pancreatic

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

... nutrients from the mother to the baby, the baby's pancreatic cells will be programmed abnormally," said princip...found no difference in pancreas size or numbers of pancreatic beta cells, which produce insulin. But cultures of the beta cells revealed the answer: the undernou...

UCSD researchers maintain stem cells without contaminated animal feeder layers

...ulate cellular growth and differentiation in human pancreatic cells. Human embryonic stem cells cultured for several weeks under these conditions showed no change in cell form and structure. The team then eliminated each factor and pluripotency was assessed. At first, the results were narrowed to three molecule...

Newly Discovered Compound Blocks Known Cancer-Causing Protein

...ound in half of all colon cancer and 90 percent of pancreatic cancers, among other cancers. Casey and his colleagues in Duke's Department of Pharmacology and Cancer Biology have already discovered and developed another class of cancer drugs aimed at inhibiting the processing pathway --the prenylation pathway ?...

Agilent Technologies releases automated literature search tool for biology researchers

... Research Institute (TGen) on melanoma, autism and pancreatic cancer. Labs researchers are focusing on proteomics and metabolomics for these diseases as a complement to Labs collaborators' work in genomics. Using Labs' systems biology informatics prototypes, Labs researchers have built qualitative biological mo...

New drug shows promise as powerful anticancer agent

...iety of human tumors, including liver, breast, and pancreatic cancers that were grown in mice. ON01910 was also highly effective and, in many cases, strongly synergistic when tested in combination with other chemotherapeutic agents. Studies examining normal human cells show that, in contrast to tumor cells, the...

Rare surgery performed to remove pancreas, prevent diabetes

...is entire pancreas and the hours-long wait for the pancreatic islet cells to be processed in a specialized UAB l...ted facilities necessary to isolate and purify the pancreatic islet cells either from a cadaver donor for transplantation or, as in this case, for infusion back i...

Genetic defects give the immune system the green light to attack the pancreas

...e in the United States have type 1 diabetes. Their pancreatic beta cells can no longer make insulin. Without this crucial hormone, their body cannot convert food into energy. To sustain life, they must get insulin through injections. The disorder can emerge in childhood, adolescence and even appear in adulthood...

Biomarkers isolated from saliva successfully predict oral and breast cancer

...er difficult to detect cancers such as ovarian and pancreatic cancers. "In my mind the biggest hurdle stems from the fact that salivary nucleic acids or protein markers might be influenced by eating, drinking, smoking, diet or oral hygiene," said Wong. "So our goal is to provide the optimized and standardized ...

Disease progression model of pancreatic cancer developed by Penn researchers

...hool of Medicine have developed an animal model of pancreatic cancer that closely mimics disease progression in ...p new treatments for this deadly disease. Advanced pancreatic cancer is among the most lethal of cancers, with a one-year survival rate after chemotherapy of only...

Newly Discovered 'Branding' Process Helps Immune System Cells Pick Their Fights

...h. He notes that insulin-producing beta cells, the pancreatic cells attacked by T cells in type 1 diabetes, also generate reactive compounds similar to those made by antigen-presenting cells. "The beta cells could therefore be modifying their own proteins in the same way that antigen-presenting cells are modif...

Precise Timing Enabled Pig-to-rat Transplants To Cure Diabetes

...n and Rogers had shown that transplantation of pig pancreatic primordia into diabetic rats cures their diabetes ...appears to be relatively little difference between pancreatic primordia from 28-day-old and 35-day-old pig embryos. "To put this in perspective, pig gestation is ...

Second messenger NAADP shows fast, dose-related impact on satiety cycle

...le in cholecystokinin-induced Ca2+ mobilization in pancreatic acinar cells. Despite the intensive study into the physiological role of NAADP in Ca2+ signaling in pancreatic anicar cells, direct demonstration of changes in NAADP levels in response to agonist-stimulations ha...

Searching the depths of the straits of Florida for disease cures

... chemicals currently showing potential in fighting pancreatic cancer. The upcoming expedition is being supported through funds appropriated by the Florida legislature and approved by Governor Jeb Bush as part of the state's response to the U.S. Commission on Ocean Policy's (USCOP) historic 2004 report. The rep...

High-powered gene profiles provide clues to genes involved in common form of lung cancer

...ompared their data for NSCLC with similar data for pancreatic cancer, and found that both diseases have some chromosomal irregularities in common, suggesting that in both disorders, some of the same genes may be driving the tumors. ...

Study: Well-known protein helps stem cells become secretory cells

... say. In juvenile (type I) diabetes, for example, pancreatic cells that normally produce and secrete insulin do...lem, the researchers note. "The key is knowing how pancreatic cells know what hormones to produce and release, or how any gland does, and the new findings add to ...

New imaging technology shown to detect pancreatic inflammation in type 1 diabetes

... reveal the otherwise undetectable inflammation of pancreatic islets in recently diagnosed diabetic mice. As T l...ood vessels of the body including the pancreas. If pancreatic vessels have become leaky from inflammation, the magnetic particles spill into nearby tissues, where...

Naturally occurring asbestos linked to lung cancer

... group, an equal number of age- and gender-matched pancreatic cancer cases was selected (since pancreatic cancer has no known association to asbestos exposure). For both the mesothelioma and pancreatic canc...

Researchers make 'embryonic-like' stem cells from umbilical cord blood

...ation. "We plan to use this technology to engineer pancreatic tissue as we work towards our goal of developing a cure for type 1 diabetes," he added. The team's report will be published in the Cell Proliferation Journal on 18 August. ...

Insight into the processes of 'positive' and 'negative' learners

...ation. "We plan to use this technology to engineer pancreatic tissue as we work towards our goal of developing a cure for type 1 diabetes," he added. The team's report will be published in the Cell Proliferation Journal on 18 August. ...

Researchers propose measures to curb lion attacks in Tanzania

...ation. "We plan to use this technology to engineer pancreatic tissue as we work towards our goal of developing a cure for type 1 diabetes," he added. The team's report will be published in the Cell Proliferation Journal on 18 August. ...

Columbia scientists develop cancer terminator viruses

...inator" virus, which was administered to mice with pancreatic cancers at both primary and distant sites (akin to metastases). As predicted, when the virus was injected directly into the primary tumor, the virus destroyed not only the primary tumor, but also distant tumors. While the infection caused by the vi...

Discarded placentas deliver researchers promising cells similar to embryonic stem cells

...euronal cells that make up the nervous system, and pancreatic cells with genetic markers for insulin and glycogen production. "In this first paper we sought to determine if amniotic epithelial cells have the potential to differentiate into many different cell types rather than focusing on ways for optimizing t...

University of Delaware researchers develop cancer 'nanobomb'

...orking to extend his method to prostate cancer and pancreatic cancer. He also foresees nano-bio-robots or nano-surgical tools that can be placed inside the body to remove tumors in areas previously inaccessible using traditional treatment methods. Panchapakesan said the team' TM s findings are the result ...

Mining biotech's data mother lode

...n example. "The medical faculty here were studying pancreatic tumours. They found 1,000 genes over expressing. Using our software they were able to find, among others, three protein interactions that were particularly relevant. Using our literature search ontology they were able to discover that two of these in...

Gene therapy potential for treatment of pancreatic cancer

...sostatin may prove a promising new way of treating pancreatic cancer, suggests research published ahead of print... suppress the development of new blood vessels and pancreatic tumour cells both in test tubes and in mice with pancreatic cancer. 'Solid' tumours, such as pancre...

Jefferson researchers find nanoparticle shows promise in reducing radiation side effects

...sostatin may prove a promising new way of treating pancreatic cancer, suggests research published ahead of print... suppress the development of new blood vessels and pancreatic tumour cells both in test tubes and in mice with pancreatic cancer. 'Solid' tumours, such as pancre...

The nude mouse tale: Omega-3 fats save the life of a terminal cancer patient

...wth of human mammary, ovarian, colon, prostate and pancreatic cancer cells that were injected into athymic mice--also known as nude mice. His studies also demonstrated that fish oil consumption improves a mouse's responsiveness to chemotherapy. Fish oil research was inspired by observations that Inuit Eskim...

Common molecular 'signature' identified in solid tumors

...ples of lung, breast, stomach, prostate, colon and pancreatic tumors and in the normal tissue surrounding them. Using microarray technology developed at Ohio State , lead investigators Stefano Volinia and George Calin found 137 different miRNAs expressed in at least half of the cancers, with 43 miRNAs allowin...

Researchers reverse juvenile diabetes in animal model

... and type 1 diabetes, and a potential cure for the pancreatic damage that causes insulin dependence. Diabetes and children statistics: The risk of developing type 1 diabetes is higher than virtually all other severe chronic diseases of childhood. Peak incidence occurs during puberty, around 10 to 12 years ...

Basic research leads to a novel cancer therapy

...ver cancer, lung cancer, melanoma, ovarian cancer, pancreatic cancer, prostate cancer, and testicular cancer. The studies are in various stages of clinical trials (phases I through III), and most of them are being carried out in combination with other therapies. Ullrich is very pleased with the quick approval ...

New test to detect rare proteins in blood

...re than 30 percent of primary breast, ovarian, and pancreatic tumors. Part of the Her2/neu molecule is shed from the surface of tumor cells and has been detected in the blood of breast-cancer patients. Higher blood concentrations of Her2/neu correlate with a lower response rate to chemotherapy and shorter survi...

Common molecular 'signature' identified in solid tumors

...ples of lung, breast, stomach, prostate, colon and pancreatic tumors and in the normal tissue surrounding them. Using microarray technology developed at Ohio State , lead investigators Stefano Volinia and George Calin found 137 different miRNAs expressed in at least half of the cancers, with 43 miRNAs allowin...

Mayo Clinic researchers discover cancer cells may move via wave stimulation

...ese cancer-growth commands at bay. Studying human pancreatic tumor cells, the Mayo researchers found that the waves store up to half the activated Epidermal Growth Factor Receptors (EGFR) from the surface of the cell and take this cache to the interior of the cells. This is important for understanding cancer b...

New lab technique churns out fungus' potential cancer fighter

...ailor-made to knock out ras-dependent cancers like pancreatic cancer. After six years, however, rasfonin's secrets remain a mystery because researchers can't make enough of it to carry out tests. To bring about a new drug, organic chemists must produce a new chemical in enough quantity to test it under many d...

New lab technique churns out fungus' potential cancer fighter

...ailor-made to knock out ras-dependent cancers like pancreatic cancer. After six years, however, rasfonin's secrets remain a mystery because researchers can't make enough of it to carry out tests. To bring about a new drug, organic chemists must produce a new chemical in enough quantity to test it under many d...

Teasing out tissue from blood

...pplication on a brew that turns the monocytes into pancreatic islet-like cells that produce insulin in response to high levels of glucose. "We now want to transplant these cultures into a diabetic mouse model," says Winnier, adding their results are being prepared for publication in a peer-reviewed journal. Al...

The molecular mechanism of a diabetes vaccine revealed

...istakenly attacks the body's own insulin-producing pancreatic cells, reducing and ultimately eliminating the pro...in preventing the destruction of insulin-producing pancreatic cells," says Cohen. Postdoctoral fellow Dr. Alexandra Zanin-Zhorov spearheaded the project; the oth...

Researchers discover which organs in Antarctic fish produce antifreeze

...strong AFGP mRNA expression came into focus in the pancreatic tissues in all notothenioids tested. The use of cD...ion is no longer universally applicable." Instead, pancreatic antifreeze expression is universal. ...

Successful transplantation from pig embryos to mice

...flicted with juvenile diabetes, transplants of the pancreatic tissue in which insulin is produced might alleviat...tems, they determined that the best time frame for pancreatic tissue was about a third of the way through gestation (from 42 to 56 days). In the new study, Reisn...

Gene screen for breast cancer better than pathologist's 'eye'

...ively easily, such as lung, head and neck cancers, pancreatic and cervical cancers." Pathologists look for telltale shapes of cells to determine if cancer is present, but molecular changes in cells, especially for early cancers, are beyond the reach of even the most powerful microscopes. Sukumar's test se...

Tumor wizardry wards off attacks from the immune system

...ty School of Medicine in St. Louis have found that pancreatic tumors hide from the body's immune surveillance by... more prevalent in patients with breast cancer and pancreatic cancer than in healthy patients," says David C. Linehan, M.D., associate professor of surgery and a ...

New study reveals signaling pathways required for expansion of pancreas stem cells

...ts from selective destruction of insulin-producing pancreatic islet beta cells by the body's immune system. Isle...P4 and Id-in causing proliferation or expansion of pancreatic progenitors. Hong Hua, a postdoctoral fellow in Sarvetnick's lab, was the lead author of this study....

Parallel evolution: Proteins do it, too

...g showed that the duplication of a gene encoding a pancreatic enzyme helped Asian colobine monkeys cope with an ... eaters. Zhang focused his attention on RNASE1, a pancreatic enzyme that breaks down bacterial RNA. Most primates have one gene encoding the enzyme, but he found...

Green tea and the 'Asian Paradox'

...al function, alcohol metabolism, kidney, liver and pancreatic function, protect skin and eyes and alleviate arthritis. Tea has been used in managing and preventing allergies, diabetes, bacterial and viral infections, cavities, reduce or cure diseases with an inflammatory component and improve neurologic and psy...

Gardenia fruit compound starting point for diabetes therapy

...ndeed contain a chemical that reverses some of the pancreatic dysfunctions that underlie the disease, researcher... underlying causes of disease in insulin-producing pancreatic beta cells. Insulin controls blood levels of glucose, the body's main energy source. In those with d...

Increased sensitivity to nerve signals keeps diabetes at bay

...ugs that boost the activity of the M3 receptors on pancreatic beta cells might have therapeutic potential, said ...y drive up the number of M3 receptors expressed in pancreatic beta cells," Wess said. "It might also be possible to enhance M3 receptor signaling in beta cells by...

New technology enables faster, more efficient cell harvest: Cell therapy meeting study

...movement after a spinal cord injury and regenerate pancreatic tissue to produce insulin for people with diabetes. Regenerative medicine promises to improve health and quality of life by supporting and activating the body's natural healing abilities. ...

Embryos exposed in 3-D

...movement after a spinal cord injury and regenerate pancreatic tissue to produce insulin for people with diabetes. Regenerative medicine promises to improve health and quality of life by supporting and activating the body's natural healing abilities. ...

Mayo Clinic Cancer Center: Harnessing the measles virus to attack cancer

...ways to use the measles virus to combat breast and pancreatic cancer. ...

Minorities, uninsured less likely to receive care at high-volume hospitals

..., cardiac valve replacement, coronary angioplasty, pancreatic cancer resection, and total knee replacement. According to this database, a total of 719,608 patients received 1 of the 10 operations. The researchers found that "in general, blacks, Asians, Hispanics, patients with Medicaid, and uninsured patients...

New biochip helps study living cells, may speed drug development

...n muscles, neurons and the release of insulin from pancreatic cells. The chip currently can detect individual levels of different ions. Porterfield believes that with some modifications, however, the chip will be able to measure multiple ions at once and perform even more advanced functions such as electric...

New data from NIH lab confirms protocol to reverse type 1 diabetes in mice

... spleen cells in the recovery of insulin-producing pancreatic islets. The new data from a study performed at th...by diabetes but also allowed the insulin-producing pancreatic islet cells to regenerate. Evidence indicated that the spleen cells were the source of at least some...

Three-dimensional, miniature endoscope opens new diagnostic possibilities

...as the salivary ducts, the fallopian tubes and the pancreatic duct. Fetal and pediatric procedures may also benefit from this tool. Eventually, SEE could give rise to new procedures that permit diagnosis and microsurgery in previously inaccessible areas of the body." ...

Nano-devices hold promise for early-stage cancer detection

...able non-invasive imagers for routine screening of pancreatic and gastrointestinal tumors; sensors that can detect food- and water-borne pathogens. "The ultimate goal is to develop reliable and inexpensive detection and imaging products that can be used in a doctor’s office or possibly even at home as ...

Replacing insulin is top-ranked breakthrough foreseen for health in developing world

...ir list: "Novel methods of insulin replacement and pancreatic islet cell regeneration for diabetes." Many panellists noted the heavy health, social and economic burdens that result from widespread diabetes in developing countries. Controlling that disease would consequently reduce complications such as blin...

Studies find general mechanism of cellular aging

...and Harvard University observed similar results in pancreatic islet cells and brain and blood stem cells. The r...udy focused on p16INK4a effects on the function of pancreatic islet cells. Islet cells are responsible for insulin production and secretion. Because p16INK4a stop...

Natural anti-viral enzyme helps keep cancer cells alive, researchers find

... in 30 percent of all cancers and in 90 percent of pancreatic cancers. The UT Southwestern scientists knew that RalB interacts with a protein complex called the exocyst, which helps small secretory packets in cells fuse to the cell membrane. The team isolated this complex, then chemically analyzed the protein...

Encouraging results in pancreatic cancer research

...t when a human protein, PNC-28, is administered to pancreatic tumor cells in animals, the tumors are destroyed. ...f a variety of human tumor cell lines, including a pancreatic cancer cell line, while not harming healthy cells. The research team has now given PNC-28 to labor...

A sweet step toward new cancer therapies

...te sugars attached to proteins in the membranes of pancreatic cancer cells. "The work is in very early stages, but we hope that by measuring unique sugars it may be possible to develop diagnostic tools or therapeutic agents to specifically target them," Hakansson said. ...

Protein found to shield pancreatic cancer cells from self-destruction

An overexpressed protein protects human pancreatic cancer cells from being forced to devour themselve...on to drug-resistant and metastatic breast cancer, pancreatic cancer and melanoma. Expression of TG2 is tightly regulated in a healthy cell, Mehta says, and is...