First 'atlas' of key brain genes could speed research on cancer, neurological diseases
... on specific TF genesregulating nerves involved in pain sensation, certain brain tumors, andspeech problem...development of theneurons that generate the severe pain that is a common symptom ofmetastatic tumors.The research was funded by the Charles Dana Foundation,...UCLA scientists transform HIV into cancer-seeking missile
...fur. The method is non-invasive and does not cause pain or harm to the animal. Though excited at proving that HIV can be used to target cancer cells, Chen emphasizes that the carrier must be further enhanced for safety and specificity before it can be tested as a gene-therapy method in humans. "Our next......s enrolled in the study will be examined for chest pain at one month, three months and six months. A total of 404 patients will be enrolled in the study at the 20 study sites across the country. The Genetic Angiogenic Stimulation Investigational Study (GENASIS) is funded by Corautus Genetics. More than ...Potential treatments for neurofibromatosis
... miserable and debilitated with chronic itching or pain from disfiguring tumors. Infants affected by the disease face possible paralysis or damage to the brain and other organs. The disease frustrates doctors because there's no effective treatment even though the responsible gene was identified more than...PET/MRI scans may help unravel mechanisms of prenatal drug damage
...logists are relying on the mother transferring the pain medication to the fetus via the placenta. But we a...now if what we give is sufficient to 'satisfy' the pain level of the fetus," said Benveniste, who is also a professor of anesthesiology at Stony Brook Unive...Discovery Promises Simpler Therapy for Sickle Cell Disease
...se itself and are instead geared toward minimizing pain and preventing infection, he added. In patients who become anemic, blood transfusions replenish the red blood cell supply in the body. The team further found that differences among patients in their ability to process nitric oxide in the blood corre...FDA Clears the Way for Generic Versions of Transdermal Patches to Treat Chronic Pain
...ed to treat patients suffering from severe chronic pain that cannot be managed with alternative analgesics...this patch technology delivers fentanyl, an opioid pain medication that is slowly absorbed into the body through the skin providing pain relief for up to th......ed to treat patients suffering from severe chronic pain that cannot be managed with alternative analgesics...this patch technology delivers fentanyl, an opioid pain medication that is slowly absorbed into the body through the skin providing pain relief for up to th...Rare surgery performed to remove pancreas, prevent diabetes
...emoving his pancreas to eliminate constant, severe pain from chronic pancreatitis. The patient, Leonard S...tis. In the past, such surgery might eliminate the pain but would leave the patient with severe, poorly-controlled diabetes, since the insulin-producing isl...Canada approves marijuana-based pain spray
...reatment for the symptomatic relief of neuropathic pain in adults with multiple sclerosis (MS). Canada bec.../risk assessment for the approved use. “Effective pain control and management are extremely important in a disease like MS,?said Dr. Allan Gordon, Neurolog...Molecular thermometers on skin cells detect heat and camphor
...rently under investigation for alleviating chronic pain target the action of a protein called TRPV1 (VR1), which is similar to TRPV3. Molecular Thermometers TRPV3 and TRPV1 are both proteins that belong to a class of molecules known as "transient receptor potential" channels. There are at least six of t...Chronic Sinus Infection Thought To Be Tissue Issue, Mayo Clinic Scientists Show It's Snot
...postnasal drip, nasal discharge, and head and face pain lasting three months or longer. It notably decreases the quality of patients' lives, impairing physical and social functioning, vitality and general health, according to the Mayo Clinic researchers. ...Enzyme's newly discovered role may make it target for arthritis treatment
... to tissue and cartilage damage in joints, causing pain and limiting mobility. "Cathepsin G affects a very early step in this kind of immune response, so inhibiting it has attractive potential for developers of therapeutics," says senior author Christine T.N. Pham, M.D., assistant professor of medicine a...Study finds adult stem cells can replicate
... to tissue and cartilage damage in joints, causing pain and limiting mobility. "Cathepsin G affects a very early step in this kind of immune response, so inhibiting it has attractive potential for developers of therapeutics," says senior author Christine T.N. Pham, M.D., assistant professor of medicine a...Morphine for Chest Pain Increases Death Risk
... with sufficient doses of nitroglycerin to relieve pain before resorting to morphine. In their analysis o...er." Morphine was first used to relieve the chest pain associated with heart attacks in 1912 and has been used regularly ever since. Nitroglycerin has been...Diabetic nerve therapy shows 'striking' results
...f neuropathy that can cause numbness and sometimes pain and weakness in the hands, arms, feet and legs. Currently, patients are treated with painkillers and antidepressants that do not treat the underlying nerve damage. Progression to amputation is not inevitable but is always a threat. Problems may als...Scripps research scientists identify infertility molecule
...- in mice, and can also participate in neuropathic pain models. Wanting to go further, they created what is known as a knock-out mouse model for a specific LPA receptor. These are special mice that lack one or more particular genes of interest -- in this case, a gene that encodes a particular LPA recepto...Scientists discover the body's marijuana-like compounds are crucial for stress-induced pain relief
...d analgesia ?the body's way of initially shielding pain after a serious injury. The work, led by scientis... possible to design a pill that will have the same pain relieving effects as smoked marijuana, but through an indirect mechanism that could also reduce unwa...Drug Offers Alternative to Surgical Treatment After Miscarriage
...omach ulcers that occur in people who take certain pain relievers for arthritis. Misoprostol is now more c...reatment with the drug could bring about abdominal pain and cramping. The researchers treated minor pain caused by the treatment with ibuprofen and treated ...Sleeping Sickness Epidemic Spreading in Uganda
...omach ulcers that occur in people who take certain pain relievers for arthritis. Misoprostol is now more c...reatment with the drug could bring about abdominal pain and cramping. The researchers treated minor pain caused by the treatment with ibuprofen and treated ...Men Estimate Men's Risks Of Common Disorders Higher Than Women Do, And Vice Versa
...(One study found that 30 year old women with chest pain were much less likely than 30 year old men to be given a cardiac diagnosis, much more likely to be given a psychiatric diagnosis, and around seven times more likely to be considered not to need medical treatment). The University of Glasgow study rev...Thinking the pain away? Study shows the brain's painkillers may cause 'placebo effect'
...lease endorphins, bringing real relief to those in pain Just thinking that a medicine will relieve pain is enough to prompt the brain to release its own natural painkillers, and soothe painful sensations,...Malfunctioning bone marrow cells sabotage nerve cells in diabetes
...s. Neuropathy is a common complication that causes pain and ultimately loss of sensation in the extremities and can lead to amputation. Previously, Chan and members of his laboratory had found that bone marrow cells were among a group of cells in organs other than the pancreas that unexpectedly produced ...Defect in gene causes 'neuralgic amyotrophy'
...eritable disease causes prolonged acute attacks of pain in the shoulder or arm, followed by temporary para...ophy (HNA) is characterized by repeated attacks of pain in a shoulder, arm, and/or hand, followed by total or partial paralysis of the affected area. The pa...Molecular miners find pain relief drugs from the sea
...ater its effectiveness in treating the neuropathic pain associated with diabetes. From the University of ... "ACV1 has been shown to be effective in treating pain in several experimental animal models of human pain syndromes, including post-surgical and neuropath...Why do aneurysms form? New studies suggest leading role for white blood cells
...hich cause few symptoms except for occasional back pain or abdominal discomfort. If they are detected during this stage, for instance on a routine physical exam, X-Ray, MRI or CT scan, they can be repaired successfully 95 percent of the time. Recently, new ideas about why aneurysms form have begun to tak...Results of world's first gene therapy trial for arthritis show approach safe, feasible
...on builds, patients experience progressively worse pain and stiffness in their affected joints. To block this process, the team sought a way to prevent the main actor, IL-1, from binding to the synovial cells, and hence, setting off the destructive chain reaction that follows. In essence, they needed a w...Scientists use gene transfer technology and common virus to block neuropathic pain in animals
...stove? Imagine what it's like to have that burning pain in your hands or feet all the time and know there'...rpes viral vector, to treat peripheral neuropathic pain in animals. Based on their success in related studies with research animals, the scientists hope to ......na have identified where emotional fear memory and pain begin by studying the biochemical processes in a d...entially create therapeutic ways to ease emotional pain in people. Imagine reducing the ability of distressing events, such as amputations, to be permanentl...Surgical Robot 'Scrubs In' At UNC, May Be More Precise Than Conventional Surgery
...rter hospital stay. We also found a reduced use of pain medications after robotic surgery, with fewer complications," said Dr. John F. Boggess, gynecological oncologist, assistant professor of obstetrics and gynecology at UNC's School of Medicine and a member of the UNC Lineberger Comprehensive Cancer Cen...Screen all at risk for HIV, plus pregnant women
...rter hospital stay. We also found a reduced use of pain medications after robotic surgery, with fewer complications," said Dr. John F. Boggess, gynecological oncologist, assistant professor of obstetrics and gynecology at UNC's School of Medicine and a member of the UNC Lineberger Comprehensive Cancer Cen...FDA: 'Highly Unlikely' Green Tea Lowers Cancer Risk
...rter hospital stay. We also found a reduced use of pain medications after robotic surgery, with fewer complications," said Dr. John F. Boggess, gynecological oncologist, assistant professor of obstetrics and gynecology at UNC's School of Medicine and a member of the UNC Lineberger Comprehensive Cancer Cen...Scientists use gene transfer technology and common virus to block neuropathic pain
...stove? Imagine what it's like to have that burning pain in your hands or feet all the time and know there'...rpes viral vector, to treat peripheral neuropathic pain in animals. Based on their success in related studies with research animals, the scientists hope to ...Experimental shingles vaccine proves effective in nationwide study
... Among all vaccine recipients, the total burden of pain and discomfort due to shingles was 61 percent lowe...therpetic neuralgia (PHN)--a form of chronic nerve pain that is the most common serious complication of shingles--by two-thirds compared with placebo. The v...Women feel more pain than men, research shows
Women feel pain more than men despite the popular notion that the ...h. Scientists investigating gender differences in pain have found that not only do women report more pain throughout the course of their lifetime, they als...Prescription pain patch abuse blamed for increase in deaths
...tch is typically prescribed to treat postoperative pain or chronic pain conditions, but in some cases is being misused, often with deadly consequences. "Because the patch ...Minimally Invasive Cancer Treatments Highlighted
...often metastasizes to bone, and can cause terrible pain that is unrelieved by narcotics and other standard pain treatments. These treatments could benefit many of the 100,000 people who develop bone metastasis in...'Nanospheres' that block pain of sensitive teeth
...e them incredibly sensitive, and that cause severe pain for millions of adults and children worldwide. P...partially blocked, the flow can be reduced and the pain stopped or significantly reduced. Currently, the only way to treat this condition is through good de...Molecular cabal contributes to stroke damage
...uch NMDARs and ASIC1a are involved in seizures and pain sensation, "a similar coupling between these two channels is likely to occur in these diseases as well." ...University of Delaware researchers develop cancer 'nanobomb'
... patient. "This is valuable in patient management, pain management and overall quality of life," he said. Furthermore, Panchapakesan said, the nanobomb is a "very simple technique" and as such will likely prove to be "more robust and with the best chance to succeed." Panchapakesan added, "We are jus...Viagra's hidden help for wildlife
...ng TCM apothecaries who use it in the treatment of pain relief, despite the widespread availability of aspirin. "But the failure to achieve an erection isn't comparable to having a headache or the many other ailments for which consumers still prefer TCM treatments. Furthermore, Viagra differs from many o...Penn Surgeons Use Completely Robotic Surgery to Successfully Treat Prostate Cancer
...fits for prostate cancer patients, including: less pain and scarring, diminished blood loss, a shorter hospital stay and reduced recovery period for a quicker return to daily activities. The actual robot consists of a tower that manipulates instruments controlled from a console that is situated a few fe...Scientists learn to predict protein-stabilizing ability of small molecules
...fits for prostate cancer patients, including: less pain and scarring, diminished blood loss, a shorter hospital stay and reduced recovery period for a quicker return to daily activities. The actual robot consists of a tower that manipulates instruments controlled from a console that is situated a few fe...Brainstem blocks pain to protect key behaviors
... contain clusters of nerve cells that can suppress pain long enough to allow the animal to eat, drink -- o...al tasks even in a difficult situation. "Escaping pain and potential dangers may be important protective behaviors, but eating, drinking, and eliminating w...MUHC investigators search for the root of sexual pain in women
...CIHR) to continue their groundbreaking research on pain suffered by some women during sexual intercourse. ...l dysfunctions, are now increasingly understood as pain disorders as a result of previous research by this team. "Approaching this problem in the context of...Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned
...oison, victims develop fever, nausea and abdominal pain or lung damage before dying within a few days of exposure. There is no antidote after the first few hours of exposure and, because symptoms do not appear until later and often mimic other illnesses, individuals often do not know if they have been exp...3D ultrasound device poised to advance minimally invasive surgery
...ethods have the advantage of reduced postoperative pain and a faster recovery. However, the two-dimensional ultrasound imaging now available offers surgeons only a limited view, which can impede their depth perception and make such procedures difficult to master. "Our ultrasound device could really advan...Rare Tibetan antelope listed as endangered
...ethods have the advantage of reduced postoperative pain and a faster recovery. However, the two-dimensional ultrasound imaging now available offers surgeons only a limited view, which can impede their depth perception and make such procedures difficult to master. "Our ultrasound device could really advan...Technique makes it easier to see mouse embryo in all its glory
...ptions that our toothpaste, artificial sweeteners, pain relievers and household cleaning chemicals are safe for pregnant mothers," he said. "The EPA (U.S. Environmental Protection Agency) and FDA (U.S. Food and Drug Administration) mandate that chemical and drug companies perform tests of reproductive saf...Simple idea to dramatically improve dengue vaccinations
... disease," Dengue is characterized by excruciating pain and was "the most important mosquito-borne viral disease affecting humans" in 2005 according to the U.S. Centers for Disease Control. The study, from bioengineers and physicists at Rice University, appears in the March 24 issue of the journal Vaccin...Pain killer fights breast cancer by targeting key enzyme
...ti-inflammatory drug (NSAID), a drug that controls pain and inflammation. Studies of other NSAIDs, such as ibuprofen, have suggested that NSAIDs may reduce breast cancer incidence by 40 percent. However, these drugs tend to halt aromatase production throughout the body. Brueggemeier presented the work w...Master genetic switch found for chronic pain
... the animals' response to "neuropathic pain." Such pain is abnormal pain that outlasts the injury and is associated with nerve and/or central nervous system changes. The ani...Great (taste) expectations: Study shows brain anticipates taste, shifts gears
...alves taken by unwitting subjects are seen to ease pain or have some other beneficial physiological effect. How the brain processes this faked input and prompts the body to respond is largely a mystery of neuroscience. Now, however, scientists have begun to peel back some of the neurological secrets of t...Study in Science holds promise for a new approach to drug therapy
...can provide better control of pathways involved in pain relief, inflammation and heart disease, while leav...me in on the site of infection. The other involves pain relief brought about by morphine. In white blood cells, the free G protein gamma-beta subunit acti...Brain differences could explain why males and females experience pain relief differently
...n may explain sex differences in the experience of pain and in the effects of certain drugs on pain. Th...s of the brain responsible for the transmission of pain sensations in the body. The study used rat brains, but a host of clinical evidence suggests that si...Therapeutic prospects beyond Vioxx
...isk using the same mechanism by which they relieve pain and inflammation". The investigators also addres...as effective as treatment with NSAIDs in models of pain and inflammation. This has prompted several large pharmaceutical companies to develop drugs targetin...Novel method reveals how menthol discovery could point towards new or improved pain therapies
... understanding could lead to potential advances in pain therapy, the researchers said. Moreover, the scie...ature-activated ion channels can result in chronic pain syndromes," said Ardem Patapoutian, associate professor at Scripps Research and member of GNF, who d...New licensing agreement to maximize AIDS drug development
...United Kingdom by ProStrakan, for the treatment of pain associated with chronic anal fissures. A similar formulation of Rectogesic is currently being sold in Australia, New Zealand, Singapore and South Korea. FortigelTM (testosterone gel), branded Tostrex® outside the United States, is marketed in Swede......l." The study of 270 individuals with chronic arm pain had two phases. In the first phase, 135 patients ...ial, and the other half in a placebo pill vs. real pain pill trial. The acupuncture trial extended four more weeks (the length believed needed to see impro...Obese people may be more sensitive to pain than people who aren't obese, a new study suggests...ee, a disease that causes inflammation and extreme pain in the knees. Participants were given a mild electrical stimulation on their left ankle to measure ...