Prognosis in Biological News

New tumor markers determine therapy intensity

... metastases at diagnosis. Patients with a poor prognosis can be treated more intensively Stefan ... material of the brain tumors, the patient's prognosis is poor. If however, one copy of chromosome 6 is ... we can reliably identify patients with a poor prognosis and treat them more intensely from the start," ...

Interleukin-8, key marker for colorectal cancer treatment

... assess the course of cancerous conditions and the prognosis of patients with respect to the development of ... IL-8 might thus be a useful tool to evaluate the prognosis of patients with CRC with meaningful consequences ... that IL-8 may serve as a useful indicator of poor prognosis and a putative target for the development of ...

New, less invasive genetic test greatly improves pregnancy rates in older women with poor prognosis

... pregnancy rate of 20%, which is exceptional considering the extremely poor prognosis of the women involved." she said. "This represents a doubling of the usual ... that the use of this technique will improve IVF success rates for poor prognosis patients. It is also likely to achieve a reduction in congenital ...

Early detection of lung cancer: New data presented at multidisciplinary meeting

... Prof Rudolf M. Huber from the University of Munich in Germany. "The prognosis of lung cancer patients is very dependent on how advanced their disease ... that they may have found a new factor that will help indicate a patient's prognosis at the time of diagnosis. Their work indicates that the expression of ...

Poor treatment for common vertebral compression fractures

... the patients are advised about exercise. "The patients are told that the prognosis is good and that most people get better after a few months, but no-one has actually investigated the prognosis and course of such acute compression fractures", says Professor Tommy ...

Fluorescent cancer cells to guide brain surgeons

... Yet, radical surgical removal of the tumor would substantially improve the prognosis of patients. Surgeons are confronted with the difficulty of discriminating ... hospitals. The scientists will monitor in a long-term study whether the prognosis of patients will improve as a result of the new method. ...

Tips from the American Journal of Pathology

... stage at which prostate cancer is diagnosed is critical for determining prognosis as well as choosing appropriate therapies. Decreased expression of the ... of intact versus cleaved galectin-3 thus might be used as a marker for prognosis of prostate cancer and a therapeutic target for the treatment of prostate ...

Gene panel predicts lung cancer survival, study finds

... stage I disease, the earliest stage, have an aggressive disease with poor prognosis while some patients with more advanced stage II disease have a relatively ... suggest that there is a potential for successfully predicting lung cancer prognosis based on gene expression, but it is likely to be more difficult to develop ...

AACR, BCRF award inaugural grants in translational breast cancer research

... genes within the MSP pathway served as highly accurate indicators of poor prognosis in patients with early breast cancer. Her current research seeks to ... test for overexpression of the MSP pathway as a biomarker for poor prognosis and to carry out preclinical tests of three MSP pathway inhibitors in ...

The way you eat may affect your risk for breast cancer

... general health benefits, maintaining an ideal body weight is also important in the specific contexts of cancer prevention and improving the prognosis of cancer patients." Based on varied findings from clinical trials, Pollak suggested that lifestyle and pharmacologic methods to reduce IGF-1 and ...

Placenta-derived stem cells may help sufferers of lung diseases

... after both xeno-and-allo-transplantation. "It is worth noting," says Dr. Parolini," that the presence of neutrophils is associated with poor prognosis for several lung diseases. However, the mechanism by which placenta-derived cells might affect infiltration by neutrophils is not known." The ...

A genetic basis for schizophrenia

... disease that is thought to have its roots in the development of the nervous system; however, major breakthroughs linking its genetics to diagnosis, prognosis and treatment are still unrealized. Jill Morris, PhD assistant professor of Pediatrics at Northwestern University's Feinberg School of Medicine and a ...

2 reproductive factors are important predictors of death from ovarian cancer

... total number of lifetime ovulatory cycles. This finding suggests that hormonal activity over the course of a woman's lifetime may influence the prognosis after an ovarian cancer diagnosis. Results of this study are published in Cancer Epidemiology, Biomarkers & Prevention , a journal of the American ...

Single thawed embryo transfer after PGD does not affect pregnancy rates

... conference: "To the best of our knowledge, our study is the first to provide reassurance that a strategy of elective single embryo transfer in good prognosis patients seeking PGD, backed by an efficient PGD cryopreservation service, can result in pregnancy rates that are comparable to those for ...

Specific genetic cause of fetal alcohol-related developmental disorders found

... "When given to the mother or newborn, this might correct the imprinting deficits induced by alcohol." "This is a promising avenue to improve the prognosis of alcohol-related neurodevelopmental disorders, for which we currently have no intervention strategy," she said. ...

Common chemotherapy drug triggers fatal allergic reactions

... "The fatal outcomes observed in patients with early-stage breast cancer were particularly striking as this is a patient population with a good prognosis that is generally treated with curative intent," said Raisch. For the report, Bennett and Raisch reviewed adverse event reports submitted to ...

Tips from the American Journal of Pathology

... Stromal Caveolin-1 Predicts Breast Cancer prognosis Two articles in the June 2009 issue of the American Journal of Pathology demonstrate the role of stromal caveolin-1 expression as a prognostic ...

LSUHSC research describes function of key protein in cancer spread

... to detach from their neighboring cells and move to and invade tissue at distant points in the body. "Because tumor metastasis leads to a poor prognosis and tremendously complicates treatment, it is of utmost importance that we understand, at a molecular level, the processes that regulate cell ...

Genetic factors may predict depression in heart disease patients

... say several mechanisms have been suggested to account for the greater prevalence of depression among cardiac patients, including the stress of a poor prognosis and systemic inflammation, although little attention has been paid to date about the possibility of a genetic cause. According to previous studies, ...

Broccoli sprouts may prevent stomach cancer by defeating Helicobacter pylori

... in H. pylori is expected to lead to a reduction in stomach cancer due to their well-established cause-and-effect link. Stomach cancer has a grim prognosis and is the second most common and the second deadliest cancer worldwide. ...

Shorter wait means longer life for kidney transplant candidates

... Ph.D., of the University of California, Los Angeles, whose group first described in the 1970s the so-called "center effect," in which a patient's prognosis depends on the center where the transplant was done. Cecka was not involved in the current research. "Unfortunately, not every patient who would ...

Unexplained chest pain can be due to stress

... the men and the women with unexplained chest pain led a more sedentary lifestyle. The thesis also looks at the development of symptoms and the prognosis for patients with unexplained chest pain over a period of time, compared with patients suffering from angina and patients who had suffered a heart ...

New technique images tumor vessel leakiness to predict breast cancer chemotherapy outcome

... of the tumor. The variability in uptake of the contrast agent by the tumors, as measured during the three-day imaging sessions, provided an accurate prognosis of the effect of liposomal doxorubicin on tumor growth rate. "When we plotted the post-treatment tumor growth rate versus the intensity of ...

Digital communication technology helps clear path to personalized therapies

... treatment regimens using only trial and error," said Dr. Paternostro. "As personalized medicine moves from the present emphasis on diagnosis and prognosis to therapy, the problem of searching for optimal drug combinations uniquely suited to the genetic and molecular profile of each patient will need to ...

Step out for PAD

... with risk factors including smoking, diabetes, obesity and high blood pressure it is on the rise. Surgical intervention can sometimes help, but the prognosis is not good. Encouragingly, new research by Ronald Terjung et al1. published in The Journal of Physiology shows that regular, moderate exercise ...

UC Davis researchers discover Achilles' heel in pancreatic cancer

... explained that average survival time for those diagnosed with pancreatic cancer is just four-and-a-half months, although chemotherapy can extend that prognosis up to six months. "There is a dire need to find new options for these patients. While our findings do not suggest a cure for pancreatic cancer, ...

U of MN study shows link between gene variations and cancer survival

... cells that produce antibodies. These results raise the possibility that a patient's genetic background exerts an important influence on the patient's prognosis and response to treatment. "Ultimately, the goal of this research is to predict drug efficacy and toxicity based on a patient's genetic profile, ...

Response to immune protein determines pathology of multiple sclerosis

... cerebellumthe part of the brain that controls sensory perception and movement. For these patients, the disease tends to progress more rapidly and the prognosis is particularly bleak. MS ensues when the body's T cells invade the brain and trigger nerve-damaging inflammation, in part by secreting proteins ...

MGH researcher Gary Ruvkun named a co-recipient of the Lasker Award

... involved in a broad range of normal and disease-related activities. Researchers have just begun exploring their potential for the diagnosis, prognosis and treatment of disorders. In addition to continuing investigation of RNA's role in controlling gene expression, Ruvkun's team studies other ...

Syntermed licenses Emory ERTb software for enhanced cardiac imaging

... related to new imaging technologies, including ERTb, at the meeting on Saturday, Sept. 13. "SPECT studies are a critical part of diagnosis and prognosis of coronary artery disease," says Garcia, who is a professor of radiology at Emory University School of Medicine. "As software imaging technologies ...

Mass. General's Warren Triennial Prize honors discoverers of microRNAs

... of these microRNAs, which are involved in a broad range of normal and pathological activities and just beginning to be explored for the diagnosis, prognosis and treatment of diseases. Ambros is a Professor of Molecular Medicine at the University of Massachusetts Medical School and Ruvkun is a Professor ...

Blood 'fingerprints' for cancer

... has the potential to transform the clinical management of various cancers and diseases through improving disease diagnosis, cancer classification, prognosis estimation, prediction of therapeutic efficacy, maintenance of surveillance following surgery, and the ability to forecast disease recurrence. The ...

CSHL scientists identify new drug target against virulent type of breast cancer

... Brk in cancer progression to good use. "We also think that Brk would be an ideal clinical marker than could be used to provide both a diagnosis and prognosis for breast cancer," said Dr. Muthuswamy. ...

Dense tissue promotes aggressive cancers

... that it's exciting to find a cellular mechanism that could explain why denser breast tissue is correlated with more aggressive tumors and a poorer prognosis for patients. "The idea that tissue rigidity leads to a more aggressive phenotype had been out there for a while," she said, "but it hadn't actually ...

A recipe for saving the world's oceans from an extinction crisis

... never be certain about every detail, and it would be irresponsible to remain silent in the face of what we already know." Despite Jackson's bleak prognosis for a "brave new ocean," he clearly identifies "lack of political will and the greed of special interests" as standing in the way of establishing ...

Oceans on the precipice: Scripps scientist warns of mass extinctions and 'rise of slime'

... rapid spiral, and only prompt and wholesale changes will slow or perhaps ultimately reverse the catastrophic problems they are facing. Such is the prognosis of Jeremy Jackson, a professor of oceanography at Scripps Institution of Oceanography at UC San Diego, in a bold new assessment of the oceans and ...

Study reveals air pollution is causing widespread and serious impacts to ecosystems

... range of habitat types (see inset). The majority of recent studies focus on one individual pollutant. Over 32 experts contributed to the effort; the prognosis is not good. "Everywhere we looked, we found evidence of air pollution harming natural resources," comments Dr. Gary M. Lovett, an ecologist at ...

Predicting acute GVHD by gene expression could improve liver stem cell transplant outcomes

... drugs, acute GVHD can develop within 100 days post-transplant. Where tissue damage in the skin, liver and gastrointestinal tract is extensive, prognosis can be poor. Although clinicians can identify a well-defined pathophysiological mechanism for acute graft-versus-host disease (GVHD), being able to ...

UCLA researchers locate and image prostate cancer as it spreads to lymph nodes

... cancer is treated. "It would represent a treatment advance in patients for whom outcome is not good," Wu said. "This would help improve the prognosis for these patients by letting us find and treat these metastases early. If we can catch the cancer before it invades other organs, we have a better ...

Treatment delays result in poor outcomes for men with breast cancer

... characteristics." If treated early enough, the disease is highly responsive to hormone therapy, Dr. Garassino said. In those cases, the prognosis may even be better than in women, she added. An ongoing case-control trial is examining this suggestion. "What is important for people to know is ...