osteoarthritis

Arthritis: What Wnt wrong?

...al knee replacement for rheumatoid arthritis (RA), osteoarthritis (OA), or non-arthritic injury. Using several molecular methods, Wakitani's group identified Wnt-7b and -10a as genes that were significantly upregulated in the arthritic knee tissues. However, protein expression studies revealed that only Wnt-7b was...

Results of world's first gene therapy trial for arthritis show approach safe, feasible

...hope to conduct additional clinical trials in both osteoarthritis and rheumatoid arthritis using AAV to transport the gene. In addition to Drs. Evans and Robbins, other authors are James H. Herndon, M.D., also now at Harvard; Steven C. Ghivizzani, Ph.D., now at the University of Florida; Mary Chester Wasko, M.D., ...

Obese people are more sensitive to pain, suggests study

...ll of the older adults who completed the study had osteoarthritis of the knee, a disease that causes inflammation an...ssive relaxation techniques would help people with osteoarthritis to better cope with the pain that the disease can cause. Also called degenerative joint disease, ost...

New genes implicated in rheumatoid arthritis

...ene expression in synovial tissue of patients with osteoarthritis (OA). Between the disease-discordant twins, minor yet measurable differences were detected in the expression of 1,163 transcripts, representing 827 uniquely name...

Matrilin-3 gene discovered to prevent onset of osteoarthritis

A gene that is associated with osteoarthritis and skeletal deformities in people has been shown to be responsible for preventing the onset of osteoarthritis in adult mice, according to a recent study led by Rhode Island Hospital. The matrilin-3 gene plays a...

Bioengineered tissue implants regenerate damaged knee cartilage

... be effectively repaired by tissue engineering and osteoarthritis does not stop the regeneration process concludes r...including in some patients with pre-existing early osteoarthritis of the knee secondary to traumatic injury. Maturation of the implanted, tissue-engineered cartilage...

Gene therapy research switches off joint inflammation; switches on genetic process of joint repair

...d functional assessments in subjects with moderate osteoarthritis of the knee. Prior to this clinical investigation Reparagen was found to be the first natural product to "silence" genes that promote joint damage while simultaneously activating the repair gene, IGF-1, in human chondrocytes.2 The clinical study b...

New engineered drug may offer prolonged arthritis relief

...the population continues to rise, the incidence of osteoarthritis will increase. Osteoarthritis had been attribute...enter, for focusing on IL-1 as a major mediator of osteoarthritis in the joint. Given the immune system's suspected role in osteoarthritis, scientists have suspecte...

Osteoarthritis may be sign of faster 'biological ageing'

...re taken of all participants to check for signs of osteoarthritis and a blood sample was taken to assess "biological...sity, age, sex, and smoking. All those with hand osteoarthritis were over 50, and the amount of telomere shortening was equivalent to that accrued over 11 years in ...

Cartilage discovery offers arthritis hope

...l provide clues to how the crippling joint disease osteoarthritis might one day be treated. The disease, which affe...facts that could prove useful in future studies on osteoarthritis and related conditions." The next stage of the team's work will be to determine the structure of t...

Experimental gene therapy 'abolishes' arthritis pain and lessens joint damage

...ey are the first genetically engineered to develop osteoarthritis like humans, with the same genetic predisposition that makes some more likely to develop the disease, the authors said. If all goes well with a follow-up study currently underway, researchers will apply to the U.S. Food and Drug Administration for pe...