Osteoarthritis in Biological News

Study suggests genetic connection between short stature and arthritis

... both extremes of height may be associated with osteoarthritis for different reasons. Shorter bones and/or less ... this case the gene we picked also is important in osteoarthritis and it's actually quite hard to find genes for ... recently have been tied to susceptibility to osteoarthritis of the hip and knees in Asian and European ...

Researchers uncover new piece to the puzzle of human height

... that common genetic variants recently linked to osteoarthritis may also play a minor role in human height. The ... recently have been tied to susceptibility to osteoarthritis of the hip and knees in Asian and European ... in human height may provide new insights into osteoarthritis and other musculoskeletal diseases. ...

Listen-up ladies: Don't postpone knee-replacement surgery

... males in the group. The women afflicted with osteoarthritis were at a much more advanced stage than the men ... are just trying to follow doctor's orders. osteoarthritis of the knee is the most common cause of ... braces in reducing pain and improving function in osteoarthritis patients. The research, which also was ...

Engineering innovative solutions for 21st century medicine

... each year as a result of osteoarthritis. Better techniques to diagnose osteoarthritis combined with more tailored interventions could mean a choice of earlier ... of the disease will also lead to new technologies to diagnose and treat osteoarthritis at a much earlier stage." KCL Medical Imaging: 10m Professor Reza ...

Exercise after knee replacement critical

... your quadriceps after you've had knee replacement surgery due to osteoarthritis is critical to your recovery. In fact, it can boost the function of your ... quality of life. While knee replacement alleviates the pain of osteoarthritis and improves function, patients exhibit impaired quadriceps strength and ...

Stem cells offer cartilage repair hope for arthritis sufferers

... even been able to identify the cells in people over 75 years of age. osteoarthritis affects over 2M people in the UK and occurs when changes in the make up of ... used to treat cartilage lesions due to trauma but also mark the onset of osteoarthritis Lead researcher Professor Charlie Archer from the Cardiff School of ...

Identification of genetic variants affecting age at menopause could help improve fertility treatment

... In addition to its effect on fertility, earlier menopause has other deleterious effects on women such as an increased risk for osteoporosis, osteoarthritis and cardiovascular disease, while it has a protective effect on the risk of breast cancer. The age of menopause varies greatly among Caucasian ...

Meet-the-expert sessions on 20 key topics to enhance scientific programme of IOFWCO-ECCEO10

... The International Osteoporosis Foundation (IOF) and the European Society for Clinical and Economic Aspects of Osteoporosis and osteoarthritis (ESCEO) will hold a joint global congress, IOF WCO- ECCEO10, in Florence, Italy from May 5-8, 2010. Complete programme information, online ...

World Congress on Osteoporosis 2010 presents outstanding scientific program

... The International Osteoporosis Foundation (IOF) and the European Society for Clinical and Economic Aspects of Osteoporosis and osteoarthritis (ESCEO) have joined forces to present an outstanding scientific programme for the upcoming IOF WCO- ECCEO10, a global congress to be held in ...

New orthopaedic society launched to promote research, use of biologic treatments

... and disseminate this important information to the orthopaedic community at large." Members' research interests include stem cell therapy for osteoarthritis and other musculoskeletal conditions; platelet-rich plasma injections for chronic tendonitis, disc regeneration, and accelerated healing; molecular ...

Exercise no danger for joints

... lower extremities. Researchers from Boston, USA, and Ainring, Germany, reviewed existing studies on the relationship between regular exercise and osteoarthritis (OA) and concluded that in the absence of existing joint injury there is no increased risk of OA from exercise. "We found that in elite athletes ...

Adult stem cell breakthrough

... Birchall's lab at the University of Bristol, and matured into cartilage cells (chondrocytes) using an adapted method originally devised for treating osteoarthritis by Professor Anthony Hollander at the University of Bristol. The donor trachea was then seeded with chondrocytes on the outside, using a novel ...

Scientists discover why a mother's high-fat diet contributes to obesity in her children

... of children and youth in the United States are obese. Obesity increases the risk of many diseases and health conditions, including: hypertension, osteoarthritis (breakdown of cartilage and its underlying bone in a joint), dyslipidemia (high total cholesterol, high levels of triglycerides), type 2 diabetes, ...

A tall story: New research adds to growing body of knowledge of genetics of height

... our height. This provides scientists with a fascinating insight into how the body grows and develops normally and may shed light on diseases such as osteoarthritis and cancer. Unlike a number of other body size characteristics such as obesity, which is caused by a mix of genetic and environmental factors (so ...

Osteoarthritis risk linked to finger length ratio

... and higher sperm counts. Reduction in this ratio has also been linked to athletic and sexual prowess. Whether this trait affects the risk of osteoarthritis (OA), the most common form of arthritis that may associate with both physical activity and oestrogen deficiency, has not been examined until now. ...

Natural product discovery by Cleveland medical researchers blocks tissue destruction

... Amazon rainforest. The discoverys unique actions suggest a broad set of applications in various joint, skin and gastrointestinal diseases, including osteoarthritis and irritable bowel syndrome. The publication revealed that Progrado, an extract from a rainforest tree called Croton palanostigma, was a ...

Osteoarthritis may be sign of faster 'biological ageing'

... taken of all participants to check for signs of osteoarthritis and a blood sample was taken to assess ... such as tobacco, alcohol, and sunlight. osteoarthritis is the most common form of arthritis, with the ... age, sex, and smoking. All those with hand osteoarthritis were over 50, and the amount of telomere ...

New engineered drug may offer prolonged arthritis relief

... Fund-Merck graduate dissertation fellowship. osteoarthritis is a degenerative joint disease that affects an ... population continues to rise, the incidence of osteoarthritis will increase. osteoarthritis had been attributed primarily to the gradual wear ...

Bioengineered tissue implants regenerate damaged knee cartilage

... be effectively repaired by tissue engineering and osteoarthritis does not stop the regeneration process concludes ... in some patients with pre-existing early osteoarthritis of the knee secondary to traumatic injury. ... many cartilage injuries will progress to osteoarthritis and the need for eventual replacement of the ...

Matrilin-3 gene discovered to prevent onset of osteoarthritis

... A gene that is associated with osteoarthritis and skeletal deformities in people has been shown to be responsible for preventing the onset of osteoarthritis in adult mice, according to a recent study led by ... bone mineral density in adulthood and prevents osteoarthritis later in life. Mutations in matrilin-3 have ...

Obese people are more sensitive to pain, suggests study

... of the older adults who completed the study had osteoarthritis of the knee, a disease that causes inflammation ... relaxation techniques would help people with osteoarthritis to better cope with the pain that the disease can cause. Also called degenerative joint disease, osteoarthritis affects more than 20 million people in the United ...

Cartilage discovery offers arthritis hope

... in what they hope will provide clues to how the crippling joint disease osteoarthritis might one day be treated. The disease, which affects more than five ... some basic scientific facts that could prove useful in future studies on osteoarthritis and related conditions." The next stage of the team's work will be to ...

Experimental gene therapy 'abolishes' arthritis pain and lessens joint damage

... study published today in the journal Arthritis and Rheumatism. While the study was done in mice, they are the first genetically engineered to develop osteoarthritis like humans, with the same genetic predisposition that makes some more likely to develop the disease, the authors said. If all goes well with a ...

Gene therapy research switches off joint inflammation; switches on genetic process of joint repair

... The double blind randomized controlled clinical trial will assess a variety of pain, mobility and functional assessments in subjects with moderate osteoarthritis of the knee. Prior to this clinical investigation Reparagen was found to be the first natural product to "silence" genes that promote joint damage ...

New genes implicated in rheumatoid arthritis

... tissues. In addition, they compared gene expression in synovial tissue of the RA patients with gene expression in synovial tissue of patients with osteoarthritis (OA). Between the disease-discordant twins, minor yet ...

Results of world's first gene therapy trial for arthritis show approach safe, feasible

... good safety profile and, in animals, facilitates more extended gene expression. The investigators hope to conduct additional clinical trials in both osteoarthritis and rheumatoid arthritis using AAV to transport the gene. In addition to Drs. Evans and Robbins, other authors are James H. Herndon, M.D., also ...

Arthritis: What Wnt wrong?

... Shinshu University School of Medicine, examined joint tissue from patients who underwent total knee replacement for rheumatoid arthritis (RA), osteoarthritis (OA), or non-arthritic injury. Using several molecular methods, Wakitani's group identified Wnt-7b and -10a as genes that were significantly ...