes. When such "mutations" occurred, the resulting recombinant enzymes also were capable of sustained replication, with the most fit replicators growing in number to dominate the mixture. "To me that's actually ...

Methods for studying DNA repair and protein modification are featured in CSH Protocols

... regulation. James Manley's laboratory at Columbia University ( http://www.columbia.edu/cu/biology/faculty/manley/ ) provides "In Vitro Sumoylation of recombinant Proteins and Subsequent Purification for Use in Enzymatic Assays," a protocol for modifying proteins in this manner, allowing one to assess the ...

Team finds breast cancer gene linked to disease spread

... on to discover that among a handful of genes in the 8q22 region, MTDH is responsible for the aggressive behavior of poor-prognosis tumors. They used recombinant DNA technology to enhance the expression of individual genes in the region, one by one, in breast tumor cells and tested their metastatic behavior in ...

UC Davis discovery offers hope for treating kidney cancer

... Weiss sought to identify compounds that could interrupt this pathway. The team tested thousands of compounds and 12 were found to bind to the recombinant protein p21. Additional tests showed that three of those compounds decreased p21 expression, blocking kidney cancer cells' ability to mend and making ...

Cold Spring Harbor Protocols features organ and cell culture methods

... ). Blanche Capel's laboratory at Duke University (http://www.cellbio.duke.edu/faculty/capel/index.html) provides "Preparing recombinant Gonad Organ Cultures." It can be useful to assay migration between any two adjacent tissues during development. This protocol assays cell migration ...

Scientists from Granada find a potential treatment to prevent diabetes and obesity

... was that interleukin-6 was naturally high in diabetic and obese persons precisely to combat such diseases. In order to prove it, we injected human recombinant interleukin-6 daily for two weeks and analysed its behaviour and its effects on the metabolism". Mark Febbraio, scientific director in the Baker ...

The Science Coalition's '10 questions' for the presidential debate

... biotech industry, a $70 billion engine of growth, would not exist without a long background of basic research. The path-breaking findings that made recombinant DNA technology feasible were discovered at leading U.S. universities. University technology transfer overall adds billions of dollars to the economy ...

American Chemical Society's Weekly PressPac -- Aug. 6, 2008

... of urine and blood samples. Many of these tests will focus on identifying human growth hormone (hGH) and erythropoietin (EPO), two products of recombinant DNA technology that athletes have used to boost muscle mass and increase endurance. Although analytical instruments have become more accurate, ...

Scientists find potential protein biomarkers for growth hormone

... proteins in mice that might act as biomarkers for growth hormone. The research could be the first step to finding a more reliable way to detect recombinant human growth hormone (rhGH), which some athletes and teenagers use illegally to boost muscle and reduce fat. At the Endocrine Society annual ...

VaxInnate to discuss seasonal and pandemic flu vaccines during BIO 2008 this week

... to developing and producing influenza vaccines is based upon a proprietary combination of toll-like receptor (TLR) mediated immune enhancement and recombinant bacterial production of vaccine antigen. This proprietary technology could significantly reduce the time required to produce supplies of influenza ...

New technology enhances therapeutic potential of cord blood stem cells

... of the University of Texas MD Anderson Cancer Center. Zweidler-McKay will discuss his team's work in the same session on Engraftin, a human recombinant enzyme technology that increases the efficiency of engraftment and reduces graft failure in transplantation of cord blood derived stem cells. ...

Vaccine for Ebola virus

... bodies producing killer T-cells before immunity is strong enough to prevent or clear an infection. The researchers have now used several different recombinant DNA techniques, which have allowed them to trigger a cell-mediated response and produce a vaccine that is effective in non-human primates. One of the ...

Carnegie Mellon scientists develop fluorescent proteins for live cell imaging, biosensor design

... an exceptionally selective biosensor for proteins at the outside of the cell surface. The FAP is a specialized single chain antibody (scFv), a recombinant fragment of full-size antibody proteins that the human immune system uses to identify intruders like bacteria or viruses. The Carnegie Mellon ...

A search for protection against chemotherapy cardiotoxicity

... of Oncology. The research team, led by Christophe Ribuot, a professor of pharmacology, explored the beneficial cardioprotective effect afforded by recombinant human erythropoietin (rhEPO) against various stresses, through experimental and clinical investigations. This study is an excellent illustration of ...

Bleeding, not inflammation, is major cause of early lung infection death

... not have CYLD, and found that very few die of S. pnuemoniae infection. The most immediate implication of this work is that we could make purified, recombinant PAI-1 and inject it directly into the lungs of these patients, and it would have a benefit, Li said. The next step will be to design a small ...