Oxidative in Biological News

Bad mitochondria may actually be good for you

... live longer than normal mice. Mitochondrial oxidative stress is a popular theory explaining the aging ... working better than normal mice. So, despite the oxidative stress, these mice experienced less deterioration ... MCLK1-defiency, they exhibited less damage and oxidative stress. In explaining this seeming paradox, ...

Caffeine appears to be beneficial in males -- but not females -- with Lou Gehrig's disease

... seem to play a role in its development, including oxidative stress. Coffee, Caffeine and ALS ... factors. One environmental factor is diet. With oxidative stress (which damages the cells) a common concern ... or chlorogenic acid supplementation in improving oxidative stress and its associated cell death mechanisms. ...

Caffeine appears to be beneficial in males -- but not females -- with Lou Gehrig's disease

... seem to play a role in its development, including oxidative stress. Coffee, Caffeine and ALS ... factors. One environmental factor is diet. With oxidative stress (which damages the cells) a common concern ... or chlorogenic acid supplementation in improving oxidative stress and its associated cell death mechanisms. ...

Quails get super fit by simply eating omega-3 diet

... improved. Measuring the activity levels of four oxidative enzymes the duo found that the enzymes' activity ... top human endurance athletes only improve their oxidative enzyme activities by 38 to 76% after 7 weeks of ... the levels of a key molecule that regulates oxidative enzyme levels, known as PPAR, Weber could not ...

DNA repair mechanisms relocate in response to stress

... found. The signal that prompts relocation is oxidative stress, an imbalance of cellular metabolism ... repair enzymes for the cover. "DNA damage and oxidative stress are very closely related," Doetsch says. ... inflicts most of its damage on DNA is through oxidative stress. The more we know about how cells respond ...

HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection

... effects on insulin secretion mediated through the oxidative stress pathway. They report a significant ... were up-regulated during nelfinavir induced oxidative stress and directly affected the ATP levels in ... tested the hypothesis that nelfinavir induced oxidative stress was responsible for the deleterious ...

Forget the antioxidants? McGill researchers cast doubt on role of free radicals in aging

... of why we get old has been tied to what is called oxidative stress. This theory postulates that when ... journal PLoS Genetics , are calling the entire oxidative stress theory into question. Their results show ... of Biology, said most of the evidence for the oxidative stress theory is circumstantial, ...

Understanding how oxidative stress impairs endothelial progenitor cell function

... the risk of heart attack or stroke by reversing oxidative stress at the cellular level," said study author ... be applied early in the disease when preventing oxidative damage is a possibility because once the damage ... reversible." High cholesterol causes increased oxidative stress, impairing the function of EPCs. In ...

Researchers at IRB Barcelona produce more data on key genes in diabetes

... to "generate" energy through a process called oxidative phosphorylation. In a study performed in 2003, ... allow mitochondria to produce energy by means of oxidative phosphorylation. Now, for the first time, a study ... expression of mitochondrial genes responsible for oxidative phosphorylation. "We have discovered what the ...

Researchers discover that growing up too fast may mean dying young in honey bees

... to mitigate the effects of ROS, and the oxidative stress model of aging and senescence suggests ... is the first to use such an approach to test the oxidative stress model of aging in a free-living organism. ... behavior should have strong affects on cellular oxidative stress and antioxidant mechanisms, especially in ...

Oxidative stress: Mechanism of cell death clarified

... If the equilibrium in the organism moves towards oxidative processes, then this is known as oxidative stress. oxidative stress, for instance, is associated with the ...

Blood pressure response to daily stress provides clues for better hypertension treatment

... Another project is exploring the role of oxidative stress, or reactive oxygen species, in raising ... pressure following stress. She's also found oxidative stress levels go up with stress. oxidative stress, or reactive oxygen species, helps make ...

Scientists learn how food affects the brain

... which is abundant in salmon. DHA, which reduces oxidative stress and enhances synaptic plasticity and ... restriction could protect the brain by reducing oxidative damage to cellular proteins, lipids and nucleic ... said. The brain is highly susceptible to oxidative damage. Blueberries have been shown to have a ...

Biosensor for measuring stress in cells

... and in aging cells, scientists have observed oxidative changes in important biomolecules. These are ... makes the difference between health and disease. oxidative stress arises when this balance shifts towards ... of new substances or plant food constituents on oxidative processes and, thus, on the stress status of ...

Green tea compounds beat OSA-related brain deficits

... have been reported to have increased markers of oxidative stress and exhibit architectural changes in their ... imposed by IH stem, at least in part, from oxidative stress and inflammatory signaling cascades. ... were then tested for markers of inflammation and oxidative stress, as well as for performance in spatial ...

Mitochondrial dysfunction and redox signaling in atrial tachyarrhythmia

... is associated with mitochondrial dysfunction and oxidative stress followed by the activation of the NF-kB ... which all are directly or indirectly linked to oxidative stress. Accordingly, blockade of the angiotensin ... that verapamil most potently prevented oxidative stress and associated signalling pathway ...

New strategies against bird flu

... in multiple lung injuries and directly links oxidative stress to innate immunity. They also report for ... on these findings, the scientists showed that oxidative stress is the common trigger that ultimately ... Microbial or chemical lung pathogens trigger the oxidative stress machinery. Oxidation products are ...

Chloroplast f and m Thioredoxins Discovered in Nonphotosynthetic Tissues

... in redox regulation or in protection against oxidative damage. Other studies have shown that TRXs can ... species and can thus protect plants against oxidative damage. Sahrawy and her team are now ... plants and in helping to protect plants against oxidative damage under stress conditions. ...

Vitamin E trials 'fatally flawed'

... levels of this micronutrient necessary to reduce oxidative stress are far higher than those that have been ... that the levels of vitamin E necessary to reduce oxidative stress as measured by accepted biomarkers of ... supposedly addressed the hypothesis that reducing oxidative stress could reduce cardiovascular disease. ...

Boston College profs study oxidative stress subcellular to discover its role in diseases

... CHESTNUT HILL, MA (9-14-07) oxidative stress is known to underlie many human diseases ... found a means to discover more about what role oxidative stress plays in the development of diseases by ... level. Available information about the oxidative stress response has come primarily from studies ...

Antioxidant overload may underlie a heritable human disease

... plenty of evidence about the damaging effects of oxidative stress, but there is another side to the coin, ... sensitive to the prevailing redox condition. oxidative stress, which consumes reducing equivalents, has ... a test traditionally used to measure the level of oxidative stress in the animals, expecting they might see ...

Source of major health benefits in olive oil revealed

... hardening of the arteries. Red blood cells are particularly susceptible to oxidative damage because they are the body's oxygen carriers. In the study, ... of four related polyphenolic compounds on red blood cells subjected to oxidative stress by a known free radical generating chemical. DHPEA-EDA was the ...

CSHL researchers identify gene that helps plant cells keep communication channels open

... the production and accumulation of callose decreased. GAT1 counters oxidative stress One of the distress signals that spur cells to synthesize ... death, and gene expression. In addition to protecting plants against oxidative damage, as the CSHL scientists have shown, thioredoxin-m3 and its cousins ...

Scientists unlock possible aging secret in genetically altered fruit fly

... Indy reduced mitochondrial reactive oxygen species production and oxidative damage," the piece includes a number of collaborators. Helfand served as ... that can alter metabolism in a way that reduces free-radical or oxidative damage and extends life span, without some of the negative consequences ...

Real-time gene monitoring developed

... the hours before the death of a fly. The genes are known to respond to oxidative stress. Lead author John Tower, associate professor of molecular and ... at USC, speculated that the genes were reacting to a sharp increase in oxidative stress as the fly began dying of natural causes. "We're really ...

Traits produced by melanin may signal the bearer's capacity to combat free radicals

... could indicate the ability of the bearer in fighting free radicals and oxidative damage. On the basis of medical bibliography, the researchers realized ... able to express these signals should be also able to fight off an oxidative challenge, as a consequence of the low levels of the cited antioxidant. ...

COPD? Eat your veggies

... showed markedly decreased levels of NRF2-dependent antioxidants, increased oxidative stress markers, a significant decrease in NRF2 protein with no change in ... antioxidants may be a novel strategy for attenuating the effects of oxidative stress in the pathogenesis of COPD." While clinical trials to date of ...

Infection blocks lung's protective response against tobacco smoke

... into its protective, reduced form," said Dr. Day. "This resulted in severe oxidative stress and increased tissue damage as measured by oxidized DNA. "These higher levels of oxidative stress and damage are likely to predispose smokers with Mycoplasma ...

Substance in red wine found to keep hearts young

... the supplement's effects on memory, physical performance, inflammation and oxidative damage, according to Steve Anton, a principal investigator of the upcoming ... plants that keep a cell functioning, are especially vulnerable to the oxidative damage that accumulates during the aging process. "In animal studies, ...

Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring

... in the human body that indicate activation of disease mechanisms such as oxidative stress, inflammation and DNA damage; and 3) integrate sensor and biomarker ... Pacific Northwest Laboratory, Richland, Wash. Protein Biomarkers of oxidative Stress and Inflammation Associated with Tobacco Smoke and Obesity ...

Methane-eating microbes can use iron and manganese oxides to 'breathe'

... scarce. Without sulfates, iron and manganese oxides may have been essential in converting methane to carbon dioxide. "Sulfate comes mostly from oxidative weathering of rocks," said Beal. "Oxygen is needed for this to occur." While manganese and iron oxides are made in today's oxygen atmosphere, they ...

Genetically engineered mice yield clues to 'knocking out' cancer

... several disease states. In humans, DNA repair genes produce enzymes called DNA glycosylases that excise sections of DNA strands already modified by oxidative stress, and thus protect the genetic material. One of these repair genes, neil1, was identified and characterized in 2002 by Sankar Mitra and his ...

Will IVF work for a particular patient? The answer may be found in her blood

... this expression were concerned with angiogenesis (the growth of new blood vessels), endothelin signalling (blood vessel constriction), inflammation, oxidative stress (damage to cell structures), vascular endothelial growth factor (signalling processes in blood vessel growth), and pyruvate metabolism (the ...

A young brain for an old bee

... revert to nursing behaviour and their brains become 'young' again. We thus hope to study the mechanisms responsible for age-dependent effects, like oxidative damage, and also to discover new ways to act against these aging processes." ...

Super-sleepers could help super-sizers!

... kingdom? The researchers speculate that a potential drawback may be the increased production of reactive oxygen species, which may in turn lead to oxidative stress. Since these small molecules are believed to cause most of the damage during periods of re-awakening, increasing mitochondrial coupling does ...

'Shock and kill' research gives new hope for HIV-1 eradication

... the 'awakening' of a portion of cells within a latently infected cell population. The researchers then repeated the experiment adding a drug inducing oxidative stress, buthionine sulfoximine (BSO). The results showed that BSO recruited cells non-responsive to the HDAC inhibitors into the responding cell ...

Studies shed light on collapse of coral reefs

... reefs are still huge, and increasing. They are being pressured by changes in ocean temperature, pollution, overfishing, sedimentation, acidification, oxidative stress and disease, and the synergistic effect of some of these problems may destroy reefs even when one cause by itself would not. Some estimates ...

Adult bone marrow stem cells injected into skeletal muscle can repair heart tissue

... tissue injury, inhibiting fibrosis, promoting angiogenesis, stimulating recruitment and proliferation of tissue stem cells, and reducing inflammatory oxidative stress, a common cause of cardiovascular disease and heart failure. "Since skeletal muscle is the most abundant tissue in the body and can ...

Risk of vibration-induced vascular injuries linked to vibration frequency differences

... directly related to the effects of vibration. The rats that experienced high frequency (125 and 250 Hz) vibration had higher levels of measures of oxidative stress, while rats that experienced the lower frequency (65 Hz) vibration showed higher levels of pro-inflammatory factors. The changes seen ...

Gutsy germs succumb to baby broccoli

... broccoli-sprout smoothies for eight weeks, there was up to a fourfold increase in the activity of two of these key enzymes that protect cells against oxidative damage. In addition, the number of Helicobacter bacteria in the mice's stomachs decreased by almost a hundredfold it did not change in infected ...