Peripheral in Biological News

New origin found for a critical immune response

... the dendritic cells were thought to move from peripheral tissues into lymph nodes to stimulate T cell ... that stimulate TH1 responses didn't come from peripheral tissues, but rather arose from monocytes, a ... the migration of activated dendritic cells from peripheral tissues to lymph nodes. The Duke researchers ...

Society of Interventional Radiology hosts 34th annual scientific meeting

... prostate and bone cancer; herniated disks; peripheral arterial disease (PAD) and related complications; ... Tuesday, March 10, 2009, 9 a.m. Eastern) peripheral Arterial Disease (PAD) Treating peripheral Arterial Disease: Stem Cell Therapy Advances ...

Nicotine activates more than just the brain's pleasure pathways

... "This is the first study to explore both the peripheral taste pathways activated by nicotine, and how ... integrated in sensory areas of the brain." The peripheral nervous system refers to nerves that are outside ... to nicotine and a capacity to integrate diverse peripheral information to create a unique sensory ...

Weill Cornell science briefs June/July 2008

... a drug previously used for depression to treat peripheral neuropathy. Diabetics often suffer from this ... sugar levels that damage nerve cells. Those with peripheral neuropathy often endure chronic pain, cramping ... with diabetes for at least one-year and who have peripheral neuropathy. For more information: Please ...

Eribulin mesylate demonstrated anti-tumor activity in patients with advanced breast cancer

... eribulin mesylate. Patients with up to Grade 2 peripheral neuropathy were included in the study. The most ... (10%; no Grade 4 events). Grade 3 peripheral neuropathy (a functional disturbance or damage to ... was reported in 5.5% of patients. No Grade 4 peripheral neuropathy events were reported. No correlation ...

Origin of cells for connective tissues of skull and face challenged

... where they spawn the cells that create the peripheral nervous system, and pigment cells in skin and ... mice that adversely affected development of the peripheral nervous system or pigmentation did not affect ... did not alter neural crest-derived pigment or peripheral nervous system cells. This paradox, he said, ...

Tumor-targeting viral therapy slows neuroblastoma, malignant peripheral nerve sheath tumors

... stubborn solid tumor cancers neuroblastoma and peripheral nerve sheath tumors without harming healthy ... and mice designed to develop neuroblastoma or peripheral nerve sheath tumors, rQT3 reduced new blood ... patients with high-risk neuroblastoma. Malignant peripheral nerve sheath tumors are cancers affecting the ...

Will IVF work for a particular patient? The answer may be found in her blood

... team chose to examine the gene expression patterns in RNA extracted from peripheral (circulating) blood, an easily accessible biological sample. Blood samples ... with those who did not," she said. The researchers found that the peripheral blood gene expression 'signature' (also known as the transcriptome) before ...

Fate in fly sensory organ precursor cells could explain human immune disorder

... begins with the Notch pathway, which controls cell fate. In the fly peripheral nervous system, two daughter cells arise from a single sensory organ ... cell division. In a screen of fruit fly mutants that have disrupted peripheral nervous system development, Akhila Rajan and An-chi Tien, two graduate ...

Peripheral nerve repair with fat precursor cells led to wider nerves and less muscle atrophy

... (USA) used biodegradable nerve guides to transplant APCs into the injured peripheral nerves of laboratory rats. "Adipose tissues, shown to be multipotent, ... transplanted human-derived APCs survived for up to 12 weeks in the injured peripheral nerve and formed a more robust nerve with nerve cells more than double the ...

When every photon counts

... whereas the less compacted euchromatin with the active DNA regions forms a peripheral shell. This unusual nuclear architecture is explained by the ... and with the transcription apparatus in three dimensions; euchromatin in a peripheral shell factually has only two dimensions for contacts. However, in ...

Risk of vibration-induced vascular injuries linked to vibration frequency differences

... responses, but both may affect the risk of developing vibration-induced peripheral vascular dysfunction. Of the 1.1 to 1.5 million U.S. workers exposed ... frequency vibration are associated with more immediate changes in the peripheral vascular system, such as those seen in workers with vibration injury, says ...

Amniotic fluid may provide new source of stem cells for future therapies

... the primary source for hematopoietic cells in developing embryos. The peripheral blood of the transplanted mice was examined every four weeks, and after ... mice were also taken and injected in a second set of mice and the peripheral blood of this new group of irradiated mice was analyzed and their ...

A missing enzyme conveys major heart protection in pre-clinical work

... of natural bypass in humans. Perhaps it could also benefit patients with peripheral artery disease, who cannot walk, for example, but who might be able to ... Stamler said his research group might look into the question of improving peripheral artery disease. "Normally if you block the major artery to a heart, ...

Spun-sugar fibers spawn sweet technique for nerve repair

... the technique. The researchers are initially concentrating on the peripheral nerves found in the limbs and throughout the body because nerve regeneration is more complex in the spinal cord. About 800,000 peripheral nerve injuries are reported annually in the United States, with about ...

Study on wildlife corridors shows how they work over time

... of central square "patch" of habitat that is connected by a corridor to a peripheral square habitat patch. There are also two other types of peripheral patches that help determine how corridors work. Unconnected "rectangular" ...

NC State first university in nation to offer canine bone marrow transplants

... to kill residual cancer cells left in the body. This treatment is called peripheral blood stem cell transplantation. The machines, once used for human ... in dogs, but the survival rate with current treatments is extremely low. peripheral blood stem cell transplantation, in conjunction with chemotherapy, has ...

At risk for peripheral arterial disease? Simple quiz provides key so you can circulate better

... FAIRFAX, Va.Ten million Americans have peripheral arterial disease (PAD), and research shows that the highest risk ... with the early detection of PAD. "Early detection and management of peripheral arterial disease, or PAD, can prevent its progression and help prevent ...

Engineer develops detergent to promote peripheral nerve healing

... suffering nerve injuries have received AVANCE grafts, all involving peripheral nerves which transmit sensory information between the brain and muscles. ... is conducting spinal-cord lab testing in animals using detergent-treated peripheral nerve grafts. She is working with post-doctoral fellow Zin Khaing, a ...

UC Davis researchers discover how HIV turns food-poisoning into lethal infection

... invaders, like Salmonella. Unlike the steady decline of T cells in peripheral blood, there is a very rapid loss of CD4+ T cells in the gut mucosa, ... muted Th17 response led to dissemination of Salmonella from the gut to the peripheral blood, Dandekar said. The team of researchers also used mice that ...

Mutation may cause inherited neuropathy

... clues leading to better treatments for a human nerve disorder known as peripheral neuropathy, which affects about three percent of all those over age 60. peripheral neuropathy results from damage to the nerves and nerve processes that are ...

USC biomedical team to participate in $6 million low vision project

... help these people, who have lost their central vision and must rely on peripheral vision to see. We plan to use some of the techniques of computer ... Once that region is damaged, an individual can only see in the peripheral region of the retina, which has far fewer cone photoreceptors and can only ...

Study shows cancer vaccines led to long-term survival for patients with metastatic melanoma

... three times a week and then monthly for five months for a total of up to eight injections. The patient's dendritic cells were obtained from their peripheral blood and mixed with a cell culture of the patient's own melanoma cells that had been self-renewing and proliferating in the laboratory. The ...

A genetic basis for schizophrenia

... in cranial neural crest (CNC) cells, which are multi-potent cells that give rise to multiple cell types including craniofacial cartilage and the peripheral nervous system during development. They also are similar to neurons in their high mobility, response to signals and cellular origin. The Morris ...

Researchers design first model motor nerve system that's insulated and organized like the human body

... myelination using the growth medium they have worked with for many years. In the body, nerve cells grow in two distinct environments: In the peripheral nervous system (PNS), cells are exposed to blood and other fluids that contain high concentrations of protein, among various other constituents, ...

Journal of Vascular and Interventional Radiology increases impact, international reach

... estimate the frequency with which an average article in a journal is cited. Additionally, JVIR ranks in the top half of 56 journals in the field of peripheral arterial disease, and its five-year impact factor is 2.956, based on citations in 2008 to items published from 2003-07. ...

Structural biology scores with protein snapshot

... in protein folding because of their work with DAGK, are now pursuing structural studies of misfolded membrane proteins that cause diseases including peripheral neuropathy (Charcot-Marie-Tooth Disease), diabetes insipidus and Alzheimer's disease. "For proteins that misfold because of mutations, we're using ...

Caltech researchers explore how cells reconcile mixed messages in decisions about growth

... prompt those cells to divide. Thus, it's possible to find a level of growth factor that will override the contact inhibition signal only for the peripheral cells, and then to find a second level that will allow division throughout the cluster. In other words, says Asthagiri, "You can tune the system; you ...

New supplement may help slow sight loss in elderly

... late AMD. When the eye disease progresses to late AMD patients are unable to read, watch television or recognise people's faces as they only have peripheral vision, not central vision. Professor Chakravarthy, who is also a Consultant Ophthalmic Surgeon at the Royal Hospital in Belfast, said: "Late AMD ...

Crustacean shell with polyester creates mixed-fiber material for nerve repair

... author of a paper now available online in the journal Advanced Materials . "This turns out to be very difficult." After an injury that severs a peripheral nerve, such as one in a finger, nerve endings continue to grow. But to regain control of the nerve surgeons must join the two fragments. For large ...

USC researchers present diabetes findings at American Diabetes Association Scientific Sessions

... will take place on Sunday, June 7 (Session: Beyond the Hypothalamus Other Sites Involved in Sensing and Responding to Recurrent Hypoglycemia; peripheral vs. Central Sensors Importance of Rate of Glucose Drop). Genetics Richard Watanabe, Ph.D., associate professor of preventive medicine, will ...

Scholar unconvinced new lie-detection methods better than old ones

... "And they would argue that (with) fMRI, since it's scanning the brain, we're getting closer to the central nervous system, not dealing with the peripheral nervous system. We're dealing with what some say is 'the organ of deceit' where the lies are happening." But according to Littlefield, the old ...

Society of Interventional Radiology Foundation awards $191,000 in grants

... This year's three recipients are Rajoo Dhangana, M.D., Rhode Island Hospital, Providence, R.I., "The LEAD Interventions Study (Lower Extremity peripheral Arterial Disease Interventions: Percutaneous-first Approach vs. Surgical-first Approach and Their Impact on Amputation Volumes Among Medicare ...

Protein identified as critical to insulating the body's wiring could also become treatment target

... College of Georgia researchers say. They report this week in Proceedings of the National Academy of Sciences Online Early Edition that in the peripheral nervous system that controls arms and legs, the protein erbin regulates the protein neuregulin 1, stabilizing and interacting with the ErbB2 receptor ...

Laughing hyenas, wailing levees, the sound of cheese and blaring bagpipes

... a gene for vascular endothelial growth factor. This therapeutic use could be important for treating ischemia in patients who have had a heart attack, peripheral artery disease, or stroke. The team is also investigating using the bubbles to transport small doses of drugs. "If you're trying to deliver a ...

ASBMB Annual Meeting to feature talks on the biochemistry of aging

... linked to this response, providing evidence that efforts in humans just might work. The Role of Insulin-like Signaling for the Central and peripheral Regulation of Nutrient Homeostasis and Life Span Morris White, Children's Hospital Boston, MA (Tue, April 21 3:30 PM - 5:50 PM, Room: 356) ...

Smoke from cigarettes, cooking oil, wood, shift male cardiovascular system into overdrive

... Results The study found that, particularly among men, exposure to smoke changed breathing patterns, raised blood pressure oscillations in peripheral arteries and shifted control of heart rate toward sympathetic domination. The sympathetic nervous system becomes active during times of stress, but ...

Smoke from cigarettes, cooking oil, wood, shift male cardiovascular system into overdrive

... Results The study found that, particularly among men, exposure to smoke changed breathing patterns, raised blood pressure oscillations in peripheral arteries and shifted control of heart rate toward sympathetic domination. The sympathetic nervous system becomes active during times of stress, but ...

Feather color is more than skin deep

... feather pigment of male crossbills in the birds' liver and blood, implying that the carotenoids are synthesized in the liver and then travel to the peripheral tissues via the bloodstream. Del Val concludes: "This surprising divergence with previous studies raises the question whether there are ...

Orientation of antenna protein in photosynthetic bacteria described

... with scarce visible light, the membrane-attached Fenna-Matthews-Olson (FMO) antenna protein serves as a sort of wire connecting the large peripheral chlorosome antenna complex with the organism's reaction center. These bacteria are related to extreme heat-loving bacteria that live at thermal vents ...