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Spleen may be source of versatile stem cells

...he MGHconducts the largest hospital-based research program in the UnitedStates, with an annual research budget of more than $400 million andmajor research centers in AIDS, cardiovascular research, cancer,cutaneous biology, medical imaging, neurodegenerative disorders,transplantation biology and photomedicine...

Newly-discovered class of genes determines ?and restricts ?stem cell fate

...ings told us that a recapitulation of an embryonic program is occurring in resident stem cells in adult skin," explains Jon Epstein, MD, Professor of Medicine, Cardiovascular Division. "These few rare stem cells were expressing genes that previously had only been known to be expressed in a developing embryo....

UW's Rosetta software to unlock secrets of many human proteins

...wn byscientists. These rules are summarized in the program and are termedthe "Rosetta score." The program tries a great many conformations andreturns those with the lowest Rosetta scores; these conformation...

Researchers find how protein allows insects to detect and respond to pheromones

...wn byscientists. These rules are summarized in the program and are termedthe "Rosetta score." The program tries a great many conformations andreturns those with the lowest Rosetta scores; these conformation...

Affymetrix Unveils Plans to Double Plant and Animal Genome Microarray Offering

...ing at Affymetrix. "We had great success with this program lastyear. By providing the plant and animal community groups with a single,standardized platform for gene expression research, they can easilycompare results, build reliable databases and move science forward morequickly."Affymetrix Consortia Program...

Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible

... microarray studies, the NCI’sDirector’s Challenge program set up this preliminary study to compareresults between labs. Twelve different tumor tissues, five cancer celllines, and five purified RNA samples were prepared, blinded, andrandomized for analysis in four laboratories: University of MichiganMedical ...

A much-needed shot in the arm for HIV vaccine development

...ates Foundation's HIV, TB, and Reproductive Health program and oneof the plan's authors. "We hope that that the Global HIV VaccineEnterprise will speed the development of a vaccine by bringing newcollaboration, resources, and strategic focus to the field.""The partners in the Global HIV Vaccine Enterprise ar...

Inexpensive, mass-produced genes core of synthetic biology advances at UH

...Houston, now allowing researchers to inexpensively program the chemicalsynthesis of entire genes on a single microchip.Xiaolian Gao, a professor in the department of biology and biochemistryat UH, works at the leading edge of this field. Her recent findings onhow to mass produce multiple genes on a single ch...

Scientists collaborate to assess health of global environment

...tions in 2001, the Millennium Ecosystem Assessment program will issue its primary report on March 30 during p...nk and others, the Millennium Ecosystem Assessment program also will evaluate future scenarios and give governments and institutions direction that Mooney desc...

Enzyme shown to help protect genomic stability

...ki Professor in the gene expression and regulation program at Wistar and senior author on the study. "Otherwise, they can recombine with themselves or with other DNA segments. In the telomeres, such events may accelerate aging or trigger cancer in humans." "We have identified a molecular mechanism to explai...

Poplar trees redirect resources in response to simulated attack

...l Thorpe who is helping to build the plant-imaging program at Brookhaven. Plants subjected to the jasmonic acid "attack" produced more radiolabeled sugar and delivered more of it to the roots than plants untreated with the hormone. "This is pretty convincing evidence that plants can respond 'passively' by r...

Critical role in programmed cell death identified

...ppear to release molecules that set the cell death program in motion. While their activity in mammalian cell ...uld have died instead live. Worms whose cell death program is blocked survive, at least in the lab, with their 131 extra cells. Such studies are impractical in...

MSI releases 'moleculizer' - a new approach to simulation of intracellular biochemical networks

... Center ofExcellence in Genomic Research. The CEGS program supportsmulti-investigator, interdisciplinary research teams to develop noveland innovative genomic research projects."Moleculizer is exactly the sort of development that one wants to seefrom multidisciplinary work," explained Dr. Brent. "The mathema...

The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures

The Protein Structure Initiative (PSI), a national program aimed at determining the three-dimensional shapes of a wide range of proteins, has now determined more than 1,000 different structures. These structures will shed light on how proteins function in many life processes and could lead to targets for the...

Bird Brains Show How Trial and Error May Contribute to Learning

...ic trials were possible with the aid of a computer program that could track the bird twitters and trigger stimulations to LMAN at precise moments to elicit measurable effects on a predetermined syllable, song after song. The researchers found that different areas of LMAN tuned the same note in different dir...

Applied Biosystems Introduces Advanced Gene Expression Service Provider Program

...ed Gene Expression Service Provider Program, a new program for service providers who are interested in access... Gene Expression Assays for target validation. The program includes a bundled product option for the entire gene expression workflow application and technical ...

Harnessing microbes, one by one, to build a better nanoworld

...ed Gene Expression Service Provider Program, a new program for service providers who are interested in access... Gene Expression Assays for target validation. The program includes a bundled product option for the entire gene expression workflow application and technical ...

International HapMap consortium expands mapping effort

...esponsiveness," said Karen Kennedy, Ph.D., science program manager at the Wellcome Trust. "When the more comprehensive version of the HapMap is completed this fall, such studies will be able to be carried out with even greater speed and efficiency." To create the HapMap, DNA was taken from blood samples fro...

Vascular structure and function improve with diet and exercise

...s and Vascular Biology. "Our lifestyle management program appears to improve the health of the vasculature, so it might lower the risk of high blood pressure, diabetes, heart attacks and stroke," said presenter and lead author Kunihiko Aizawa, M.Sc., a Ph.D. candidate at the University of Western Ontario in...

Children's taste sensitivity and food choices influenced by taste gene

... continues and extends Monell's long-term research program exploring development of taste and flavor preferences during childhood, a critical time for learning about food. Mennella comments, "Our previous studies focused on how early experience influences preferences for foods and flavors. Now, we have a too...

Supercomputer Dedicated To Bioengineering, Computational Biology Installed

...tional Biomedical Computational Resource (NBCR), a program funded by the National Institutes of Health, and director of Life Sciences Initiatives at UCSD. Arzberger said the Department of Bioengineering and NBCR Dell Rocks Cluster will be quickly integrated into a computational grid to provide the resource ...

Effective Cancer Treatments Follow The Clock

...he moved to Cleveland and established her research program in the Department of Cancer Biology at the Cleveland Clinic Foundation. To examine the mechanism for this difference, Antoch and her colleagues used mice that genetically lack different components of the body's internal clock. “Knowing the molecular...

Surprising findings reported about iron overload

...tern European descent. In fact, a health-screening program conducted by Barton and Acton at an Alabama forest products mill detected the disorder in 0.39 percent of all white participants, and 0.53 percent of white men. Acton and Barton said they hope that results of the study will prompt more primary care ...

Scientists discuss improved biopesticides for locust control in West Africa

...me and food supply loss. Larry Vaughan, associate program director of the USAID-funded Integrated Pest Management Collaborative Research Support Program (IPM CRSP) and research associate in the Office of International Research, Education, and Development (OIRED), and Foster Agblevor, associate professor of ...

World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics

...e idea of starting a living donor islet transplant program in Kyoto while lecturing there three years ago. Cadaveric organ donors are scarce in Japan, and living donation has very established roots in liver and kidney transplantation there. "Living donor islet transplants could allow many more desperate pat...

Programmable cells: Engineer turns bacteria into living computers

...body. "We are really moving beyond the ability to program individual cells to programming a large collection...se a behavior they want from cells, and a computer program will create a genetic circuit to accomplish the task. "Then we can do an experiment to see if the co...

New online portal merges vast data on Gulf of Maine ecosystem

...ecology. Launched today by the Gulf of Maine Area program of the Census of Marine Life, the Dynamic Atlas of...ortant international resource," says Evan Richert, program director for the Gulf of Maine program. "The new portal is the door to a treasure of data, much of i...

Not-for-profit publishers call NIH public access rule a missed opportunity

...an Society of Hematology. "The 'Free Back Issues' program at Stanford's HighWire Press already gives the pub...plicative because NIH will create a new government program to supplant existing and highly successful private efforts; # It will divert federal dollars away fr...

Researchers devise way to mass-produce embryonic stem cells

...flask. The researchers are now working on ways to program embryonic stem cells so that they differentiate into specific types of cells. In preliminary work, Ouyang has created a network of neurons from undifferentiated embryonic stem cells. The next step is to use human embryonic stem cells, and the resear...

Controlling protein diversity

...g out some of the code results in a very different program than what would have resulted if all the components had been included or different parts had been left out. In this instance, leaving out part of the gene changes the protein. "The question is, 'How is this controlled?'" said O'Malley. He and his c...

Robot-based system developed at Carnegie Mellon detects life in Chile's Atacama desert

... mid-October ?was the second phase of a three-year program whose goal is to understand how life can be detected by a rover that is being controlled by a remote science team. The project is part of NASA's Astrobiology Science and Technology Program for Exploring Planets, or ASTEP, which concentrates on pushin...

Alaskan puzzles, monitoring provide insight about North Pacific salmon runs

...mpling scope and sophistication. The Alaska-based program has applications for Pacific salmon all along the ...nment understand the size of salmon runs, early UW program leaders also collected basic information about weather, lake levels, emerging insects, zooplankton l...

Nanoscale Diagnostic Sets Sights on Alzheimer's

...pported by both NSF's Engineering Research Centers program and the NSF Office on International Science and En...Sohi Rastegar, a bioengineering expert and the NSF program director who oversees the agency's support of the Northwestern NSEC and several other bioengineering...

Researchers discover chemical compounds that affect plant growth

...on's Research Experiences for Undergraduates (REU) program in 2003 and has remained to contribute to research efforts while studying at UCR. The team's chemical genomics approach focuses on the use of small molecules to modify or disrupt the functions of specific genes or proteins. NASA supported the resear...

New winter hulless barley has high protein

...s barley cultivar, "Doyce," in 2003. The breeding program is developing both traditional soft red winter wheat cultivars and new cultivars with unique and high-value end-use characteristics such as higher protein content, quality, and white seed color. The Virginia Tech wheat cultivars "Tribute" and "Renwoo...

Gene therapy promising for growing tooth-supporting bone

...al Research. Giannobile is part of a cross-campus program called Tissue Engineering at Michigan, funded in part by the National Institute for Dental and Craniofacial Research. TEAM aims to provide an interdisciplinary, research-intensive environment for those pursuing careers in the oral sciences, with a fo...

Affymetrix Licenses Microfluidics Technology From Caliper Life Sciences

...the second agreement since Caliper began an active program to out-license its intellectual property portfolio. The new "LabChip Driven" program was put in place to support the company's microfluidics adoption strategy and to broaden and acceler...

Computational Method Speeds Mapping of Cell Signaling Networks

...eir interactions, such as tissues and organs. NSF program manager Carter Kimsey thinks this study will open up a wide range of research opportunities. "There is no reason to think that this mathematical tool is for health-related fields only, there are many possible applications in biology," she says. Dana...

GeneNotes - A novel information management software for biologists

...f genes. GeneNotes is free for academic usage. The program and the tutorials are available at: http://bayes.fas.harvard.edu/genenotes/. GeneNotes provides a novel human-computer interface to assist researchers to collect and manage biological information. It also provides a platform for studying how users b...

Microbial forensics: The next great forensic challenge

... process of developing a strong microbial forensic program to attribute and prosecute such attacks, and perha... Randall S. Murch, associate director for research program development at Virginia Tech, formerly deputy director of the FBI's Laboratory and Investigative Tec...

Survey finds silver contamination in North Pacific waters

... of Pollution in the Marine Environment (GIPME), a program of the UNESCO Intergovernmental Oceanographic Commission. Ranville and Flegal reported their findings in the March 9 issue of Geochemistry, Geophysics, Geosystems, an electronic journal published by the American Geophysical Union and the Geochemical ...

Scientists identify genetic pathways essential to RNA interference

...e MGH conducts the largest hospital-based research program in the United States, with an annual research budget of more than $450 million and major research centers in AIDS, cardiovascular research, cancer, cutaneous biology, medical imaging, neurodegenerative disorders, transplantation biology and photomedi...

Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells

...e Center for Development and Learning, UNC-CH. The program is dedicated to tracking the natural history and the effects of new therapies in children with rare diseases. In the new study, eleven asymptomatic newborns (ages 12 to 44 days) and 14 symptomatic infants (ages 142 days to a year) were treated with ...

Emergence of cancer as major cause of childhood death in developing countries is not being adequately addressed

...ound that recruiting local oncologists to serve as program directors gives the best results,?Ribeiro said. “The recruited oncologists serve as program directors, advocates of pediatric oncology units and coordinators of training for essential cancer c...

CoPub Mapper: mining MEDLINE based on search term co-publication

...ed genes based on co-occurrence. The CoPub Mapper program allows for quick and versatile querying of co-published genes and keywords and can be successfully used to cluster predefined groups of genes and microarray data. ...

Scientists journey to southern Africa to unravel the secret world of elephant communication

...cation." In 1995 she was accepted to the doctoral program in ecology at UC-Davis and began working with Professor Lynette Hart, an authority on the social behavior of large mammals. Their first goal was to prove to themselves, and to the scientific community, that elephants actually have the physical capabi...

First technology to remove prions that cause vCJD from blood launched

...l is continuing its prion research and development program to apply its technologies to meet the specific requirements of each nation throughout Europe, followed by Canada and the US. The Company is also developing an ante mortem test to detect infectious prions in cattle prior to entering the food supply. ...

Chromosome Deletion Predicts Aggressive Neuroblastoma

...eh works in a comprehensive neuroblastoma research program at Children's Hospital, directed by John M. Maris, M.D., the senior author of the abstract. Co-authors of the study, in addition to Drs. Attiyeh and Maris, included Katherine K. Matthay, M.D., of the University of California, San Francisco; and Yael...

Roots Engage in Underground Chemical Warfare

...eaders of the 21st century. Parag Chitnis, the NSF program manager of Vivanco's award said, "This work is an ... way to understand and combat crop diseases." The program manager for Ausubel's award, Michael Mishkind said, "The puzzle of why so few bacterial species are ...

New project aims to make large-scale lobster farms feasible

...cientists have received new funding for a research program they hope will make large-scale culturing of spiny...any began working with Harbor Branch's aquaculture program and other groups to determine if commercial-scale quantities of larvae could be collected from the c...

Study reveals candidate targets for anti-retroviral therapeutics

...lifecycle. Together, they developed an interactive program (GOnet) allowing them to search through large amounts of genetic and biochemical data to identify "clusters," or related groups of genes, that are most likely to affect key points in the Ty3 lifecycle. In total, they identified 130 genes that affect ...

Man-made wetland's effectiveness similar to natural marsh

...k, a student in the environmental science graduate program at Ohio State. Often called the "kidneys" of the environment, wetlands act as buffer zones between land and waterways. They also act as sinks ?wetlands filter out chemicals in water that runs off from farm fields, roads, parking lots and other surfa...

Basis for DNA ejection from single phage particles

...y the Centre National de la Recherche Scientifique program "Dynamique et Réactivité des Assemblages Biologiques" and by SFB 563 "Bioorganic Functional Systems on Solids." Publishing in Current Biology, Volume 15, Number 5, March 8, 2005, pages 430-435. http://www.current-biology.com ...

Infants with Rare Genetic Disease Saved By Cord Blood Stem Cells

...e Center for Development and Learning, UNC-CH. The program is dedicated to tracking the natural history and the effects of new therapies in children with rare diseases. In the new study, eleven asymptomatic newborns (ages 12 to 44 days) and 14 symptomatic infants (ages 142 days to a year) were treated with ...

Finding hidden invaders in a Hawaiian rain forest

...rain forests, Carnegie's ecological remote sensing program has focused on the area as the ideal outdoor research laboratory for devising the next generation of aircraft and spacecraft observations. Now we've added a major focus on the application of our techniques to invasive species problems in the Hawaiian...

wFleaBase: the Daphnia genome database

...m (DGC) has launched an interdisciplinary research program to create the resources needed to study genes that affect ecological and evolutionary success in natural environments. Description These tools include the genome database wFleaBase, which currently contains functions to search and extract information...

Unchecked DNA replication drives earliest steps toward cancer

...rofessor in the molecular and cellular oncogenesis program at Wistar and senior author on the Nature study. "...d leader of the molecular and cellular oncogenesis program at Wistar. The remaining coauthors are Panagiotis Karakaidos, Panayotis Zacharatos, Athanassios Kots...

Science study holds implications for gene therapy and stem cell biology

... a research team in the molecular and gene therapy program in the Division of Experimental Hematology at Cincinnati Children's under the direction of David Williams, MD, and in collaboration with Christof von Kalle, MD, PhD, a physician/researcher also noted for achievements in gene therapy. The team interac...

Python a 'hearty' eater

...is supported by the Integrative Organismal Biology program at the National Science Foundation. ...

Mouse with designer liver has enhanced glucose tolerance, insulin response

...e Burnham Institute-UCSD's joint graduate training program in Molecular Pathology. Jerrold Olefsky, Ph.D. and Andrea Hevener, Ph.D. are Professor and Adjunct Associate Professor, respectively, in the Department of Medicine at the University of California, San Diego. This project was supported by grants fro...
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(Date:5/16/2008)...s of shipments involving regulated radioactive mat...g concern to safety and industry experts. Meeting ... on an action plan for the Mediterranean region th... centres and organizations that rely on timely del...pment issues have surfaced over the past several y...
(Date:5/16/2008)...the Canadian Journal of Forest Research presents t...in one of the first landscape-scale experiments on...ine ecosystems. , The Blacks Mountain Interdisci..., Humboldt State University, Oregon State Universi...life Conservation Society scientists collaborating...
(Date:5/16/2008)...team of experts in biomechanics and physiology fro...the Massachusetts Institute of Technologys Media L...orn by Oscar Pistorius, a 21-year-old South Africa...h an unfair advantage in the 400-meter race. Their...ice University Locomotion Laboratory, under the di...
(Date:5/15/2008)...d global climate change has long been a concern fo...lic policy issue, the problem of excessive reactiv...nd a growing circle of environmental scientists wh...ment and negatively alters local and global ecosys...ew papers by leading environmental scientists brin...
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(Date:5/16/2008)...hy Back Acquires Rival JoAnne,s Bed & Back; Merger... Company Owned Back Retail Chain, LORTON, Va., Ma...,company whose focus on home and workplace back we...ed all substantial assets of its rival,JoAnne,s B...division,claimed 2007 revenues of $40million. JoAn...
(Date:5/16/2008)NEW YORK, May 16 /PRNewswire/ -- There,s more to a healthy mouth than,flashing a set of pearly whites. Here,s the scoop on America,s oral care,habits - and what it means for our overall health.,
(Date:5/16/2008)...rs could report side effects, but critics want age...ay 16 (HealthDay News) -- Direct-to-consumer drug ... number that would allow consumers to report adver...day. , The experts serve on a panel that advise...e numbers are already mandated by the FDA for prin...
(Date:5/16/2008)...long Campaign to Emphasize the Importance of Oral ...wswire/ -- National dental insurer United,Concordi...llaboration,between Oral Health America and the Br...rtance of oral health to overall health. Beginning...ted States for the first time,making it the large...
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