Nucleoside in Biological News

American Chemical Society's Weekly PressPac -- Sept. 3, 2008

... strategies to date involves the use of so-called nucleoside analogues, artificial pieces of DNA that inhibit ... by substituting for natural segments. Most nucleoside analogues directly target the active site of the ... preliminary lab studies, could lead to improved nucleoside analogues with fewer side effects, he says. ...

Nobel Laureate finds 'elegant' explanation for DNA transcribing enzyme's high fidelity

... of the process. The researchers found that a portion of the enzyme known as the trigger loop acts like a “trap door,?swinging beneath a matching nucleoside triphosphate (NTP) building block, to close off the active center and form an extensive network of interactions with the NTP and other parts of the ...

Major WHO study concludes calcium supplements can reduce complications during pregnancy

... term, highly active antiretroviral therapy, or HAART therapy. Current HAART regimens generally include three antiretroviral drugs, usually two nucleoside analogs and either a protease inhibitor or a non-nucleoside reverse-transcriptase inhibitor. This drug regimen has, in some cases, been effective in ...

Computer simulation hints at new HIV drug target

... term, highly active antiretroviral therapy, or HAART therapy. Current HAART regimens generally include three antiretroviral drugs, usually two nucleoside analogs and either a protease inhibitor or a non-nucleoside reverse-transcriptase inhibitor. This drug regimen has, in some cases, been effective in ...

Viral 'fitness' explains different resistance patterns to aids drugs

... either one NNRTI or protease inhibitor (non-boosted or boosted with a small amount of another potent PI) and two different antiretrovirals from the nucleoside reverse transcriptase inhibitor class. ...

Hepatitis C responds best to combo of ribavirin and interferon, study concludes

... virus cells and inhibiting the ability of viruses to make new copies of themselves and proliferate. Ribavirin belongs to a class of drugs called nucleoside analogues, which includes some anti-HIV drugs such as AZT (zidovudine). Ribavirin used alone does not have any effect on HCV but in combination with ...

High fidelity keeps human DNA assembly line humming

... is made. Burton explains that it is similar to an industrial assembly line, with DNA being a conveyer belt to load building blocks, or bases, called nucleoside triphosphates (NTPs) to hook up with a growing strand of RNA. Burton's insight was to discover that the NTP bases preload to the DNA template ...