Pancreatic in Biological News

Stem cell research: From molecular physiology to therapeutic applications

... Parkinson's disease and his research using pancreatic progenitor cells for treating diabetes has ... of human embryonic stem cells into pancreatic beta cells to treat diabetes. He is one of the ... stem cell differentiation into functional pancreatic islet cells and discusses the challenges for ...

USC researchers present diabetes findings at American Diabetes Association Scientific Sessions

... avoid "post exercise hypoglycemia," the role of pancreatic beta cells in the progression of diabetes, and ... and Post-Exercise Induced Hypoglycemia). pancreatic Beta Cell Mass in Development of Diabetes Tom ... Center will discuss his research on the role of pancreatic beta cell mass in the regulation of blood sugar, ...

Newly discovered epidermal growth factor receptor active in human pancreatic cancers

... Finally some promising news about pancreatic cancer, one of the most fatal cancers, due to the ... active in approximately a third of the 250 human pancreatic cancers studied. In a presentation April ... of both a new treatment for a large subset of pancreatic cancers and a potential blood or urine screening ...

Compendium of pancreatic cancer biomarkers established as strategic approach to early-detection

... that might herald the furtive presence of pancreatic cancer. With limited resources available for ... literature to amass 2,516 potential biomarkers of pancreatic cancer, Pandey and his team are publishing their ... the genes and proteins that are overexpressed in pancreatic cancer patients, then characterized and compared ...

HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection

... mitochondrial SOD levels remained unaffected in pancreatic beta-cells (INS-1 cells) exposed to nelfinavir. ... HIV-1 protease inhibitor on insulin production by pancreatic beta-cells and they further investigated the ... mitochondrial antioxidant. Indeed pretreatment of pancreatic beta-cells with thymoquinone caused a reversal of ...

Tiny samples could yield big predictive markers for pancreatic cancer

... studies, could represent reliable indicators of pancreatic cancer or precancerous pancreatic lesions, which would allow for earlier, perhaps ... technologies have become very good at identifying pancreatic cysts when they appear, but we know very little ...

U-M researchers ID gene involved in pancreatic cancer

... a gene that is overexpressed in 90 percent of pancreatic cancers, the most deadly type of cancer. ... called ATDC, is on average 20 times higher in pancreatic cancer cells than in cells from a normal pancreas. What's more, the gene appears to make pancreatic cancer cells resistant to current therapies. ...

DNA repair patterns may predict risk of pancreatic cancer

... in DNA repair patterns may increase risk of pancreatic cancer by as much as threefold or decrease it by ... the American Association for Cancer Research. pancreatic cancer is often identified in late stages, and ... of seven DNA repair genes among 734 patients with pancreatic cancer and 780 people without cancer. DNA repair ...

Researchers engineer pancreatic cell transplants to evade immune response

... a technique for transplanting insulin-producing pancreatic cells that causes only a minimal immune response ... immune system mistakenly destroys the body's own pancreatic beta cells. Beta cells produce insulin, which ... the new cells replace the recipients' destroyed pancreatic beta cells. Although such transplants can control ...

New scientific knowledge on juvenile diabetes

... the immune system attacks the insulin producing pancreatic beta cells. The gradual loss of beta cells ... has been the development of autoimmunity to pancreatic beta cells in the measurable form of islet ... several months prior to autoimmunity to pancreatic beta cells. The metabolic profile was partially ...

UC Davis researchers discover Achilles' heel in pancreatic cancer

... have discovered a metabolic deficiency in pancreatic cancer cells that can be used to slow the ... Journal of Cancer , study results indicate that pancreatic cancer cells cannot produce the amino acid ... models, the team was able to significantly reduce pancreatic cancer-cell proliferation. "There have been ...

Bayhill Therapeutics and the Juvenile Diabetes Research Foundation announce research collaboration

... diabetes, and slow down or halt further loss of pancreatic beta cell function. "We are very pleased to ... safety, pharmacodynamics, immune tolerance and pancreatic function in patients with T1D. Preliminary data ... as well as the induction of immune tolerance to pancreatic autoantigens. Clinical Trial Criteria Key ...

Jefferson Department of Surgery announces new pancreas tumor registry

... of the registry is to further study whether pancreatic cancer occurs more frequently in families with a ... and occupational risk factors to which pancreatic cancer patients have been exposed." The JPTR ... scientific and epidemiological breakthroughs in pancreatic cancer. Participants are asked to complete a ...

Where optics meets medicine

... Potential Non-Invasive Optical Detection of pancreatic Cancer A NEW LOOK AT MINI-STROKES Like a ... POTENTIAL NON-INVASIVE OPTICAL DETECTION OF pancreatic CANCER At the University of Michigan, a ... and treatment to produce better patient outcomes. pancreatic cancer is the fourth leading cause of cancer ...

Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells

... Jefferson, has achieved a substantial "kill" of pancreatic cancer cells by using nanoparticles to ... time this unique strategy has been tested in pancreatic cancer cells, and the success seen offers promise ... toxin gene inhibited a basic function of pancreatic tumor cells by over 95 percent, resulting in ...

New studies on the Mediterranean diet confirm its effectiveness for chronic disease prevention

... these works, there is a new research line about pancreatic cancer cells. Emilio Martnez de Victoria Muoz, ... of the Mediterranean diet on a cell line on pancreatic cancer cells' (UGR-Junta de Andaluca) they have ... themselves from the aggressions which cause pancreatic alterations". The objective is to expose olive ...

TG2 identified as potential therapeutic target in chemo-resistant ovarian cancer

... and metastatic melanoma, breast cancer and pancreatic cancer. "Drug resistance and metastasis are ... Therapeutics at M. D. Anderson. TG2 fuels pancreatic cancer differently Sood and Lopez-Berestein, ... toward Phase I clinical trials for ovarian and pancreatic cancers. TG2 acts through different pathways ...

Cellular self-eating promotes pancreatitis

... mice with pancreatitis the level of autophagy in pancreatic cells surges. Pancreatitis occurs when the enzyme trypsin dissolves cells from within. Normally, pancreatic cells fashion and discharge an inactive form of ... before its release, it can damage or kill a pancreatic cell. Hashimoto et al. tested whether autophagy ...

Mouse model developed at UT Southwestern mimics hyperglycemia, aids in diabetes research

... engineered a laboratory mouse in which pancreatic beta cells can regenerate after being induced to ... develops when the body's immune system destroys pancreatic beta cells, as well as in type 2 diabetes, where ... genetically manipulated mature, insulin-positive pancreatic beta cells in the PANIC-ATTAC mice so that these ...

2 new therapies show promise for cancer patients

... FACG, focused on basal cell carcinoma (BCC) and pancreatic cancer. The Arizona trials were conducted at ... Karmanos Cancer Institute, Detroit, Michigan. pancreatic Cancer In the second trial, Von Hoff and ... clinical benefit in more than 80 percent of pancreatic cancer patients. Unfortunately, most patients ...

Stem cell breakthrough offers diabetes hope

... embryonic stem cells into insulin-producing pancreatic tissue in what could prove a significant ... particular condition in the case of diabetes, pancreatic cells. Unprompted, the majority of stem cells ... cells would normally become insulin-producing pancreatic cells, so the challenge has been to find a way of ...

Mounting evidence shows red wine antioxidant kills cancer

... in grape skins and red wine can help destroy pancreatic cancer cells by reaching to the cell's core ... Biology. The study also showed that when the pancreatic cancer cells were doubly assaulted -- pre-treated ... stops the cancer. Researchers divided pancreatic cancer cells into two groups: cells treated ...

Taking the fight against cancer to heart

... Hormones produced by the heart eliminated human pancreatic cancer in more than three-quarters of the mice ... Using colon, ovarian, breast, prostate and pancreatic cancer cells, among others, Vesely found that the ... turned to trials with mice, injecting some with pancreatic cancer cells and others with breast cancer cells. ...

Mesothelin engineered on virus-like particles provides treatment clues for pancreatic cancer

... of a protein that spurs the growth of pancreatic cancer could lead to a new vaccine against the ... appears to play an important role in promoting pancreatic cancer growth, said the senior author Dr. Qizhi ... BCM. However, we didnt know the role it played in pancreatic cancer: until she and her colleagues reported in ...

Naturally-occurring apple compounds reduce risk of pancreatic cancer

... foods like apples may help reduce the risk of pancreatic cancer, says a team of international researchers. ... flavonols in preventing and reducing the risk of pancreatic cancer. Although the overall risk was reduced ... found specifically in plants on developing pancreatic cancer. According to the research paper, only a ...

Birth records hold pancreatic cancer clue

... 1960s and 1970s may hold vital clues about how pancreatic cancer and diabetes are linked. According to ... diabetes had a higher risk of developing pancreatic cancer later in life. The research team drawn ... gestational diabetes, five eventually developed pancreatic cancer. There were 54 cases ...

Low levels of key protein may indicate pancreatic cancer risk

... predict which people are at increased risk for pancreatic cancer, new research by Dana-Farber Cancer ... called IGFBP-1 were twice as likely to develop pancreatic cancer as those with higher levels. Though much ... binding protein-1 -- is a reliable indicator of pancreatic cancer risk, the finding adds to the scientific ...

Obesity and lack of exercise could enhance the risk of pancreatic cancer

... an indicator for an increased risk of developing pancreatic cancer. Researchers from the Dana Farber Cancer ... Research. In a study of 144 patients with pancreatic cancer and 429 people without the disease, a ... at approximately twice the risk of developing pancreatic cancer. Low blood levels of this protein have ...

LSUHSC student awarded top national honor for diabetes research

... that the improvement in glucose stability could be achieved by enhancing pancreatic beta cell function. Beta cells are located in islet cell clusters ... the LSUHSC research team found that ACE2 gene therapy improves pancreatic beta cell function and restores glucose stability by increasing the ...

Human adult testes cells can become embryonic-like

... of morphing into any cell type that a body needs, from brain neurons to pancreatic tissue. And because they produced these stem cells without the use of ... that uses testes spermatogonial stem/progenitor cells that morphed into pancreatic cells to treat diabetes in mouse models of human diabetes. ...

TGen's Dr. Von Hoff wins award for cancer research

... Hoff, a world-renowned cancer scientist and one of the leading experts in pancreatic cancer. In November, Dr. Von Hoff was named Arizona's Community Service ... many of which have been shown to increase patient survival. Study of pancreatic and other forms of cancer. Dedication to teaching. Entrepreneurial ...

New journal shows half-broken gene is enough to cause cancer

... that only one allele of SMAD4 has to be damaged to put a person at risk of pancreatic and colorectal cancer. Riccardo Fodde led a team of researchers from ... Rotterdam, who investigated SMAD4, a tumor suppressor gene implicated in pancreatic and colorectal cancer. They found that having one mutated SMAD4 allele was ...

4 Stanford faculty named Howard Hughes Medical Institute Investigators

... that research into treatments for diseases, such as diabetes and pancreatic cancer. He works with stem and progenitor cells to replace pancreatic function, studies how insulin-producing beta cells proliferate and ...

Protein handlers should be effective treatment target for cancer and Alzheimer's

... that control some of them, disables tumor formation in the liver and probably the breast. Researchers are also now examining brain tumors as well as pancreatic and prostate cancer. They also want to know whether ramping up the activity of molecular chaperone can essentially make them act young again and ...

Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers

... that binds to it, the growth factor pleiotrophin (PTN), are both also over-expressed in other difficult-to-treat cancers, such as melanoma and pancreatic tumors. "We have found that PTN drives metastasis of those cancers, suggesting that antibody treatment may be additionally useful in those cancers," ...

Fox Chase researchers uncover one force behind the MYC oncogene in many cancers

... promotes the activity of a gene known as MYC, which evidence has demonstrated is a potent factor in numerous cancers, including lymphoma, lung and pancreatic cancer. Their studies were performed in mouse cancer models and in human cell cultures. "While MYC has a definite role in cancer, MYC also has an ...

'Normal' cells far from cancer give nanosignals of trouble

... A new Northwestern University-led study of human colon, pancreatic and lung cells is the first to report that cancer cells and their non-cancerous cell neighbors, although quite different under the microscope, share ...

Trio of signals converge to induce liver and pancreas cell development in the embryo

... tissues regenerate and how stem cells can be used for new therapies. With regenerated cells, researchers hope to one day fill the acute shortage in pancreatic and liver tissue available for transplantation in cases of type I diabetes and acute liver failure. Previous studies on pancreas and liver ...

Colon cancer screening technique shows continued promise in new study

... way for multicenter clinical validation. The work builds on previous success in using a suite of optical technologies to detect both colon and pancreatic cancer. ...

Society of Interventional Radiology Foundation awards $191,000 in grants

... Radiology Foundation's Dr. Ernest J. Ring Academic Development Grant for his research in "MR-guided Transplantation of Magnetoencapsulated Human pancreatic Islet Cells in a Diabetic Swine Model." This grant, named after the founder of the SIR Foundation, is designed to provide support to junior ...