Phase in Biological News

First human gets new antibody aimed at hepatitis C virus

... School (UMMS) today announced the beginning of a phase 1 clinical trial, testing the safety and activity ... the next step in this program, which will be a phase 2 study in liver transplant patients." HCV ... who have volunteered to participate in this phase 1 study. These subjects' participation will help ...

Stanford researchers publish comprehensive model for medical device development

... major phases and decision gates include: phase 1/Gate 1: Initiation, opportunity, and risk analysis. phase 2/Gate 2: Formulation, concept, and feasibility. phase 3/Gate 3: Design, development, verification, and ...

DuoCort: New chronotherapy for adrenal insufficiency

... b3c newswire / - DuoCort publishes data from its phase I study for the rare and life threatening disease ... improve outcomes for patients. Results from the phase I study in healthy volunteers, evaluating the ... adrenal insufficiency. Data from a subsequent phase II/III trial in patients with primary adrenal ...

NIH expands Human Microbiome Project; funds sequencing centers and disease projects

... centers that participated in the initial phase of the project. These centers will work together ... Mass., which participated in the jumpstart phase of the Human Microbiome Project, is expected to participate in this phase of the project. The Human Microbiome Project ...

Caltech scientists reveal how neuronal activity is timed in brain's memory-making circuits

... fired relative to the rat's position and to the phase of the theta oscillations. They did these studies ... just happen any timethey pay attention to the phase of the ongoing theta oscillation. If you have access to the phase at which the neuron fired, you have additional ...

Conservationists seek to identify prime stopover sites for migrating birds

... extent and diversity of wood cover. A pilot phase funded with $35,000 from the Nature Conservancy ... three-year effort begins in the fall. The next phase will focus on 72 sites selected by the model ... extent and diversity of wood cover. The follow-up phase to the site-identification project may involve ...

Lyncean Technologies Inc. receives $1.2 M from NCRR to develop new imaging technique

... Lyncean Technologies, Inc. has just received a phase I SBIR grant of $1,296,403 from the National ... Resources (NCRR) to develop "Differential phase Contrast Imaging" using the unique x-ray beam ... beam employed a technique called Differential phase Contrast Imaging (DPCI) developed by Professor ...

Clinical trials for shingles drug take an important step forward

... by scientists based at Cardiff University, a phase II clinical trial with FV-100 has recently been ... to make it to the marketplace." In phase I trials of FV-100, Inhibitex reported no serious ... Inhibitex anticipates completing its first phase II trial of FV-100 in the first half of 2010. ...

Biolex presents Locteron US Phase 2a hepatitis C data at EASL

... announced that the results from its United States phase 2a clinical trial (the "PLUS" trial) of Locteron ... commencement of patient dosing in the SELECT-2, a phase 2b trial of Locteron in the United States and Europe. The PLUS phase 2a clinical trial was conducted in 32 chronic ...

Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies

... lead anti-PS antibody bavituximab is currently in phase II clinical trials in advanced breast and lung ... Bavituximab currently is in two separate phase II combination therapy trials for the treatment of advanced breast cancer and a phase II combination therapy trial for the treatment of ...

New drug shows promise in treating drug-resistant prostate cancer

... trials. The drug has successfully completed phase 1 and phase 2 clinical trials, and the Food and Drug ... to begin what Jung described as "the pivotal phase 3 clinical trials." The results of clinical ...

Bird feathers produce color through structure similar to beer foam

... to examples of materials undergoing phase separation, in which mixtures of different ... as the bubbles grow. I think our hypothesis that phase separation is involved provides less opportunity ... to think about other ways birds might be using phase separation." Eric Dufresne, lead author of the ...

UC Davis bench-to-bedside research: Promising treatment in clinical trials

... hypertension and inflammatory has entered phase II of human clinical trials to evaluate its ... Motrin and other are active," he said. phase 1 evaluated the safety, safe dosage range and side effects of the drug candidate. It then entered phase IIa. UC Davis physicians and scientists ...

CellThera and WPI advance in regeneration study

... "We are very pleased to be moving into the next phase of this work," said Raymond Page, PhD, research ... established in 2006, when DARPA funded the first phase of the tissue regeneration program. In that initial phase of the research, the CellThera/WPI team, working ...

Lancet study supports new, highly effective treatment for blood disorder

... results of an international, multicenter phase III clinical trial, led by ... Medical College. The study follows a previous phase II study published late 2007 in the New England ... bleeding in adult subjects with chronic ITP. The phase II study's results also determined the most ...

An end to fear

... was that the memory is established after this phase and can, therefore, no longer be altered. ... the memory and so there is once again a labile phase at that moment. The researchers managed to ... elicited any emotional response. In the next phase of the research, Kindt and her colleagues shall ...

After a few drinks, older adults more impaired than they think

... to a peak, then dissipates. During the first phase of the metabolic process, alcohol has a ... a sedative or depressive effect. During each phase at 25 minutes and 75 minutes after alcohol ... they didn't think they were. And in the second phase an hour and 15 minutes after having alcohol ...

Forget the freezer: Research suggests novel way to control water behavior

... unknown. "This research suggests the idea that phase transitions can be controlled by understanding ... the simulations demonstrated a previously unknown phase of water consisting of a layer of mobile water ... at room temperature. The "ice sandwich" phase persisted throughout the length of the ...

Acorda Therapeutics submits new drug application for Fampridine-SR in multiple sclerosis

... and efficacy of Fampridine-SR, including two phase 3 trials that involved 540 people with MS and ... profile of Fampridine-SR was consistent across phase 2 and phase 3 trials. Overall, the NDA filing included more ...

TGen Clinical Research Services at Scottsdale Healthcare and Mayo Clinic study new cancer drug

... contribute to relapse," Dr. Weiss said. phase 1 and phase 1/2 trials are underway to investigate the safety ... evidence of tumor activity was observed in the phase 1 trial in patients with advanced melanoma both ...

TGen, Scottsdale Healthcare, Mayo Clinic study new drug to stimulate immune system of cancer victims

... of activity,'' Dr. Ramanathan said. The phase I trial, a yearlong first-in-humans test, will study the drug's safety. If successful, a phase II trial will test the drug's effectiveness on ... and Chief Business Officer at VentiRx. "Entering phase I clinical trials represents a significant ...

Montana State partnership receives $66.9M for carbon sequestration

... Wyoming. The award marks the third and final phase of federal funding for the Big Sky partnership, ... The award will allow the partnership to begin its phase III project, a commercial-scale, eight-year ... of CO 2 . The Big Sky partnership will use the phase III project to demonstrate that underground ...

Positive results in Phase 2 trial of treatment of C-difficile-associated diarrhea

... Medical School (UMMS) today announced that a phase 2 trial of an anti- C. difficile antibody ... randomized, double-blind, placebo-controlled phase 2 trial indicated a statistically significant ... safe and well-tolerated. Full results from this phase 2 trial are planned to be presented at a future ...

Bayhill Therapeutics and the Juvenile Diabetes Research Foundation announce research collaboration

... a partnership to support Bayhill's ongoing phase I/II human clinical trial of BHT-3021, a DNA ... JDRF will provide up to $3 million toward the phase I/II clinical trial. Funding will be based on ... Patient enrollment is currently underway in a phase I/II placebo-controlled clinical trial of ...

Phase III data show efficacy/safety of iclaprim in patients with complicated skin infections

... presented the combined results from two pivotal phase III clinical trials at the 48th Interscience ... Skin and Skin Structure Infection STudy) pivotal phase III studies involving a total of 991 patients. In ... and well-tolerated at a dose of 0.8 mg/kg in the phase III ASSIST trials. Adverse events were found to ...

Singapore opens Fusionopolis, its second major R&D hub in 5 years

... Two research institutes have moved into phase 1 of the development, and another four will move ... 13 corporate laboratories, which are located at phase 1 of the development. These include Vestas, ... 800 scientists, engineers and game developers in phase 1 of Fusionopolis. This number will increase to ...

Decline in Alaskan sea otters affects bald eagles' diet

... at Santa Cruz. "The otter decline has caused a phase shift in the coastal ecosystem from a kelp dominated phase state to a deforested phase state." This shift means many fewer kelp ...

Sweat it out: UH study examines ability of sweat patches to monitor bone loss

... a read-out to the user," said Clarke. The first phase of the study will determine if sweat can be used ... with bone loss. The last phase of the study will look specifically at the MSP ... performed in the department. Clarke expects this phase of the project to span at least eight months. ...

Media invitation: 20th EORTC-NCI-ACR Symposium on Molecular Targets and Cancer Therapeutics

... New "spindle poisoning" drug shows promise in phase I trial of solid tumours: phase II trials planned; Scientists discover ... disease, including medullary thyroid cancer. phase III trials planned; Researchers discover that ...

PTC124 shows activity in cystic fibrosis; Phase 2 proof-of-concept data published in Lancet

... SOUTH PLAINFIELD, NJ August 20, 2008 New phase 2 data published today in The Lancet show that ... PRODUCTION OF CFTR PROTEIN IN PATIENTS This phase 2 Israeli study enrolled 23 adult patients ... "Based on these results, we intend to initiate a phase 2b study later this year to evaluate the clinical ...

Ikaria(R) Receives FDA Orphan Drug Designation for Inhaled Carbon Monoxide for Delayed Graft Function in Solid Organ Transplants

... single-blind, placebo controlled, dose-escalating phase 2 study of inhaled carbon monoxide in ... INOmax product, Ikaria is engaged in a number of phase 2 trials with Covox(R) (carbon monoxide) for inhalation and phase 1 trials with hydrogen sulfide (H2S) for various ...

Caltech scientists awarded $20 million to 'Power the Planet'

... closer to reality. In 2005, NSF granted three phase I CBC awards. Gray formed a group of Caltech and ... who spent the $1.5 million and three years of phase I conducting initial research and establishing ... outreach plans for their idea. Of the three phase I projects, Caltech's is the only one to advance ...

Ikaria(R) Receives FDA Orphan Drug Designation for Inhaled Carbon Monoxide for Delayed Graft Function in Solid Organ Transplants

... single-blind, placebo controlled, dose-escalating phase 2 study of inhaled carbon monoxide in ... INOmax product, Ikaria is engaged in a number of phase 2 trials with Covox(R) (carbon monoxide) for inhalation and phase 1 trials with hydrogen sulfide (H2S) for various ...

Prostate cancer vaccines more effective with hormone therapy

... said Arlen. Building on the results of this phase II study, researchers have developed another ... this one are adding to our knowledge, and other phase III trials are getting ready to publish their data," said Arlen. "If the phase II data hold up ...

A gentle touch for better control, a quantum mechanical con, and milestone PRL papers

... the 1982 Nobel Prize in physics for his theory of phase transitions based on what is called the ... 1982 press release. Evidence for a New phase of Solid He3 D. D. Osheroff, R. C. Richardson, ... Osheroff, Richardson, and Lee were looking for a phase transition to a kind of magnetic order in solid ...

Ozone hole recovery may reshape southern hemisphere climate change

... patterns are collectively known as a positive phase of the Southern Annular Mode, or SAM. The ... gradient that currently favors the positive phase of SAM, said the research team. The ... well. Other studies have shown that the positive phase of SAM is associated with cooler temperatures ...

2 new therapies show promise for cancer patients

... promise for patients battling cancer. The phase I clinical trial findings, presented at the this ... by other investigators, was the basis for this phase I clinical trial that Von Hoff presented at AACR. ... eventually be a 42-patient trial. This was a phase I trial, ...

AACR annual meeting showcases developments in understanding and targeting cancers

... to the clinic. Special sessions will also feature phase I and phase II studies of novel therapeutic agents in early stage clinical trials, as well as late-breaking phase III clinical trial data. "We are in an ...

Eat less or exercise more? Either way leads to more youthful hearts

... youthful state so that during the heart's filling phase (called diastole) it took less time for ... to measure the diastolic or filling phase of the cardiac cycle because it is a crucial ... horn you squeeze it (the analog of the ejection phase of the cardiac cycle), then let go (the analog of ...

University-industry team developing coal cleaning technology in India

... of the dry beneficiation processes in India. In phase 1, a pilot-scale deshaling unit with a maximum ... at different mine sites and/or power plants. In phase 2, a detailed flow sheet and engineering diagrams ... plant in India. The successful completion of phase 2 will constitute a fully operational and ...