nucleoside

High fidelity keeps human DNA assembly line humming

...yer belt to load building blocks, or bases, called nucleoside triphosphates (NTPs) to hook up with a growing strand of RNA. Burton's insight was to discover that the NTP bases preload to the DNA template several steps before they are added to the growing RNA chain. This idea contradicts the prevalent view of ...

Hepatitis C responds best to combo of ribavirin and interferon, study concludes

...ate. Ribavirin belongs to a class of drugs called nucleoside analogues, which includes some anti-HIV drugs such as AZT (zidovudine). Ribavirin used alone does not have any effect on HCV but in combination with interferon it appears to boost the immune system and help slow virus replication. The researchers we...

Viral 'fitness' explains different resistance patterns to aids drugs

...ent PI) and two different antiretrovirals from the nucleoside reverse transcriptase inhibitor class. ...

Computer simulation hints at new HIV drug target

...ly include three antiretroviral drugs, usually two nucleoside analogs and either a protease inhibitor or a non-nucleoside reverse-transcriptase inhibitor. This drug regimen has, in some cases, been effective in controlling the progression of disease and prolonging survival. It has succeeded where other therapie...

Major WHO study concludes calcium supplements can reduce complications during pregnancy

...ly include three antiretroviral drugs, usually two nucleoside analogs and either a protease inhibitor or a non-nucleoside reverse-transcriptase inhibitor. This drug regimen has, in some cases, been effective in controlling the progression of disease and prolonging survival. It has succeeded where other therapie...

Nobel Laureate finds 'elegant' explanation for DNA transcribing enzyme's high fidelity

...cts like a “trap door,?swinging beneath a matching nucleoside triphosphate (NTP) building block, to close off the active center and form an extensive network of interactions with the NTP and other parts of the enzyme. Those interactions leave another side chain in the trigger loop precisely positioned, such tha...